Inhibition of melanogenesis in response to oxidative stress: Transient downregulation of melanocyte differentiation markers and possible involvement of microphthalmia transcription factor

Journal of Cell Science

Volumn 114, Issue 12, 2001, Pages 2335-2344

  Jiménez Cervantes, Celia ^a   Martínez Esparza, María ^a   Pérez, Cristina ^a   Daum, Nicole ^a   Solano, Francisco ^a   García Borrón, José Carlos ^a  

^a UNIVERSITY OF MURCIA   (Spain)

Author keywords

Hydrogen peroxide; Hypopigmentation; Melanogenesis; Microphthalmia; Oxidative stress

Indexed keywords

CELL MARKER; DOPACHROME TAUTOMERASE; GLUTATHIONE; HYDROGEN PEROXIDE; MELANIN; MELANOCORTIN 1 RECEPTOR; MESSENGER RNA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MONOPHENOL MONOOXYGENASE; PHORBOL 13 ACETATE 12 MYRISTATE; REACTIVE OXYGEN METABOLITE; SILVER PROTEIN; TRANSCRIPTION FACTOR; TYROSINAE RELATED PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXPOSURE; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOPIGMENTATION; LIPID PEROXIDATION; MAMMAL; MELANOCYTE; MELANOGENESIS; MICROPHTHALMIA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SKIN; TIME; ULTRAVIOLET RADIATION;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; KINETICS; LIPID PEROXIDATION; MELANINS; MELANOCYTES; MELANOMA; MEMBRANE GLYCOPROTEINS; MICE; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MONOPHENOL MONOOXYGENASE; OXIDATIVE STRESS; OXIDOREDUCTASES; PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TYROSINE 3-MONOOXYGENASE;

EID: 0034935241     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Abe, J. and Berk, B. (1999). Fyn and JAK2 mediate Ras activation by reactive oxygen species. J. Biol. Chem. 274, 21003-21010.
2. Adachi, S., Morii, E., Kim, D., Ogihara, H., Jippo, T., Ito, A., Lee, Y. and Kitamura, Y. (2000). Involvement of mi-transcription factor in expression of alpha-melanocyte-stimulating hormone receptor in cultured mast cells of mice. J. Immunol. 164, 855-860.
3. Aksan, I. and Goding, C. (1998). Targeting of Microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo. Mol. Cell. Biol. 18, 6930-6938.
4. Aroca, P., García-Borrón, J. C., Solano, F. and Lozano, J. A. (1990). Regulation of distal mammalian melanogenesis. Partial purification and characterization of a dopachrome converting factor: dopachrome tautomerase. Biochim. Biophys. Acta, 1035, 266-275.
5. S6k signaling pathway. J. Biol. Chem. 274, 32596-32602.
6. Bae, Y. S., Kang, S. W., Seo, M. S., Baines, I. C., Tekle, E., Chock, P. B. and Rhee, S. G. (1997). Epidermal growth factor-induced generation of hydrogen peroxide. J. Biol. Chem. 272, 217-221.
7. Bentley, N. J., Eisen, T. and Goding, C. R. (1994). Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator. Mol. Cell. Biol. 14, 7996-8006.
8. Bertololto, C., Bille, K., Ortonne, J. P. and Ballotti, R. (1996). Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product. J. Cell Biol. 134, 747-755.
9. Bertolotto, C., Busca, R., Abbe, P., Bille, K., Aberdam, E., Ortonne, J. P. and Ballotti, R. (1998a). Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cAMP: pivotal role of M Boxes (GTCATGTGCT) and of microphthalmia. Mol. Cell. Biol. 18, 694-702.
10. Bertolotto, C., Bille, K., Ortonne, J. P. and Ballotti, R. (1998b). In B16 mouse melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter. Oncogene 16, 1665-1670.
11. Bittinger, F., González-García J. L., Klein, C. L., Brochhausen, C., Offner, F. and Kirkpatrick, C. J. (1998). Production of superoxide by human malignant melanoma cells. Melanoma Res. 8, 381-387.
12. Yasumoto, K., Yokoyama, K., Shibata, K., Tomita, Y. and Shibahara, S. (1994). Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. Mol. Cell. Biol. 14, 8058-8070.