메뉴 건너뛰기




Volumn 132, Issue 9, 2012, Pages 2255-2262

Defining MC1R regulation in human melanocytes by its agonist α-melanocortin and antagonists agouti signaling protein and Β-defensin 3

Author keywords

[No Author keywords available]

Indexed keywords

4 O METHYLPHORBOL 13 ACETATE 12 MYRISTATE; ADENYLATE CYCLASE; AGOUTI PROTEIN; ALPHA MELANOCORTIN; BETA ARRESTIN 1; BETA DEFENSIN 3; FORSKOLIN; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 3; G PROTEIN COUPLED RECEPTOR KINASE 5; G PROTEIN COUPLED RECEPTOR KINASE 6; MELANOCORTIN; MELANOCORTIN 1 RECEPTOR; MONOPHENOL MONOOXYGENASE; PROTEIN KINASE C; UNCLASSIFIED DRUG;

EID: 84865327547     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.135     Document Type: Article
Times cited : (90)

References (47)
  • 1
    • 0028920049 scopus 로고
    • Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides
    • Abdel-Malek Z, Swope VB, Suzuki I et al. (1995) Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proc Natl Acad Sci USA 92:1789-93
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1789-1793
    • Abdel-Malek, Z.1    Swope, V.B.2    Suzuki, I.3
  • 2
    • 0035064572 scopus 로고    scopus 로고
    • The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes
    • Abdel-Malek ZA, Scott MC, Furumura M et al. (2001) The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes. J Cell Sci 114:1019-24
    • (2001) J Cell Sci , vol.114 , pp. 1019-1024
    • Abdel-Malek, Z.A.1    Scott, M.C.2    Furumura, M.3
  • 3
    • 0035976916 scopus 로고    scopus 로고
    • Desensitization of the Y1 cell adrenocorticotropin receptor: Evidence for a restricted heterologous mechanism implying a role for receptor-effector complexes
    • Baig AH, Swords FM, Noon LA et al. (2001) Desensitization of the Y1 cell adrenocorticotropin receptor: evidence for a restricted heterologous mechanism implying a role for receptor-effector complexes. J Biol Chem 276:44792-7
    • (2001) J Biol Chem , vol.276 , pp. 44792-44797
    • Baig, A.H.1    Swords, F.M.2    Noon, L.A.3
  • 4
    • 26444449038 scopus 로고    scopus 로고
    • Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk
    • Beaumont KA, Newton RA, Smit DJ et al. (2005) Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk. Hum Mol Genet 14:2145-54
    • (2005) Hum Mol Genet , vol.14 , pp. 2145-2154
    • Beaumont, K.A.1    Newton, R.A.2    Smit, D.J.3
  • 5
    • 79955930958 scopus 로고    scopus 로고
    • Melanocortin MC receptor in human genetics and model systems
    • Beaumont KA, Wong SS, Ainger SA et al. (2011) Melanocortin MC receptor in human genetics and model systems. Eur J Pharmacol 660:103-10
    • (2011) Eur J Pharmacol , vol.660 , pp. 103-110
    • Beaumont, K.A.1    Wong, S.S.2    Ainger, S.A.3
  • 6
    • 0034837773 scopus 로고    scopus 로고
    • MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations
    • Box NF, Duffy DL, Chen W et al. (2001) MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. Am J Hum Genet 69:765-73
    • (2001) Am J Hum Genet , vol.69 , pp. 765-773
    • Box, N.F.1    Duffy, D.L.2    Chen, W.3
  • 7
    • 0030782275 scopus 로고    scopus 로고
    • Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair
    • Box NF, Wyeth JR, O'Gorman LE et al. (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. Hum Mol Gen 6:1891-7
    • (1997) Hum Mol Gen , vol.6 , pp. 1891-1897
    • Box, N.F.1    Wyeth, J.R.2    O'Gorman, L.E.3
  • 8
    • 0344780741 scopus 로고    scopus 로고
    • G-protein coupled receptor kinases as modulators of G-protein signalling
    • Bunemann M, Hosey MM (1999) G-protein coupled receptor kinases as modulators of G-protein signalling. J Physiol 517(Part 1):5-23
    • (1999) J Physiol , vol.517 , Issue.PART 1 , pp. 5-23
    • Bunemann, M.1    Hosey, M.M.2
  • 9
    • 33751048740 scopus 로고    scopus 로고
    • Cell signaling and trafficking of human melanocortin receptors in real time using two-photon fluorescence and confocal laser microscopy: Differentiation of agonists and antagonists
    • Cai M, Varga EV, Stankova M et al. (2006) Cell signaling and trafficking of human melanocortin receptors in real time using two-photon fluorescence and confocal laser microscopy: differentiation of agonists and antagonists. Chem Biol Drug Des 68:183-93
    • (2006) Chem Biol Drug des , vol.68 , pp. 183-193
    • Cai, M.1    Varga, E.V.2    Stankova, M.3
  • 10
    • 36749008499 scopus 로고    scopus 로고
    • A-defensin mutation causes black coat color in domestic dogs
    • Candille SI, Kaelin CB, Cattanach BM et al. (2007) A-defensin mutation causes black coat color in domestic dogs. Science 318:1418-23
    • (2007) Science , vol.318 , pp. 1418-1423
    • Candille, S.I.1    Kaelin, C.B.2    Cattanach, B.M.3
  • 11
    • 0027103724 scopus 로고
    • The expression of functional MSH receptors on cultured human melanocytes
    • Donatien PD, Hunt G, Pieron C et al. (1992) The expression of functional MSH receptors on cultured human melanocytes. Arch Dermatol Res 284:424-6
    • (1992) Arch Dermatol Res , vol.284 , pp. 424-426
    • Donatien, P.D.1    Hunt, G.2    Pieron, C.3
  • 12
    • 0035101820 scopus 로고    scopus 로고
    • Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
    • Ferguson SS (2001) Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 53:1-24
    • (2001) Pharmacol Rev , vol.53 , pp. 1-24
    • Ferguson, S.S.1
  • 13
    • 0031868040 scopus 로고    scopus 로고
    • Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes: Evidence for a regulatory role of ultraviolet B, interleukin-1alpha, interleukin-1beta, endothelin-1 and tumour necrosis factor-alpha
    • Funasaka Y, Chakraborty AK, Hayashi Y et al. (1998) Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes: evidence for a regulatory role of ultraviolet B, interleukin-1alpha, interleukin-1beta, endothelin-1 and tumour necrosis factor-alpha. Br J Dermatol 139:216-24
    • (1998) Br J Dermatol , vol.139 , pp. 216-224
    • Funasaka, Y.1    Chakraborty, A.K.2    Hayashi, Y.3
  • 15
  • 16
    • 0035937107 scopus 로고    scopus 로고
    • Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic
    • Harder J, Bartels J, Christophers E et al. (2001) Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 276:5707-13
    • (2001) J Biol Chem , vol.276 , pp. 5707-5713
    • Harder, J.1    Bartels, J.2    Christophers, E.3
  • 17
    • 33745757131 scopus 로고    scopus 로고
    • Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes
    • Hauser JE, Kadekaro AL, Kavanagh RJ et al. (2006) Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes. Pigment Cell Res 19:303-14
    • (2006) Pigment Cell Res , vol.19 , pp. 303-314
    • Hauser, J.E.1    Kadekaro, A.L.2    Kavanagh, R.J.3
  • 18
    • 19544392728 scopus 로고    scopus 로고
    • Eumelanin and pheomelanin concentrations in human epidermis before and after UVB irradiation
    • Hennessy A, Oh C, Diffey B et al. (2005) Eumelanin and pheomelanin concentrations in human epidermis before and after UVB irradiation. Pigment Cell Res 18:220-3
    • (2005) Pigment Cell Res , vol.18 , pp. 220-223
    • Hennessy, A.1    Oh, C.2    Diffey, B.3
  • 19
    • 0028981255 scopus 로고
    • 7 α-melanocytestimulating hormone increases the eumelanin:phaeomelanin ratio in cultured human melanocytes
    • Hunt G, Kyne S, Wakamatsu K et al. (1995) Nle4DPhe7 α- melanocytestimulating hormone increases the eumelanin:phaeomelanin ratio in cultured human melanocytes. J Invest Dermatol 104:83-5
    • (1995) J Invest Dermatol , vol.104 , pp. 83-85
    • Hunt, G.1    Kyne, S.2    Wakamatsu, K.3
  • 20
    • 0031963866 scopus 로고    scopus 로고
    • Activation of the cyclic AMP pathway by a-melanotropin mediates the response of human melanocytes to ultraviolet B radiation
    • Im S, Moro O, Peng F et al. (1998) Activation of the cyclic AMP pathway by a-melanotropin mediates the response of human melanocytes to ultraviolet B radiation. Cancer Res 58:47-54
    • (1998) Cancer Res , vol.58 , pp. 47-54
    • Im, S.1    Moro, O.2    Peng, F.3
  • 21
    • 20144377250 scopus 로고    scopus 로고
    • A-Melanocortin and endothelin-1 activate anti-apoptotic pathways and reduce DNA damage in human melanocytes
    • Kadekaro AL, Kavanagh R, Kanto H et al. (2005) a-Melanocortin and endothelin-1 activate anti-apoptotic pathways and reduce DNA damage in human melanocytes. Cancer Res 65:4292-9
    • (2005) Cancer Res , vol.65 , pp. 4292-4299
    • Kadekaro, A.L.1    Kavanagh, R.2    Kanto, H.3
  • 22
    • 77957856003 scopus 로고    scopus 로고
    • Melanocortin 1 receptor genotype: An important determinant of the damage response of melanocytes to ultraviolet radiation
    • Kadekaro AL, Leachman S, Kavanagh RJ et al. (2010) Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation. FASEB J 24:3850-60
    • (2010) FASEB J , vol.24 , pp. 3850-3860
    • Kadekaro, A.L.1    Leachman, S.2    Kavanagh, R.J.3
  • 23
    • 0035722059 scopus 로고    scopus 로고
    • Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color
    • Kennedy C, ter Huurne J, Berkhout M et al. (2001) Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color. J Invest Dermatol 117:294-300
    • (2001) J Invest Dermatol , vol.117 , pp. 294-300
    • Kennedy, C.1    Ter Huurne, J.2    Berkhout, M.3
  • 24
    • 77953977632 scopus 로고    scopus 로고
    • Expression of antimicrobial peptides in cutaneous infections after skin surgery
    • Kesting MR, Stoeckelhuber M, Holzle F et al. (2010) Expression of antimicrobial peptides in cutaneous infections after skin surgery. Br J Dermatol 163:121-7
    • (2010) Br J Dermatol , vol.163 , pp. 121-127
    • Kesting, M.R.1    Stoeckelhuber, M.2    Holzle, F.3
  • 25
    • 33645877973 scopus 로고    scopus 로고
    • Human melanocortin receptor 2 expression and functionality: Effects of protein kinase A and protein kinase C on desensitization and internalization
    • Kilianova Z, Basora N, Kilian P et al. (2006) Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. Endocrinol 147:2325-37
    • (2006) Endocrinol , vol.147 , pp. 2325-2337
    • Kilianova, Z.1    Basora, N.2    Kilian, P.3
  • 26
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-8
    • (2001) Method. Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 27
    • 13444265991 scopus 로고    scopus 로고
    • Structures of the agouti signaling protein
    • McNulty JC, Jackson PJ, Thompson DA et al. (2005) Structures of the agouti signaling protein. J Mol Biol 346:1059-70
    • (2005) J Mol Biol , vol.346 , pp. 1059-1070
    • McNulty, J.C.1    Jackson, P.J.2    Thompson, D.A.3
  • 28
    • 0026800892 scopus 로고
    • The cloning of a family of genes that encode the melanocortin receptors
    • Mountjoy KG, Robbins LS, Mortrud MT et al. (1992) The cloning of a family of genes that encode the melanocortin receptors. Science 257:1248-51
    • (1992) Science , vol.257 , pp. 1248-1251
    • Mountjoy, K.G.1    Robbins, L.S.2    Mortrud, M.T.3
  • 29
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann MM, Wilson BD, Yang Y-K et al. (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135-8
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.-K.3
  • 30
    • 0033910271 scopus 로고    scopus 로고
    • Melanocortin-1 receptor polymorphisms and risk of melanoma: Is the association explained solely by pigmentation phenotype?
    • Palmer JS, Duffy DL, Box N et al. (2000) Melanocortin-1 receptor polymorphisms and risk of melanoma: Is the association explained solely by pigmentation phenotype? Am J Hum Genet 66:176-86
    • (2000) Am J Hum Genet , vol.66 , pp. 176-186
    • Palmer, J.S.1    Duffy, D.L.2    Box, N.3
  • 32
    • 33947375174 scopus 로고    scopus 로고
    • Physiological roles of G protein-coupled receptor kinases and arrestins
    • Premont RT, Gainetdinov RR (2007) Physiological roles of G protein-coupled receptor kinases and arrestins. Annu Rev Physiol 69:511-34
    • (2007) Annu Rev Physiol , vol.69 , pp. 511-534
    • Premont, R.T.1    Gainetdinov, R.R.2
  • 33
    • 33646162635 scopus 로고    scopus 로고
    • GRKs and beta-arrestins: Roles in receptor silencing, trafficking and signaling
    • Reiter E, Lefkowitz RJ (2006) GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab 17:159-65
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 159-165
    • Reiter, E.1    Lefkowitz, R.J.2
  • 34
    • 6344275551 scopus 로고    scopus 로고
    • Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair
    • Ringholm A, Klovins J, Rudzish R et al. (2004) Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair. J Invest Dermatol 123:917-23
    • (2004) J Invest Dermatol , vol.123 , pp. 917-923
    • Ringholm, A.1    Klovins, J.2    Rudzish, R.3
  • 35
    • 0027413475 scopus 로고
    • Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function
    • Robbins LS, Nadeau JH, Johnson KR et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72:827-34
    • (1993) Cell , vol.72 , pp. 827-834
    • Robbins, L.S.1    Nadeau, J.H.2    Johnson, K.R.3
  • 36
    • 33644765872 scopus 로고    scopus 로고
    • Dimerization of the human melanocortin 1 receptor: Functional consequences and dominant-negative effects
    • Sanchez-Laorden BL, Sanchez-Mas J, Martinez-Alonso E et al. (2006) Dimerization of the human melanocortin 1 receptor: functional consequences and dominant-negative effects. J Invest Dermatol 126:172-81
    • (2006) J Invest Dermatol , vol.126 , pp. 172-181
    • Sanchez-Laorden, B.L.1    Sanchez-Mas, J.2    Martinez-Alonso, E.3
  • 37
    • 15444365234 scopus 로고    scopus 로고
    • Role of G protein-coupled receptor kinases in the homologous desensitization of the human and mouse melanocortin 1 receptors
    • Sanchez-Mas J, Guillo LA, Zanna P et al. (2005) Role of G protein-coupled receptor kinases in the homologous desensitization of the human and mouse melanocortin 1 receptors. Mol Endocrinol 19:1035-48
    • (2005) Mol Endocrinol , vol.19 , pp. 1035-1048
    • Sanchez-Mas, J.1    Guillo, L.A.2    Zanna, P.3
  • 38
    • 19944413653 scopus 로고    scopus 로고
    • Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection
    • Sawamura D, Goto M, Shibaki A et al. (2005) Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection. Gene Ther 12:857-61
    • (2005) Gene Ther , vol.12 , pp. 857-861
    • Sawamura, D.1    Goto, M.2    Shibaki, A.3
  • 39
    • 18744402160 scopus 로고    scopus 로고
    • Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors, and by UV radiation
    • Scott MC, Suzuki I, Abdel-Malek ZA (2002a) Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors, and by UV radiation. Pigment Cell Res 15:433-9
    • (2002) Pigment Cell Res , vol.15 , pp. 433-439
    • Scott, M.C.1    Suzuki, I.2    Abdel-Malek, Z.A.3
  • 40
    • 0036591966 scopus 로고    scopus 로고
    • Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation
    • Scott MC, Wakamatsu K, Ito S et al. (2002b) Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation. J Cell Sci 115:2349-55
    • (2002) J Cell Sci , vol.115 , pp. 2349-2355
    • Scott, M.C.1    Wakamatsu, K.2    Ito, S.3
  • 41
    • 0037387146 scopus 로고    scopus 로고
    • Regulation of melanocortin-4 receptor signaling: Agonist-mediated desensitization and internalization
    • Shinyama H, Masuzaki H, Fang H et al. (2003) Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization. Endocrinology 144:1301-14
    • (2003) Endocrinology , vol.144 , pp. 1301-1314
    • Shinyama, H.1    Masuzaki, H.2    Fang, H.3
  • 43
    • 7144254441 scopus 로고    scopus 로고
    • Melanocortin 1 receptor variants in Irish population
    • Smith R, Healy E, Siddiqui S et al. (1998) Melanocortin 1 receptor variants in Irish population. J Invest Dermatol 111:119-22
    • (1998) J Invest Dermatol , vol.111 , pp. 119-122
    • Smith, R.1    Healy, E.2    Siddiqui, S.3
  • 44
    • 0029863304 scopus 로고    scopus 로고
    • Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis
    • Suzuki I, Cone R, Im S et al. (1996) Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis. Endocrinology 137:1627-33
    • (1996) Endocrinology , vol.137 , pp. 1627-1633
    • Suzuki, I.1    Cone, R.2    Im, S.3
  • 45
    • 0030970586 scopus 로고    scopus 로고
    • Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to a-melanotropin
    • Suzuki I, Tada A, Ollmann MM et al. (1997) Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to a-melanotropin. J Invest Dermatol 108:838-42
    • (1997) J Invest Dermatol , vol.108 , pp. 838-842
    • Suzuki, I.1    Tada, A.2    Ollmann, M.M.3
  • 46
    • 0021206553 scopus 로고
    • Action of the e locus of mice in the response of phaeomelanic hair follicles to α-melanocyte-stimulating hormone in vitro
    • Tamate HB, Takeuchi T (1984) Action of the e locus of mice in the response of phaeomelanic hair follicles to α-melanocyte-stimulating hormone in vitro. Science 224:1241-2
    • (1984) Science , vol.224 , pp. 1241-1242
    • Tamate, H.B.1    Takeuchi, T.2
  • 47
    • 0028231062 scopus 로고
    • Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: Ectopic expression of the agouti gene
    • Yen TT, Gill AM, Frigeri LG et al. (1994) Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: Ectopic expression of the agouti gene. FASEB J 8: 479-88
    • (1994) FASEB J , vol.8 , pp. 479-488
    • Yen, T.T.1    Gill, A.M.2    Frigeri, L.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.