Unexpectedly severe acute radiotherapy side effects are associated with single nucleotide polymorphisms of the melanocortin-1 receptor

International Journal of Radiation Oncology Biology Physics

Volumn 77, Issue 5, 2010, Pages 1486-1492

  Fogarty, Gerald B ^a   Muddle, Rory ^b   Sprung, Carl N ^a,c   Chen, Wei ^b   Duffy, David ^d   Sturm, Richard A ^b   McKay, Michael J ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Acute radiation reaction; MC1R; predictive assays; R160W; single nucleotide polymorphisms

Indexed keywords

MC1R; PREDICTIVE ASSAYS; R160W; RADIATION REACTIONS; SINGLE NUCLEOTIDE POLYMORPHISMS;

DNA; IONIZING RADIATION; NUCLEOTIDES; ORGANIC ACIDS; POLYMORPHISM; POPULATION STATISTICS;

RADIOTHERAPY;

MELANOCORTIN 1 RECEPTOR; MELANIN;

ALLELE; ARTICLE; AUSTRALIA; CANCER RADIOTHERAPY; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA SEQUENCE; GENE FREQUENCY; GENETIC DIFFERENCE; GENOTYPE; HUMAN; IONIZING RADIATION; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; RADIATION SICKNESS; RADIOSENSITIVITY; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; ACUTE DISEASE; BIOSYNTHESIS; CASE CONTROL STUDY; GENETICS; HAIR COLOR; METHODOLOGY; RADIATION DOSE; RADIATION INJURY; RADIOTHERAPY; RISK; SKIN PIGMENTATION;

ACUTE DISEASE; ALLELES; AUSTRALIA; CASE-CONTROL STUDIES; COHORT STUDIES; CONFIDENCE INTERVALS; HAIR COLOR; HUMANS; MELANINS; ODDS RATIO; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RADIATION INJURIES; RADIATION TOLERANCE; RADIOTHERAPY; RECEPTOR, MELANOCORTIN, TYPE 1; SEQUENCE ANALYSIS, DNA; SKIN PIGMENTATION;

EID: 77955477012     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.07.1690     Document Type: Article

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