The E92K melanocortin 1 receptor mutant induces camp production and arrestin recruitment but not ERK activity indicating biased constitutive signaling

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Benned Jensen, Tau ^a   Mokrosinski, Jacek ^a   Rosenkilde, Mette M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; BETA ARRESTIN; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MELANOCORTIN 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE; RETINA S ANTIGEN;

AMINO ACID SUBSTITUTION; ARTICLE; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERNALIZATION; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CONFOCAL MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; METABOLISM; MOUSE; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS;

MUS;

ALPHA-MSH; ANIMALS; ARRESTIN; CELL LINE; CYCLIC AMP; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MICE; MICROSCOPY, CONFOCAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHORYLATION; RECEPTOR, MELANOCORTIN, TYPE 1; SIGNAL TRANSDUCTION;

EID: 80052743080     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024644     Document Type: Article

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