-
1
-
-
84863987464
-
Inhibition of amyloid formation
-
Härd T, Lendel C (2012) Inhibition of amyloid formation. J Mol Biol 421(4-5):441-465.
-
(2012)
J Mol Biol
, vol.421
, Issue.4-5
, pp. 441-465
-
-
Härd, T.1
Lendel, C.2
-
2
-
-
0030058382
-
Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide
-
Solomon B, Koppel R, Hanan E, Katzav T (1996) Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc Natl Acad Sci USA 93(1):452-455.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, Issue.1
, pp. 452-455
-
-
Solomon, B.1
Koppel, R.2
Hanan, E.3
Katzav, T.4
-
3
-
-
1542357652
-
Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments
-
Emadi S, et al. (2004) Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments. Biochemistry 43(10):2871-2878.
-
(2004)
Biochemistry
, vol.43
, Issue.10
, pp. 2871-2878
-
-
Emadi, S.1
-
4
-
-
84855987854
-
Structure-based design of conformation- and sequence-specific antibodies against amyloid β
-
Perchiacca JM, Ladiwala AR, Bhattacharya M, Tessier PM (2012) Structure-based design of conformation- and sequence-specific antibodies against amyloid β. Proc Natl Acad Sci USA 109(1):84-89.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.1
, pp. 84-89
-
-
Perchiacca, J.M.1
Ladiwala, A.R.2
Bhattacharya, M.3
Tessier, P.M.4
-
5
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R, et al. (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300(5618):486-489.
-
(2003)
Science
, vol.300
, Issue.5618
, pp. 486-489
-
-
Kayed, R.1
-
6
-
-
36749078121
-
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
-
Kayed R, et al. (2007) Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener 2:18.
-
(2007)
Mol Neurodegener
, vol.2
, pp. 18
-
-
Kayed, R.1
-
7
-
-
0037022297
-
Conformational Abs recognizing a generic amyloid fibril epitope
-
O'Nuallain B, Wetzel R (2002) Conformational Abs recognizing a generic amyloid fibril epitope. Proc Natl Acad Sci USA 99(3):1485-1490.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.3
, pp. 1485-1490
-
-
O'Nuallain, B.1
Wetzel, R.2
-
8
-
-
41249087476
-
Comprehensive analysis of the factors contributing to the stability and solubility of autonomous humanVHdomains
-
Barthelemy PA, et al. (2008) Comprehensive analysis of the factors contributing to the stability and solubility of autonomous humanVHdomains.J BiolChem283(6):3639-3654.
-
(2008)
J BiolChem
, vol.283
, Issue.6
, pp. 3639-3654
-
-
Barthelemy, P.A.1
-
9
-
-
84867016746
-
Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions
-
Perchiacca JM, Ladiwala AR, Bhattacharya M, Tessier PM (2012) Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions. Protein Eng Des Sel 25(10):591-602.
-
(2012)
Protein Eng Des Sel
, vol.25
, Issue.10
, pp. 591-602
-
-
Perchiacca, J.M.1
Ladiwala, A.R.2
Bhattacharya, M.3
Tessier, P.M.4
-
10
-
-
84863799510
-
Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity
-
Ladiwala AR, et al. (2012) Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity. J Biol Chem 287(29):24765-24773.
-
(2012)
J Biol Chem
, vol.287
, Issue.29
, pp. 24765-24773
-
-
Ladiwala, A.R.1
-
11
-
-
44849087785
-
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
-
Ehrnhoefer DE, et al. (2008) EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat Struct Mol Biol 15(6):558-566.
-
(2008)
Nat Struct Mol Biol
, vol.15
, Issue.6
, pp. 558-566
-
-
Ehrnhoefer, D.E.1
-
12
-
-
79952796718
-
Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathways
-
Ladiwala AR, Dordick JS, Tessier PM (2011) Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathways. J Biol Chem 286(5):3209-3218.
-
(2011)
J Biol Chem
, vol.286
, Issue.5
, pp. 3209-3218
-
-
Ladiwala, A.R.1
Dordick, J.S.2
Tessier, P.M.3
-
13
-
-
77954218832
-
Substoichiometric inhibition of Abeta(1-40) aggregation by a tandem Abeta(40-1-Gly8-1-40) peptide
-
Mustafi SM, Garai K, Crick SL, Baban B, Frieden C (2010) Substoichiometric inhibition of Abeta(1-40) aggregation by a tandem Abeta(40-1-Gly8-1-40) peptide. Biochem Biophys Res Commun 397(3):509-512.
-
(2010)
Biochem Biophys Res Commun
, vol.397
, Issue.3
, pp. 509-512
-
-
Mustafi, S.M.1
Garai, K.2
Crick, S.L.3
Baban, B.4
Frieden, C.5
-
14
-
-
33845918172
-
Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro
-
Evans CG, Wisén S, Gestwicki JE (2006) Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro. J Biol Chem 281(44):33182-33191.
-
(2006)
J Biol Chem
, vol.281
, Issue.44
, pp. 33182-33191
-
-
Evans, C.G.1
Wisén, S.2
Gestwicki, J.E.3
-
15
-
-
56749117866
-
Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibitfibril assembly
-
Luk KC, Mills IP, Trojanowski JQ, Lee VM (2008) Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibitfibril assembly. Biochemistry 47(47):12614-12625.
-
(2008)
Biochemistry
, vol.47
, Issue.47
, pp. 12614-12625
-
-
Luk, K.C.1
Mills, I.P.2
Trojanowski, J.Q.3
Lee, V.M.4
-
16
-
-
17644383748
-
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species
-
Dedmon MM, Christodoulou J, Wilson MR, Dobson CM (2005) Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species. J Biol Chem 280(15):14733-14740.
-
(2005)
J Biol Chem
, vol.280
, Issue.15
, pp. 14733-14740
-
-
Dedmon, M.M.1
Christodoulou, J.2
Wilson, M.R.3
Dobson, C.M.4
-
17
-
-
84864515731
-
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers
-
Mannini B, et al. (2012) Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers. Proc Natl Acad Sci USA 109(31):12479-12484.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.31
, pp. 12479-12484
-
-
Mannini, B.1
-
18
-
-
0026654926
-
Islet amyloid polypeptide: Mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus
-
Johnson KH, O'Brien TD, Betsholtz C, Westermark P (1992) Islet amyloid polypeptide: Mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus. Lab Invest 66(5):522-535.
-
(1992)
Lab Invest
, vol.66
, Issue.5
, pp. 522-535
-
-
Johnson, K.H.1
O'Brien, T.D.2
Betsholtz, C.3
Westermark, P.4
-
20
-
-
4143133235
-
A comparative study of the relationship between protein structure and beta-aggregation in globular and intrinsically disordered proteins
-
Linding R, Schymkowitz J, Rousseau F, Diella F, Serrano L (2004) A comparative study of the relationship between protein structure and beta-aggregation in globular and intrinsically disordered proteins. J Mol Biol 342(1):345-353.
-
(2004)
J Mol Biol
, vol.342
, Issue.1
, pp. 345-353
-
-
Linding, R.1
Schymkowitz, J.2
Rousseau, F.3
Diella, F.4
Serrano, L.5
-
21
-
-
33947517558
-
AGGRESCAN: A server for the prediction and evaluation of "hot spots" of aggregation in polypeptides
-
Conchillo-Solé O, et al. (2007) AGGRESCAN: A server for the prediction and evaluation of "hot spots" of aggregation in polypeptides. BMC Bioinformatics 8:65.
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 65
-
-
Conchillo-Solé, O.1
-
22
-
-
33645238380
-
The 3D profile method for identifying fibril-forming segments of proteins
-
Thompson MJ, et al. (2006) The 3D profile method for identifying fibril-forming segments of proteins. Proc Natl Acad Sci USA 103(11):4074-4078.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.11
, pp. 4074-4078
-
-
Thompson, M.J.1
-
23
-
-
36248964819
-
The PASTA server for protein aggregation prediction
-
Trovato A, Seno F, Tosatto SC (2007) The PASTA server for protein aggregation prediction. Protein Eng Des Sel 20(10):521-523.
-
(2007)
Protein Eng Des Sel
, vol.20
, Issue.10
, pp. 521-523
-
-
Trovato, A.1
Seno, F.2
Tosatto, S.C.3
-
24
-
-
77649265357
-
Exploring the sequence determinants of amyloid structure using position-specific scoring matrices
-
Maurer-Stroh S, et al. (2010) Exploring the sequence determinants of amyloid structure using position-specific scoring matrices. Nat Methods 7(3):237-242.
-
(2010)
Nat Methods
, vol.7
, Issue.3
, pp. 237-242
-
-
Maurer-Stroh, S.1
-
25
-
-
0029910347
-
A strategy for designing inhibitors of beta-amyloid toxicity
-
Ghanta J, Shen CL, Kiessling LL, Murphy RM (1996) A strategy for designing inhibitors of beta-amyloid toxicity. J Biol Chem 271(47):29525-29528.
-
(1996)
J Biol Chem
, vol.271
, Issue.47
, pp. 29525-29528
-
-
Ghanta, J.1
Shen, C.L.2
Kiessling, L.L.3
Murphy, R.M.4
-
26
-
-
0031873102
-
Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy
-
Soto C, et al. (1998) Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy. Nat Med 4(7):822-826.
-
(1998)
Nat Med
, vol.4
, Issue.7
, pp. 822-826
-
-
Soto, C.1
-
27
-
-
79960065022
-
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
-
Sievers SA, et al. (2011) Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature 475(7354):96-100.
-
(2011)
Nature
, vol.475
, Issue.7354
, pp. 96-100
-
-
Sievers, S.A.1
-
28
-
-
0029994633
-
Arrest of beta-amyloid fibril formation by a pentapeptide ligand
-
Tjernberg LO, et al. (1996) Arrest of beta-amyloid fibril formation by a pentapeptide ligand. J Biol Chem 271(15):8545-8548.
-
(1996)
J Biol Chem
, vol.271
, Issue.15
, pp. 8545-8548
-
-
Tjernberg, L.O.1
-
29
-
-
57349107392
-
Peptide and protein mimetics inhibiting amyloid betapeptide aggregation
-
Takahashi T, Mihara H (2008) Peptide and protein mimetics inhibiting amyloid betapeptide aggregation. Acc Chem Res 41(10):1309-1318.
-
(2008)
Acc Chem Res
, vol.41
, Issue.10
, pp. 1309-1318
-
-
Takahashi, T.1
Mihara, H.2
-
30
-
-
0036305837
-
Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis
-
Scrocchi LA, et al. (2002) Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis. J Mol Biol 318(3):697-706.
-
(2002)
J Mol Biol
, vol.318
, Issue.3
, pp. 697-706
-
-
Scrocchi, L.A.1
-
31
-
-
0036300750
-
Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity
-
Kapurniotu A, Schmauder A, Tenidis K (2002) Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity. J Mol Biol 315(3):339-350.
-
(2002)
J Mol Biol
, vol.315
, Issue.3
, pp. 339-350
-
-
Kapurniotu, A.1
Schmauder, A.2
Tenidis, K.3
-
32
-
-
79952498441
-
Solid-state NMR spectroscopic investigation of Aβ protofibrils: Implication of a β-sheet remodeling upon maturation into terminal amyloid fibrils
-
Scheidt HA, Morgado I, Rothemund S, Huster D, Fändrich M (2011) Solid-state NMR spectroscopic investigation of Aβ protofibrils: Implication of a β-sheet remodeling upon maturation into terminal amyloid fibrils. Angew Chem Int Ed Engl 50(12):2837-2840.
-
(2011)
Angew Chem Int Ed Engl
, vol.50
, Issue.12
, pp. 2837-2840
-
-
Scheidt, H.A.1
Morgado, I.2
Rothemund, S.3
Huster, D.4
Fändrich, M.5
-
33
-
-
33746781304
-
Structural differences in Abeta amyloid protofibrils and fibrils mapped by hydrogen exchange - Mass spectrometry with on-line proteolytic fragmentation
-
Kheterpal I, Chen M, Cook KD, Wetzel R (2006) Structural differences in Abeta amyloid protofibrils and fibrils mapped by hydrogen exchange - mass spectrometry with on-line proteolytic fragmentation. J Mol Biol 361(4):785-795.
-
(2006)
J Mol Biol
, vol.361
, Issue.4
, pp. 785-795
-
-
Kheterpal, I.1
Chen, M.2
Cook, K.D.3
Wetzel, R.4
-
34
-
-
37649019187
-
Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils
-
Habicht G, et al. (2007) Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils. Proc Natl Acad Sci USA 104(49):19232-19237.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.49
, pp. 19232-19237
-
-
Habicht, G.1
-
35
-
-
74049152516
-
Inherent anti-amyloidogenic activity of human immunoglobulin gamma heavy chains
-
Adekar SP, et al. (2010) Inherent anti-amyloidogenic activity of human immunoglobulin gamma heavy chains. J Biol Chem 285(2):1066-1074.
-
(2010)
J Biol Chem
, vol.285
, Issue.2
, pp. 1066-1074
-
-
Adekar, S.P.1
-
36
-
-
33646865770
-
Diagnostic and therapeutic potential of amyloid-reactive IgG antibodies contained in human sera
-
O'Nuallain B, Hrncic R, Wall JS, Weiss DT, Solomon A (2006) Diagnostic and therapeutic potential of amyloid-reactive IgG antibodies contained in human sera. J Immunol 176(11):7071-7078.
-
(2006)
J Immunol
, vol.176
, Issue.11
, pp. 7071-7078
-
-
O'Nuallain, B.1
Hrncic, R.2
Wall, J.S.3
Weiss, D.T.4
Solomon, A.5
-
37
-
-
41349107779
-
Immunoreactivity of phage library-derived human singlechain antibodies to amyloid beta conformers in vitro
-
Yoshihara T, et al. (2008) Immunoreactivity of phage library-derived human singlechain antibodies to amyloid beta conformers in vitro. J Biochem 143(4):475-486.
-
(2008)
J Biochem
, vol.143
, Issue.4
, pp. 475-486
-
-
Yoshihara, T.1
-
38
-
-
0033103657
-
High affinity binding of monoclonal antibodies to the sequential epitope EFRH of beta-amyloid peptide is essential for modulation of fibrillar aggregation
-
Frenkel D, Balass M, Katchalski-Katzir E, Solomon B (1999) High affinity binding of monoclonal antibodies to the sequential epitope EFRH of beta-amyloid peptide is essential for modulation of fibrillar aggregation. J Neuroimmunol 95(1-2):136-142.
-
(1999)
J Neuroimmunol
, vol.95
, Issue.1-2
, pp. 136-142
-
-
Frenkel, D.1
Balass, M.2
Katchalski-Katzir, E.3
Solomon, B.4
-
39
-
-
14844342887
-
Incorporation of pseudoproline derivatives allows the facile synthesis of human IAPP, a highly amyloidogenic and aggregation-prone polypeptide
-
Abedini A, Raleigh DP (2005) Incorporation of pseudoproline derivatives allows the facile synthesis of human IAPP, a highly amyloidogenic and aggregation-prone polypeptide. Org Lett 7(4):693-696.
-
(2005)
Org Lett
, vol.7
, Issue.4
, pp. 693-696
-
-
Abedini, A.1
Raleigh, D.P.2
-
40
-
-
34548359337
-
Investigation of alpha-synuclein fibril structure by site-directed spin labeling
-
Chen M, Margittai M, Chen J, Langen R (2007) Investigation of alpha-synuclein fibril structure by site-directed spin labeling. J Biol Chem 282(34):24970-24979.
-
(2007)
J Biol Chem
, vol.282
, Issue.34
, pp. 24970-24979
-
-
Chen, M.1
Margittai, M.2
Chen, J.3
Langen, R.4
|