Mutational approaches to improve the biophysical properties of human single-domain antibodies

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1844, Issue 11, 2014, Pages 1983-2001

  Kim, Dae Young ^a   Hussack, Greg ^a   Kandalaft, Hiba ^a   Tanha, Jamshid ^a,b,c  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF GUELPH   (Canada)

Author keywords

Aggregation; Mutation; Single domain antibody; Stability; VH; VL

Indexed keywords

NANOBODY; REAGENT;

ANTIBODY ENGINEERING; HUMAN; IMMUNOGENICITY; MOLECULE; MUTATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN UNFOLDING; REVIEW; THERMOSTABILITY;

EID: 84907938432     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2014.07.008     Document Type: Review

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