Loop-swapped chimeras of the agouti-related protein and the agouti signaling protein identify contacts required for melanocortin 1 receptor selectivity and antagonism

Journal of Molecular Biology

Volumn 404, Issue 1, 2010, Pages 45-55

  Patel, Mira P ^a   Cribb Fabersunne, Camila S ^a   Yang, Ying Kui ^b   Kaelin, Christopher B ^c   Barsh, Gregory S ^c   Millhauser, Glenn L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Kentucky   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Agouti signaling protein; Agouti related protein; Chimera; Melanocortin receptors; Pigmentation

Indexed keywords

AGOUTI PROTEIN; AGOUTI RELATED PROTEIN; CYSTEINE; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 3 RECEPTOR;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHIMERA; DISULFIDE BOND; DRUG SELECTIVITY; ENERGY BALANCE; INVERSE AGONISM; MOLECULAR INTERACTION; MOLECULAR MODEL; PIGMENTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; WILD TYPE;

AGOUTI;

EID: 78049429422     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.08.054     Document Type: Article

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