Human skin pigmentation as an adaptation to UV radiation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue SUPPL. 2, 2010, Pages 8962-8968

  Jablonski, Nina G ^a   Chaplin, George ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Folate; Melanin; Tanning; UVB; Vitamin D

Indexed keywords

FOLIC ACID; VITAMIN D; 5 METHYLTETRAHYDROFOLIC ACID; 5-METHYLTETRAHYDROFOLATE; REACTIVE OXYGEN METABOLITE; TETRAHYDROFOLIC ACID DERIVATIVE;

ADAPTATION; ARTICLE; CELL DIVISION; HUMAN; MELANOGENESIS; PHOTOLYSIS; PRIORITY JOURNAL; SKIN PIGMENTATION; TROPICS; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; ULTRAVIOLET RADIATION; CHEMISTRY; EVOLUTION; FEMALE; GENETIC VARIABILITY; GEOGRAPHY; MALE; METABOLISM; PATHOLOGY; RADIATION EXPOSURE; SKIN; SUNLIGHT;

ADAPTATION, PHYSIOLOGICAL; EVOLUTION; FEMALE; FOLIC ACID; GENETIC VARIATION; GEOGRAPHY; HUMANS; MALE; PHOTOLYSIS; REACTIVE OXYGEN SPECIES; SKIN; SKIN PIGMENTATION; SUNLIGHT; TETRAHYDROFOLATES; ULTRAVIOLET RAYS;

EID: 77952326915     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914628107     Document Type: Article

References (80)

1. Darwin C (1871) The Descent of Man, and Selection in Relation to Sex (John Murray, London).
2. Desmond AJ, Moore JR (2009) Darwin's Sacred Cause: How a Hatred of Slavery Shaped Darwin's Views on Human Evolution (Houghton Mifflin Harcourt, Boston, MA).
3. van Wyhe J (2007) Mind the gap: Did Darwin avoid publishing his theory for many years? Notes and Records of the Royal Society 61:177-205.
4. Isaac B (2004) The Invention of Racism in Classical Antiquity (Princeton University Press, Princeton, NJ).
5. Smith SS, Jordan W-D (1965) An Essay on the Causes of the Variety of Complexion and Figure in the Human Species (The Belknap Press of Harvard University Press, Cambridge, MA).
6. Mitchell J, Collinson P (1744) An essay upon the causes of the different colours of people in different climates.. Philosophical Transactions(1683-1775 43:102-150.
7. Jablonski NG, Chaplin G (2000) The evolution of human skin coloration. J Hum Evol 39:57-106.
8. Zihlman A, Cohn BA (1988) The adaptive response of human skin to the savanna. Hum Evol 3:397-409.
9. Folk GEJ, Jr, Semken HAJ, Jr (1991) The evolution of sweat glands. Int J Biometeorol 35:180-186.
10. Elias PM(2005) Stratum corneum defensive functions: an integrated view. J InvestDermatol 125:183-200. (Pubitemid 41648149)
11. Montagna W (1981) The consequences of having a naked skin. Birth Defects Orig Artic Ser 17:1-7.
12. Chimpanzee Sequencing and Analysis Consortium (2005) Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 437:69-87. (Pubitemid 41613428)
13. Moll R, Divo M, Langbein L (2008) The human keratins: Biology and pathology. Histochem Cell Biol 129:705-733.
14. Rogers AR, Iltis D, Wooding S (2004) Genetic variation at the MC1R locus and the time since loss of human body hair. Curr Anthropol 45:105-124.
15. Roberts DF, Kahlon DPS (1976) Environmental correlations of skin colour. Ann Hum Biol 3:11-22.
16. Walter H (1971) Remarks on the environmental adaptation of man. Humangenetik 13:85-97.
17. Chaplin G (2004) Geographic distribution of environmental factors influencing human skin coloration. Am J Phys Anthropol 125:292-302. (Pubitemid 39363385)
18. Blum HF (1961) Does the melanin pigment of human skin have adaptive value? An essay in human skin have adaptive value? An essay in human ecology and the evolution of race. Q Rev Biol 36:50-63.
19. Loomis WF (1967) Skin-pigment regulation of vitamin-D biosynthesis in man. Science 157:501-506.
20. Ricotti C, Bouzari N, Agadi A, Cockerell CJ (2009) Malignant skin neoplasms. Med Clin North Am 93:1241-1264.
21. MacKie RM, Hauschild A, Eggermont AMM (2009) Epidemiology of invasive cutaneous melanoma. Ann Oncol 20 (Suppl 6):vi1-vi7.
22. NanH, Kraft P, Hunter DJ, Han J (2009)Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians. Int J Cancer 125:909-917.
23. 3 photosynthesis in man: Skin pigment is not an essential regulator. Science 211:590-593.
24. Branda RF, Eaton JW (1978) Skin color and nutrient photolysis: an evolutionary hypothesis. Science 201:625-626.
25. Off MK, et al. (2005) Ultraviolet photodegradation of folic acid. J Photochem Photobiol B 80:47-55.
26. Steindal AH, Juzeniene A, Johnsson A, Moan J (2006) Photodegradation of 5-methyltetrahydrofolate: biophysical aspects. Photochem Photobiol 82:1651-1655.
27. Tam TTT, Juzeniene A, Steindal AH, Iani V, Moan J (2009) Photodegradation of 5-methyltetrahydrofolate in the presence of Uroporphyrin. J Photochem Photobiol B 94:201-204.
28. Steindal AH, Tam TTT, Lu XY, Juzeniene A, Moan J (2008) 5-Methyltetrahydrofolate is photosensitive in the presence of riboflavin. Photochem Photobiol Sci 7:814-818.
29. Lawrence VA (1983) Demographic analysis of serum folate and folate-binding capacity in hospitalized patients. Acta Haematol 69:289-293.
30. Lamparelli RD, et al. (1988) Nutritional anaemia in pregnant coloured women in Johannesburg. S Afr Med J 73:477-481.
31. Buccimazza SS, Molteno CD, Dunne TT, Viljoen DL (1994) Prevalence of neural tube defects in Cape Town, South Africa. Teratology 50:194-199.
32. Leck IAN (1984) The geographical distribution of neural tube defects and oral clefts. Br Med Bull 40:390-395.
33. Han J, Colditz GA, Hunter DJ (2007) Polymorphisms in the MTHFR and VDR genes and skin cancer risk. Carcinogenesis 28:390-397. (Pubitemid 46321855)
34. Stover PJ (2009) One-carbon metabolism-genome interactions in folate-associated pathologies. J Nutr 139:2402-2405.
35. Group MVSR, MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338:131-137.
36. Fleming A, Copp AJ (1998) Embryonic folate metabolism and mouse neural tube defects. Science 280:2107-2109. (Pubitemid 28366201)
37. Blom HJ, Shaw GM, den Heijer M, Finnell RH (2006) Neural tube defects and folate: case far from closed. Nat Rev Neurosci 7:724-731.
38. Shi W, Meininger CJ, Haynes TE, Hatakeyama K, Wu G (2004) Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells. Cell BiochemBiophys 41:415-434. (Pubitemid 41270753)
39. Schallreuter KU, Kothari S, Chavan B, Spencer JD (2008) Regulation of melanogenesis -controversies and new concepts. Exp Dermatol 17:395-404. (Pubitemid 351513953)
40. Schallreuter KU (2007) Advances in melanocyte basic science research. Dermatol Clin 25:283-291, vii.
41. John PR, Makova K, Li WH, Jenkins T, Ramsay M (2003) DNA polymorphism and selection at the melanocortin-1 receptor gene in normally pigmented southern African individuals. Ann N Y Acad Sci 994:299-306. (Pubitemid 36793880)
42. Makova K, Norton HL (2005) Worldwide polymorphism at the MC1R locus and normal pigmentation variation in humans. Peptides 26:1901-1908. (Pubitemid 41354548)
43. Harding RM, et al. (2000) Evidence for variable selective pressures at MC1R. Am J Hum Genet 66:1351-1361.
44. Reich D, Thangaraj K, Patterson N, Price AL, Singh L (2009) Reconstructing Indian population history. Nature 461:489-494.
45. Bonilla C, Gutiérrez G, Parra EJ, Kline C, Shriver MD (2005) Admixture analysis of a rural population of the state of Guerrero, Mexico. Am J Phys Anthropol 128:861-869. (Pubitemid 41746203)
46. Murray FG (1934) Pigmentation, sunlight, and nutritional disease. Am Anthropol 36:438-445.
47. Lips P (2006) Vitamin D physiology. Prog Biophys Mol Biol 92:4-8.
48. Mawer EB, Davies M (2001) Vitamin D nutrition and bone disease in adults. Rev Endocr Metab Disord 2:153-164.
49. Chaplin G, Jablonski NG(2009) Vitamin D and the evolution of human depigmentation.Am J Phys Anthropol 139:451-461.
50. Köstner K, et al. (2009) The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. Anticancer Res 29:3511-3536.
51. Norman AW (2008) From vitamin D to hormone D: Fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 88:491S-499S.
52. Holick MF (2004) Vitamin D: Importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 79:362-371.
53. Yuen AWC, Jablonski NG (2010) Vitamin D: In the evolution of human skin colour. Med Hypotheses 74:39-44.
54. Lamason RL, et al. (2005) SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science 310:1782-1786.
55. Norton HL, et al. (2007) Genetic evidence for the convergent evolution of light skin in Europeans and East Asians. Mol Biol Evol 24:710-722.
56. Lalueza-Fox C, et al. (2007) A melanocortin 1 receptor allele suggests varying pigmentation among Neanderthals. Science 318:1453-1455. (Pubitemid 350208956)
57. Sturm RA (2009) Molecular genetics of human pigmentation diversity. Hum Mol Genet 18 (R1):R9-R17.
58. Caldwell MM, et al. (1998) Effects of increased solar ultraviolet radiation on terrestrial ecosystems. J Photochem Photobiol B 46:40-52. (Pubitemid 29017149)
59. Madronich S, McKenzie RL, Björn LO, Caldwell MM(1998) Changes in biologically active ultraviolet radiation reaching the Earth's surface. J Photochem Photobiol B 46:5-19. (Pubitemid 29017147)
60. Chaplin G, Jablonski NG (1998) Hemispheric difference in human skin color. Am J Phys Anthropol 107:221-223, discussion 223-224. (Pubitemid 28460618)
61. Brueckner GE (1981) The variability of the sun's ultraviolet radiation. Adv Space Res 1:101-115.
62. Fligge M, Solanki SK (2000) The solar spectral irradiance since 1700. Geophys Res Lett 27:2157-2160.
63. Rottman G (2007) Solar Variability and Planetary Climates, eds Calisesi Y, Bonnet R, Gray L, Langen J, Lockwood M (Springer, New York), pp 39-51.
64. Solanki SK, Usoskin IG, Kromer B, Schüssler M, Beer J (2004) Unusual activity of the Sun during recent decades compared to the previous 11,000 years. Nature 431:1084-1087. (Pubitemid 39472229)
65. Relethford JH (1997) Hemispheric difference in human skin color. Am J Phys Anthropol 104:449-457.
66. Rothschild LJ (1999) The influence of UV radiation on protistan evolution. J Eukaryot Microbiol 46:548-555.
67. Agar N, Young AR (2005) Melanogenesis: A photoprotective response to DNA damage? Mutat Res 571:121-132.
68. Routaboul C, Denis A, Vinche A (1999) Immediate pigment darkening: Description, kinetic and biological function. Eur J Dermatol 9:95-99. (Pubitemid 29158975)
69. Suh KS, et al. (2007) A long-term evaluation of erythema and pigmentation induced by ultraviolet radiations of different wavelengths. Skin Res Technol 13:360-368. (Pubitemid 47506398)
70. Gibbs S, et al. (2000) Melanosome capping of keratinocytes in pigmented reconstructed epidermis - effect of ultraviolet radiation and 3-isobutyl-1-methyl-xanthine on melanogenesis. Pigment Cell Res 13:458-466. (Pubitemid 32122279)
71. Kollias N, et al. (1996) Erythema and melanogenesis action spectra in heavily pigmented individuals as compared to fair-skinned Caucasians. Photodermatol Photoimmunol Photomed 12:183-188. (Pubitemid 27132833)
72. Tadokoro T, et al. (2005) Mechanisms of skin tanning in different racial/ethnic groups in response to ultraviolet radiation. J Invest Dermatol 124:1326-1332. (Pubitemid 40847423)
73. Yamaguchi Y, et al. (2006) Human skin responses to UV radiation: Pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. FASEB J 20:1486-1488. (Pubitemid 44943806)
74. Sheehan JM, Potten CS, Young AR (1998) Tanning in human skin types II and III offers modest photoprotection against erythema. Photochem Photobiol 68:588-592.
75. Sheehan JM, Cragg N, Chadwick CA, Potten CS, Young AR (2002) Repeated ultraviolet exposure affords the same protection against DNA photodamage and erythema in human skin types II and IV but is associated with faster DNA repair in skin type IV. J Invest Dermatol 118:825-829. (Pubitemid 34526545)
76. Miller AJ, Tsao H (2009) New insights into pigmentary pathways and skin cancer. Br J Dermatol 162:22-28.
77. Robins AH (1991) Biological Perspectives on Human Pigmentation (Cambridge University Press, Cambridge, UK).
78. Quevedo WC, Szabó G, Virks J (1969) Influence of age and UV on the populations of dopa-positive melanocytes in human skin. J Invest Dermatol 52:287-290.
79. Herman J & Celarier E (1996) TOMS Version 7 UV-erythemal exposure: 1978-1993.
80. Roberts DF (1977) Human pigmentation: Its geographical and racial distribution and biological significance. J Soc Cosmet Chem 28:329-342.