Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility

Protein Engineering, Design and Selection

Volumn 27, Issue 6, 2014, Pages 191-198

  Hussack, Greg ^a   Riazi, Ali ^b   Ryan, Shannon ^a   Van Faassen, Henk ^a   Mackenzie, Roger ^a,c   Tanha, Jamshid ^a,c,d   Arbabi Ghahroudi, Mehdi ^a,c,e  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b AbCelex Technologies Inc   (Canada)

^c UNIVERSITY OF GUELPH   (Canada)

^d UNIVERSITY OF OTTAWA   (Canada)

^e CARLETON UNIVERSITY   (Canada)

Author keywords

C. jejuni; motility; protease resistance; protein stability

Indexed keywords

BACTERIA; CELLS; STABILITY;

C. JEJUNI; CAMPYLOBACTER JEJUNI; GASTROINTESTINAL; HEAVY-CHAIN ANTIBODIES; MOTILITY; PROTEIN STABILITY; PROTEOLYTIC STABILITY; SINGLE-DOMAIN ANTIBODIES;

ANTIBODIES;

CHYMOTRYPSIN; NANOBODY; PROTEINASE; TRYPSIN; ANTIINFECTIVE AGENT; FLAGELLIN; PEPSIN A; PROTEIN BINDING; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ARTICLE; BACTERIAL FLAGELLUM; BACTERIAL PHENOMENA AND FUNCTIONS; BACTERIUM MUTANT; BINDING AFFINITY; CAMPYLOBACTER JEJUNI; CAMPYLOBACTER JEJUNI MOTILITY; CIRCULAR DICHROISM; CONTROLLED STUDY; DISULFIDE BOND; ENZYME PURIFICATION; ENZYME STABILITY; NONHUMAN; PH; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN STABILITY; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; DRUG EFFECTS; FLAGELLUM; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN DENATURATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; CAMPYLOBACTER JEJUNI; CHYMOTRYPSIN; DIRECTED MOLECULAR EVOLUTION; FLAGELLA; FLAGELLIN; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; PEPSIN A; PROTEIN BINDING; PROTEIN DENATURATION; PROTEOLYSIS; SINGLE-CHAIN ANTIBODIES; TRYPSIN;

EID: 84901440938     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzu011     Document Type: Article

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