Sequence determinants of protein aggregation in human VH domains

Protein Engineering, Design and Selection

Volumn 22, Issue 3, 2009, Pages 217-220

  Dudgeon, Kip ^a   Famm, Kristoffer ^b   Christ, Daniel ^a  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Antibodies; Combinatorial repertoire; Molecular evolution; Phage display; Protein aggregation

Indexed keywords

BETA SHEETS; COMBINATORIAL REPERTOIRE; HUMAN ANTIBODIES; MOLECULAR EVOLUTION; NEGATIVE CHARGES; PHAGE DISPLAY; PHYSICO-CHEMICAL PROPERTIES; PROTEIN AGGREGATION; SEQUENCE DETERMINANTS;

MOLECULAR BIOLOGY;

ANTIBODIES;

AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; HYDROPHOBICITY; PHAGE DISPLAY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DENATURATION; PROTEIN DOMAIN;

EVOLUTION, MOLECULAR; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; PEPTIDE LIBRARY; PHYSICOCHEMICAL PHENOMENA; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; TEMPERATURE;

EID: 60749084140     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzn059     Document Type: Article

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