메뉴 건너뛰기




Volumn 342, Issue 2, 2012, Pages 318-326

Selected melanocortin 1 receptor single-nucleotide polymorphisms differentially alter multiple signaling pathways

Author keywords

[No Author keywords available]

Indexed keywords

1 [1 (3 METHYL LEVO HISTIDYL O METHYL DEXTRO TYROSYL) 4 PHENYL 4 PIPERIDINYL] 1 BUTANONE; ALPHA INTERMEDIN; CYCLIC AMP; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 84864131402     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.194548     Document Type: Article
Times cited : (26)

References (40)
  • 2
    • 45549092254 scopus 로고    scopus 로고
    • Pharmacological analysis of human D1 and D2 dopamine receptor missense variants
    • Al-Fulaij MA, Ren Y, Beinborn M, and Kopin AS (2008) Pharmacological analysis of human D1 AND D2 dopamine receptor missense variants. J Mol Neurosci 34:211-223.
    • (2008) J Mol Neurosci , vol.34 , pp. 211-223
    • Al-Fulaij, M.A.1    Ren, Y.2    Beinborn, M.3    Kopin, A.S.4
  • 3
    • 77957056141 scopus 로고    scopus 로고
    • The melanocortin-1 receptor gene polymorphism and association with human skin cancer
    • Beaumont KA, Liu YY, and Sturm RA (2009) The melanocortin-1 receptor gene polymorphism and association with human skin cancer. Prog Mol Biol Transl Sci 88:85-153.
    • (2009) Prog Mol Biol Transl Sci , vol.88 , pp. 85-153
    • Beaumont, K.A.1    Liu, Y.Y.2    Sturm, R.A.3
  • 4
    • 26444449038 scopus 로고    scopus 로고
    • Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk
    • DOI 10.1093/hmg/ddi219
    • Beaumont KA, Newton RA, Smit DJ, Leonard JH, Stow JL, and Sturm RA (2005) Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk. Hum Mol Genet 14:2145-2154. (Pubitemid 41418014)
    • (2005) Human Molecular Genetics , vol.14 , Issue.15 , pp. 2145-2154
    • Beaumont, K.A.1    Newton, R.A.2    Smit, D.J.3    Leonard, J.H.4    Stow, J.L.5    Sturm, R.A.6
  • 5
    • 34548385653 scopus 로고    scopus 로고
    • Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles
    • DOI 10.1093/hmg/ddm177
    • Beaumont KA, Shekar SN, Shekar SL, Newton RA, James MR, Stow JL, Duffy DL, and Sturm RA (2007) Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles. Hum Mol Genet 16:2249-2260. (Pubitemid 47354907)
    • (2007) Human Molecular Genetics , vol.16 , Issue.18 , pp. 2249-2260
    • Beaumont, K.A.1    Shekar, S.L.2    Newton, R.A.3    James, M.R.4    Stow, J.L.5    Duffy, D.L.6    Sturm, R.A.7
  • 6
    • 1342308287 scopus 로고    scopus 로고
    • Ligand Function at Constitutively Active Receptor Mutants Is Affected by Two Distinct Yet Interacting Mechanisms
    • DOI 10.1124/mol.65.3.753
    • Beinborn M, Ren Y, Bläker M, Chen C, and Kopin AS (2004) Ligand function at constitutively active receptor mutants is affected by two distinct yet interacting mechanisms. Mol Pharmacol 65:753-760. (Pubitemid 38264043)
    • (2004) Molecular Pharmacology , vol.65 , Issue.3 , pp. 753-760
    • Beinborn, M.1    Ren, Y.2    Blaker, M.3    Chen, C.4    Kopin, A.S.5
  • 7
    • 33645459968 scopus 로고    scopus 로고
    • Lipoxin A4 regulates bronchial epithelial cell responses to acid injury
    • Bonnans C, Fukunaga K, Levy MA, and Levy BD (2006) Lipoxin A4 regulates bronchial epithelial cell responses to acid injury. Am J Pathol 168:1064-1072.
    • (2006) Am J Pathol , vol.168 , pp. 1064-1072
    • Bonnans, C.1    Fukunaga, K.2    Levy, M.A.3    Levy, B.D.4
  • 9
    • 0034659736 scopus 로고    scopus 로고
    • Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes
    • Buscà R, Abbe P, Mantoux F, Aberdam E, Peyssonnaux C, Eychène A, Ortonne JP, and Ballotti R (2000) Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes. EMBO J 19:2900-2910. (Pubitemid 30386762)
    • (2000) EMBO Journal , vol.19 , Issue.12 , pp. 2900-2910
    • Busca, R.1    Abbe, P.2    Mantoux, F.3    Aberdam, E.4    Peyssonnaux, C.5    Eychene, A.6    Ortonne, J.-P.7    Ballotti, R.8
  • 10
    • 1542347163 scopus 로고    scopus 로고
    • Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation
    • DOI 10.1124/pr.56.1.1
    • Catania A, Gatti S, Colombo G, and Lipton JM (2004) Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol Rev 56:1-29. (Pubitemid 38314578)
    • (2004) Pharmacological Reviews , vol.56 , Issue.1 , pp. 1-29
    • Catania, A.1    Gatti, S.2    Colombo, G.3    Lipton, J.M.4
  • 12
    • 77949325574 scopus 로고    scopus 로고
    • Trafficking of G-protein-coupled receptors to the plasma membrane: Insights for pharmacoperone drugs
    • Conn PM and Ulloa-Aguirre A (2010) Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs. Trends Endocrinol Metab 21:190-197.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 190-197
    • Conn, P.M.1    Ulloa-Aguirre, A.2
  • 16
    • 66049138465 scopus 로고    scopus 로고
    • Membrane-tethered ligands are effective probes for exploring class B1 G proteincoupled receptor function
    • Fortin JP, Zhu Y, Choi C, Beinborn M, Nitabach MN, and Kopin AS (2009) Membrane-tethered ligands are effective probes for exploring class B1 G proteincoupled receptor function. Proc Natl Acad Sci U S A 106:8049-8054.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 8049-8054
    • Fortin, J.P.1    Zhu, Y.2    Choi, C.3    Beinborn, M.4    Nitabach, M.N.5    Kopin, A.S.6
  • 18
    • 0036804765 scopus 로고    scopus 로고
    • Melanocortin peptides and their receptors: New targets for antiinflammatory therapy
    • Getting SJ (2002) Melanocortin peptides and their receptors: new targets for antiinflammatory therapy. Trends Pharmacol Sci 23:447-449.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 447-449
    • Getting, S.J.1
  • 19
    • 33646814991 scopus 로고    scopus 로고
    • Targeting melanocortin receptors as potential novel therapeutics
    • Getting SJ (2006) Targeting melanocortin receptors as potential novel therapeutics. Pharmacol Ther 111:1-15.
    • (2006) Pharmacol Ther , vol.111 , pp. 1-15
    • Getting, S.J.1
  • 20
    • 84864146166 scopus 로고    scopus 로고
    • A role for melanocortin peptides in modulating oxidative stress induced inflammation in A549 cells
    • Getting S, Kaneva M and Kerrigan M (2008) A role for melanocortin peptides in modulating oxidative stress induced inflammation in A549 cells. Proc Br Pharmacol Soc 6:C020.
    • (2008) Proc Br Pharmacol Soc , vol.6
    • Getting, S.1    Kaneva, M.2    Kerrigan, M.3
  • 22
    • 70349438983 scopus 로고    scopus 로고
    • Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways
    • Herraiz C, Jiménez-Cervantes C, Zanna P, and García- Borrón JC (2009) Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways. FEBS Lett 583:3269-3274.
    • (2009) FEBS Lett , vol.583 , pp. 3269-3274
    • Herraiz, C.1    Jiménez-Cervantes, C.2    Zanna, P.3    García- Borrón, J.C.4
  • 23
    • 78650881154 scopus 로고    scopus 로고
    • Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT
    • Herraiz C, Journé F, Abdel-Malek Z, Ghanem G, Jiménez- Cervantes C, and García- Borrón JC (2011) Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT. Mol Endocrinol 25:138-156.
    • (2011) Mol Endocrinol , vol.25 , pp. 138-156
    • Herraiz, C.1    Journé, F.2    Abdel-Malek, Z.3    Ghanem, G.4    Jiménez- Cervantes, C.5    García-Borrón, J.C.6
  • 25
    • 0038050991 scopus 로고    scopus 로고
    • DNA polymorphism and selection at the melanocortin-1 receptor gene in normally pigmented Southern African individuals
    • John PR, Makova K, Li WH, Jenkins T, and Ramsay M (2003) DNA polymorphism and selection at the melanocortin-1 receptor gene in normally pigmented southern African individuals. Ann NY Acad Sci 994:299-306. (Pubitemid 36793880)
    • (2003) Annals of the New York Academy of Sciences , vol.994 , pp. 299-306
    • John, P.R.1    Makova, K.2    Li, W.-H.3    Jenkins, T.4    Ramsay, M.5
  • 28
    • 0027297275 scopus 로고
    • Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
    • Lefkowitz RJ, Cotecchia S, Samama P, and Costa T (1993) Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol Sci 14:303-307. (Pubitemid 23242583)
    • (1993) Trends in Pharmacological Sciences , vol.14 , Issue.8 , pp. 303-307
    • Lefkowitz, R.J.1    Cotecchia, S.2    Samama, P.3    Costa, T.4
  • 29
    • 0032531035 scopus 로고    scopus 로고
    • α-Melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-κB activation induced by various inflammatory agents
    • Manna SK and Aggarwal BB (1998) α-Melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-κB activation induced by various inflammatory agents. J Immunol 161:2873-2880. (Pubitemid 28425709)
    • (1998) Journal of Immunology , vol.161 , Issue.6 , pp. 2873-2880
    • Manna, S.K.1    Aggarwal, B.B.2
  • 31
    • 6344275551 scopus 로고    scopus 로고
    • Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair
    • DOI 10.1111/j.0022-202X.2004.23444.x
    • Ringholm A, Klovins J, Rudzish R, Phillips S, Rees JL, and Schiöth HB (2004) Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair. J Invest Dermatol 123:917-923. (Pubitemid 39391938)
    • (2004) Journal of Investigative Dermatology , vol.123 , Issue.5 , pp. 917-923
    • Ringholm, A.1    Klovins, J.2    Rudzish, R.3    Phillips, S.4    Rees, J.L.5    Schioth, H.B.6
  • 33
    • 0037079229 scopus 로고    scopus 로고
    • Human melanocortin 1 receptor (MC1R) gene variants alter melanoma cell growth and adhesion to extracellular matrix
    • DOI 10.1038/sj.onc.1205913
    • Robinson SJ and Healy E (2002) Human melanocortin 1 receptor (MC1R) gene variants alter melanoma cell growth and adhesion to extracellular matrix. Oncogene 21:8037-8046. (Pubitemid 35430614)
    • (2002) Oncogene , vol.21 , Issue.52 , pp. 8037-8046
    • Robinson, S.J.1    Healy, E.2
  • 35
    • 0000448866 scopus 로고
    • 4-Norleucine, 7-d-phenylalanine-α-melanocyte-stimulating hormone: A highly potent α-melanotropin with ultralong biological activity
    • DOI 10.1073/pnas.77.10.5754
    • Sawyer TK, Sanfilippo PJ, Hruby VJ, Engel MH, Heward CB, Burnett JB, and Hadley ME (1980) 4-Norleucine, 7-D-phenylalanine-α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultralong biological activity. Proc Natl Acad Sci U S A 77:5754-5758. (Pubitemid 11206397)
    • (1980) Proceedings of the National Academy of Sciences of the United States of America , vol.77 , Issue.10 II , pp. 5754-5758
    • Sawyer, T.K.1    Sanfilippo, P.J.2    Hruby, V.J.3
  • 36
    • 0028835502 scopus 로고
    • Characterisation of melanocortin receptor subtypes by radioligand binding analysis
    • Schiöth HB, Muceniece R, Wikberg JE, and Chhajlani V (1995) Characterisation of melanocortin receptor subtypes by radioligand binding analysis. Eur J Pharmacol 288:311-317.
    • (1995) Eur J Pharmacol , vol.288 , pp. 311-317
    • Schiöth, H.B.1    Muceniece, R.2    Wikberg, J.E.3    Chhajlani, V.4
  • 37
    • 0344330997 scopus 로고    scopus 로고
    • Chimeric melanocortin MC1 and MC3 receptors: Identification of domains participating in binding of melanocyte-stimulating hormone peptides
    • Schiöth HB, Yook P, Muceniece R, Wikberg JE, and Szardenings M (1998) Chimeric melanocortin MC1 and MC3 receptors: identification of domains participating in binding of melanocyte-stimulating hormone peptides. Mol Pharmacol 54:154-161. (Pubitemid 28337598)
    • (1998) Molecular Pharmacology , vol.54 , Issue.1 , pp. 154-161
    • Schioth, H.B.1    Yook, P.2    Muceniece, R.3    Wikberg, J.E.S.4    Szardenings, M.5
  • 40
    • 0041856376 scopus 로고    scopus 로고
    • α-Melanocyte-stimulating hormone inhibits lipopolysaccharide- induced tumor necrosis factor-α production in leukocytes by modulating protein kinase A, p38 kinase, and nuclear factor κB signaling pathways
    • Yoon SW, Goh SH, Chun JS, Cho EW, Lee MK, Kim KL, Kim JJ, Kim CJ, and Poo H (2003) α-Melanocyte-stimulating hormone inhibits lipopolysaccharide- induced tumor necrosis factor-α production in leukocytes by modulating protein kinase A, p38 kinase, and nuclear factor κB signaling pathways. J Biol Chem 278:32914-32920.
    • (2003) J Biol Chem , vol.278 , pp. 32914-32920
    • Yoon, S.W.1    Goh, S.H.2    Chun, J.S.3    Cho, E.W.4    Lee, M.K.5    Kim, K.L.6    Kim, J.J.7    Kim, C.J.8    Poo, H.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.