Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn2+ as a structural and functional probe

Annals of the New York Academy of Sciences

Volumn 994, Issue , 2003, Pages 1-11

  Holst, Birgitte ^a,b   Schwartz, Thue W ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b 7TM Pharma A S   (Denmark)

Author keywords

7TM receptor; Agouti; AGRP; Alpha MSH; Constitutive signaling; MC4; Metal ion; Receptor activation; Zinc; Zn2+

Indexed keywords

7TM RECEPTOR; AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; ASPARTIC ACID; CYSTEINE; G PROTEIN COUPLED RECEPTOR; INTERMEDIN DERIVATIVE; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR; PEPTIDE DERIVATIVE; PROLINE; UNCLASSIFIED DRUG; ZINC ION;

AGONISM; AGONIST; CHEMICAL STRUCTURE; CONFERENCE PAPER; CONFORMATION; CONSTITUTIVE SIGNALING; DISULFIDE BOND; HUMAN; INVERSE AGONISM; LIGAND BINDING; MOLECULAR BIOLOGY; MOLECULAR PROBE; NONHUMAN; PROTEIN BINDING; RECEPTOR BINDING; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

AGOUTI;

EID: 0037713347     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb03156.x     Document Type: Conference Paper

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