Induction of constitutive melanogenesis in amelanotic mouse melanoma cells by transfection of the human melanocortin-1 receptor gene

Journal of Cell Science

Volumn 109, Issue 8, 1996, Pages 2023-2030

  Chluba De Tapia, Johanna ^a,b   Bagutti, Claudia ^a,c   Cotti, Renato ^a   Eberle, Alex N ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

melanocyte stimulating hormone ( MSH); Agouti; Constitutive activation; Melanin; Melanoma; Receptor; Transfection

Indexed keywords

ALPHA INTERMEDIN; CYCLIC AMP; MELANIN;

ANIMAL CELL; ARTICLE; CELL CLONE; CELL LINE; GENETIC TRANSFECTION; MELANOGENESIS; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALPHA-MSH; ANIMALS; ANTINEOPLASTIC AGENTS; CYCLIC AMP; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MELANINS; MELANOCYTE-STIMULATING HORMONES; MELANOMA; MICE; PROTEINS; RECEPTORS, PITUITARY HORMONE; TRANSFECTION; TUMOR CELLS, CULTURED;

AGOUTI; ANIMALIA;

EID: 0029831484     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Banerjee, P., Berry-Kravis, E., Bonafede-Chhabra, D. and Dawson, G. (1993). Heterologous expression of the serotonin 5-HT 1A receptor in neural and non-neural cell lines. Biochem. Biophys. Res. Commun. 192, 104-110.
2. Birnbaumer, M. (1995). Mutations and diseases of G protein coupled receptors. J. Receptor Signal Transduction Res. 15, 131-160.
3. Birnbaumer, L. and Birnbaumer, M. (1995). Signal transduction by G proteins: 1994 edition. J. Receptor Signal Transduction Res. 15, 213-252.
4. Buffey, J., Thody, A. J., Bleehen, S. S. and MacNeil, S. (1992). α-Melanocyte-stimulating hormone stimulates protein kinase C activity in murine B16 melanoma. J. Endocrinol. 133, 333-340.
5. Chhajlani, V. and Wikberg, J. E. S. (1992). Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett. 309, 417-420.
6. Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J. and Rutter, W. J. (1979). Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294-5299.
7. Chluba-de Tapia, J., Bagutti, C., Wikberg, J. E. S., Chhajlani, V. and Eberle, A. N. (1995). Stable expression of the human MSH receptor in a mouse melanoma cell line. J. Receptor Signal Transduction Res. 15, 43-53.
8. Cone, R. D., Mountjoy, K. G., Robbins, L. S., Nadeau, J. H., Johnson, K. R., Roselli-Rehfuss, L. and Mortrud, M. T. (1993). Cloning and functional characterization of a family of receptors for the melanotropic peptides. Ann. NY Acad. Sci. 680, 342-363.
9. Costa, T., Ogino, Y., Munson, P. J., Onaran, H. O. and Rodbard, D. (1992). Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand. Mol. Pharmacol. 41, 549-560.
10. Davis, L. G., Dibner, M. D. and Battey, J. F. (1986). In Basic Methods in Molecular Biology (ed. L. G. Davis, M. D. Dibner and J. F. Battey), pp. 286-289, Elsevier, Amsterdam, The Netherlands.
11. De Luca, M., Siegrist, W., Bondanza, S., Mathor, M., Cancedda, R. and Eberle, A. N. (1993). αMelanocyte stimulating hormone (αMSH) stimulates normal human melanocyte growth by binding to high-affinity receptors. J. Cell Sci. 105, 1079-1084.
12. Donatien, P. D., Hunt, G., Pieron, C., Lunec, J., Taieb, A. and Thody, A. J. (1992). The expression of functional MSH receptors on cultured human melanocytes. Arch. Dermatol. Res. 284, 424-426.
13. Eberle, A. N. (1988a). In The Melanotropins: Chemistry, Physiology and Mechanisms of Action (ed. A. N. Eberle), pp. 397-407. Karger, Basel, Switzerland.
14. Eberle, A. N. (1988b). In The Melanotropins: Chemistry, Physiology and Mechanisms of Action (ed. A. N. Eberle), pp. 128-140. Karger, Basel, Switzerland.
15. Eberle, A. N. (1988c). In The Melanotropins: Chemistry, Physiology and Mechanisms of Action (ed. A. N. Eberle), pp. 242-247. Karger, Basel, Switzerland.
16. Eberle, A. N., Jäggin Verin, V., Solca, F., Siegrist, W., Küenlin, C., Bagutti, C., Stutz, S. and Girard, J. (1991). Biologically active monoiodinated α-MSH derivatives for receptor binding studies using human melanoma cells. J. Receptor Res. 11, 311-322.
17. Eberle, A. N., Siegrist, W., Bagutti, C., Chluba-de Tapia, J., Solca, F., Wikberg, J. E. S. and Chhajlani, V. (1993). Receptors for melanocyte-stimulating hormone on melanoma cells. Ann. NY Acad. Sci. 680, 320-341.
18. Fidler, I. J. (1973). Selection of successive tumour lines for metastasis. Nature New Biol. 242, 148-149.
19. 7]-α-MSH at the melanocortin-1 receptor. Biochem. Biophys. Res. Commun. 202, 1266-1271.
20. Ghanem, G., Comunale, J., Libert, A., Vercammen, A. and Lejeune, F. (1988). Evidence for α-melanocyte stimulating hormone (α-MSH) receptors on human malignant melanoma cells. Int. J. Cancer 41, 248-255.
21. Ghanem, G., Loir, B., Hadley, M., Abdel Malek, Z., Libert, A., Del Marmol, V., Lejeune, F., Lozano, J. and Garcia-Borron, J. C. (1992). Partial characterization of IR-α-MSH peptides found in melanoma tumors. Peptides 13, 989-994.
22. Halaban, R. (1993). Growth regulation in normal and malignant melanocytes. Recent Results Cancer Res. 128, 133-150.
23. 2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J. Med. Chem. 38, 3454-3461.
24. 7αMSH affect morphology, tyrosinase activity and melanogenesis in cultured human melanocytes. J. Cell Sci. 107, 205-211.
25. Hunt, G., Donatien, P. D., Lunec, J., Todd, C., Kyne, S. and Thody, A. J. (1994b). Cultured human melanocytes respond to MSH peptides and ACTH. Pigment Cell Res. 7, 217-221.
26. Hunt, G. and Thody, A. J. (1995). Agouti protein can act independently of melanocyte-stimulating hormone to inhibit melanogenesis. J. Endocrinol. 147, R1-4.
27. Lefkowitz, R. J., Cotecchia, S., Samama, P. and Costa, T. (1993). Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol. Sci. 14, 303-307.
28. Lerner, A. B. (1993). The discovery of the melanotropins: a history of pituitary endocrinology. Ann. NY Acad Sci. 680, 1-12.
29. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
30. Lu, D., Willard, D. H., Patel, I. R., Kadwell, S., Overton, L., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O. and Cone, R. D. (1994). Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor. Nature 371, 799-802.
31. Lunec, J., Pieron, C., Sherbet, G. V. and Thody, A. J. (1990). α-Melanocyte-stimulating hormone immunoreactivity in melanoma cells. Pathobiology 58, 193-197.
32. Mountjoy, K. G., Robbins, L. S., Mortrud, M. T. and Cone, R. D. (1992). The cloning of a family of genes that encode the melanocortin receptors. Science 257, 1248-1251.
33. Mumby, S. M., Kahn, R. A., Manning, D. R. and Gilman, A. G. (1986). Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proc. Nat. Acad. Sci. USA 83, 265-269.
34. Munson, P. J. and Rodbard, D. (1980). Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107, 220-239.
35. olf proteins and adenylyl cyclases in mouse brain membranes. Brain Res. 643, 50-58.
36. Robbins, L. S., Nadeau, J. H., Johnson, K. R., Kelly, M. A., Roselli-Rehfuss, L., Baack, E., Mountjoy, K. G. and Cone, R. D. (1993). Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72, 827-834.
37. Robishaw, J. D., Smigel, M. D. and Gilman, A. G. (1986). Molecular basis for two forms of the G protein that stimulates adenylate cyclase. J. Biol. Chem. 261, 9587-9590.
38. Sato, M., Kataoka, R., Dingus, J., Wilcox, M., Hildebrandt, J. D. and Lanier, S. M. (1995). Factors determining specificity of signal transduction by G-protein-coupled receptors. J. Biol. Chem. 270, 15269-15276.
39. Siegrist, W. and Eberle, A. N. (1986). In situ melanin assay for MSH using mouse B16 melanoma cells in culture. Anal. Biochem. 159, 191-197.
40. Siegrist, W., Oestreicher, M., Stutz, S., Girard, J., Eberle, A. N. (1988). Radioreceptor assay for α-MSH using mouse B16 melanoma cells. J. Receptor Res. 8, 323-343.
41. Siegrist, W., Solca, F., Stutz, S., Giuffrè, L., Carrel, S., Girard, J. and Eberle, A. N. (1989). Characterization of receptors for α-melanocyte-stimulating hormone (α-MSH) on human melanoma cells. Cancer Res. 49, 6352-6358.
42. Siegrist, W. and Eberle, A. N. (1993). Homologous regulation of the MSH receptor in melanoma cells. J. Receptor Res. 13, 263-281.
43. Siegrist, W., Stutz, S. and Eberle, A. N. (1994). Homologous and heterologous regulation of α-melanocyte stimulating hormone (α-MSH) receptors in human melanoma cell lines. Cancer Res. 54, 2604-2610.
44. Siegrist, W. and Eberle, A. N. (1995). Melanocortins and their implication in melanoma. Trends Endocrinol. Metab. 6, 115-120.
45. Siegrist, W., Willard, D. H., Wilkison, W. O. and Eberle, A. N. (1996a) Agouti protein inhibits growth of B16 melanoma cells in vitro by acting through melanocortin receptors. Biochem. Biophys. Res. Commun. 218, 171-175.
46. Siegrist, W., Drozdz, R., Cotti, R., Willard, D. H., Wilkison, W. O. and Eberle, A. N. (1996b). Interactions of α-melanotropin and agouti on B16 melanoma cells: evidence for inverse agonism of agouti. J. Receptor Signal Transduction Res. (in press).
47. Solca, F., Siegrist, W., Drozdz, R., Girard, J. and Eberle, A. N. (1989). The receptor for α-melanotropin of mouse and human melanoma cells. J. Biol. Chem. 264, 14277-14281.
48. Solca, F., Chluba-de Tapia, J., Iwata, K. and Eberle, A. N. (1993). B16-G4F mouse melanoma cells: an MSH receptor-deficient cell clone. FEBS Lett. 322, 177-180.
49. Valverde, P., Healy, E., Jackson, I., Rees, J. I. and Thody, A. J. (1995). Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nature Genet. 11, 328-330.
50. Willard, D. H., Bodnar, W., Harris, C., Kiefer, L., Nichols, J. S., Blanchard, S., Hoffman, C., Moyer, M., Burkhart, W., Weiel, J., Luther, M. A., Wilkison, W. O. and Rocque, W. J. (1995). Agouti structure and function: characterization of a potent α-melanocyte stimulating hormone receptor antagonist. Biochemistry 34, 12341-12346.
51. Yagami T. (1995). Differential coupling of glucagon and β-adrenergic receptors with the small and large forms of the stimulatory G protein. Mol. Pharmacol. 48, 849-854.