-
1
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of predefined specificity
-
Kohler G., Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 256:1975;495-497.
-
(1975)
Nature
, vol.256
, pp. 495-497
-
-
Kohler, G.1
Milstein, C.2
-
2
-
-
0024461313
-
Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
-
Ward E.S., et al. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature. 341:1989;544-546.
-
(1989)
Nature
, vol.341
, pp. 544-546
-
-
Ward, E.S.1
-
3
-
-
0023096246
-
Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein
-
Hendershot L., et al. Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein. J. Cell Biol. 104:1987;761-767.
-
(1987)
J. Cell Biol.
, vol.104
, pp. 761-767
-
-
Hendershot, L.1
-
4
-
-
0026555251
-
Franklin's disease: Igγ2H chain mutant BUR
-
Prelli F., Frangione B. Franklin's disease: Igγ2H chain mutant BUR. J. Immunol. 148:1992;949-952.
-
(1992)
J. Immunol.
, vol.148
, pp. 949-952
-
-
Prelli, F.1
Frangione, B.2
-
6
-
-
0001724846
-
Dromedary IgG: Purification, characterisation and quantitation in sera of dams and newborns
-
Ungar-Waron H., et al. Dromedary IgG: purification, characterisation and quantitation in sera of dams and newborns. Israel J. Vet. Med. 43:1987;198-203.
-
(1987)
Israel J. Vet. Med.
, vol.43
, pp. 198-203
-
-
Ungar-Waron, H.1
-
7
-
-
0030767656
-
Selection and identification of single domain antibody fragments from camel heavy-chain antibodies
-
Arbabi Ghahroudi M., et al. Selection and identification of single domain antibody fragments from camel heavy-chain antibodies. FEBS Lett. 414:1997;521-526.
-
(1997)
FEBS Lett.
, vol.414
, pp. 521-526
-
-
Arbabi Ghahroudi, M.1
-
8
-
-
0344447084
-
Potent enzyme inhibitors derived from dromedary heavy-chain antibodies
-
Lauwereys M., et al. Potent enzyme inhibitors derived from dromedary heavy-chain antibodies. EMBO J. 17:1998;3512-3520.
-
(1998)
EMBO J.
, vol.17
, pp. 3512-3520
-
-
Lauwereys, M.1
-
9
-
-
0032578554
-
Structural analysis of the nurse shark (new) antigen receptor (NAR): Molecular convergence of NAR and unusual mammalian immunoglobulins
-
Roux K.H., et al. Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins. Proc. Natl. Acad. Sci. U. S. A. 95:1998;11804-11809.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 11804-11809
-
-
Roux, K.H.1
-
10
-
-
0032763794
-
H molecules with a unique interface
-
H molecules with a unique interface. J. Mol. Biol. 290:1999;685-698.
-
(1999)
J. Mol. Biol.
, vol.290
, pp. 685-698
-
-
Reiter, Y.1
-
12
-
-
0035854524
-
Building novel binding ligands to B7.1 and B7.2 based on human antibody single variable light chain domains
-
van den Beucken T., et al. Building novel binding ligands to B7.1 and B7.2 based on human antibody single variable light chain domains. J. Mol. Biol. 310:2001;591-601.
-
(2001)
J. Mol. Biol.
, vol.310
, pp. 591-601
-
-
Van Den Beucken, T.1
-
13
-
-
0026317443
-
By-passing immunization. Human antibodies from V-gene libraries displayed on phage
-
Marks J.D., et al. By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 222:1991;581-597.
-
(1991)
J. Mol. Biol.
, vol.222
, pp. 581-597
-
-
Marks, J.D.1
-
14
-
-
0028291823
-
Isolation of high affinity human antibodies directly from large synthetic repertoires
-
Griffiths A.D., et al. Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J. 13:1994;3245-3260.
-
(1994)
EMBO J.
, vol.13
, pp. 3245-3260
-
-
Griffiths, A.D.1
-
15
-
-
0032477886
-
Cardiolipin binding a light chain from lupus-prone mice
-
Pereira B., et al. Cardiolipin binding a light chain from lupus-prone mice. Biochemistry. 37:1998;1430-1437.
-
(1998)
Biochemistry
, vol.37
, pp. 1430-1437
-
-
Pereira, B.1
-
16
-
-
0029764698
-
The crystal structure of a llama heavy chain variable domain
-
Spinelli S., et al. The crystal structure of a llama heavy chain variable domain. Nat. Struct. Biol. 3:1996;752-757.
-
(1996)
Nat. Struct. Biol.
, vol.3
, pp. 752-757
-
-
Spinelli, S.1
-
17
-
-
0033561250
-
A single-domain antibody fragment in complex with RNase A: Non-canonical loop structures and nanomolar affinity using two CDR loops
-
Decanniere K., et al. A single-domain antibody fragment in complex with RNase A: non-canonical loop structures and nanomolar affinity using two CDR loops. Struct. Fold. Des. 7:1999;361-370.
-
(1999)
Struct. Fold. Des.
, vol.7
, pp. 361-370
-
-
Decanniere, K.1
-
20
-
-
0037047012
-
L interface
-
L interface. Biochemistry. 41:2002;8570-8579.
-
(2002)
Biochemistry
, vol.41
, pp. 8570-8579
-
-
Vranken, W.1
-
21
-
-
0034733379
-
Canonical antigen-binding loop structures in immunoglobulins: More structures, more canonical classes?
-
Decanniere K., et al. Canonical antigen-binding loop structures in immunoglobulins: more structures, more canonical classes? J. Mol. Biol. 300:2000;83-91.
-
(2000)
J. Mol. Biol.
, vol.300
, pp. 83-91
-
-
Decanniere, K.1
-
22
-
-
0028168145
-
H domain from naturally occurring camel heavy chain immunoglobulins lacking light chains
-
H domain from naturally occurring camel heavy chain immunoglobulins lacking light chains. Protein Eng. 7:1994;1129-1135.
-
(1994)
Protein Eng.
, vol.7
, pp. 1129-1135
-
-
Muyldermans, S.1
-
23
-
-
0034673109
-
Camelid heavy-chain variable domains provide efficient combining sites to haptens
-
Spinelli S., et al. Camelid heavy-chain variable domains provide efficient combining sites to haptens. Biochemistry. 39:2000;1217-1222.
-
(2000)
Biochemistry
, vol.39
, pp. 1217-1222
-
-
Spinelli, S.1
-
24
-
-
0029764444
-
H antibody fragment in complex with lysozyme
-
H antibody fragment in complex with lysozyme. Nat. Struct. Biol. 3:1996;803-811.
-
(1996)
Nat. Struct. Biol.
, vol.3
, pp. 803-811
-
-
Desmyter, A.1
-
25
-
-
0037189507
-
HH domains in complex with porcine pancreatic α-amylase. Inhibition and versatility of binding topology
-
HH domains in complex with porcine pancreatic α-amylase. Inhibition and versatility of binding topology. J. Biol. Chem. 277:2002;23645-23650.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 23645-23650
-
-
Desmyter, A.1
-
26
-
-
0034161488
-
HH and specific mechanisms enlarge the antigen-binding repertoire
-
HH and specific mechanisms enlarge the antigen-binding repertoire. EMBO J. 19:2000;921-930.
-
(2000)
EMBO J.
, vol.19
, pp. 921-930
-
-
Nguyen, V.K.1
-
27
-
-
0030922759
-
H domain antibody inhibitor of hepatitis C virus NS3 protease
-
H domain antibody inhibitor of hepatitis C virus NS3 protease. Protein Eng. 10:1997;607-614.
-
(1997)
Protein Eng.
, vol.10
, pp. 607-614
-
-
Martin, F.1
-
28
-
-
0029070931
-
H domain of anti-neuraminidase antibody NC41
-
H domain of anti-neuraminidase antibody NC41. J. Protein Chem. 14:1995;167-178.
-
(1995)
J. Protein Chem.
, vol.14
, pp. 167-178
-
-
Kortt, A.A.1
-
29
-
-
0034697979
-
H domain into a more tractable species
-
H domain into a more tractable species. J. Mol. Biol. 300:2000;963-973.
-
(2000)
J. Mol. Biol.
, vol.300
, pp. 963-973
-
-
Voordijk, S.1
-
30
-
-
0030250670
-
H domains: Residues in all three hypervariable regions affect antigen binding
-
H domains: residues in all three hypervariable regions affect antigen binding. Immunotechnology. 2:1996;169-179.
-
(1996)
Immunotechnology
, vol.2
, pp. 169-179
-
-
Davies, J.1
Riechmann, L.2
-
33
-
-
0027212854
-
Length distribution of CDRH3 in antibodies
-
Wu T.T., et al. Length distribution of CDRH3 in antibodies. Proteins Struct. Funct. Genet. 16:1993;1-7.
-
(1993)
Proteins Struct. Funct. Genet.
, vol.16
, pp. 1-7
-
-
Wu, T.T.1
-
34
-
-
0035816720
-
Optimal design features of camelized human single-domain antibody libraries
-
Tanha J., et al. Optimal design features of camelized human single-domain antibody libraries. J. Biol. Chem. 276:2001;24774-24780.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 24774-24780
-
-
Tanha, J.1
-
35
-
-
0037227517
-
Biophysical properties of human antibody variable domains
-
Ewert S., et al. Biophysical properties of human antibody variable domains. J. Mol. Biol. 325:2003;531-553.
-
(2003)
J. Mol. Biol.
, vol.325
, pp. 531-553
-
-
Ewert, S.1
-
36
-
-
0037133506
-
H3 domains
-
H3 domains. Biochemistry. 41:2002;3628-3636.
-
(2002)
Biochemistry
, vol.41
, pp. 3628-3636
-
-
Ewert, S.1
-
37
-
-
0032955291
-
HH antibody fragments and mouse monoclonal antibodies
-
HH antibody fragments and mouse monoclonal antibodies. Biochim. Biophys. Acta. 1431:1999;37-46.
-
(1999)
Biochim. Biophys. Acta
, vol.1431
, pp. 37-46
-
-
Van Der Linden, R.H.1
-
38
-
-
0036182644
-
Single-domain antibody fragments with high conformational stability
-
Dumoulin M., et al. Single-domain antibody fragments with high conformational stability. Protein Sci. 11:2002;500-515.
-
(2002)
Protein Sci.
, vol.11
, pp. 500-515
-
-
Dumoulin, M.1
-
39
-
-
0035830445
-
Thermal unfolding of a llama antibody fragment: A two-state reversible process
-
Perez J.M., et al. Thermal unfolding of a llama antibody fragment: a two-state reversible process. Biochemistry. 40:2001;74-83.
-
(2001)
Biochemistry
, vol.40
, pp. 74-83
-
-
Perez, J.M.1
-
40
-
-
0035793208
-
Stability engineering of antibody single-chain Fv fragments
-
Worn A., Pluckthun A. Stability engineering of antibody single-chain Fv fragments. J. Mol. Biol. 305:2001;989-1010.
-
(2001)
J. Mol. Biol.
, vol.305
, pp. 989-1010
-
-
Worn, A.1
Pluckthun, A.2
-
41
-
-
0037452533
-
H domains with a generalizable approach
-
H domains with a generalizable approach. Biochemistry. 42:2003;1517-1528.
-
(2003)
Biochemistry
, vol.42
, pp. 1517-1528
-
-
Ewert, S.1
-
42
-
-
0026785856
-
H segments with different hypervariable loops
-
H segments with different hypervariable loops. J. Mol. Biol. 227:1992;776-798.
-
(1992)
J. Mol. Biol.
, vol.227
, pp. 776-798
-
-
Tomlinson, I.M.1
-
44
-
-
0032560552
-
Synthetic human antibodies and a strategy for protein engineering
-
Winter G. Synthetic human antibodies and a strategy for protein engineering. FEBS Lett. 430:1998;92-94.
-
(1998)
FEBS Lett.
, vol.430
, pp. 92-94
-
-
Winter, G.1
-
45
-
-
0032581610
-
Exploiting sequence space: Shuffling in vivo formed complementarity determining regions into a master framework
-
Jirholt P., et al. Exploiting sequence space: shuffling in vivo formed complementarity determining regions into a master framework. Gene. 215:1998;471-476.
-
(1998)
Gene
, vol.215
, pp. 471-476
-
-
Jirholt, P.1
-
46
-
-
0026699293
-
Selection of phage antibodies by binding affinity. Mimicking affinity maturation
-
Hawkins R.E., et al. Selection of phage antibodies by binding affinity. Mimicking affinity maturation. J. Mol. Biol. 226:1992;889-896.
-
(1992)
J. Mol. Biol.
, vol.226
, pp. 889-896
-
-
Hawkins, R.E.1
-
47
-
-
0005229135
-
Mimicking somatic hypermutation: Affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain
-
Low N.M., et al. Mimicking somatic hypermutation: affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain. J. Mol. Biol. 260:1996;359-368.
-
(1996)
J. Mol. Biol.
, vol.260
, pp. 359-368
-
-
Low, N.M.1
-
48
-
-
0024834564
-
A reliable method for random mutagenesis: The generation of mutant libraries using spiked oligodeoxyribonucleotide primers
-
Hermes J.D., et al. A reliable method for random mutagenesis: the generation of mutant libraries using spiked oligodeoxyribonucleotide primers. Gene. 84:1989;143-151.
-
(1989)
Gene
, vol.84
, pp. 143-151
-
-
Hermes, J.D.1
-
49
-
-
14744300211
-
By-passing immunization: Building high affinity human antibodies by chain shuffling
-
Marks J.D., et al. By-passing immunization: building high affinity human antibodies by chain shuffling. Biotechnology. 10:1992;779-783.
-
(1992)
Biotechnology
, vol.10
, pp. 779-783
-
-
Marks, J.D.1
-
50
-
-
0034268896
-
L-domain of monoclonal antibody F11
-
L-domain of monoclonal antibody F11. Biochemistry (Mosc.). 65:2000;1011-1018.
-
(2000)
Biochemistry (Mosc.)
, vol.65
, pp. 1011-1018
-
-
Dubnovitsky, A.P.1
-
51
-
-
0037042225
-
H domain of the mouse anti-ferritin antibody F11
-
H domain of the mouse anti-ferritin antibody F11. FEBS Lett. 518:2002;177-182.
-
(2002)
FEBS Lett.
, vol.518
, pp. 177-182
-
-
Martsev, S.P.1
-
52
-
-
0035313135
-
Protein refolding for industrial processes
-
Clark E.D. Protein refolding for industrial processes. Curr. Opin. Biotechnol. 12:2001;202-207.
-
(2001)
Curr. Opin. Biotechnol.
, vol.12
, pp. 202-207
-
-
Clark, E.D.1
-
53
-
-
0142232284
-
The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi
-
Joosten V., et al. The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi. Microbial Cell Factories. 2:2003;1.
-
(2003)
Microbial Cell Factories
, vol.2
, pp. 1
-
-
Joosten, V.1
-
54
-
-
0033961580
-
HH antibody fragments and their high level secretion by Saccharomyces cerevisiae
-
HH antibody fragments and their high level secretion by Saccharomyces cerevisiae. J. Biotechnol. 78:2000;11-21.
-
(2000)
J. Biotechnol.
, vol.78
, pp. 11-21
-
-
Frenken, L.G.1
-
55
-
-
0037070507
-
HH antibody fragments by Saccharomyces cerevisiae
-
HH antibody fragments by Saccharomyces cerevisiae. Enzyme Microb. Technol. 30:2002;273-278.
-
(2002)
Enzyme Microb. Technol.
, vol.30
, pp. 273-278
-
-
Thomassen, Y.E.1
-
56
-
-
0034647452
-
Improved production and function of llama heavy chain antibody fragments by molecular evolution
-
van der Linden R.H., et al. Improved production and function of llama heavy chain antibody fragments by molecular evolution. J. Biotechnol. 80:2000;261-270.
-
(2000)
J. Biotechnol.
, vol.80
, pp. 261-270
-
-
Van Der Linden, R.H.1
-
57
-
-
0036900866
-
Antibody manufacture in transgenic animals and comparisons with other systems
-
Houdebine L.M. Antibody manufacture in transgenic animals and comparisons with other systems. Curr. Opin. Biotechnol. 13:2002;625-629.
-
(2002)
Curr. Opin. Biotechnol.
, vol.13
, pp. 625-629
-
-
Houdebine, L.M.1
-
58
-
-
0037212233
-
Avian transgenesis: Progress towards the promise
-
Ivarie R. Avian transgenesis: progress towards the promise. Trends Biotechnol. 21:2003;14-19.
-
(2003)
Trends Biotechnol.
, vol.21
, pp. 14-19
-
-
Ivarie, R.1
-
59
-
-
0036535775
-
Plantibodies: Applications, advantages and bottlenecks
-
Stoger E., et al. Plantibodies: applications, advantages and bottlenecks. Curr. Opin. Biotechnol. 13:2002;161-166.
-
(2002)
Curr. Opin. Biotechnol.
, vol.13
, pp. 161-166
-
-
Stoger, E.1
-
60
-
-
0037225784
-
Immunomodulation of enzyme function in plants by single-domain antibody fragments
-
Jobling S.A., et al. Immunomodulation of enzyme function in plants by single-domain antibody fragments. Nat. Biotechnol. 21:2003;77-80.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 77-80
-
-
Jobling, S.A.1
-
61
-
-
0035831483
-
Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs
-
Conrath K.E., et al. Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs. J. Biol. Chem. 276:2001;7346-7350.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7346-7350
-
-
Conrath, K.E.1
-
62
-
-
0037139394
-
Efficient tumor targeting by single-domain antibody fragments of camels
-
Cortez-Retamozo V., et al. Efficient tumor targeting by single-domain antibody fragments of camels. Int. J. Cancer. 98:2002;456-462.
-
(2002)
Int. J. Cancer
, vol.98
, pp. 456-462
-
-
Cortez-Retamozo, V.1
-
63
-
-
0035524114
-
Improving the efficacy of antibody-based cancer therapies
-
Carter P. Improving the efficacy of antibody-based cancer therapies. Nat. Rev. Cancer. 1:2001;118-129.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 118-129
-
-
Carter, P.1
-
64
-
-
0037124466
-
PEGylated antibodies and antibody fragments for improved therapy: A review
-
Chapman A.P. PEGylated antibodies and antibody fragments for improved therapy: a review. Adv. Drug Deliv. Rev. 54:2002;531-545.
-
(2002)
Adv. Drug Deliv. Rev.
, vol.54
, pp. 531-545
-
-
Chapman, A.P.1
-
66
-
-
0034803881
-
Prolonged in vivo residence times of antibody fragments associated with albumin
-
Smith B.J., et al. Prolonged in vivo residence times of antibody fragments associated with albumin. Bioconjug. Chem. 12:2001;750-756.
-
(2001)
Bioconjug. Chem.
, vol.12
, pp. 750-756
-
-
Smith, B.J.1
-
67
-
-
0037144397
-
Albumin binding as a general strategy for improving the pharmacokinetics of proteins
-
Dennis M.S., et al. Albumin binding as a general strategy for improving the pharmacokinetics of proteins. J. Biol. Chem. 277:2002;35035-35043.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35035-35043
-
-
Dennis, M.S.1
-
68
-
-
0031038715
-
An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries
-
Persic L., et al. An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries. Gene. 187:1997;9-18.
-
(1997)
Gene
, vol.187
, pp. 9-18
-
-
Persic, L.1
-
69
-
-
0027232106
-
Recombinant human antibodies: Linkage of an Fab fragment from a combinatorial library to an Fc fragment for expression in mammalian cell culture
-
Bender E., et al. Recombinant human antibodies: linkage of an Fab fragment from a combinatorial library to an Fc fragment for expression in mammalian cell culture. Hum. Antibodies Hybridomas. 4:1993;74-79.
-
(1993)
Hum. Antibodies Hybridomas
, vol.4
, pp. 74-79
-
-
Bender, E.1
-
70
-
-
0035342590
-
Expression of single-chain Fv-Fc fusions in Pichia pastoris
-
Powers D.B., et al. Expression of single-chain Fv-Fc fusions in Pichia pastoris. J. Immunol. Methods. 251:2001;123-135.
-
(2001)
J. Immunol. Methods
, vol.251
, pp. 123-135
-
-
Powers, D.B.1
-
71
-
-
14744301121
-
Human antibody fragments specific for human blood group antigens from a phage display library
-
Marks J.D., et al. Human antibody fragments specific for human blood group antigens from a phage display library. Biotechnology. 11:1993;1145-1149.
-
(1993)
Biotechnology
, vol.11
, pp. 1145-1149
-
-
Marks, J.D.1
-
72
-
-
0036480118
-
Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium
-
Muruganandam A., et al. Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium. FASEB J. 16:2002;240-242.
-
(2002)
FASEB J.
, vol.16
, pp. 240-242
-
-
Muruganandam, A.1
-
73
-
-
0027933750
-
Clonal selection and amplification of phage displayed antibodies by linking antigen recognition and phage replication
-
Duenas M., Borrebaeck C.A. Clonal selection and amplification of phage displayed antibodies by linking antigen recognition and phage replication. Biotechnology. 12:1994;999-1002.
-
(1994)
Biotechnology
, vol.12
, pp. 999-1002
-
-
Duenas, M.1
Borrebaeck, C.A.2
-
74
-
-
0031759422
-
Proteolytic selection for protein folding using filamentous bacteriophages
-
Kristensen P., Winter G. Proteolytic selection for protein folding using filamentous bacteriophages. Fold. Des. 3:1998;321-328.
-
(1998)
Fold. Des.
, vol.3
, pp. 321-328
-
-
Kristensen, P.1
Winter, G.2
|