Design of synthetic autonomous VH domain libraries and structural analysis of a VH domain bound to vascular endothelial growth factor

Journal of Molecular Biology

Volumn 425, Issue 12, 2013, Pages 2247-2259

  Ma, Xiaolei ^a   Barthelemy, Pierre A ^a   Rouge, Lionel ^a   Wiesmann, Christian ^a   Sidhu, Sachdev S ^b  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

antibody; combinatorial mutagenesis; phage display; protein engineering; VEGF

Indexed keywords

PROTEIN A; VASCULOTROPIN;

ANTIBODY COMBINING SITE; ANTIBODY LIBRARY; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; COMPLEMENTARITY DETERMINING REGION; CRYSTAL STRUCTURE; ENTROPY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE MUTATION; HEAVY CHAIN; HUMAN; LIGHT CHAIN; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; STOP CODON; STRUCTURE ANALYSIS;

EID: 84878225457     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.03.020     Document Type: Article

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