Disulfide linkage engineering for improving biophysical properties of human VH domains

Protein Engineering, Design and Selection

Volumn 25, Issue 10, 2012, Pages 581-589

  Kim, Dae Young ^a   Kandalaft, Hiba ^a   Ding, Wen ^a   Ryan, Shannon ^a   Van Faassen, Henk ^a   Hirama, Tomoko ^a,d   Foote, Simon J ^a   MacKenzie, Roger ^a,b   Tanha, Jamshid ^a,b,c  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d NONE   (Japan)

Author keywords

aggregation; antibody variable domains; disulfide linkage engineering; thermostability

Indexed keywords

AGGLOMERATION; AMINO ACIDS; ANTIBODIES; BINDERS; DICHROISM; LIGHT SCATTERING; SIZE EXCLUSION CHROMATOGRAPHY; STABILITY;

BIOPHYSICAL PROPERTIES; CONFORMATIONAL CHANGE; DISULFIDE LINKAGES; HEAVY-CHAIN ANTIBODIES; MULTI-ANGLE LIGHT SCATTERINGS; THERAPEUTIC POTENTIALS; THERMOSTABILITY; VARIABLE DOMAIN;

SULFUR COMPOUNDS;

ANTIBODY; CYSTEINE; DISULFIDE; HEAVY CHAIN ANTIBODY VARIABLE DOMAIN; PROTEIN A; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; ARTIODACTYLA; BINDING AFFINITY; BIOPHYSICS; CIRCULAR DICHROISM; COVALENT BOND; DISULFIDE LINKAGE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; THERMOSTABILITY; TURBIDITY;

CAMELIDAE;

EID: 84866973089     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs055     Document Type: Article

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