Quantitative evaluation of colloidal stability of antibody solutions using PEG-induced liquid-liquid phase separation

Molecular Pharmaceutics

Volumn 11, Issue 5, 2014, Pages 1391-1402

  Wang, Ying ^a   Latypov, Ramil F ^d   Lomakin, Aleksey ^a   Meyer, Julie A ^d   Kerwin, Bruce A ^d   Vunnum, Suresh ^d   Benedek, George B ^a,b,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Department of Physics ^*  (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d AMGEN INC   (United States)

Author keywords

antibody; binding energy; colloidal stability; liquid liquid phase separation; PEG

Indexed keywords

IMMUNOGLOBULIN G; MACROGOL; MONOCLONAL ANTIBODY; PROTEIN; ANTIBODY; COLLOID; MACROGOL DERIVATIVE; SOLUTION AND SOLUBILITY;

ANTIBODY BLOOD LEVEL; ARTICLE; CRYSTALLIZATION; FREEZING; GELATION; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; LIQUID LIQUID PHASE SEPARATION; LOW TEMPERATURE; MOLECULAR WEIGHT; PHASE SEPARATION; PRECIPITATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN STABILITY; CHEMISTRY; COLLOID; SOLUTION AND SOLUBILITY;

ANTIBODIES; COLLOIDS; PHARMACEUTICAL SOLUTIONS; POLYETHYLENE GLYCOLS; SOLUTIONS;

EID: 84899858498     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400521b     Document Type: Article

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