Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color

Journal of Investigative Dermatology

Volumn 117, Issue 2, 2001, Pages 294-300

  Kennedy, Cornelis ^a   Ter Huurne, Jeanet ^a   Berkhout, Marjo ^a   Gruis, Nelleke ^a   Bastiaens, Maarten ^a   Bergman, W ^a   Willemze, R ^a   Bouwes Bavinck, Jan Nico ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Epidemiology; Melanocortin 1 receptor gene; Melanoma

Indexed keywords

MELANOCORTIN 1 RECEPTOR;

ADULT; AGED; ALLELE; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA SEQUENCE; FEMALE; HAIR COLOR; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MELANOMA; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; SKIN;

EID: 0035722059     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202x.2001.01421.x     Document Type: Article

References (38)

1. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides
2. The genetics of pigmentation: From fancy genes to complex traits
3. Melanocortin-1 receptor gene variants determine the risk of non-melanoma skin cancer independent of fair skin type and red hair
4. Risk of cutaneous melanoma associated with pigmentation characteristics and freckling: Systematic overview of 10 case-control studies
5. Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair
6. Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma
7. Melanocyte-stimulating hormone, tyrosinase activity and the regulation of eumelanogenesis and phaeomelanogenesis in the hair follicular melanocytes of the mouse
8. Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture regulation by ultraviolet B
9. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA
10. The melanocortin receptors: Agonists, antagonists, and the hormonal control of pigmentation
11. The relation between smoking and skin cancer
12. Alpha melanocyte stimulating hormone (MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors
13. The validity and practicality of sun-reactive skin type I through VI
14. Pleitropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation
15. Human pigmentation phenotype: A point mutation generates nonfunctional MSH receptor
16. Evidence for variable selective pressure at MC1R
17. α-Melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines
18. The human Mc1r
19. Skin type, melanoma, and melanocortin 1 receptor variants
20. Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair
21. Alpha-melanocyte stimulating hormone inhibits tumour necrosis factor-alpha stimulated intercellular adhesion molecule- 1 expression in normal cutaneous human melanocytes an in melanoma cell lines
22. Susceptibility to melanoma: Influence of skin type and polymorphism in the melanocyte stimulating hormone receptor gene
23. Cutaneous malignant melanoma and sun exposure
24. Identification of common polymorphisms in the coding sequence of the human MSH receptor (MC1R) with possible biological effects
25. Cutaneous immunomodulation and coordination of skin stress responses by-melanocyte-stimulating hormone
26. Alpha-melanocyte-stimulating hormone immunoreactivity in melanoma cells
27. A simple salting out procedure for extracting DNA from human nucleated cells
28. Modulation of ICAM-1 expression by alpha-MSH in human melanoma cells and melanocytes
29. The cloning of a family of genes that encode the melanocortin receptors
30. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
31. Melanocortin-1 receptor polymorphisms and risk of melanoma: Is the association explained solely by pigmentation phenotype?
32. Melanocortin receptors, red hair, and skin cancer
33. Loss of function mutations of the human melanocortin 1 receptor are common and are associated with red hair
34. Melanocortin 1 receptor variants in an Irish population
35. Binding of melanotrophic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis
36. Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans
37. The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma
38. Proopiomelanocortin its derived peptides, and the skin