Affinity improvement of single antibody VH domains: Residues in all three hypervariable regions affect antigen binding

Immunotechnology

Volumn 2, Issue 3, 1996, Pages 169-179

  Davies, Julian ^a   Riechmann, Lutz ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Antibody engineering; Camel; Combining site; Immunoglobulin; Phage display

Indexed keywords

ANTIBODY AFFINITY; ANTIGEN BINDING; ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; IMMUNOGLOBULIN VARIABLE REGION; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DOMAIN; SOLID TUMOR; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANTIGENS; BINDING SITES, ANTIBODY; DNA; HAPTENS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; SENSITIVITY AND SPECIFICITY;

EID: 0030250670     PISSN: 13802933     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1380-2933(96)00045-0     Document Type: Article

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