Agouti: From mouse to man, from skin to fat

Pigment Cell Research

Volumn 15, Issue 1, 2002, Pages 10-18

  Voisey, Joanne ^a   Van Daal, Angela ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Melanocortin 1 receptor; Melanocortin 4 receptor; Obesity; Pigmentation

Indexed keywords

AGOUTI;

AGOUTI PROTEIN; BIOLOGICAL MARKER; CORTICOTROPIN RECEPTOR; FAT; MC3R PROTEIN, MOUSE; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN RECEPTOR; PIGMENT; PROTEIN; SIGNAL PEPTIDE;

ANIMAL; GENETICS; HUMAN; METABOLISM; MOUSE; OBESITY; PHYSIOLOGY; PIGMENTATION; REVIEW; SKIN;

ANIMALS; BIOLOGICAL MARKERS; FATS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; OBESITY; PIGMENTATION; PIGMENTS, BIOLOGICAL; PROTEINS; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; SKIN;

EID: 0035999728     PISSN: 08935785     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0749.2002.00039.x     Document Type: Review

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5. Isolation, cloning, and sequencing of porcine agouti exon 2 (PorAex2)
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8. Structure and function of ASP, the human homolog of the mouse agouti gene
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13. Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to alpha-melanotropin
14. Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans
15. The melanocyte stimulating hormone receptor polymorphism: Association of the V92M and A294H alleles with basal cell carcinoma
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20. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation
21. A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation
22. The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein
23. Pleiotropic effects of the mouse lethal yellow (Ay) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs
24. Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage
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26. Neomorphic agouti mutations in obese yellow mice
27. Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur
28. Molecular analysis of reverse mutations from nonagouti (a) to black-and- tan (a (t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts
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31. A polymorphism study of the human agouti gene and its association with MC1R
32. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
33. In situ localization of agouti signal protein in murine skin using immunohistochemistry with an ASP-specific antibody
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35. Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated
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42. Mutations in the carboxyl terminus of the agouti protein decrease agouti inhibition of ligand binding to the melanocortin receptors
43. Effects of recombinant agouti-signaling protein on melanocortin action
44. Agouti structure and function: Characterization of a potent alpha-melanocyte stimulating hormone receptor antagonist
45. Melanocortin receptor binding determinants in the agouti protein
46. The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes
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48. Agouti protein can act independently of melanocyte-stimulating hormone to inhibit melanogenesis
49. Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions
50. Secreted and membrane attractin result from alternative splicing of the human ATRN gene
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56. Overexpression of an Agouti cDNA in the skin of transgenic mice recapitulates dominant coat color phenotypes of spontaneous mutants
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59. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
60. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
61. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice
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63. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo
64. The role of agouti-related protein in regulating body weight
65. Association between an agouti-related protein gene polymorphism and anorexia nervosa
66. Weight-reducing effects of the plasma protein encoded by the obese gene
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68. Regulation of leptin by agouti
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70. 2+-dependent mechanism
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83. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
84. Systematic mutation screening of the pro-opiomelanocortin gene: Identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes