Hyperinsulinemia as an independent risk factor for ischemic heart disease

New England Journal of Medicine

Volumn 334, Issue 15, 1996, Pages 952-957

  Després, Jean Pierre ^a   Lamarche, Benoît ^a   Mauriège, Pascale ^a   Cantin, Bernard ^a   Dagenais, Gilles R ^b   Moorjani, Sital ^a   Lupien, Paul J ^a  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; CORONARY RISK; HUMAN; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; ISCHEMIC HEART DISEASE; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; STATISTICAL ANALYSIS;

AGED; APOLIPOPROTEINS B; CASE-CONTROL STUDIES; CHOLESTEROL; COHORT STUDIES; HUMANS; INSULIN; LOGISTIC MODELS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; ODDS RATIO; RISK FACTORS; TRIGLYCERIDES;

EID: 0029862973     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199604113341504     Document Type: Article

References (33)

1. Reaven GM Role of insulin resistance in human disease. Diabetes 1988,37: 1595-607.
2. Laws A, Reaven GM. Evidence for an independent relationship between insulin resistance and fasting plasma HDL-cholesterol, triglyceride and instilin concentrations. J Intern Med 1992;231:25-30.
3. Pyöralä K Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care 1979;2:131-41.
4. Welborn TA, Wearne K. Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations. Diabetes Care 1979;2:154-60
5. Eschwège E, Richard JL, Thibult N, et al Coronary heart disease mortality in relation with diabetes, blood glucose and plasma insulin levels' the Paris Prospective Study, ten years later Horm Metab Res Suppl 1985;15:41-6
6. Yarnell JWG, Sweetnam PM, Marks V, Teale JD, Bolton CH. Insulin in ischaemic heart disease: are associations explained by triglyceride concentrations? The Caerphilly prospective study. Br Heart J 1994;171.293-6
7. Wingard DL, Barrett-Connor EL, Ferrara A Is insulin really a heart disease risk factor? Diabetes Care 1995;18:1299-304.
8. Fontbonne A. Why can high insulin levels indicate a risk for coronary heart disease? Diabetologia 1994;37:953-5.
9. Fontbonne A, Eschwège E, Cambien F, et al. Hypertriglyceridacmia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes: results from the 11-year follow-up of the Paris Prospective Study. Diabetologia 1989;32:300-4
10. Fontbonne A, Charles MA, Thibult N, et al. Hyperinsulinaemia as a predictor of coronary heart disease mortality in a healthy population: the Paris Prospective Study, 15-year follow-up. Diabetologia 1991,34:356-61.
11. Dagenais GR, Robitaille NM, Lupien PJ, et al. First coronary heart disease event rates in relation to major risk factors: Québec Cardiovascular Study Can J Cardiol 1990;6:274-80.
12. Lamarche B, Després JP, Moorjani M, Cantin B, Dagenais GR, Lupien PJ. Prevalence of dyslipidemic phenotypes m ischemic heart disease (prospective results from the Québec Cardiovascular Study) Am J Cardiol 1995;75: 1189-95.
13. Castelli WP, Garrison RJ, Wilson PWF, Abbott RD, Kalousdian S, Kannel WB Incidence of coronary heart disease and lipoprotein cholesterol levels, the Framingham Study. JAMA 1986;256 2835-8.
14. Gillum RF, Fortmann SP, Prineas RJ, Kottke TE International diagnostic criteria for acute myocardial infarction and acute stroke. Am Heart J 1984; 108:150-8.
15. Marmot MG. Alcohol and coronary heart disease Int J Epidemiol 1984;13. 160-7.
16. Moorjani S, Dupont A, Labrie F, et al Increase in plasma high-density lipoprotein concentration following complete androgen blockage in men with prostatic carcinoma Metabolism 1987.36:244-50.
17. Albers JJ, Warnick GR, Wiebe D, et al. Multi-laboratory comparison of three heparin Mn2+ precipitation procedures for estimating cholesterol in high-density lipoprotein Clin Chem 1978;24:853-6.
18. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972,18:499-502,
19. Laurell CB, Electroimmuno assay. Scand J Clin Lab Med Suppl 1972;124: 21-37
20. Morgan CR, Lazarow A. Immunoassay of insulin: two antibody system plasma insulin levels in normal, subdiabetic and diabetic rats Diabetes 1963;12:115-26
21. Orchard TJ, Becker DJ, Bates M, Kuller LH, Drash AL. Plasma insulin and lipoprotein concentrations: an atherogenic association? Am J Epidemiol 1983,118:326-37.
22. Zavaroni I, Bonora E, Pagliara M, et al Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med 1989;320:702-6
23. Juhan-Vague I, Alessi MC, Vague P. Increased plasma plasminogen activator inhibitor 1 levels: a possible link between insulin resistance and atherothrombosis Diabetologia 1991,34:457-62.
24. Kaplan NM. The deadly quartet: upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med 1989;149.1514-20.
25. Després JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis 1990;10:497-511.
26. Després JP. Dyslipidaemia and obesity. Baillieres Clin Endocrinol Metab 1994;8.629-60.
27. Després JP, Nadeau A, Tremblay A, et al Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes 1989;38:304-9.
28. Després JP, Moorjani S, Perland M, et al. Adipose tissue distribution and plasma lipoprotein levels in obese women: importance of infra-abdominal fat Arteriosclerosis 1989;9:203-10.
29. Pouliot MC, Després JP, Nadeau A, et al. Visceral obesity in men: associations with glucose tolerance, plasma insulin and lipoprotein levels. Diabetes 1992;41:826-34.
30. Casassus P, Fontbonne A, Thibult N, et al. Upper-body fat distribution, a hyperinsulinemia-independent predictor of coronary heart disease mortality: the Paris Prospective Study. Arterioscler Thromb 1992;12:1387-92.
31. Bierman EL. Atherogenesis in diabetes. Arterioscler Thromb 1992;12:647-56.
32. Haffner SM, Mykkänen L, Stern MP, Valdez RA, Heisserman JA, Bowsher RR. Relationship of proinsulin and insulin to cardiovascular risk factors in nondiabetic subjects. Diabetes 1993;42:1297-302.
33. Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 1992;340:925-9.