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Volumn 27, Issue 5, 2014, Pages 699-720

MC1R, the cAMP pathway, and the response to solar UV: Extending the horizon beyond pigmentation

Author keywords

CAMP; MC1R variants; Melanocortin 1 receptor; Melanocytes; Melanoma; Ultraviolet radiation

Indexed keywords

CYCLIC AMP; LIGAND; MELANOCORTIN 1 RECEPTOR;

EID: 84907976862     PISSN: 17551471     EISSN: 1755148X     Source Type: Journal    
DOI: 10.1111/pcmr.12257     Document Type: Review
Times cited : (154)

References (255)
  • 2
    • 33845698356 scopus 로고    scopus 로고
    • Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity
    • Abdel-Malek, Z.A., Kadekaro, A.L., Kavanagh, R.J. et al. (2006). Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity. FASEB J. 20, 1561-1563.
    • (2006) FASEB J. , vol.20 , pp. 1561-1563
    • Abdel-Malek, Z.A.1    Kadekaro, A.L.2    Kavanagh, R.J.3
  • 6
    • 80955179986 scopus 로고    scopus 로고
    • Effect of MC1R variant allele status on MSH-ligand induction of dopachrome tautomerase in melanocytes co-cultured with keratinocytes
    • Ainger, S.A., Wong, S.S., Roberts, D.W., Leonard, J.H., and Sturm, R.A. (2011). Effect of MC1R variant allele status on MSH-ligand induction of dopachrome tautomerase in melanocytes co-cultured with keratinocytes. Exp. Dermatol. 20, 681-684.
    • (2011) Exp. Dermatol. , vol.20 , pp. 681-684
    • Ainger, S.A.1    Wong, S.S.2    Roberts, D.W.3    Leonard, J.H.4    Sturm, R.A.5
  • 7
    • 0037144311 scopus 로고    scopus 로고
    • Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R)
    • Aoki, H., and Moro, O. (2002). Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R). Life Sci. 71, 2171-2179.
    • (2002) Life Sci. , vol.71 , pp. 2171-2179
    • Aoki, H.1    Moro, O.2
  • 8
    • 84871286519 scopus 로고    scopus 로고
    • Restructuring G-protein- coupled receptor activation
    • Audet, M., and Bouvier, M. (2012). Restructuring G-protein- coupled receptor activation. Cell 151, 14-23.
    • (2012) Cell , vol.151 , pp. 14-23
    • Audet, M.1    Bouvier, M.2
  • 9
    • 0036936818 scopus 로고    scopus 로고
    • Agonist activated adrenocorticotropin receptor internalizes via a clathrin-mediated G protein receptor kinase dependent mechanism
    • Baig, A.H., Swords, F.M., Szaszak, M., King, P.J., Hunyady, L., and Clark, A.J. (2002). Agonist activated adrenocorticotropin receptor internalizes via a clathrin-mediated G protein receptor kinase dependent mechanism. Endocr. Res. 28, 281-289.
    • (2002) Endocr. Res. , vol.28 , pp. 281-289
    • Baig, A.H.1    Swords, F.M.2    Szaszak, M.3    King, P.J.4    Hunyady, L.5    Clark, A.J.6
  • 10
    • 0020713174 scopus 로고
    • Structural requirements of N-glycosylation of proteins. Studies with proline peptides as conformational probes
    • Bause, E. (1983). Structural requirements of N-glycosylation of proteins. Studies with proline peptides as conformational probes. Biochem. J. 209, 331-336.
    • (1983) Biochem. J. , vol.209 , pp. 331-336
    • Bause, E.1
  • 11
    • 26444449038 scopus 로고    scopus 로고
    • Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk
    • Beaumont, K.A., Newton, R.A., Smit, D.J., Leonard, J.H., Stow, J.L., and Sturm, R.A. (2005). Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk. Hum. Mol. Genet. 14, 2145-2154.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 2145-2154
    • Beaumont, K.A.1    Newton, R.A.2    Smit, D.J.3    Leonard, J.H.4    Stow, J.L.5    Sturm, R.A.6
  • 12
  • 13
    • 79955930958 scopus 로고    scopus 로고
    • Melanocortin MC(1) receptor in human genetics and model systems
    • Beaumont, K.A., Wong, S.S., Ainger, S.A. et al. (2011). Melanocortin MC(1) receptor in human genetics and model systems. Eur. J. Pharmacol. 660, 103-110.
    • (2011) Eur. J. Pharmacol. , vol.660 , pp. 103-110
    • Beaumont, K.A.1    Wong, S.S.2    Ainger, S.A.3
  • 15
    • 77951214780 scopus 로고    scopus 로고
    • p38 regulates pigmentation via proteasomal degradation of tyrosinase
    • Bellei, B., Maresca, V., Flori, E., Pitisci, A., Larue, L., and Picardo, M. (2010). p38 regulates pigmentation via proteasomal degradation of tyrosinase. J. Biol. Chem. 285, 7288-7299.
    • (2010) J. Biol. Chem. , vol.285 , pp. 7288-7299
    • Bellei, B.1    Maresca, V.2    Flori, E.3    Pitisci, A.4    Larue, L.5    Picardo, M.6
  • 16
    • 84858143046 scopus 로고    scopus 로고
    • Inhibition of melanogenesis by the pyridinyl imidazole class of compounds: possible involvement of the Wnt/beta-catenin signaling pathway
    • Bellei, B., Pitisci, A., Izzo, E., and Picardo, M. (2012). Inhibition of melanogenesis by the pyridinyl imidazole class of compounds: possible involvement of the Wnt/beta-catenin signaling pathway. PLoS ONE 7, e33021.
    • (2012) PLoS ONE , vol.7 , pp. e33021
    • Bellei, B.1    Pitisci, A.2    Izzo, E.3    Picardo, M.4
  • 17
    • 80052743080 scopus 로고    scopus 로고
    • The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling
    • Benned-Jensen, T., Mokrosinski, J., and Rosenkilde, M.M. (2011). The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling. PLoS ONE 6, e24644.
    • (2011) PLoS ONE , vol.6 , pp. e24644
    • Benned-Jensen, T.1    Mokrosinski, J.2    Rosenkilde, M.M.3
  • 18
    • 0031828003 scopus 로고    scopus 로고
    • Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes
    • Bertolotto, C., Abbe, P., Hemesath, T.J., Bille, K., Fisher, D.E., Ortonne, J.P., and Ballotti, R. (1998). Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes. J. Cell Biol. 142, 827-835.
    • (1998) J. Cell Biol. , vol.142 , pp. 827-835
    • Bertolotto, C.1    Abbe, P.2    Hemesath, T.J.3    Bille, K.4    Fisher, D.E.5    Ortonne, J.P.6    Ballotti, R.7
  • 19
    • 45549087818 scopus 로고    scopus 로고
    • The tissue-specific processing of pro-opiomelanocortin
    • Bicknell, A.B. (2008). The tissue-specific processing of pro-opiomelanocortin. J. Neuroendocrinol. 20, 692-699.
    • (2008) J. Neuroendocrinol. , vol.20 , pp. 692-699
    • Bicknell, A.B.1
  • 20
    • 0344412889 scopus 로고    scopus 로고
    • Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization
    • Biebermann, H., Krude, H., Elsner, A., Chubanov, V., Gudermann, T., and Gruters, A. (2003). Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization. Diabetes 52, 2984-2988.
    • (2003) Diabetes , vol.52 , pp. 2984-2988
    • Biebermann, H.1    Krude, H.2    Elsner, A.3    Chubanov, V.4    Gudermann, T.5    Gruters, A.6
  • 22
    • 14044260140 scopus 로고    scopus 로고
    • alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage
    • Bohm, M., Wolff, I., Scholzen, T.E., Robinson, S.J., Healy, E., Luger, T.A., Schwarz, T., and Schwarz, A. (2005). alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage. J. Biol. Chem. 280, 5795-5802.
    • (2005) J. Biol. Chem. , vol.280 , pp. 5795-5802
    • Bohm, M.1    Wolff, I.2    Scholzen, T.E.3    Robinson, S.J.4    Healy, E.5    Luger, T.A.6    Schwarz, T.7    Schwarz, A.8
  • 23
    • 33747331352 scopus 로고    scopus 로고
    • Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology
    • Bohm, M., Luger, T.A., Tobin, D.J., and Garcia-Borron, J.C. (2006). Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. J. Invest Dermatol. 126, 1966-1975.
    • (2006) J. Invest Dermatol. , vol.126 , pp. 1966-1975
    • Bohm, M.1    Luger, T.A.2    Tobin, D.J.3    Garcia-Borron, J.C.4
  • 24
    • 0024366776 scopus 로고
    • UVB-induced melanogenesis may be mediated through the MSH-receptor system
    • Bolognia, J., Murray, M., and Pawelek, J. (1989). UVB-induced melanogenesis may be mediated through the MSH-receptor system. J. Invest Dermatol. 92, 651-656.
    • (1989) J. Invest Dermatol. , vol.92 , pp. 651-656
    • Bolognia, J.1    Murray, M.2    Pawelek, J.3
  • 25
    • 20244369752 scopus 로고    scopus 로고
    • The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans
    • Bonilla, C., Boxill, L.A., Donald, S.A. et al. (2005). The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans. Hum. Genet. 116, 402-406.
    • (2005) Hum. Genet. , vol.116 , pp. 402-406
    • Bonilla, C.1    Boxill, L.A.2    Donald, S.A.3
  • 26
    • 0030782275 scopus 로고    scopus 로고
    • Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair
    • Box, N.F., Wyeth, J.R., O'Gorman, L.E., Martin, N.G., and Sturm, R.A. (1997). Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. Hum. Mol. Genet. 6, 1891-1897.
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 1891-1897
    • Box, N.F.1    Wyeth, J.R.2    O'Gorman, L.E.3    Martin, N.G.4    Sturm, R.A.5
  • 28
    • 33845972656 scopus 로고    scopus 로고
    • The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors
    • Breit, A., Wolff, K., Kalwa, H., Jarry, H., Buch, T., and Gudermann, T. (2006). The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors. J. Biol. Chem. 281, 37447-37456.
    • (2006) J. Biol. Chem. , vol.281 , pp. 37447-37456
    • Breit, A.1    Wolff, K.2    Kalwa, H.3    Jarry, H.4    Buch, T.5    Gudermann, T.6
  • 29
    • 42549140099 scopus 로고    scopus 로고
    • The protective role of melanin against UV damage in human skin
    • Brenner, M., and Hearing, V.J. (2008). The protective role of melanin against UV damage in human skin. Photochem. Photobiol. 84, 539-549.
    • (2008) Photochem. Photobiol. , vol.84 , pp. 539-549
    • Brenner, M.1    Hearing, V.J.2
  • 30
    • 0034127724 scopus 로고    scopus 로고
    • Cyclic AMP a key messenger in the regulation of skin pigmentation
    • Busca, R., and Ballotti, R. (2000). Cyclic AMP a key messenger in the regulation of skin pigmentation. Pigment Cell Res. 13, 60-69.
    • (2000) Pigment Cell Res. , vol.13 , pp. 60-69
    • Busca, R.1    Ballotti, R.2
  • 31
    • 0034659736 scopus 로고    scopus 로고
    • Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes
    • Busca, R., Abbe, P., Mantoux, F., Aberdam, E., Peyssonnaux, C., Eychene, A., Ortonne, J.P., and Ballotti, R. (2000). Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes. EMBO J. 19, 2900-2910.
    • (2000) EMBO J. , vol.19 , pp. 2900-2910
    • Busca, R.1    Abbe, P.2    Mantoux, F.3    Aberdam, E.4    Peyssonnaux, C.5    Eychene, A.6    Ortonne, J.P.7    Ballotti, R.8
  • 32
    • 36749008499 scopus 로고    scopus 로고
    • A -defensin mutation causes black coat color in domestic dogs
    • Candille, S.I., Kaelin, C.B., Cattanach, B.M. et al. (2007). A -defensin mutation causes black coat color in domestic dogs. Science 318, 1418-1423.
    • (2007) Science , vol.318 , pp. 1418-1423
    • Candille, S.I.1    Kaelin, C.B.2    Cattanach, B.M.3
  • 33
    • 84882657764 scopus 로고    scopus 로고
    • MC1R is a potent regulator of PTEN after UV exposure in melanocytes
    • Cao, J., Wan, L., Hacker, E. et al. (2013). MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Mol. Cell 51, 409-422.
    • (2013) Mol. Cell , vol.51 , pp. 409-422
    • Cao, J.1    Wan, L.2    Hacker, E.3
  • 36
    • 10744221862 scopus 로고    scopus 로고
    • Inverse agonist activity of agouti and agouti-related protein
    • Chai, B.X., Neubig, R.R., Millhauser, G.L. et al. (2003). Inverse agonist activity of agouti and agouti-related protein. Peptides 24, 603-609.
    • (2003) Peptides , vol.24 , pp. 603-609
    • Chai, B.X.1    Neubig, R.R.2    Millhauser, G.L.3
  • 37
    • 0025758173 scopus 로고
    • Structural/functional relationships between internal and external MSH receptors: modulation of expression in Cloudman melanoma cells by UVB radiation
    • Chakraborty, A.K., Orlow, S.J., Bolognia, J.L., and Pawelek, J.M. (1991). Structural/functional relationships between internal and external MSH receptors: modulation of expression in Cloudman melanoma cells by UVB radiation. J. Cell. Physiol. 147, 1-6.
    • (1991) J. Cell. Physiol. , vol.147 , pp. 1-6
    • Chakraborty, A.K.1    Orlow, S.J.2    Bolognia, J.L.3    Pawelek, J.M.4
  • 38
    • 0001466640 scopus 로고    scopus 로고
    • Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B
    • Chakraborty, A.K., Funasaka, Y., Slominski, A., Ermak, G., Hwang, J., Pawelek, J.M., and Ichihashi, M. (1996). Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B. Biochim. Biophys. Acta 1313, 130-138.
    • (1996) Biochim. Biophys. Acta , vol.1313 , pp. 130-138
    • Chakraborty, A.K.1    Funasaka, Y.2    Slominski, A.3    Ermak, G.4    Hwang, J.5    Pawelek, J.M.6    Ichihashi, M.7
  • 39
    • 0029762318 scopus 로고    scopus 로고
    • Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA (FEBS 11553)
    • Chhajlani, V., and Wikberg, J.E. (1996). Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA (FEBS 11553). FEBS Lett. 390, 238.
    • (1996) FEBS Lett. , vol.390 , pp. 238
    • Chhajlani, V.1    Wikberg, J.E.2
  • 40
    • 0029831484 scopus 로고    scopus 로고
    • Induction of constitutive melanogenesis in amelanotic mouse melanoma cells by transfection of the human melanocortin-1 receptor gene
    • Chluba-de, T.J., Bagutti, C., Cotti, R., and Eberle, A.N. (1996). Induction of constitutive melanogenesis in amelanotic mouse melanoma cells by transfection of the human melanocortin-1 receptor gene. J. Cell Sci. 109(Pt 8), 2023-2030.
    • (1996) J. Cell Sci. , vol.109 , pp. 2023-2030
    • Chluba-de, T.J.1    Bagutti, C.2    Cotti, R.3    Eberle, A.N.4
  • 41
    • 0034739827 scopus 로고    scopus 로고
    • Multi-facet expressions of adenylate cyclase isoforms in B16-F10 melanoma cells differentiated by forskolin treatment
    • Cho, D.H., Bae, C.D., and Juhnn, Y.S. (2000). Multi-facet expressions of adenylate cyclase isoforms in B16-F10 melanoma cells differentiated by forskolin treatment. Exp. Mol. Med. 32, 235-242.
    • (2000) Exp. Mol. Med. , vol.32 , pp. 235-242
    • Cho, D.H.1    Bae, C.D.2    Juhnn, Y.S.3
  • 42
    • 34447265905 scopus 로고    scopus 로고
    • Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling
    • Conti, M., and Beavo, J. (2007). Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu. Rev. Biochem. 76, 481-511.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 481-511
    • Conti, M.1    Beavo, J.2
  • 43
    • 0242468744 scopus 로고    scopus 로고
    • Regulation and organization of adenylyl cyclases and cAMP
    • Cooper, D.M. (2003). Regulation and organization of adenylyl cyclases and cAMP. Biochem. J. 375, 517-529.
    • (2003) Biochem. J. , vol.375 , pp. 517-529
    • Cooper, D.M.1
  • 44
    • 10944271997 scopus 로고    scopus 로고
    • UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1)
    • Corre, S., Primot, A., Sviderskaya, E., Bennett, D.C., Vaulont, S., Goding, C.R., and Galibert, M.D. (2004). UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1). J. Biol. Chem. 279, 51226-51233.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51226-51233
    • Corre, S.1    Primot, A.2    Sviderskaya, E.3    Bennett, D.C.4    Vaulont, S.5    Goding, C.R.6    Galibert, M.D.7
  • 46
    • 67650550793 scopus 로고    scopus 로고
    • Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation
    • Corre, S., Primot, A., Baron, Y., Le, S.J., Goding, C., and Galibert, M.D. (2009). Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation. J. Biol. Chem. 284, 18851-18862.
    • (2009) J. Biol. Chem. , vol.284 , pp. 18851-18862
    • Corre, S.1    Primot, A.2    Baron, Y.3    Le, S.J.4    Goding, C.5    Galibert, M.D.6
  • 47
    • 33847422145 scopus 로고    scopus 로고
    • Central role of p53 in the suntan response and pathologic hyperpigmentation
    • Cui, R., Widlund, H.R., Feige, E. et al. (2007). Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell 128, 853-864.
    • (2007) Cell , vol.128 , pp. 853-864
    • Cui, R.1    Widlund, H.R.2    Feige, E.3
  • 48
    • 33847197910 scopus 로고    scopus 로고
    • Two G-rich regulatory elements located adjacent to and 440 nucleotides downstream of the core poly(A) site of the intronless melanocortin receptor 1 gene are critical for efficient 3′ end processing
    • Dalziel, M., Nunes, N.M., and Furger, A. (2007). Two G-rich regulatory elements located adjacent to and 440 nucleotides downstream of the core poly(A) site of the intronless melanocortin receptor 1 gene are critical for efficient 3′ end processing. Mol. Cell. Biol. 27, 1568-1580.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 1568-1580
    • Dalziel, M.1    Nunes, N.M.2    Furger, A.3
  • 50
    • 84865334617 scopus 로고    scopus 로고
    • Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study
    • Davies, J.R., Randerson-Moor, J., Kukalizch, K. et al. (2012). Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study. Pigment Cell Melanoma Res. 25, 384-394.
    • (2012) Pigment Cell Melanoma Res. , vol.25 , pp. 384-394
    • Davies, J.R.1    Randerson-Moor, J.2    Kukalizch, K.3
  • 51
    • 78650854802 scopus 로고    scopus 로고
    • Beta-arrestins as regulators of signal termination and transduction: how do they determine what to scaffold?
    • DeFea, K.A. (2011). Beta-arrestins as regulators of signal termination and transduction: how do they determine what to scaffold? Cell. Signal. 23, 621-629.
    • (2011) Cell. Signal. , vol.23 , pp. 621-629
    • DeFea, K.A.1
  • 52
    • 77958585653 scopus 로고    scopus 로고
    • Involvement of the melanocortin-1 receptor in acute pain and pain of inflammatory but not neuropathic origin
    • Delaney, A., Keighren, M., Fleetwood-Walker, S.M., and Jackson, I.J. (2010). Involvement of the melanocortin-1 receptor in acute pain and pain of inflammatory but not neuropathic origin. PLoS ONE 5, e12498.
    • (2010) PLoS ONE , vol.5 , pp. e12498
    • Delaney, A.1    Keighren, M.2    Fleetwood-Walker, S.M.3    Jackson, I.J.4
  • 53
    • 77958609747 scopus 로고    scopus 로고
    • Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study
    • Demenais, F., Mohamdi, H., Chaudru, V. et al. (2010). Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study. J. Natl Cancer Inst. 102, 1568-1583.
    • (2010) J. Natl Cancer Inst. , vol.102 , pp. 1568-1583
    • Demenais, F.1    Mohamdi, H.2    Chaudru, V.3
  • 54
    • 80052397478 scopus 로고    scopus 로고
    • Melanocortin 1 receptor variants: functional role and pigmentary associations
    • Dessinioti, C., Antoniou, C., Katsambas, A., and Stratigos, A.J. (2011). Melanocortin 1 receptor variants: functional role and pigmentary associations. Photochem. Photobiol. 87, 978-987.
    • (2011) Photochem. Photobiol. , vol.87 , pp. 978-987
    • Dessinioti, C.1    Antoniou, C.2    Katsambas, A.3    Stratigos, A.J.4
  • 56
    • 78650811543 scopus 로고    scopus 로고
    • Central role for cAMP signaling in pigmentation and UV resistance
    • D'Orazio, J., and Fisher, D.E. (2011). Central role for cAMP signaling in pigmentation and UV resistance. Cell Cycle 10, 8-9.
    • (2011) Cell Cycle , vol.10 , pp. 8-9
    • D'Orazio, J.1    Fisher, D.E.2
  • 57
    • 33748920021 scopus 로고    scopus 로고
    • Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning
    • D'Orazio, J.A., Nobuhisa, T., Cui, R. et al. (2006). Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature 443, 340-344.
    • (2006) Nature , vol.443 , pp. 340-344
    • D'Orazio, J.A.1    Nobuhisa, T.2    Cui, R.3
  • 58
    • 84864131402 scopus 로고    scopus 로고
    • Selected melanocortin 1 receptor single-nucleotide polymorphisms differentially alter multiple signaling pathways
    • Doyle, J.R., Fortin, J.P., Beinborn, M., and Kopin, A.S. (2012). Selected melanocortin 1 receptor single-nucleotide polymorphisms differentially alter multiple signaling pathways. J. Pharmacol. Exp. Ther. 342, 318-326.
    • (2012) J. Pharmacol. Exp. Ther. , vol.342 , pp. 318-326
    • Doyle, J.R.1    Fortin, J.P.2    Beinborn, M.3    Kopin, A.S.4
  • 60
    • 77949510059 scopus 로고    scopus 로고
    • Functional MC1R-gene variants are associated with increased risk for severe photoaging of facial skin
    • Elfakir, A., Ezzedine, K., Latreille, J. et al. (2010). Functional MC1R-gene variants are associated with increased risk for severe photoaging of facial skin. J. Invest Dermatol. 130, 1107-1115.
    • (2010) J. Invest Dermatol. , vol.130 , pp. 1107-1115
    • Elfakir, A.1    Ezzedine, K.2    Latreille, J.3
  • 61
    • 84879919443 scopus 로고    scopus 로고
    • A review and update on melanocyte stimulating hormone therapy: afamelanotide
    • Fabrikant, J., Touloei, K., and Brown, S.M. (2013). A review and update on melanocyte stimulating hormone therapy: afamelanotide. J. Drugs Dermatol. 12, 775-779.
    • (2013) J. Drugs Dermatol. , vol.12 , pp. 775-779
    • Fabrikant, J.1    Touloei, K.2    Brown, S.M.3
  • 62
    • 77951667623 scopus 로고    scopus 로고
    • MC1R variants increase melanoma risk in families with CDKN2A mutations: a meta-analysis
    • Fargnoli, M.C., Gandini, S., Peris, K., Maisonneuve, P., and Raimondi, S. (2010). MC1R variants increase melanoma risk in families with CDKN2A mutations: a meta-analysis. Eur. J. Cancer 46, 1413-1420.
    • (2010) Eur. J. Cancer , vol.46 , pp. 1413-1420
    • Fargnoli, M.C.1    Gandini, S.2    Peris, K.3    Maisonneuve, P.4    Raimondi, S.5
  • 63
    • 77955477012 scopus 로고    scopus 로고
    • Unexpectedly severe acute radiotherapy side effects are associated with single nucleotide polymorphisms of the melanocortin-1 receptor
    • Fogarty, G.B., Muddle, R., Sprung, C.N., Chen, W., Duffy, D., Sturm, R.A., and McKay, M.J. (2010). Unexpectedly severe acute radiotherapy side effects are associated with single nucleotide polymorphisms of the melanocortin-1 receptor. Int. J. Radiat. Oncol. Biol. Phys. 77, 1486-1492.
    • (2010) Int. J. Radiat. Oncol. Biol. Phys. , vol.77 , pp. 1486-1492
    • Fogarty, G.B.1    Muddle, R.2    Sprung, C.N.3    Chen, W.4    Duffy, D.5    Sturm, R.A.6    McKay, M.J.7
  • 64
    • 0345084470 scopus 로고    scopus 로고
    • Human pigmentation phenotype: a point mutation generates nonfunctional MSH receptor
    • Frandberg, P.A., Doufexis, M., Kapas, S., and Chhajlani, V. (1998). Human pigmentation phenotype: a point mutation generates nonfunctional MSH receptor. Biochem. Biophys. Res. Commun. 245, 490-492.
    • (1998) Biochem. Biophys. Res. Commun. , vol.245 , pp. 490-492
    • Frandberg, P.A.1    Doufexis, M.2    Kapas, S.3    Chhajlani, V.4
  • 65
    • 0034815978 scopus 로고    scopus 로고
    • Cysteine residues are involved in structure and function of melanocortin 1 receptor: substitution of a cysteine residue in transmembrane segment two converts an agonist to antagonist
    • Frandberg, P.A., Doufexis, M., Kapas, S., and Chhajlani, V. (2001). Cysteine residues are involved in structure and function of melanocortin 1 receptor: substitution of a cysteine residue in transmembrane segment two converts an agonist to antagonist. Biochem. Biophys. Res. Commun. 281, 851-857.
    • (2001) Biochem. Biophys. Res. Commun. , vol.281 , pp. 851-857
    • Frandberg, P.A.1    Doufexis, M.2    Kapas, S.3    Chhajlani, V.4
  • 66
    • 0019474724 scopus 로고
    • Endocrine responsiveness in human melanocytes and melanoma cells in culture
    • Fuller, B.B., and Meyskens, F.L. Jr (1981). Endocrine responsiveness in human melanocytes and melanoma cells in culture. J. Natl Cancer Inst. 66, 799-802.
    • (1981) J. Natl Cancer Inst. , vol.66 , pp. 799-802
    • Fuller, B.B.1    Meyskens Jr, F.L.2
  • 67
    • 0031868040 scopus 로고    scopus 로고
    • Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes: evidence for a regulatory role of ultraviolet B, interleukin-1alpha, interleukin-1beta, endothelin-1 and tumour necrosis factor-alpha
    • Funasaka, Y., Chakraborty, A.K., Hayashi, Y., Komoto, M., Ohashi, A., Nagahama, M., Inoue, Y., Pawelek, J., and Ichihashi, M. (1998). Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes: evidence for a regulatory role of ultraviolet B, interleukin-1alpha, interleukin-1beta, endothelin-1 and tumour necrosis factor-alpha. Br. J. Dermatol. 139, 216-224.
    • (1998) Br. J. Dermatol. , vol.139 , pp. 216-224
    • Funasaka, Y.1    Chakraborty, A.K.2    Hayashi, Y.3    Komoto, M.4    Ohashi, A.5    Nagahama, M.6    Inoue, Y.7    Pawelek, J.8    Ichihashi, M.9
  • 68
    • 84934436666 scopus 로고    scopus 로고
    • In vivo and in vitro tools to identify and study transcriptional regulation of USF-1 target genes
    • Galibert, M.D., and Corre, S. (2010). In vivo and in vitro tools to identify and study transcriptional regulation of USF-1 target genes. Methods Mol. Biol. 647, 339-355.
    • (2010) Methods Mol. Biol. , vol.647 , pp. 339-355
    • Galibert, M.D.1    Corre, S.2
  • 69
    • 0035801675 scopus 로고    scopus 로고
    • The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression
    • Galibert, M.D., Carreira, S., and Goding, C.R. (2001). The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression. EMBO J. 20, 5022-5031.
    • (2001) EMBO J. , vol.20 , pp. 5022-5031
    • Galibert, M.D.1    Carreira, S.2    Goding, C.R.3
  • 70
    • 60849127578 scopus 로고    scopus 로고
    • Genetic determinants of hair color and Parkinson's disease risk
    • Gao, X., Simon, K.C., Han, J., Schwarzschild, M.A., and Ascherio, A. (2009). Genetic determinants of hair color and Parkinson's disease risk. Ann. Neurol. 65, 76-82.
    • (2009) Ann. Neurol. , vol.65 , pp. 76-82
    • Gao, X.1    Simon, K.C.2    Han, J.3    Schwarzschild, M.A.4    Ascherio, A.5
  • 72
    • 34247647905 scopus 로고    scopus 로고
    • Comprehensive evaluation of allele frequency differences of MC1R variants across populations
    • Gerstenblith, M.R., Goldstein, A.M., Fargnoli, M.C., Peris, K., and Landi, M.T. (2007). Comprehensive evaluation of allele frequency differences of MC1R variants across populations. Hum. Mutat. 28, 495-505.
    • (2007) Hum. Mutat. , vol.28 , pp. 495-505
    • Gerstenblith, M.R.1    Goldstein, A.M.2    Fargnoli, M.C.3    Peris, K.4    Landi, M.T.5
  • 73
    • 0013983954 scopus 로고
    • Change in hair color in mice induced by injection of alpha-MSH
    • Geschwind, I.I. (1966). Change in hair color in mice induced by injection of alpha-MSH. Endocrinology 79, 1165-1167.
    • (1966) Endocrinology , vol.79 , pp. 1165-1167
    • Geschwind, I.I.1
  • 74
    • 0031241557 scopus 로고    scopus 로고
    • Agouti protein inhibits the production of eumelanin and phaeomelanin in the presence and absence of alpha-melanocyte stimulating hormone
    • Graham, A., Wakamatsu, K., Hunt, G., Ito, S., and Thody, A.J. (1997). Agouti protein inhibits the production of eumelanin and phaeomelanin in the presence and absence of alpha-melanocyte stimulating hormone. Pigment Cell Res. 10, 298-303.
    • (1997) Pigment Cell Res. , vol.10 , pp. 298-303
    • Graham, A.1    Wakamatsu, K.2    Hunt, G.3    Ito, S.4    Thody, A.J.5
  • 75
    • 84876793037 scopus 로고    scopus 로고
    • Variants in melanocortin 1 receptor gene contribute to risk of melanoma-a direct sequencing analysis in a Texas population
    • Guan, X., Niu, J., Liu, Z., Wang, L.E., Amos, C.I., Lee, J.E., Gershenwald, J.E., Grimm, E.A., and Wei, Q. (2013). Variants in melanocortin 1 receptor gene contribute to risk of melanoma-a direct sequencing analysis in a Texas population. Pigment Cell Melanoma Res. 26, 422-425.
    • (2013) Pigment Cell Melanoma Res. , vol.26 , pp. 422-425
    • Guan, X.1    Niu, J.2    Liu, Z.3    Wang, L.E.4    Amos, C.I.5    Lee, J.E.6    Gershenwald, J.E.7    Grimm, E.A.8    Wei, Q.9
  • 76
    • 45549097424 scopus 로고    scopus 로고
    • ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma
    • Gudbjartsson, D.F., Sulem, P., Stacey, S.N. et al. (2008). ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma. Nat. Genet. 40, 886-891.
    • (2008) Nat. Genet. , vol.40 , pp. 886-891
    • Gudbjartsson, D.F.1    Sulem, P.2    Stacey, S.N.3
  • 77
    • 33845870964 scopus 로고    scopus 로고
    • Arrestins: ubiquitous regulators of cellular signaling pathways
    • Gurevich, E.V., and Gurevich, V.V. (2006). Arrestins: ubiquitous regulators of cellular signaling pathways. Genome Biol. 7, 236.
    • (2006) Genome Biol. , vol.7 , pp. 236
    • Gurevich, E.V.1    Gurevich, V.V.2
  • 78
    • 83555168220 scopus 로고    scopus 로고
    • G protein-coupled receptor kinases: more than just kinases and not only for GPCRs
    • Gurevich, E.V., Tesmer, J.J., Mushegian, A., and Gurevich, V.V. (2012). G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol. Ther. 133, 40-69.
    • (2012) Pharmacol. Ther. , vol.133 , pp. 40-69
    • Gurevich, E.V.1    Tesmer, J.J.2    Mushegian, A.3    Gurevich, V.V.4
  • 79
    • 84886286570 scopus 로고    scopus 로고
    • The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma
    • Hacker, E., Boyce, Z., Kimlin, M.G., Wockner, L., Pollak, T., Vaartjes, S.A., Hayward, N.K., and Whiteman, D.C. (2013). The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma. Pigment Cell Melanoma Res. 26, 835-844.
    • (2013) Pigment Cell Melanoma Res. , vol.26 , pp. 835-844
    • Hacker, E.1    Boyce, Z.2    Kimlin, M.G.3    Wockner, L.4    Pollak, T.5    Vaartjes, S.A.6    Hayward, N.K.7    Whiteman, D.C.8
  • 80
    • 0027223731 scopus 로고
    • Pigmentation and proliferation of human melanocytes and the effects of melanocyte-stimulating hormone and ultraviolet B light
    • Halaban, R., Tyrrell, L., Longley, J., Yarden, Y., and Rubin, J. (1993). Pigmentation and proliferation of human melanocytes and the effects of melanocyte-stimulating hormone and ultraviolet B light. Ann. N. Y. Acad. Sci. 680, 290-301.
    • (1993) Ann. N. Y. Acad. Sci. , vol.680 , pp. 290-301
    • Halaban, R.1    Tyrrell, L.2    Longley, J.3    Yarden, Y.4    Rubin, J.5
  • 81
    • 0033927855 scopus 로고    scopus 로고
    • Evidence for variable selective pressures at MC1R
    • Harding, R.M., Healy, E., Ray, A.J. et al. (2000). Evidence for variable selective pressures at MC1R. Am. J. Hum. Genet. 66, 1351-1361.
    • (2000) Am. J. Hum. Genet. , vol.66 , pp. 1351-1361
    • Harding, R.M.1    Healy, E.2    Ray, A.J.3
  • 84
    • 0032518262 scopus 로고    scopus 로고
    • MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
    • Hemesath, T.J., Price, E.R., Takemoto, C., Badalian, T., and Fisher, D.E. (1998). MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature 391, 298-301.
    • (1998) Nature , vol.391 , pp. 298-301
    • Hemesath, T.J.1    Price, E.R.2    Takemoto, C.3    Badalian, T.4    Fisher, D.E.5
  • 85
    • 70349438983 scopus 로고    scopus 로고
    • Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways
    • Herraiz, C., Jimenez-Cervantes, C., Zanna, P., and Garcia-Borron, J.C. (2009). Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways. FEBS Lett. 583, 3269-3274.
    • (2009) FEBS Lett. , vol.583 , pp. 3269-3274
    • Herraiz, C.1    Jimenez-Cervantes, C.2    Zanna, P.3    Garcia-Borron, J.C.4
  • 86
    • 78650881154 scopus 로고    scopus 로고
    • Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT
    • Herraiz, C., Journe, F., Abdel-Malek, Z., Ghanem, G., Jimenez-Cervantes, C., and Garcia-Borron, J.C. (2011a). Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT. Mol. Endocrinol. 25, 138-156.
    • (2011) Mol. Endocrinol. , vol.25 , pp. 138-156
    • Herraiz, C.1    Journe, F.2    Abdel-Malek, Z.3    Ghanem, G.4    Jimenez-Cervantes, C.5    Garcia-Borron, J.C.6
  • 87
    • 79956058158 scopus 로고    scopus 로고
    • N-glycosylation of the human melanocortin 1 receptor: occupancy of glycosylation sequons and functional role
    • Herraiz, C., Sanchez-Laorden, B.L., Jimenez-Cervantes, C., and Garcia-Borron, J.C. (2011b). N-glycosylation of the human melanocortin 1 receptor: occupancy of glycosylation sequons and functional role. Pigment Cell Melanoma Res. 24, 479-489.
    • (2011) Pigment Cell Melanoma Res. , vol.24 , pp. 479-489
    • Herraiz, C.1    Sanchez-Laorden, B.L.2    Jimenez-Cervantes, C.3    Garcia-Borron, J.C.4
  • 88
    • 84866983432 scopus 로고    scopus 로고
    • Functional status and relationships of melanocortin 1 receptor signaling to the cAMP and extracellular signal-regulated protein kinases 1 and 2 pathways in human melanoma cells
    • Herraiz, C., Journe, F., Ghanem, G., Jimenez-Cervantes, C., and Garcia-Borron, J.C. (2012). Functional status and relationships of melanocortin 1 receptor signaling to the cAMP and extracellular signal-regulated protein kinases 1 and 2 pathways in human melanoma cells. Int. J. Biochem. Cell Biol. 44, 2244-2252.
    • (2012) Int. J. Biochem. Cell Biol. , vol.44 , pp. 2244-2252
    • Herraiz, C.1    Journe, F.2    Ghanem, G.3    Jimenez-Cervantes, C.4    Garcia-Borron, J.C.5
  • 89
    • 69449093677 scopus 로고    scopus 로고
    • Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway
    • Hida, T., Wakamatsu, K., Sviderskaya, E.V. et al. (2009). Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway. Pigment Cell Melanoma Res. 22, 623-634.
    • (2009) Pigment Cell Melanoma Res. , vol.22 , pp. 623-634
    • Hida, T.1    Wakamatsu, K.2    Sviderskaya, E.V.3
  • 90
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis, E., Watson, I.R., Kryukov, G.V. et al. (2012). A landscape of driver mutations in melanoma. Cell 150, 251-263.
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1    Watson, I.R.2    Kryukov, G.V.3
  • 91
    • 0037713347 scopus 로고    scopus 로고
    • Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe
    • Holst, B., and Schwartz, T.W. (2003). Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe. Ann. N. Y. Acad. Sci. 994, 1-11.
    • (2003) Ann. N. Y. Acad. Sci. , vol.994 , pp. 1-11
    • Holst, B.1    Schwartz, T.W.2
  • 92
    • 75749117558 scopus 로고    scopus 로고
    • Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
    • Houslay, M.D. (2010). Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown. Trends Biochem. Sci. 35, 91-100.
    • (2010) Trends Biochem. Sci. , vol.35 , pp. 91-100
    • Houslay, M.D.1
  • 93
    • 0028788787 scopus 로고
    • Agouti protein can act independently of melanocyte-stimulating hormone to inhibit melanogenesis
    • Hunt, G., and Thody, A.J. (1995). Agouti protein can act independently of melanocyte-stimulating hormone to inhibit melanogenesis. J. Endocrinol. 147, R1-R4.
    • (1995) J. Endocrinol. , vol.147 , pp. R1-R4
    • Hunt, G.1    Thody, A.J.2
  • 95
    • 0029348767 scopus 로고
    • Eumelanin and phaeomelanin contents of human epidermis and cultured melanocytes
    • Hunt, G., Kyne, S., Ito, S., Wakamatsu, K., Todd, C., and Thody, A. (1995). Eumelanin and phaeomelanin contents of human epidermis and cultured melanocytes. Pigment Cell Res. 8, 202-208.
    • (1995) Pigment Cell Res. , vol.8 , pp. 202-208
    • Hunt, G.1    Kyne, S.2    Ito, S.3    Wakamatsu, K.4    Todd, C.5    Thody, A.6
  • 97
    • 7344236227 scopus 로고    scopus 로고
    • Susceptibility to melanoma: influence of skin type and polymorphism in the melanocyte stimulating hormone receptor gene
    • Ichii-Jones, F., Lear, J.T., Heagerty, A.H. et al. (1998). Susceptibility to melanoma: influence of skin type and polymorphism in the melanocyte stimulating hormone receptor gene. J. Invest Dermatol. 111, 218-221.
    • (1998) J. Invest Dermatol. , vol.111 , pp. 218-221
    • Ichii-Jones, F.1    Lear, J.T.2    Heagerty, A.H.3
  • 98
    • 0031963866 scopus 로고    scopus 로고
    • Activation of the cyclic AMP pathway by alpha-melanotropin mediates the response of human melanocytes to ultraviolet B radiation
    • Im, S., Moro, O., Peng, F., Medrano, E.E., Cornelius, J., Babcock, G., Nordlund, J.J., and Abdel-Malek, Z.A. (1998). Activation of the cyclic AMP pathway by alpha-melanotropin mediates the response of human melanocytes to ultraviolet B radiation. Cancer Res. 58, 47-54.
    • (1998) Cancer Res. , vol.58 , pp. 47-54
    • Im, S.1    Moro, O.2    Peng, F.3    Medrano, E.E.4    Cornelius, J.5    Babcock, G.6    Nordlund, J.J.7    Abdel-Malek, Z.A.8
  • 99
  • 100
    • 0042733275 scopus 로고    scopus 로고
    • Quantitative analysis of eumelanin and pheomelanin in humans, mice, and other animals: a comparative review
    • Ito, S., and Wakamatsu, K. (2003). Quantitative analysis of eumelanin and pheomelanin in humans, mice, and other animals: a comparative review. Pigment Cell Res. 16, 523-531.
    • (2003) Pigment Cell Res. , vol.16 , pp. 523-531
    • Ito, S.1    Wakamatsu, K.2
  • 101
    • 78651426731 scopus 로고    scopus 로고
    • Human hair melanins: what we have learned and have not learned from mouse coat color pigmentation
    • Ito, S., and Wakamatsu, K. (2011). Human hair melanins: what we have learned and have not learned from mouse coat color pigmentation. Pigment Cell Melanoma Res. 24, 63-74.
    • (2011) Pigment Cell Melanoma Res. , vol.24 , pp. 63-74
    • Ito, S.1    Wakamatsu, K.2
  • 102
    • 77952326915 scopus 로고    scopus 로고
    • Colloquium paper: human skin pigmentation as an adaptation to UV radiation
    • Jablonski, N.G., and Chaplin, G. (2010). Colloquium paper: human skin pigmentation as an adaptation to UV radiation. Proc. Natl. Acad. Sci. U. S. A. 107(Suppl 2), 8962-8968.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 8962-8968
    • Jablonski, N.G.1    Chaplin, G.2
  • 103
    • 0034935241 scopus 로고    scopus 로고
    • Inhibition of melanogenesis in response to oxidative stress: transient downregulation of melanocyte differentiation markers and possible involvement of microphthalmia transcription factor
    • Jimenez-Cervantes, C., Martinez-Esparza, M., Perez, C., Daum, N., Solano, F., and Garcia-Borron, J.C. (2001a). Inhibition of melanogenesis in response to oxidative stress: transient downregulation of melanocyte differentiation markers and possible involvement of microphthalmia transcription factor. J. Cell Sci. 114, 2335-2344.
    • (2001) J. Cell Sci. , vol.114 , pp. 2335-2344
    • Jimenez-Cervantes, C.1    Martinez-Esparza, M.2    Perez, C.3    Daum, N.4    Solano, F.5    Garcia-Borron, J.C.6
  • 105
    • 20144377250 scopus 로고    scopus 로고
    • alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes
    • Kadekaro, A.L., Kavanagh, R., Kanto, H. et al. (2005). alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes. Cancer Res. 65, 4292-4299.
    • (2005) Cancer Res. , vol.65 , pp. 4292-4299
    • Kadekaro, A.L.1    Kavanagh, R.2    Kanto, H.3
  • 106
    • 77957856003 scopus 로고    scopus 로고
    • Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation
    • Kadekaro, A.L., Leachman, S., Kavanagh, R.J. et al. (2010). Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation. FASEB J. 24, 3850-3860.
    • (2010) FASEB J. , vol.24 , pp. 3850-3860
    • Kadekaro, A.L.1    Leachman, S.2    Kavanagh, R.J.3
  • 107
    • 84862550078 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes
    • Kadekaro, A.L., Chen, J., Yang, J., Chen, S., Jameson, J., Swope, V.B., Cheng, T., Kadakia, M., and Abdel-Malek, Z. (2012). Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes. Mol. Cancer Res. 10, 778-786.
    • (2012) Mol. Cancer Res. , vol.10 , pp. 778-786
    • Kadekaro, A.L.1    Chen, J.2    Yang, J.3    Chen, S.4    Jameson, J.5    Swope, V.B.6    Cheng, T.7    Kadakia, M.8    Abdel-Malek, Z.9
  • 108
    • 77950461682 scopus 로고    scopus 로고
    • Melanocortin 1 receptor (MC1R), pigmentary characteristics and sun exposure: findings from a case-control study of diffuse large B-cell and follicular lymphoma
    • Kane, E.V., Painter, D., Roman, E., Allan, J., Law, G., and Lightfoot, T. (2010). Melanocortin 1 receptor (MC1R), pigmentary characteristics and sun exposure: findings from a case-control study of diffuse large B-cell and follicular lymphoma. Cancer Epidemiol. 34, 136-141.
    • (2010) Cancer Epidemiol. , vol.34 , pp. 136-141
    • Kane, E.V.1    Painter, D.2    Roman, E.3    Allan, J.4    Law, G.5    Lightfoot, T.6
  • 109
    • 0036181358 scopus 로고    scopus 로고
    • A polymorphism in the agouti signaling protein gene is associated with human pigmentation
    • Kanetsky, P.A., Swoyer, J., Panossian, S., Holmes, R., Guerry, D., and Rebbeck, T.R. (2002). A polymorphism in the agouti signaling protein gene is associated with human pigmentation. Am. J. Hum. Genet. 70, 770-775.
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 770-775
    • Kanetsky, P.A.1    Swoyer, J.2    Panossian, S.3    Holmes, R.4    Guerry, D.5    Rebbeck, T.R.6
  • 110
    • 33749481705 scopus 로고    scopus 로고
    • Population-based study of natural variation in the melanocortin-1 receptor gene and melanoma
    • Kanetsky, P.A., Rebbeck, T.R., Hummer, A.J. et al. (2006). Population-based study of natural variation in the melanocortin-1 receptor gene and melanoma. Cancer Res. 66, 9330-9337.
    • (2006) Cancer Res. , vol.66 , pp. 9330-9337
    • Kanetsky, P.A.1    Rebbeck, T.R.2    Hummer, A.J.3
  • 111
    • 84872221774 scopus 로고    scopus 로고
    • Structure-function of the G protein-coupled receptor superfamily
    • Katritch, V., Cherezov, V., and Stevens, R.C. (2013). Structure-function of the G protein-coupled receptor superfamily. Annu. Rev. Pharmacol. Toxicol. 53, 531-556.
    • (2013) Annu. Rev. Pharmacol. Toxicol. , vol.53 , pp. 531-556
    • Katritch, V.1    Cherezov, V.2    Stevens, R.C.3
  • 112
    • 0035722059 scopus 로고    scopus 로고
    • Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color
    • Kennedy, C., Ter, H.J., Berkhout, M., Gruis, N., Bastiaens, M., Bergman, W., Willemze, R., and Bavinck, J.N. (2001). Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color. J. Invest Dermatol. 117, 294-300.
    • (2001) J. Invest Dermatol. , vol.117 , pp. 294-300
    • Kennedy, C.1    Ter, H.J.2    Berkhout, M.3    Gruis, N.4    Bastiaens, M.5    Bergman, W.6    Willemze, R.7    Bavinck, J.N.8
  • 113
    • 77958617776 scopus 로고    scopus 로고
    • Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit
    • Khaled, M., Levy, C., and Fisher, D.E. (2010). Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit. Genes Dev. 24, 2276-2281.
    • (2010) Genes Dev. , vol.24 , pp. 2276-2281
    • Khaled, M.1    Levy, C.2    Fisher, D.E.3
  • 115
    • 33645877973 scopus 로고    scopus 로고
    • Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization
    • Kilianova, Z., Basora, N., Kilian, P., Payet, M.D., and Gallo-Payet, N. (2006). Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. Endocrinology 147, 2325-2337.
    • (2006) Endocrinology , vol.147 , pp. 2325-2337
    • Kilianova, Z.1    Basora, N.2    Kilian, P.3    Payet, M.D.4    Gallo-Payet, N.5
  • 116
    • 84863942861 scopus 로고    scopus 로고
    • Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development
    • Kinsler, V.A., Abu-Amero, S., Budd, P. et al. (2012). Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development. J. Invest Dermatol. 132, 2026-2032.
    • (2012) J. Invest Dermatol. , vol.132 , pp. 2026-2032
    • Kinsler, V.A.1    Abu-Amero, S.2    Budd, P.3
  • 117
    • 67649648241 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf-dependent gene expression in human skin
    • Kokot, A., Metze, D., Mouchet, N., Galibert, M.D., Schiller, M., Luger, T.A., and Bohm, M. (2009). Alpha-melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf-dependent gene expression in human skin. Endocrinology 150, 3197-3206.
    • (2009) Endocrinology , vol.150 , pp. 3197-3206
    • Kokot, A.1    Metze, D.2    Mouchet, N.3    Galibert, M.D.4    Schiller, M.5    Luger, T.A.6    Bohm, M.7
  • 118
    • 84865684161 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
    • Krauthammer, M., Kong, Y., Ha, B.H. et al. (2012). Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat. Genet. 44, 1006-1014.
    • (2012) Nat. Genet. , vol.44 , pp. 1006-1014
    • Krauthammer, M.1    Kong, Y.2    Ha, B.H.3
  • 119
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G., and Gruters, A. (1998). Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. Genet. 19, 155-157.
    • (1998) Nat. Genet. , vol.19 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Gruters, A.6
  • 120
    • 36749025107 scopus 로고    scopus 로고
    • A melanocortin 1 receptor allele suggests varying pigmentation among Neanderthals
    • Lalueza-Fox, C., Rompler, H., Caramelli, D. et al. (2007). A melanocortin 1 receptor allele suggests varying pigmentation among Neanderthals. Science 318, 1453-1455.
    • (2007) Science , vol.318 , pp. 1453-1455
    • Lalueza-Fox, C.1    Rompler, H.2    Caramelli, D.3
  • 121
    • 21244446712 scopus 로고    scopus 로고
    • MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population
    • Landi, M.T., Kanetsky, P.A., Tsang, S. et al. (2005). MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population. J. Natl Cancer Inst. 97, 998-1007.
    • (2005) J. Natl Cancer Inst. , vol.97 , pp. 998-1007
    • Landi, M.T.1    Kanetsky, P.A.2    Tsang, S.3
  • 122
    • 33746589029 scopus 로고    scopus 로고
    • MC1R germline variants confer risk for BRAF-mutant melanoma
    • Landi, M.T., Bauer, J., Pfeiffer, R.M. et al. (2006). MC1R germline variants confer risk for BRAF-mutant melanoma. Science 313, 521-522.
    • (2006) Science , vol.313 , pp. 521-522
    • Landi, M.T.1    Bauer, J.2    Pfeiffer, R.M.3
  • 123
    • 47249161236 scopus 로고    scopus 로고
    • Regulation of eumelanin/pheomelanin synthesis and visible pigmentation in melanocytes by ligands of the melanocortin 1 receptor
    • Le Pape, E., Wakamatsu, K., Ito, S., Wolber, R., and Hearing, V.J. (2008). Regulation of eumelanin/pheomelanin synthesis and visible pigmentation in melanocytes by ligands of the melanocortin 1 receptor. Pigment Cell Melanoma Res. 21, 477-486.
    • (2008) Pigment Cell Melanoma Res. , vol.21 , pp. 477-486
    • Le Pape, E.1    Wakamatsu, K.2    Ito, S.3    Wolber, R.4    Hearing, V.J.5
  • 124
    • 60549100311 scopus 로고    scopus 로고
    • Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r
    • Le Pape, E., Passeron, T., Giubellino, A., Valencia, J.C., Wolber, R., and Hearing, V.J. (2009). Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r. Proc. Natl. Acad. Sci. U. S. A. 106, 1802-1807.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 1802-1807
    • Le Pape, E.1    Passeron, T.2    Giubellino, A.3    Valencia, J.C.4    Wolber, R.5    Hearing, V.J.6
  • 125
    • 36949078628 scopus 로고
    • Effect of alpha- and betamelanocyte stimulating hormones on the skin colour of man
    • Lerner, A.B., and McGuire, J.S. (1961). Effect of alpha- and betamelanocyte stimulating hormones on the skin colour of man. Nature 189, 176-179.
    • (1961) Nature , vol.189 , pp. 176-179
    • Lerner, A.B.1    McGuire, J.S.2
  • 126
    • 0000094045 scopus 로고
    • Melanocyte-stimulating hormone and adrenocorticotrophic hormone. their relation to pigmentation
    • Lerner, A.B., and McGuire, J.S. (1964). Melanocyte-stimulating hormone and adrenocorticotrophic hormone. their relation to pigmentation. N. Engl. J. Med. 270, 539-546.
    • (1964) N. Engl. J. Med. , vol.270 , pp. 539-546
    • Lerner, A.B.1    McGuire, J.S.2
  • 128
    • 33747882661 scopus 로고    scopus 로고
    • MITF: master regulator of melanocyte development and melanoma oncogene
    • Levy, C., Khaled, M., and Fisher, D.E. (2006). MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol. Med. 12, 406-414.
    • (2006) Trends Mol. Med. , vol.12 , pp. 406-414
    • Levy, C.1    Khaled, M.2    Fisher, D.E.3
  • 129
    • 33847188116 scopus 로고    scopus 로고
    • Melanocyte biology and skin pigmentation
    • Lin, J.Y., and Fisher, D.E. (2007). Melanocyte biology and skin pigmentation. Nature 445, 843-850.
    • (2007) Nature , vol.445 , pp. 843-850
    • Lin, J.Y.1    Fisher, D.E.2
  • 130
    • 0028112970 scopus 로고
    • Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
    • Lu, D., Willard, D., Patel, I.R. et al. (1994). Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371, 799-802.
    • (1994) Nature , vol.371 , pp. 799-802
    • Lu, D.1    Willard, D.2    Patel, I.R.3
  • 131
    • 0032230291 scopus 로고    scopus 로고
    • A ligand-mimetic model for constitutive activation of the melanocortin-1 receptor
    • Lu, D., Vage, D.I., and Cone, R.D. (1998). A ligand-mimetic model for constitutive activation of the melanocortin-1 receptor. Mol. Endocrinol. 12, 592-604.
    • (1998) Mol. Endocrinol. , vol.12 , pp. 592-604
    • Lu, D.1    Vage, D.I.2    Cone, R.D.3
  • 132
    • 77952415656 scopus 로고    scopus 로고
    • Beyond desensitization: physiological relevance of arrestin-dependent signaling
    • Luttrell, L.M., and Gesty-Palmer, D. (2010). Beyond desensitization: physiological relevance of arrestin-dependent signaling. Pharmacol. Rev. 62, 305-330.
    • (2010) Pharmacol. Rev. , vol.62 , pp. 305-330
    • Luttrell, L.M.1    Gesty-Palmer, D.2
  • 134
    • 9944264993 scopus 로고    scopus 로고
    • Melanocortin receptors form constitutive homo- and heterodimers
    • Mandrika, I., Petrovska, R., and Wikberg, J. (2005). Melanocortin receptors form constitutive homo- and heterodimers. Biochem. Biophys. Res. Commun. 326, 349-354.
    • (2005) Biochem. Biophys. Res. Commun. , vol.326 , pp. 349-354
    • Mandrika, I.1    Petrovska, R.2    Wikberg, J.3
  • 135
    • 77949409651 scopus 로고    scopus 로고
    • MC1R stimulation by alpha-MSH induces catalase and promotes its re-distribution to the cell periphery and dendrites
    • Maresca, V., Flori, E., Bellei, B., Aspite, N., Kovacs, D., and Picardo, M. (2010). MC1R stimulation by alpha-MSH induces catalase and promotes its re-distribution to the cell periphery and dendrites. Pigment Cell Melanoma Res. 23, 263-275.
    • (2010) Pigment Cell Melanoma Res. , vol.23 , pp. 263-275
    • Maresca, V.1    Flori, E.2    Bellei, B.3    Aspite, N.4    Kovacs, D.5    Picardo, M.6
  • 136
    • 84872542072 scopus 로고    scopus 로고
    • Alternative mRNA splicing of G protein-coupled receptors
    • Markovic, D. (2013). Alternative mRNA splicing of G protein-coupled receptors. Methods Enzymol. 520, 323-335.
    • (2013) Methods Enzymol. , vol.520 , pp. 323-335
    • Markovic, D.1
  • 137
    • 70350512023 scopus 로고    scopus 로고
    • Alternative splicing of G protein-coupled receptors: physiology and pathophysiology
    • Markovic, D., and Challiss, R.A. (2009). Alternative splicing of G protein-coupled receptors: physiology and pathophysiology. Cell. Mol. Life Sci. 66, 3337-3352.
    • (2009) Cell. Mol. Life Sci. , vol.66 , pp. 3337-3352
    • Markovic, D.1    Challiss, R.A.2
  • 139
    • 84890387883 scopus 로고    scopus 로고
    • Simultaneous purifying selection on the ancestral MC1R allele and positive selection on the melanoma-risk allele V60L in south Europeans
    • Martinez-Cadenas, C., Lopez, S., Ribas, G. et al. (2013). Simultaneous purifying selection on the ancestral MC1R allele and positive selection on the melanoma-risk allele V60L in south Europeans. Mol. Biol. Evol. 30, 2654-2665.
    • (2013) Mol. Biol. Evol. , vol.30 , pp. 2654-2665
    • Martinez-Cadenas, C.1    Lopez, S.2    Ribas, G.3
  • 140
    • 0031041070 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 inhibits basal melanogenesis in B16/F10 mouse melanoma cells by increasing the rate of degradation of tyrosinase and tyrosinase-related protein-1
    • Martinez-Esparza, M., Jimenez-Cervantes, C., Beermann, F., Aparicio, P., Lozano, J.A., and Garcia-Borron, J.C. (1997). Transforming growth factor-beta1 inhibits basal melanogenesis in B16/F10 mouse melanoma cells by increasing the rate of degradation of tyrosinase and tyrosinase-related protein-1. J. Biol. Chem. 272, 3967-3972.
    • (1997) J. Biol. Chem. , vol.272 , pp. 3967-3972
    • Martinez-Esparza, M.1    Jimenez-Cervantes, C.2    Beermann, F.3    Aparicio, P.4    Lozano, J.A.5    Garcia-Borron, J.C.6
  • 142
    • 0033219669 scopus 로고    scopus 로고
    • Independent regulation of tyrosinase by the hypopigmenting cytokines TGF beta1 and TNF alpha and the melanogenic hormone alpha-MSH in B16 mouse melanocytes
    • Martinez-Esparza, M., Solano, F., and Garcia-Borron, J.C. (1999). Independent regulation of tyrosinase by the hypopigmenting cytokines TGF beta1 and TNF alpha and the melanogenic hormone alpha-MSH in B16 mouse melanocytes. Cell Mol. Biol. (Noisy. -le-grand). 45, 991-1000.
    • (1999) Cell Mol. Biol. (Noisy. -le-grand). , vol.45 , pp. 991-1000
    • Martinez-Esparza, M.1    Solano, F.2    Garcia-Borron, J.C.3
  • 144
    • 0034811354 scopus 로고    scopus 로고
    • Redox regulation in human melanocytes and melanoma
    • Meyskens, F.L. Jr, Farmer, P., and Fruehauf, J.P. (2001). Redox regulation in human melanocytes and melanoma. Pigment Cell Res. 14, 148-154.
    • (2001) Pigment Cell Res. , vol.14 , pp. 148-154
    • Meyskens Jr, F.L.1    Farmer, P.2    Fruehauf, J.P.3
  • 145
    • 26844540509 scopus 로고    scopus 로고
    • Association study of the g.8818A>G polymorphism of the human agouti gene with melanoma risk and pigmentary characteristics in a French population
    • Meziani, R., Descamps, V., Gerard, B. et al. (2005). Association study of the g.8818A>G polymorphism of the human agouti gene with melanoma risk and pigmentary characteristics in a French population. J. Dermatol. Sci. 40, 133-136.
    • (2005) J. Dermatol. Sci. , vol.40 , pp. 133-136
    • Meziani, R.1    Descamps, V.2    Gerard, B.3
  • 146
    • 58349119363 scopus 로고    scopus 로고
    • Identification of the minimal melanocyte-specific promoter in the melanocortin receptor 1 gene
    • Miccadei, S., Pascucci, B., Picardo, M., Natali, P.G., and Civitareale, D. (2008). Identification of the minimal melanocyte-specific promoter in the melanocortin receptor 1 gene. J. Exp. Clin. Cancer Res. 27, 71.
    • (2008) J. Exp. Clin. Cancer Res. , vol.27 , pp. 71
    • Miccadei, S.1    Pascucci, B.2    Picardo, M.3    Natali, P.G.4    Civitareale, D.5
  • 147
    • 0027256438 scopus 로고
    • Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation
    • Miller, M.W., Duhl, D.M., Vrieling, H., Cordes, S.P., Ollmann, M.M., Winkes, B.M., and Barsh, G.S. (1993). Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev. 7, 454-467.
    • (1993) Genes Dev. , vol.7 , pp. 454-467
    • Miller, M.W.1    Duhl, D.M.2    Vrieling, H.3    Cordes, S.P.4    Ollmann, M.M.5    Winkes, B.M.6    Barsh, G.S.7
  • 148
    • 33947314576 scopus 로고    scopus 로고
    • Regulation of receptor trafficking by GRKs and arrestins
    • Moore, C.A., Milano, S.K., and Benovic, J.L. (2007). Regulation of receptor trafficking by GRKs and arrestins. Annu. Rev. Physiol. 69, 451-482.
    • (2007) Annu. Rev. Physiol. , vol.69 , pp. 451-482
    • Moore, C.A.1    Milano, S.K.2    Benovic, J.L.3
  • 149
    • 0033610058 scopus 로고    scopus 로고
    • Characterization of the promoter region of the human melanocortin-1 receptor (MC1R) gene
    • Moro, O., Ideta, R., and Ifuku, O. (1999). Characterization of the promoter region of the human melanocortin-1 receptor (MC1R) gene. Biochem. Biophys. Res. Commun. 262, 452-460.
    • (1999) Biochem. Biophys. Res. Commun. , vol.262 , pp. 452-460
    • Moro, O.1    Ideta, R.2    Ifuku, O.3
  • 150
    • 0026800892 scopus 로고
    • The cloning of a family of genes that encode the melanocortin receptors
    • Mountjoy, K.G., Robbins, L.S., Mortrud, M.T., and Cone, R.D. (1992). The cloning of a family of genes that encode the melanocortin receptors. Science 257, 1248-1251.
    • (1992) Science , vol.257 , pp. 1248-1251
    • Mountjoy, K.G.1    Robbins, L.S.2    Mortrud, M.T.3    Cone, R.D.4
  • 151
    • 80051741396 scopus 로고    scopus 로고
    • Spatial and temporal localization of the melanocortin 1 receptor and its ligand alpha-melanocyte-stimulating hormone during cutaneous wound repair
    • Muffley, L.A., Zhu, K.Q., Engrav, L.H., Gibran, N.S., and Hocking, A.M. (2011). Spatial and temporal localization of the melanocortin 1 receptor and its ligand alpha-melanocyte-stimulating hormone during cutaneous wound repair. J. Histochem. Cytochem. 59, 278-288.
    • (2011) J. Histochem. Cytochem. , vol.59 , pp. 278-288
    • Muffley, L.A.1    Zhu, K.Q.2    Engrav, L.H.3    Gibran, N.S.4    Hocking, A.M.5
  • 152
    • 77950533215 scopus 로고    scopus 로고
    • Expression and role of phosphodiesterase 5 in human malignant melanoma cell line
    • Murata, T., Shimizu, K., Watanabe, Y., Morita, H., Sekida, M., and Tagawa, T. (2010). Expression and role of phosphodiesterase 5 in human malignant melanoma cell line. Anticancer Res. 30, 355-358.
    • (2010) Anticancer Res. , vol.30 , pp. 355-358
    • Murata, T.1    Shimizu, K.2    Watanabe, Y.3    Morita, H.4    Sekida, M.5    Tagawa, T.6
  • 153
    • 84865087497 scopus 로고    scopus 로고
    • The effect of hair colour on anaesthetic requirements and recovery time after surgery
    • Myles, P.S., Buchanan, F.F., and Bain, C.R. (2012). The effect of hair colour on anaesthetic requirements and recovery time after surgery. Anaesth. Intensive Care 40, 683-689.
    • (2012) Anaesth. Intensive Care , vol.40 , pp. 683-689
    • Myles, P.S.1    Buchanan, F.F.2    Bain, C.R.3
  • 154
    • 33645014606 scopus 로고    scopus 로고
    • Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians
    • Nakayama, K., Soemantri, A., Jin, F. et al. (2006). Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians. Hum. Genet. 119, 322-330.
    • (2006) Hum. Genet. , vol.119 , pp. 322-330
    • Nakayama, K.1    Soemantri, A.2    Jin, F.3
  • 155
    • 34548546877 scopus 로고    scopus 로고
    • A role for cyclic nucleotide phosphodiesterase 4 in regulation of the growth of human malignant melanoma cells
    • Narita, M., Murata, T., Shimizu, K., Nakagawa, T., Sugiyama, T., Inui, M., Hiramoto, K., and Tagawa, T. (2007). A role for cyclic nucleotide phosphodiesterase 4 in regulation of the growth of human malignant melanoma cells. Oncol. Rep. 17, 1133-1139.
    • (2007) Oncol. Rep. , vol.17 , pp. 1133-1139
    • Narita, M.1    Murata, T.2    Shimizu, K.3    Nakagawa, T.4    Sugiyama, T.5    Inui, M.6    Hiramoto, K.7    Tagawa, T.8
  • 156
    • 25144468766 scopus 로고    scopus 로고
    • Activation of the cAMP pathway by variant human MC1R alleles expressed in HEK and in melanoma cells
    • Newton, R.A., Smit, S.E., Barnes, C.C., Pedley, J., Parsons, P.G., and Sturm, R.A. (2005). Activation of the cAMP pathway by variant human MC1R alleles expressed in HEK and in melanoma cells. Peptides 26, 1818-1824.
    • (2005) Peptides , vol.26 , pp. 1818-1824
    • Newton, R.A.1    Smit, S.E.2    Barnes, C.C.3    Pedley, J.4    Parsons, P.G.5    Sturm, R.A.6
  • 157
    • 36148947881 scopus 로고    scopus 로고
    • Human melanocytes expressing MC1R variant alleles show impaired activation of multiple signaling pathways
    • Newton, R.A., Roberts, D.W., Leonard, J.H., and Sturm, R.A. (2007). Human melanocytes expressing MC1R variant alleles show impaired activation of multiple signaling pathways. Peptides 28, 2387-2396.
    • (2007) Peptides , vol.28 , pp. 2387-2396
    • Newton, R.A.1    Roberts, D.W.2    Leonard, J.H.3    Sturm, R.A.4
  • 158
    • 84879348280 scopus 로고    scopus 로고
    • Molecular and functional analysis of human beta-defensin 3 action at melanocortin receptors
    • Nix, M.A., Kaelin, C.B., Ta, T., Weis, A., Morton, G.J., Barsh, G.S., and Millhauser, G.L. (2013). Molecular and functional analysis of human beta-defensin 3 action at melanocortin receptors. Chem. Biol. 20, 784-795.
    • (2013) Chem. Biol. , vol.20 , pp. 784-795
    • Nix, M.A.1    Kaelin, C.B.2    Ta, T.3    Weis, A.4    Morton, G.J.5    Barsh, G.S.6    Millhauser, G.L.7
  • 159
    • 44649104515 scopus 로고    scopus 로고
    • Endosomal colocalization of melanocortin-3 receptor and beta-arrestins in CAD cells with altered modification of AKT/PKB
    • Nyan, D.C., Anbazhagan, R., Hughes-Darden, C.A., and Wachira, S.J. (2008). Endosomal colocalization of melanocortin-3 receptor and beta-arrestins in CAD cells with altered modification of AKT/PKB. Neuropeptides 42, 355-366.
    • (2008) Neuropeptides , vol.42 , pp. 355-366
    • Nyan, D.C.1    Anbazhagan, R.2    Hughes-Darden, C.A.3    Wachira, S.J.4
  • 160
    • 42449107733 scopus 로고    scopus 로고
    • Genetic mutations that prevent pain: implications for future pain medication
    • Oertel, B., and Lotsch, J. (2008). Genetic mutations that prevent pain: implications for future pain medication. Pharmacogenomics 9, 179-194.
    • (2008) Pharmacogenomics , vol.9 , pp. 179-194
    • Oertel, B.1    Lotsch, J.2
  • 161
    • 73349128434 scopus 로고    scopus 로고
    • A Japanese piebald patient with auburn hair colour associated with a novel mutation p. P832L in the KIT gene and a homozygous variant p.I120T in the MC1R gene
    • Oiso, N., Kishida, K., Fukai, K., Motokawa, T., Hosomi, N., Suzuki, T., Mitsuhashi, Y., Tsuboi, R., and Kawada, A. (2009). A Japanese piebald patient with auburn hair colour associated with a novel mutation p. P832L in the KIT gene and a homozygous variant p.I120T in the MC1R gene. Br. J. Dermatol. 161, 468-469.
    • (2009) Br. J. Dermatol. , vol.161 , pp. 468-469
    • Oiso, N.1    Kishida, K.2    Fukai, K.3    Motokawa, T.4    Hosomi, N.5    Suzuki, T.6    Mitsuhashi, Y.7    Tsuboi, R.8    Kawada, A.9
  • 162
    • 0032005006 scopus 로고    scopus 로고
    • Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo
    • Ollmann, M.M., Lamoreux, M.L., Wilson, B.D., and Barsh, G.S. (1998). Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo. Genes Dev. 12, 316-330.
    • (1998) Genes Dev. , vol.12 , pp. 316-330
    • Ollmann, M.M.1    Lamoreux, M.L.2    Wilson, B.D.3    Barsh, G.S.4
  • 164
    • 0030601351 scopus 로고    scopus 로고
    • Alpha-melanocyte stimulating hormone-induced pigmentation is blocked by depletion of protein kinase C
    • Park, H.Y., Russakovsky, V., Ao, Y., Fernandez, E., and Gilchrest, B.A. (1996). Alpha-melanocyte stimulating hormone-induced pigmentation is blocked by depletion of protein kinase C. Exp. Cell Res. 227, 70-79.
    • (1996) Exp. Cell Res. , vol.227 , pp. 70-79
    • Park, H.Y.1    Russakovsky, V.2    Ao, Y.3    Fernandez, E.4    Gilchrest, B.A.5
  • 165
    • 78049429422 scopus 로고    scopus 로고
    • Loop-swapped chimeras of the agouti-related protein and the agouti signaling protein identify contacts required for melanocortin 1 receptor selectivity and antagonism
    • Patel, M.P., Cribb Fabersunne, C.S., Yang, Y.K., Kaelin, C.B., Barsh, G.S., and Millhauser, G.L. (2010). Loop-swapped chimeras of the agouti-related protein and the agouti signaling protein identify contacts required for melanocortin 1 receptor selectivity and antagonism. J. Mol. Biol. 404, 45-55.
    • (2010) J. Mol. Biol. , vol.404 , pp. 45-55
    • Patel, M.P.1    Cribb Fabersunne, C.S.2    Yang, Y.K.3    Kaelin, C.B.4    Barsh, G.S.5    Millhauser, G.L.6
  • 166
    • 0015740394 scopus 로고
    • Molecular biology of pigment cells. Molecular controls in mammalian pigmentation
    • Pawelek, J., Wong, G., Sansone, M., and Morowitz, J. (1973). Molecular biology of pigment cells. Molecular controls in mammalian pigmentation. Yale J. Biol. Med. 46, 430-443.
    • (1973) Yale J. Biol. Med. , vol.46 , pp. 430-443
    • Pawelek, J.1    Wong, G.2    Sansone, M.3    Morowitz, J.4
  • 167
    • 66749100686 scopus 로고    scopus 로고
    • Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients
    • Perez Oliva, A.B., Fernendez, L.P., Detorre, C. et al. (2009). Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients. Hum. Mutat.
    • (2009) Hum. Mutat.
    • Perez Oliva, A.B.1    Fernendez, L.P.2    Detorre, C.3
  • 168
    • 84879973967 scopus 로고    scopus 로고
    • Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2
    • Piechowski, C.L., Rediger, A., Lagemann, C. et al. (2013). Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2. J. Mol. Endocrinol. 51, 109-118.
    • (2013) J. Mol. Endocrinol. , vol.51 , pp. 109-118
    • Piechowski, C.L.1    Rediger, A.2    Lagemann, C.3
  • 169
    • 0037228055 scopus 로고    scopus 로고
    • High frequency of BRAF mutations in nevi
    • Pollock, P.M., Harper, U.L., Hansen, K.S. et al. (2003). High frequency of BRAF mutations in nevi. Nat. Genet. 33, 19-20.
    • (2003) Nat. Genet. , vol.33 , pp. 19-20
    • Pollock, P.M.1    Harper, U.L.2    Hansen, K.S.3
  • 170
    • 0032484206 scopus 로고    scopus 로고
    • alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome
    • Price, E.R., Horstmann, M.A., Wells, A.G., Weilbaecher, K.N., Takemoto, C.M., Landis, M.W., and Fisher, D.E. (1998). alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome. J. Biol. Chem. 273, 33042-33047.
    • (1998) J. Biol. Chem. , vol.273 , pp. 33042-33047
    • Price, E.R.1    Horstmann, M.A.2    Wells, A.G.3    Weilbaecher, K.N.4    Takemoto, C.M.5    Landis, M.W.6    Fisher, D.E.7
  • 171
    • 84860862555 scopus 로고    scopus 로고
    • Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor
    • Pucci, M., Pasquariello, N., Battista, N. et al. (2012). Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. J. Biol. Chem. 287, 15466-15478.
    • (2012) J. Biol. Chem. , vol.287 , pp. 15466-15478
    • Pucci, M.1    Pasquariello, N.2    Battista, N.3
  • 172
    • 0038757730 scopus 로고    scopus 로고
    • Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function
    • Qanbar, R., and Bouvier, M. (2003). Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function. Pharmacol. Ther. 97, 1-33.
    • (2003) Pharmacol. Ther. , vol.97 , pp. 1-33
    • Qanbar, R.1    Bouvier, M.2
  • 173
    • 0032918729 scopus 로고    scopus 로고
    • High polymorphism at the human melanocortin 1 receptor locus
    • Rana, B.K., Hewett-Emmett, D., Jin, L. et al. (1999). High polymorphism at the human melanocortin 1 receptor locus. Genetics 151, 1547-1557.
    • (1999) Genetics , vol.151 , pp. 1547-1557
    • Rana, B.K.1    Hewett-Emmett, D.2    Jin, L.3
  • 174
    • 6344290128 scopus 로고    scopus 로고
    • The genetics of sun sensitivity in humans
    • Rees, J.L. (2004). The genetics of sun sensitivity in humans. Am. J. Hum. Genet. 75, 739-751.
    • (2004) Am. J. Hum. Genet. , vol.75 , pp. 739-751
    • Rees, J.L.1
  • 175
    • 6344275551 scopus 로고    scopus 로고
    • Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair
    • Ringholm, A., Klovins, J., Rudzish, R., Phillips, S., Rees, J.L., and Schioth, H.B. (2004). Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair. J. Invest Dermatol. 123, 917-923.
    • (2004) J. Invest Dermatol. , vol.123 , pp. 917-923
    • Ringholm, A.1    Klovins, J.2    Rudzish, R.3    Phillips, S.4    Rees, J.L.5    Schioth, H.B.6
  • 176
    • 0027413475 scopus 로고
    • Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function
    • Robbins, L.S., Nadeau, J.H., Johnson, K.R., Kelly, M.A., Roselli-Rehfuss, L., Baack, E., Mountjoy, K.G., and Cone, R.D. (1993). Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72, 827-834.
    • (1993) Cell , vol.72 , pp. 827-834
    • Robbins, L.S.1    Nadeau, J.H.2    Johnson, K.R.3    Kelly, M.A.4    Roselli-Rehfuss, L.5    Baack, E.6    Mountjoy, K.G.7    Cone, R.D.8
  • 178
    • 34848838267 scopus 로고    scopus 로고
    • MC1R expression in skin: is it confined to melanocytes?
    • Roberts, D.W., Newton, R.A., and Sturm, R.A. (2007). MC1R expression in skin: is it confined to melanocytes? J. Invest Dermatol. 127, 2472-2473.
    • (2007) J. Invest Dermatol. , vol.127 , pp. 2472-2473
    • Roberts, D.W.1    Newton, R.A.2    Sturm, R.A.3
  • 179
    • 40949154726 scopus 로고    scopus 로고
    • Melanocytes expressing MC1R polymorphisms associated with red hair color have altered MSH-ligand activated pigmentary responses in coculture with keratinocytes
    • Roberts, D.W., Newton, R.A., Leonard, J.H., and Sturm, R.A. (2008). Melanocytes expressing MC1R polymorphisms associated with red hair color have altered MSH-ligand activated pigmentary responses in coculture with keratinocytes. J. Cell. Physiol. 215, 344-355.
    • (2008) J. Cell. Physiol. , vol.215 , pp. 344-355
    • Roberts, D.W.1    Newton, R.A.2    Leonard, J.H.3    Sturm, R.A.4
  • 180
    • 84864359242 scopus 로고    scopus 로고
    • Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and beta-arrestins 1/2
    • Rodrigues, A.R., Almeida, H., and Gouveia, A.M. (2012). Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and beta-arrestins 1/2. Mol. Cell. Endocrinol. 361, 69-79.
    • (2012) Mol. Cell. Endocrinol. , vol.361 , pp. 69-79
    • Rodrigues, A.R.1    Almeida, H.2    Gouveia, A.M.3
  • 181
    • 84884620346 scopus 로고    scopus 로고
    • Structural determinants regulating cell surface targeting of melanocortin receptors
    • Rodrigues, A.R., Sousa, D., Almeida, H., and Gouveia, A.M. (2013). Structural determinants regulating cell surface targeting of melanocortin receptors. J. Mol. Endocrinol. 51, R23-R32.
    • (2013) J. Mol. Endocrinol. , vol.51 , pp. R23-R32
    • Rodrigues, A.R.1    Sousa, D.2    Almeida, H.3    Gouveia, A.M.4
  • 182
    • 84876787120 scopus 로고    scopus 로고
    • The masters talk: the PGC-1alpha-MITF axis as a melanoma energizer
    • Ronai, Z. (2013). The masters talk: the PGC-1alpha-MITF axis as a melanoma energizer. Pigment Cell Melanoma Res 26, 294-295.
    • (2013) Pigment Cell Melanoma Res , vol.26 , pp. 294-295
    • Ronai, Z.1
  • 183
    • 0642334382 scopus 로고    scopus 로고
    • Regulation of melanocortin 1 receptor expression at the mRNA and protein levels by its natural agonist and antagonist
    • Rouzaud, F., Annereau, J.P., Valencia, J.C., Costin, G.E., and Hearing, V.J. (2003). Regulation of melanocortin 1 receptor expression at the mRNA and protein levels by its natural agonist and antagonist. FASEB J. 17, 2154-2156.
    • (2003) FASEB J. , vol.17 , pp. 2154-2156
    • Rouzaud, F.1    Annereau, J.P.2    Valencia, J.C.3    Costin, G.E.4    Hearing, V.J.5
  • 184
    • 33845587599 scopus 로고    scopus 로고
    • Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms
    • Rouzaud, F., Costin, G.E., Yamaguchi, Y. et al. (2006). Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms. FASEB J. 20, 1927-1929.
    • (2006) FASEB J. , vol.20 , pp. 1927-1929
    • Rouzaud, F.1    Costin, G.E.2    Yamaguchi, Y.3
  • 185
    • 74949125668 scopus 로고    scopus 로고
    • Role of asparagine-linked glycosylation in cell surface expression and function of the human adrenocorticotropin receptor (melanocortin 2 receptor) in 293/FRT cells
    • Roy, S., Perron, B., and Gallo-Payet, N. (2010). Role of asparagine-linked glycosylation in cell surface expression and function of the human adrenocorticotropin receptor (melanocortin 2 receptor) in 293/FRT cells. Endocrinology 151, 660-670.
    • (2010) Endocrinology , vol.151 , pp. 660-670
    • Roy, S.1    Perron, B.2    Gallo-Payet, N.3
  • 186
    • 79952068392 scopus 로고    scopus 로고
    • Adrenocorticotropin hormone (ACTH) effects on MAPK phosphorylation in human fasciculata cells and in embryonic kidney 293 cells expressing human melanocortin 2 receptor (MC2R) and MC2R accessory protein (MRAP)beta
    • Roy, S., Pinard, S., Chouinard, L., and Gallo-Payet, N. (2011a). Adrenocorticotropin hormone (ACTH) effects on MAPK phosphorylation in human fasciculata cells and in embryonic kidney 293 cells expressing human melanocortin 2 receptor (MC2R) and MC2R accessory protein (MRAP)beta. Mol. Cell. Endocrinol. 336, 31-40.
    • (2011) Mol. Cell. Endocrinol. , vol.336 , pp. 31-40
    • Roy, S.1    Pinard, S.2    Chouinard, L.3    Gallo-Payet, N.4
  • 187
    • 80054972845 scopus 로고    scopus 로고
    • Mechanisms of melanocortin-2 receptor (MC2R) internalization and recycling in human embryonic kidney (hek) cells: identification of Key Ser/Thr (S/T) amino acids
    • Roy, S., Roy, S.J., Pinard, S., Taillefer, L.D., Rached, M., Parent, J.L., and Gallo-Payet, N. (2011b). Mechanisms of melanocortin-2 receptor (MC2R) internalization and recycling in human embryonic kidney (hek) cells: identification of Key Ser/Thr (S/T) amino acids. Mol. Endocrinol. 25, 1961-1977.
    • (2011) Mol. Endocrinol. , vol.25 , pp. 1961-1977
    • Roy, S.1    Roy, S.J.2    Pinard, S.3    Taillefer, L.D.4    Rached, M.5    Parent, J.L.6    Gallo-Payet, N.7
  • 188
    • 33750572874 scopus 로고    scopus 로고
    • Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB
    • Saha, B., Singh, S.K., Sarkar, C., Bera, R., Ratha, J., Tobin, D.J., and Bhadra, R. (2006). Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB. Pigment Cell Res. 19, 595-605.
    • (2006) Pigment Cell Res. , vol.19 , pp. 595-605
    • Saha, B.1    Singh, S.K.2    Sarkar, C.3    Bera, R.4    Ratha, J.5    Tobin, D.J.6    Bhadra, R.7
  • 190
    • 18544367370 scopus 로고    scopus 로고
    • Tissue distribution and differential expression of melanocortin 1 receptor, a malignant melanoma marker
    • Salazar-Onfray, F., Lopez, M., Lundqvist, A. et al. (2002). Tissue distribution and differential expression of melanocortin 1 receptor, a malignant melanoma marker. Br. J. Cancer 87, 414-422.
    • (2002) Br. J. Cancer , vol.87 , pp. 414-422
    • Salazar-Onfray, F.1    Lopez, M.2    Lundqvist, A.3
  • 191
    • 84875809798 scopus 로고    scopus 로고
    • MC1R gene mutation and its association with oculocutaneous albinism type (OCA) phenotype in a consanguineous Pakistani family
    • Saleha, S.B., Ajaml, M., Jamil, M., Nasir, M., and Hameed, A. (2013). MC1R gene mutation and its association with oculocutaneous albinism type (OCA) phenotype in a consanguineous Pakistani family. J. Dermatol. Sci. 70, 68-70.
    • (2013) J. Dermatol. Sci. , vol.70 , pp. 68-70
    • Saleha, S.B.1    Ajaml, M.2    Jamil, M.3    Nasir, M.4    Hameed, A.5
  • 193
    • 0036451652 scopus 로고    scopus 로고
    • Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function
    • Sanchez, M.J., Olivares, S.C., Ghanem, G., Haycock, J., Lozano Teruel, J.A., Garcia-Borron, J.C., and Jimenez-Cervantes, C. (2002). Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function. Eur. J. Biochem. 269, 6133-6141.
    • (2002) Eur. J. Biochem. , vol.269 , pp. 6133-6141
    • Sanchez, M.J.1    Olivares, S.C.2    Ghanem, G.3    Haycock, J.4    Lozano Teruel, J.A.5    Garcia-Borron, J.C.6    Jimenez-Cervantes, C.7
  • 196
    • 34047270236 scopus 로고    scopus 로고
    • Regulation of human melanocortin 1 receptor signaling and trafficking by Thr-308 and Ser-316 and its alteration in variant alleles associated with red hair and skin cancer
    • Sanchez-Laorden, B.L., Jimenez-Cervantes, C., and Garcia-Borron, J.C. (2007). Regulation of human melanocortin 1 receptor signaling and trafficking by Thr-308 and Ser-316 and its alteration in variant alleles associated with red hair and skin cancer. J. Biol. Chem. 282, 3241-3251.
    • (2007) J. Biol. Chem. , vol.282 , pp. 3241-3251
    • Sanchez-Laorden, B.L.1    Jimenez-Cervantes, C.2    Garcia-Borron, J.C.3
  • 197
    • 67650400328 scopus 로고    scopus 로고
    • Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgi
    • Sanchez-Laorden, B.L., Herraiz, C., Valencia, J.C., Hearing, V.J., Jimenez-Cervantes, C., and Garcia-Borron, J.C. (2009). Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgi. J. Cell. Physiol. 220, 640-654.
    • (2009) J. Cell. Physiol. , vol.220 , pp. 640-654
    • Sanchez-Laorden, B.L.1    Herraiz, C.2    Valencia, J.C.3    Hearing, V.J.4    Jimenez-Cervantes, C.5    Garcia-Borron, J.C.6
  • 199
    • 15444365234 scopus 로고    scopus 로고
    • Role of G protein-coupled receptor kinases in the homologous desensitization of the human and mouse melanocortin 1 receptors
    • Sanchez-Mas, J., Guillo, L.A., Zanna, P., Jimenez-Cervantes, C., and Garcia-Borron, J.C. (2005a). Role of G protein-coupled receptor kinases in the homologous desensitization of the human and mouse melanocortin 1 receptors. Mol. Endocrinol. 19, 1035-1048.
    • (2005) Mol. Endocrinol. , vol.19 , pp. 1035-1048
    • Sanchez-Mas, J.1    Guillo, L.A.2    Zanna, P.3    Jimenez-Cervantes, C.4    Garcia-Borron, J.C.5
  • 200
    • 25144432755 scopus 로고    scopus 로고
    • The melanocortin-1 receptor carboxyl terminal pentapeptide is essential for MC1R function and expression on the cell surface
    • Sanchez-Mas, J., Sanchez-Laorden, B.L., Guillo, L.A., Jimenez-Cervantes, C., and Garcia-Borron, J.C. (2005b). The melanocortin-1 receptor carboxyl terminal pentapeptide is essential for MC1R function and expression on the cell surface. Peptides 26, 1848-1857.
    • (2005) Peptides , vol.26 , pp. 1848-1857
    • Sanchez-Mas, J.1    Sanchez-Laorden, B.L.2    Guillo, L.A.3    Jimenez-Cervantes, C.4    Garcia-Borron, J.C.5
  • 202
    • 0020378771 scopus 로고
    • Comparative biological activities of highly potent active-site analogues of alpha-melanotropin
    • Sawyer, T.K., Hruby, V.J., Wilkes, B.C., Draelos, M.T., Hadley, M.E., and Bergsneider, M. (1982). Comparative biological activities of highly potent active-site analogues of alpha-melanotropin. J. Med. Chem. 25, 1022-1027.
    • (1982) J. Med. Chem. , vol.25 , pp. 1022-1027
    • Sawyer, T.K.1    Hruby, V.J.2    Wilkes, B.C.3    Draelos, M.T.4    Hadley, M.E.5    Bergsneider, M.6
  • 203
    • 77956190317 scopus 로고    scopus 로고
    • Genetics of pigmentation in skin cancer-a review
    • Scherer, D., and Kumar, R. (2010). Genetics of pigmentation in skin cancer-a review. Mutat. Res. 705, 141-153.
    • (2010) Mutat. Res. , vol.705 , pp. 141-153
    • Scherer, D.1    Kumar, R.2
  • 205
    • 18744402160 scopus 로고    scopus 로고
    • Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation
    • Scott, M.C., Suzuki, I., and Abdel-Malek, Z.A. (2002a). Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation. Pigment Cell Res. 15, 433-439.
    • (2002) Pigment Cell Res. , vol.15 , pp. 433-439
    • Scott, M.C.1    Suzuki, I.2    Abdel-Malek, Z.A.3
  • 206
    • 0036591966 scopus 로고    scopus 로고
    • Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation
    • Scott, M.C., Wakamatsu, K., Ito, S. et al. (2002b). Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation. J. Cell Sci. 115, 2349-2355.
    • (2002) J. Cell Sci. , vol.115 , pp. 2349-2355
    • Scott, M.C.1    Wakamatsu, K.2    Ito, S.3
  • 207
    • 69249146126 scopus 로고    scopus 로고
    • Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking
    • Sebag, J.A., and Hinkle, P.M. (2009). Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking. J. Biol. Chem. 284, 22641-22648.
    • (2009) J. Biol. Chem. , vol.284 , pp. 22641-22648
    • Sebag, J.A.1    Hinkle, P.M.2
  • 208
    • 0037387146 scopus 로고    scopus 로고
    • Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization
    • Shinyama, H., Masuzaki, H., Fang, H., and Flier, J.S. (2003). Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization. Endocrinology 144, 1301-1314.
    • (2003) Endocrinology , vol.144 , pp. 1301-1314
    • Shinyama, H.1    Masuzaki, H.2    Fang, H.3    Flier, J.S.4
  • 209
    • 0028356398 scopus 로고
    • Homologous and heterologous regulation of alpha-melanocyte-stimulating hormone receptors in human and mouse melanoma cell lines
    • Siegrist, W., Stutz, S., and Eberle, A.N. (1994). Homologous and heterologous regulation of alpha-melanocyte-stimulating hormone receptors in human and mouse melanoma cell lines. Cancer Res. 54, 2604-2610.
    • (1994) Cancer Res. , vol.54 , pp. 2604-2610
    • Siegrist, W.1    Stutz, S.2    Eberle, A.N.3
  • 211
    • 15944374337 scopus 로고    scopus 로고
    • Human placental lipid induces melanogenesis through p38 MAPK in B16F10 mouse melanoma
    • Singh, S.K., Sarkar, C., Mallick, S., Saha, B., Bera, R., and Bhadra, R. (2005). Human placental lipid induces melanogenesis through p38 MAPK in B16F10 mouse melanoma. Pigment Cell Res. 18, 113-121.
    • (2005) Pigment Cell Res. , vol.18 , pp. 113-121
    • Singh, S.K.1    Sarkar, C.2    Mallick, S.3    Saha, B.4    Bera, R.5    Bhadra, R.6
  • 212
    • 84872201612 scopus 로고    scopus 로고
    • Bone morphogenetic proteins differentially regulate pigmentation in human skin cells
    • Singh, S.K., Abbas, W.A., and Tobin, D.J. (2012). Bone morphogenetic proteins differentially regulate pigmentation in human skin cells. J. Cell Sci. 125, 4306-4319.
    • (2012) J. Cell Sci. , vol.125 , pp. 4306-4319
    • Singh, S.K.1    Abbas, W.A.2    Tobin, D.J.3
  • 213
    • 0033946195 scopus 로고    scopus 로고
    • Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress
    • Slominski, A., Wortsman, J., Luger, T., Paus, R., and Solomon, S. (2000). Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol. Rev. 80, 979-1020.
    • (2000) Physiol. Rev. , vol.80 , pp. 979-1020
    • Slominski, A.1    Wortsman, J.2    Luger, T.3    Paus, R.4    Solomon, S.5
  • 214
    • 4644237315 scopus 로고    scopus 로고
    • Melanin pigmentation in mammalian skin and its hormonal regulation
    • Slominski, A., Tobin, D.J., Shibahara, S., and Wortsman, J. (2004). Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol. Rev. 84, 1155-1228.
    • (2004) Physiol. Rev. , vol.84 , pp. 1155-1228
    • Slominski, A.1    Tobin, D.J.2    Shibahara, S.3    Wortsman, J.4
  • 215
    • 14244269885 scopus 로고    scopus 로고
    • Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background
    • Slominski, A., Plonka, P.M., Pisarchik, A., Smart, J.L., Tolle, V., Wortsman, J., and Low, M.J. (2005). Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background. Endocrinology 146, 1245-1253.
    • (2005) Endocrinology , vol.146 , pp. 1245-1253
    • Slominski, A.1    Plonka, P.M.2    Pisarchik, A.3    Smart, J.L.4    Tolle, V.5    Wortsman, J.6    Low, M.J.7
  • 216
  • 217
    • 0034617367 scopus 로고    scopus 로고
    • The involvement of p38 mitogen-activated protein kinase in the alpha-melanocyte stimulating hormone (alpha-MSH)-induced melanogenic and anti-proliferative effects in B16 murine melanoma cells
    • Smalley, K., and Eisen, T. (2000). The involvement of p38 mitogen-activated protein kinase in the alpha-melanocyte stimulating hormone (alpha-MSH)-induced melanogenic and anti-proliferative effects in B16 murine melanoma cells. FEBS Lett. 476, 198-202.
    • (2000) FEBS Lett. , vol.476 , pp. 198-202
    • Smalley, K.1    Eisen, T.2
  • 218
    • 0035999075 scopus 로고    scopus 로고
    • Differentiation of human melanoma cells through p38 MAP kinase is associated with decreased retinoblastoma protein phosphorylation and cell cycle arrest
    • Smalley, K.S., and Eisen, T.G. (2002). Differentiation of human melanoma cells through p38 MAP kinase is associated with decreased retinoblastoma protein phosphorylation and cell cycle arrest. Melanoma Res. 12, 187-192.
    • (2002) Melanoma Res. , vol.12 , pp. 187-192
    • Smalley, K.S.1    Eisen, T.G.2
  • 219
    • 7144254441 scopus 로고    scopus 로고
    • Melanocortin 1 receptor variants in an Irish population
    • Smith, R., Healy, E., Siddiqui, S. et al. (1998). Melanocortin 1 receptor variants in an Irish population. J. Invest Dermatol. 111, 119-122.
    • (1998) J. Invest Dermatol. , vol.111 , pp. 119-122
    • Smith, R.1    Healy, E.2    Siddiqui, S.3
  • 220
    • 0035960920 scopus 로고    scopus 로고
    • The human melanocortin-1 receptor locus: analysis of transcription unit, locus polymorphism and haplotype evolution
    • Smith, A.G., Box, N.F., Marks, L.H., Chen, W., Smit, D.J., Wyeth, J.R., Huttley, G.A., Easteal, S., and Sturm, R.A. (2001). The human melanocortin-1 receptor locus: analysis of transcription unit, locus polymorphism and haplotype evolution. Gene 281, 81-94.
    • (2001) Gene , vol.281 , pp. 81-94
    • Smith, A.G.1    Box, N.F.2    Marks, L.H.3    Chen, W.4    Smit, D.J.5    Wyeth, J.R.6    Huttley, G.A.7    Easteal, S.8    Sturm, R.A.9
  • 221
    • 45549108249 scopus 로고    scopus 로고
    • Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells
    • Smith, A.G., Luk, N., Newton, R.A., Roberts, D.W., Sturm, R.A., and Muscat, G.E. (2008). Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells. J. Biol. Chem. 283, 12564-12570.
    • (2008) J. Biol. Chem. , vol.283 , pp. 12564-12570
    • Smith, A.G.1    Luk, N.2    Newton, R.A.3    Roberts, D.W.4    Sturm, R.A.5    Muscat, G.E.6
  • 222
    • 70350102180 scopus 로고    scopus 로고
    • alpha-MSH activates immediate defense responses to UV-induced oxidative stress in human melanocytes
    • Song, X., Mosby, N., Yang, J., Xu, A., Abdel-Malek, Z., and Kadekaro, A.L. (2009). alpha-MSH activates immediate defense responses to UV-induced oxidative stress in human melanocytes. Pigment Cell Melanoma Res. 22, 809-818.
    • (2009) Pigment Cell Melanoma Res. , vol.22 , pp. 809-818
    • Song, X.1    Mosby, N.2    Yang, J.3    Xu, A.4    Abdel-Malek, Z.5    Kadekaro, A.L.6
  • 223
    • 84873495253 scopus 로고    scopus 로고
    • Replication and predictive value of SNPs associated with melanoma and pigmentation traits in a Southern European case-control study
    • Stefanaki, I., Panagiotou, O.A., Kodela, E. et al. (2013). Replication and predictive value of SNPs associated with melanoma and pigmentation traits in a Southern European case-control study. PLoS ONE 8, e55712.
    • (2013) PLoS ONE , vol.8 , pp. e55712
    • Stefanaki, I.1    Panagiotou, O.A.2    Kodela, E.3
  • 224
    • 77956336561 scopus 로고    scopus 로고
    • The Multiple Sclerosis Severity Score: associations with MC1R single nucleotide polymorphisms and host response to ultraviolet radiation
    • Strange, R.C., Ramachandran, S., Zeegers, M.P., Emes, R.D., Abraham, R., Raveendran, V., Boggild, M., Gilford, J., and Hawkins, C.P. (2010). The Multiple Sclerosis Severity Score: associations with MC1R single nucleotide polymorphisms and host response to ultraviolet radiation. Mult. Scler. 16, 1109-1116.
    • (2010) Mult. Scler. , vol.16 , pp. 1109-1116
    • Strange, R.C.1    Ramachandran, S.2    Zeegers, M.P.3    Emes, R.D.4    Abraham, R.5    Raveendran, V.6    Boggild, M.7    Gilford, J.8    Hawkins, C.P.9
  • 225
    • 33746121511 scopus 로고    scopus 로고
    • Melanocortin receptor-1 gene polymorphisms and the risk of cutaneous melanoma in a low-risk southern European population
    • Stratigos, A.J., Dimisianos, G., Nikolaou, V. et al. (2006). Melanocortin receptor-1 gene polymorphisms and the risk of cutaneous melanoma in a low-risk southern European population. J. Invest Dermatol. 126, 1842-1849.
    • (2006) J. Invest Dermatol. , vol.126 , pp. 1842-1849
    • Stratigos, A.J.1    Dimisianos, G.2    Nikolaou, V.3
  • 228
    • 0029863304 scopus 로고    scopus 로고
    • Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis
    • Suzuki, I., Cone, R.D., Im, S., Nordlund, J., and Abdel-Malek, Z.A. (1996). Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis. Endocrinology 137, 1627-1633.
    • (1996) Endocrinology , vol.137 , pp. 1627-1633
    • Suzuki, I.1    Cone, R.D.2    Im, S.3    Nordlund, J.4    Abdel-Malek, Z.A.5
  • 230
    • 0026064107 scopus 로고
    • Interleukins 1 alpha and 6 and tumor necrosis factor-alpha are paracrine inhibitors of human melanocyte proliferation and melanogenesis
    • Swope, V.B., Abdel-Malek, Z., Kassem, L.M., and Nordlund, J.J. (1991). Interleukins 1 alpha and 6 and tumor necrosis factor-alpha are paracrine inhibitors of human melanocyte proliferation and melanogenesis. J. Invest Dermatol. 96, 180-185.
    • (1991) J. Invest Dermatol. , vol.96 , pp. 180-185
    • Swope, V.B.1    Abdel-Malek, Z.2    Kassem, L.M.3    Nordlund, J.J.4
  • 231
    • 84865327547 scopus 로고    scopus 로고
    • Defining MC1R regulation in human melanocytes by its agonist alpha-melanocortin and antagonists agouti signaling protein and beta-defensin 3
    • Swope, V.B., Jameson, J.A., McFarland, K.L. et al. (2012). Defining MC1R regulation in human melanocytes by its agonist alpha-melanocortin and antagonists agouti signaling protein and beta-defensin 3. J. Invest Dermatol. 132, 2255-2262.
    • (2012) J. Invest Dermatol. , vol.132 , pp. 2255-2262
    • Swope, V.B.1    Jameson, J.A.2    McFarland, K.L.3
  • 232
    • 84902513344 scopus 로고    scopus 로고
    • Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation
    • Swope, V.B., Alexander, C., Starner, R. et al. (2014). Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation. Pigment Cell Melanoma Res, doi: 10.1111/pcmr.12252
    • (2014) Pigment Cell Melanoma Res
    • Swope, V.B.1    Alexander, C.2    Starner, R.3
  • 233
    • 42549172689 scopus 로고    scopus 로고
    • The Arg160Trp allele of melanocortin-1 receptor gene might protect against vitiligo
    • Szell, M., Baltas, E., Bodai, L. et al. (2008). The Arg160Trp allele of melanocortin-1 receptor gene might protect against vitiligo. Photochem. Photobiol. 84, 565-571.
    • (2008) Photochem. Photobiol. , vol.84 , pp. 565-571
    • Szell, M.1    Baltas, E.2    Bodai, L.3
  • 234
    • 0031844198 scopus 로고    scopus 로고
    • Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation
    • Tada, A., Suzuki, I., Im, S., Davis, M.B., Cornelius, J., Babcock, G., Nordlund, J.J., and Abdel-Malek, Z.A. (1998). Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation. Cell Growth Differ. 9, 575-584.
    • (1998) Cell Growth Differ. , vol.9 , pp. 575-584
    • Tada, A.1    Suzuki, I.2    Im, S.3    Davis, M.B.4    Cornelius, J.5    Babcock, G.6    Nordlund, J.J.7    Abdel-Malek, Z.A.8
  • 236
    • 0021206553 scopus 로고
    • Action of the e locus of mice in the response of phaeomelanic hair follicles to alpha-melanocyte-stimulating hormone in vitro
    • Tamate, H.B., and Takeuchi, T. (1984). Action of the e locus of mice in the response of phaeomelanic hair follicles to alpha-melanocyte-stimulating hormone in vitro. Science 224, 1241-1242.
    • (1984) Science , vol.224 , pp. 1241-1242
    • Tamate, H.B.1    Takeuchi, T.2
  • 237
    • 0032898736 scopus 로고    scopus 로고
    • Molecular analysis of a new splice variant of the human melanocortin-1 receptor
    • Tan, C.P., McKee, K.K., Weinberg, D.H. et al. (1999). Molecular analysis of a new splice variant of the human melanocortin-1 receptor. FEBS Lett. 451, 137-141.
    • (1999) FEBS Lett. , vol.451 , pp. 137-141
    • Tan, C.P.1    McKee, K.K.2    Weinberg, D.H.3
  • 238
    • 84866729606 scopus 로고    scopus 로고
    • Assembly of allosteric macromolecular switches: lessons from PKA
    • Taylor, S.S., Ilouz, R., Zhang, P., and Kornev, A.P. (2012). Assembly of allosteric macromolecular switches: lessons from PKA. Nat. Rev. Mol. Cell Biol. 13, 646-658.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 646-658
    • Taylor, S.S.1    Ilouz, R.2    Zhang, P.3    Kornev, A.P.4
  • 239
    • 84860717405 scopus 로고    scopus 로고
    • An atypical case of familial glucocorticoid deficiency without pigmentation caused by coexistent homozygous mutations in MC2R (T152K) and MC1R (R160W)
    • Turan, S., Hughes, C., Atay, Z., Guran, T., Haliloglu, B., Clark, A.J., Bereket, A., and Metherell, L.A. (2012). An atypical case of familial glucocorticoid deficiency without pigmentation caused by coexistent homozygous mutations in MC2R (T152K) and MC1R (R160W). J. Clin. Endocrinol. Metab. 97, E771-E774.
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. E771-E774
    • Turan, S.1    Hughes, C.2    Atay, Z.3    Guran, T.4    Haliloglu, B.5    Clark, A.J.6    Bereket, A.7    Metherell, L.A.8
  • 240
    • 0028786945 scopus 로고
    • Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans
    • Valverde, P., Healy, E., Jackson, I., Rees, J.L., and Thody, A.J. (1995). Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat. Genet. 11, 328-330.
    • (1995) Nat. Genet. , vol.11 , pp. 328-330
    • Valverde, P.1    Healy, E.2    Jackson, I.3    Rees, J.L.4    Thody, A.J.5
  • 243
    • 0035999728 scopus 로고    scopus 로고
    • Agouti: from mouse to man, from skin to fat
    • Voisey, J., and van Daal, A. (2002). Agouti: from mouse to man, from skin to fat. Pigment Cell Res. 15, 10-18.
    • (2002) Pigment Cell Res. , vol.15 , pp. 10-18
    • Voisey, J.1    van Daal, A.2
  • 244
    • 33646809751 scopus 로고    scopus 로고
    • A polymorphism in the agouti signalling protein (ASIP) is associated with decreased levels of mRNA
    • Voisey, J., Gomez-Cabrera, M.C., Smit, D.J., Leonard, J.H., Sturm, R.A., and Van, D.A. (2006). A polymorphism in the agouti signalling protein (ASIP) is associated with decreased levels of mRNA. Pigment Cell Res. 19, 226-231.
    • (2006) Pigment Cell Res. , vol.19 , pp. 226-231
    • Voisey, J.1    Gomez-Cabrera, M.C.2    Smit, D.J.3    Leonard, J.H.4    Sturm, R.A.5    Van, D.A.6
  • 245
  • 246
    • 77954729226 scopus 로고    scopus 로고
    • Shades of meaning: the pigment-type switching system as a tool for discovery
    • Walker, W.P., and Gunn, T.M. (2010). Shades of meaning: the pigment-type switching system as a tool for discovery. Pigment Cell Melanoma Res. 23, 485-495.
    • (2010) Pigment Cell Melanoma Res. , vol.23 , pp. 485-495
    • Walker, W.P.1    Gunn, T.M.2
  • 248
    • 34247383616 scopus 로고    scopus 로고
    • Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis
    • Wolfe, B.L., and Trejo, J. (2007). Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis. Traffic 8, 462-470.
    • (2007) Traffic , vol.8 , pp. 462-470
    • Wolfe, B.L.1    Trejo, J.2
  • 249
    • 0030293901 scopus 로고    scopus 로고
    • Binding and internalization of the melanocyte stimulating hormone receptor ligand [Nle4, D-Phe7] alpha-MSH in B16 melanoma cells
    • Wong, W., and Minchin, R.F. (1996). Binding and internalization of the melanocyte stimulating hormone receptor ligand [Nle4, D-Phe7] alpha-MSH in B16 melanoma cells. Int. J. Biochem. Cell Biol. 28, 1223-1232.
    • (1996) Int. J. Biochem. Cell Biol. , vol.28 , pp. 1223-1232
    • Wong, W.1    Minchin, R.F.2
  • 250
    • 0342735588 scopus 로고
    • Control of phenotypic expression of cultured melanoma cells by melanocyte stimulating hormones
    • Wong, G., and Pawelek, J. (1973). Control of phenotypic expression of cultured melanoma cells by melanocyte stimulating hormones. Nat. New Biol. 241, 213-215.
    • (1973) Nat. New Biol. , vol.241 , pp. 213-215
    • Wong, G.1    Pawelek, J.2
  • 251
    • 84859739604 scopus 로고    scopus 로고
    • MC1R variant allele effects on UVR-induced phosphorylation of p38, p53, and DDB2 repair protein responses in melanocytic cells in culture
    • Wong, S.S., Ainger, S.A., Leonard, J.H., and Sturm, R.A. (2012). MC1R variant allele effects on UVR-induced phosphorylation of p38, p53, and DDB2 repair protein responses in melanocytic cells in culture. J. Invest Dermatol. 132, 1452-1461.
    • (2012) J. Invest Dermatol. , vol.132 , pp. 1452-1461
    • Wong, S.S.1    Ainger, S.A.2    Leonard, J.H.3    Sturm, R.A.4
  • 252
    • 78650771153 scopus 로고    scopus 로고
    • Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response
    • Wu, G.S., Luo, H.R., Dong, C., Mastronardi, C., Licinio, J., and Wong, M.L. (2011). Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response. Psychiatr. Genet. 21, 14-18.
    • (2011) Psychiatr. Genet. , vol.21 , pp. 14-18
    • Wu, G.S.1    Luo, H.R.2    Dong, C.3    Mastronardi, C.4    Licinio, J.5    Wong, M.L.6
  • 253
    • 79955933804 scopus 로고    scopus 로고
    • Structure, function and regulation of the melanocortin receptors
    • Yang, Y. (2011). Structure, function and regulation of the melanocortin receptors. Eur. J. Pharmacol. 660, 125-130.
    • (2011) Eur. J. Pharmacol. , vol.660 , pp. 125-130
    • Yang, Y.1
  • 254
    • 0028231062 scopus 로고
    • Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene
    • Yen, T.T., Gill, A.M., Frigeri, L.G., Barsh, G.S., and Wolff, G.L. (1994). Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene. FASEB J. 8, 479-488.
    • (1994) FASEB J. , vol.8 , pp. 479-488
    • Yen, T.T.1    Gill, A.M.2    Frigeri, L.G.3    Barsh, G.S.4    Wolff, G.L.5


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