Simultaneous purifying selection on the Ancestral MC1R allele and positive selection on the melanoma-risk Allele V60L in South Europeans

Molecular Biology and Evolution

Volumn 30, Issue 12, 2013, Pages 2654-2665

  Martínez Cadenas, Conrado ^a   López, Saioa ^b   Ribas, Gloria ^c   Flores, Carlos ^d,e   García, Oscar ^f   Sevilla, Arrate ^b   Smith Zubiaga, Isabel ^b   Ibarrola Villaba, Maider ^c   Pino Yanes, Maria Del Mar ^d,e,g   Gardeazabal, Jesús ^h   Boyano, Dolores ^b   García De Galdeano, Alicia ^b   Izagirre, Neskuts ^b   De La Rúa, Concepción ^b   Alonso, Santos ^b  

^a UNIVERSITAT JAUME I   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c Instituto Universitario IVI INCLIVA   (Spain)

^d HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

^f Basque Country Police   (Spain)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h HOSPITAL DE CRUCES   (Spain)

Author keywords

adaptive evolution; MC1R; melanoma; skin pigmentation

Indexed keywords

MELANOCORTIN 1 RECEPTOR;

ADAPTATION; ADAPTIVE EVOLUTION; ALLELE; ARTICLE; CANCER RISK; DEPIGMENTATION; EUROPE; EVOLUTION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAIR COLOR; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MELANOMA; NUCLEOTIDE SEQUENCE; POPULATION GENETICS; PRINCIPAL COMPONENT ANALYSIS; SKIN COLOR; SKIN PIGMENTATION; SPAIN; ULTRAVIOLET B RADIATION;

ADAPTIVE EVOLUTION; MC1R; MELANOMA; SKIN PIGMENTATION;

ALLELES; EUROPEAN CONTINENTAL ANCESTRY GROUP; EVOLUTION, MOLECULAR; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HAPLOTYPES; HOMOZYGOTE; HUMANS; MELANOMA; MUTATION; PHENOTYPE; RECEPTOR, MELANOCORTIN, TYPE 1; SELECTION, GENETIC; SKIN PIGMENTATION; SPAIN; ULTRAVIOLET RAYS;

EID: 84890387883     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/mst158     Document Type: Article

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