-
2
-
-
84860371953
-
Epigenetic protein families: A new frontier for drug discovery
-
C.H. Arrowsmith Epigenetic protein families: a new frontier for drug discovery Nat. Rev. Drug Discov. 11 2012 384 400
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 384-400
-
-
Arrowsmith, C.H.1
-
4
-
-
59349115177
-
Chemical mechanisms of histone lysine and arginine modifications
-
B.C. Smith, and J.M. Denu Chemical mechanisms of histone lysine and arginine modifications Biochim. Biophys. Acta 1789 2009 45 57
-
(2009)
Biochim. Biophys. Acta
, vol.1789
, pp. 45-57
-
-
Smith, B.C.1
Denu, J.M.2
-
5
-
-
84857704319
-
Small molecules DNA methyltransferases inhibitors
-
N. Martinet Small molecules DNA methyltransferases inhibitors Med. Chem. Commun. 3 2012 263 273
-
(2012)
Med. Chem. Commun.
, vol.3
, pp. 263-273
-
-
Martinet, N.1
-
6
-
-
43749098985
-
DNA methylation landscapes: Provocative insights from epigenomics
-
M.M. Suzuki, and A. Bird DNA methylation landscapes: provocative insights from epigenomics Nat. Rev. Genet. 9 2008 465 476
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 465-476
-
-
Suzuki, M.M.1
Bird, A.2
-
7
-
-
67649510355
-
Oxygenase catalyzed 5-methylcytosine hydroxylation
-
C. Loenarz, and C.J. Schofield Oxygenase catalyzed 5-methylcytosine hydroxylation Chem. Biol. 16 2009 580 583
-
(2009)
Chem. Biol.
, vol.16
, pp. 580-583
-
-
Loenarz, C.1
Schofield, C.J.2
-
8
-
-
84867395940
-
DNA methylation inhibitors in cancer: Recent and future approaches
-
C. Gros DNA methylation inhibitors in cancer: recent and future approaches Biochimie 94 2012 2280 2296
-
(2012)
Biochimie
, vol.94
, pp. 2280-2296
-
-
Gros, C.1
-
9
-
-
84870375316
-
Histone lysine methylation dynamics: Establishment, regulation, and biological impact
-
J.C. Black Histone lysine methylation dynamics: establishment, regulation, and biological impact Mol. Cell 48 2012 491 507
-
(2012)
Mol. Cell
, vol.48
, pp. 491-507
-
-
Black, J.C.1
-
10
-
-
80055019988
-
Selective inhibitors of histone methyltransferase DOT1L: Design, synthesis, and crystallographic studies
-
Y. Yao Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies J. Am. Chem. Soc. 133 2011 16746 16749
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 16746-16749
-
-
Yao, Y.1
-
11
-
-
84877954369
-
Histone methyltransferase inhibitors: Novel epigenetic agents for cancer treatment
-
C. Zagni Histone methyltransferase inhibitors: novel epigenetic agents for cancer treatment Curr. Med. Chem. 20 2013 167 185
-
(2013)
Curr. Med. Chem.
, vol.20
, pp. 167-185
-
-
Zagni, C.1
-
12
-
-
33749576106
-
Histone demethylation by hydroxylation: Chemistry in action
-
J. Schneider, and A. Shilatifard Histone demethylation by hydroxylation: chemistry in action ACS Chem. Biol. 1 2006 75 81
-
(2006)
ACS Chem. Biol.
, vol.1
, pp. 75-81
-
-
Schneider, J.1
Shilatifard, A.2
-
13
-
-
79958247128
-
Enantioselective synthesis of tranylcypromine analogues as lysine demethylases (LSD1) inhibitors
-
H. Benelkebir Enantioselective synthesis of tranylcypromine analogues as lysine demethylases (LSD1) inhibitors Bioorg. Med. Chem. 19 2011 3709 3716
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 3709-3716
-
-
Benelkebir, H.1
-
14
-
-
34249881352
-
Structural basis of histone demethylation by LSD1 revealed by suicide inactivation
-
M. Yang Structural basis of histone demethylation by LSD1 revealed by suicide inactivation Nat. Struct. Mol. Biol. 14 2007 535 539
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 535-539
-
-
Yang, M.1
-
15
-
-
58149295717
-
Protein arginine methylation in mammals: Who, what, and why
-
M.T. Bedford, and S.G. Clarke Protein arginine methylation in mammals: who, what, and why Mol. Cell 33 2009 1 13
-
(2009)
Mol. Cell
, vol.33
, pp. 1-13
-
-
Bedford, M.T.1
Clarke, S.G.2
-
16
-
-
84875221875
-
Novel symmetrical ureas as modulators of protein arginine methyl transferases
-
N. Fontán Novel symmetrical ureas as modulators of protein arginine methyl transferases Bioorg. Med. Chem. 21 2013 2056 2067
-
(2013)
Bioorg. Med. Chem.
, vol.21
, pp. 2056-2067
-
-
Fontán, N.1
-
17
-
-
70349311616
-
Histone acetyl transferases as emerging drug targets
-
F.J. Dekker, and H.J. Haisma Histone acetyl transferases as emerging drug targets Drug Discov. Today 14 2009 942 948
-
(2009)
Drug Discov. Today
, vol.14
, pp. 942-948
-
-
Dekker, F.J.1
Haisma, H.J.2
-
18
-
-
84876811944
-
The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis
-
F.M. Perez-Campo The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis Immunology 139 2013 161 165
-
(2013)
Immunology
, vol.139
, pp. 161-165
-
-
Perez-Campo, F.M.1
-
19
-
-
84859748655
-
Expansion of the lysine acylation landscape
-
C.A. Olsen Expansion of the lysine acylation landscape Angew. Chem. Int. Ed. 51 2012 3755 3756
-
(2012)
Angew. Chem. Int. Ed.
, vol.51
, pp. 3755-3756
-
-
Olsen, C.A.1
-
20
-
-
78649894738
-
Histone acetylation modulation by small molecules: A chemical approach
-
M.W. Rekowski, and A. Giannis Histone acetylation modulation by small molecules: a chemical approach Biochim. Biophys. Acta 1799 2010 760 767
-
(2010)
Biochim. Biophys. Acta
, vol.1799
, pp. 760-767
-
-
Rekowski, M.W.1
Giannis, A.2
-
21
-
-
25144496904
-
The Sir 2 family of protein deacetylases
-
J.M. Denu The Sir 2 family of protein deacetylases Curr. Opin. Chem. Biol. 9 2005 431 440
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 431-440
-
-
Denu, J.M.1
-
22
-
-
77950860448
-
Inside HDACs with HDAC inhibitors
-
P. Bertrand Inside HDACs with HDAC inhibitors Eur. J. Med. Chem. 45 2010 2095 2116
-
(2010)
Eur. J. Med. Chem.
, vol.45
, pp. 2095-2116
-
-
Bertrand, P.1
-
23
-
-
79957839068
-
Interpreting clinical trials for histone deacetylase inhibitors
-
N. Martinet, and P. Bertrand Interpreting clinical trials for histone deacetylase inhibitors Cancer Manag. Res. 3 2011 117 141
-
(2011)
Cancer Manag. Res.
, vol.3
, pp. 117-141
-
-
Martinet, N.1
Bertrand, P.2
-
24
-
-
77952575335
-
Tumor-selective delivery of macromolecular drugs via the EPR effect: Background and future prospects
-
H. Maeda Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects Bioconjug. Chem. 21 2010 797 802
-
(2010)
Bioconjug. Chem.
, vol.21
, pp. 797-802
-
-
Maeda, H.1
-
25
-
-
34547607522
-
Polymer-drug conjugation, recent achievements and general strategies
-
G. Pasut, and F.M. Veronese Polymer-drug conjugation, recent achievements and general strategies Prog. Polym. Sci. 32 2007 933 961
-
(2007)
Prog. Polym. Sci.
, vol.32
, pp. 933-961
-
-
Pasut, G.1
Veronese, F.M.2
-
26
-
-
75749096347
-
The endocytic matrix
-
G. Scita, and P.P. Di Fiore The endocytic matrix Nature 463 2010 464 473
-
(2010)
Nature
, vol.463
, pp. 464-473
-
-
Scita, G.1
Di Fiore, P.P.2
-
27
-
-
24944523300
-
Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers
-
M. Kirkham, and R.G. Parton Clathrin-independent endocytosis: new insights into caveolae and non-caveolar lipid raft carriers Biochim. Biophys. Acta 1745 2005 273 286
-
(2005)
Biochim. Biophys. Acta
, vol.1745
, pp. 273-286
-
-
Kirkham, M.1
Parton, R.G.2
-
28
-
-
0020030456
-
Tumor-selective modification of cellular microenvironment in vivo: Effect of glucose infusion on the pH in normal and malignant rat tissues
-
E. Jähde, and M.F. Rajewsky Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues Cancer Res. 42 1982 1505 1512
-
(1982)
Cancer Res.
, vol.42
, pp. 1505-1512
-
-
Jähde, E.1
Rajewsky, M.F.2
-
29
-
-
0014098952
-
Glucose consumption by transplanted tumors in vivo
-
P.P. Gullino Glucose consumption by transplanted tumors in vivo Cancer Res. 27 1967 1031 1040
-
(1967)
Cancer Res.
, vol.27
, pp. 1031-1040
-
-
Gullino, P.P.1
-
30
-
-
0034047785
-
The relationship between intracellular and extracellular pH in spontaneous canine tumors
-
D.M. Prescott The relationship between intracellular and extracellular pH in spontaneous canine tumors Clin. Cancer Res. 6 2000 2501 2505
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2501-2505
-
-
Prescott, D.M.1
-
31
-
-
0032812153
-
Role of organelle pH in tumor cell biology and drug resistance
-
S.M. Simon Role of organelle pH in tumor cell biology and drug resistance Drug Discov. Today 4 1999 32 38
-
(1999)
Drug Discov. Today
, vol.4
, pp. 32-38
-
-
Simon, S.M.1
-
32
-
-
84880445847
-
Organelle targeting: Third level of drug targeting
-
N.M. Sakhrani, and H. Padh Organelle targeting: third level of drug targeting Drug Des. Dev. Ther. 7 2013 585 599
-
(2013)
Drug Des. Dev. Ther.
, vol.7
, pp. 585-599
-
-
Sakhrani, N.M.1
Padh, H.2
-
33
-
-
33745031316
-
Enzymes involved in the bioconversion of ester-based prodrugs
-
B.M. Liederer, and R.T. Borchardt Enzymes involved in the bioconversion of ester-based prodrugs J. Pharm. Sci. 95 2006 1177 1195
-
(2006)
J. Pharm. Sci.
, vol.95
, pp. 1177-1195
-
-
Liederer, B.M.1
Borchardt, R.T.2
-
34
-
-
33645958909
-
Carboxylesterases: Detoxifying enzymes and targets for drug therapy
-
P.M. Potter, and R.M. Wadkins Carboxylesterases: detoxifying enzymes and targets for drug therapy Curr. Med. Chem. 13 2006 1045 1054
-
(2006)
Curr. Med. Chem.
, vol.13
, pp. 1045-1054
-
-
Potter, P.M.1
Wadkins, R.M.2
-
35
-
-
14644422580
-
Mammalian carboxylesterases: From drug targets to protein therapeutics
-
M.R. Redinbo, and P.M. Potter Mammalian carboxylesterases: from drug targets to protein therapeutics Drug Discov. Today 10 2005 313 325
-
(2005)
Drug Discov. Today
, vol.10
, pp. 313-325
-
-
Redinbo, M.R.1
Potter, P.M.2
-
36
-
-
84874865201
-
Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells
-
S.E. Pratt Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells Clin. Cancer Res. 19 2013 1159 1168
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 1159-1168
-
-
Pratt, S.E.1
-
37
-
-
0026652116
-
The biological chemistry of folate receptors
-
A.C. Antony The biological chemistry of folate receptors Blood 79 1992 2807 2820
-
(1992)
Blood
, vol.79
, pp. 2807-2820
-
-
Antony, A.C.1
-
38
-
-
79956362344
-
Metabolism as a key to histone deacetylase inhibition
-
P. Rajendran Metabolism as a key to histone deacetylase inhibition Crit. Rev. Biochem. Mol. Biol. 46 2011 181 199
-
(2011)
Crit. Rev. Biochem. Mol. Biol.
, vol.46
, pp. 181-199
-
-
Rajendran, P.1
-
39
-
-
0036735385
-
FK228 (depsipeptide) as a natural prodrug that inhibits class i histone deacetylases
-
R. Furumai FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases Cancer Res. 62 2002 4916 4921
-
(2002)
Cancer Res.
, vol.62
, pp. 4916-4921
-
-
Furumai, R.1
-
40
-
-
33847657556
-
Psammaplin A is a natural prodrug that inhibits class i histone deacetylase
-
D.H. Kim Psammaplin A is a natural prodrug that inhibits class I histone deacetylase Exp. Mol. Med. 39 2007 47 55
-
(2007)
Exp. Mol. Med.
, vol.39
, pp. 47-55
-
-
Kim, D.H.1
-
41
-
-
0012473279
-
The nuclear receptor superfamily: The second decade
-
D.J. Mangelsdorf The nuclear receptor superfamily: the second decade Cell 83 1995 835 839
-
(1995)
Cell
, vol.83
, pp. 835-839
-
-
Mangelsdorf, D.J.1
-
42
-
-
0034673671
-
Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells
-
S.M. Sirchia Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells Oncogene 19 2000 1556 1563
-
(2000)
Oncogene
, vol.19
, pp. 1556-1563
-
-
Sirchia, S.M.1
-
43
-
-
0029962932
-
Phenylbutyrate induces apoptosis in human prostate cancer and is more potent than phenylacetate
-
M.A. Carducci Phenylbutyrate induces apoptosis in human prostate cancer and is more potent than phenylacetate Clin. Cancer Res. 2 1996 379 387
-
(1996)
Clin. Cancer Res.
, vol.2
, pp. 379-387
-
-
Carducci, M.A.1
-
44
-
-
58549087523
-
Inhibition of PCAF histone acetyl transferase and cell proliferation by isothiazolones
-
F.J. Dekker Inhibition of PCAF histone acetyl transferase and cell proliferation by isothiazolones Bioorg. Med. Chem. 17 2009 460 466
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 460-466
-
-
Dekker, F.J.1
-
45
-
-
70449640307
-
Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase
-
M. Ghizzoni Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase Eur. J. Med. Chem. 44 2009 4855 4861
-
(2009)
Eur. J. Med. Chem.
, vol.44
, pp. 4855-4861
-
-
Ghizzoni, M.1
-
46
-
-
79952159097
-
Isothiazolones; Thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF
-
R. Wisastra Isothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF Org. Biomol. Chem. 9 2011 1817 1822
-
(2011)
Org. Biomol. Chem.
, vol.9
, pp. 1817-1822
-
-
Wisastra, R.1
-
47
-
-
77954204335
-
Virtual ligand screening of the p300/CBP histone acetyltransferase: Identification of a selective small molecule inhibitor
-
E.M. Bowers Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor Chem. Biol. 17 2010 471 482
-
(2010)
Chem. Biol.
, vol.17
, pp. 471-482
-
-
Bowers, E.M.1
-
48
-
-
0037805679
-
Small molecule modulators of histone acetyltransferase p300
-
K. Balasubramanyam Small molecule modulators of histone acetyltransferase p300 J. Biol. Chem. 278 2003 19134 19140
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19134-19140
-
-
Balasubramanyam, K.1
-
49
-
-
84855795338
-
6-Alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site
-
M. Ghizzoni 6-Alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site Eur. J. Med. Chem. 47 2012 337 344
-
(2012)
Eur. J. Med. Chem.
, vol.47
, pp. 337-344
-
-
Ghizzoni, M.1
-
50
-
-
84881111643
-
Basic nuclear processes affect by histone acetyltransferase and histone deacetylase inhibitors
-
S. Legartova Basic nuclear processes affect by histone acetyltransferase and histone deacetylase inhibitors Epigenomics 5 2013 1 18
-
(2013)
Epigenomics
, vol.5
, pp. 1-18
-
-
Legartova, S.1
-
51
-
-
79959204866
-
A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases
-
X. Luo A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases J. Am. Chem. Soc. 133 2011 9451 9456
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 9451-9456
-
-
Luo, X.1
-
52
-
-
34347341518
-
AN-113, a novel prodrug of 4-phenylbutyrate with increased anti-neoplastic activity in glioma cell lines
-
M. Entin-Meer AN-113, a novel prodrug of 4-phenylbutyrate with increased anti-neoplastic activity in glioma cell lines Cancer Lett. 253 2007 205 214
-
(2007)
Cancer Lett.
, vol.253
, pp. 205-214
-
-
Entin-Meer, M.1
-
53
-
-
13944275513
-
The role of intracellularly released formaldehyde and butyric acid in the anticancer activity of acyloxyalkyl esters
-
A. Nudelman The role of intracellularly released formaldehyde and butyric acid in the anticancer activity of acyloxyalkyl esters J. Med. Chem. 48 2005 1042 1054
-
(2005)
J. Med. Chem.
, vol.48
, pp. 1042-1054
-
-
Nudelman, A.1
-
54
-
-
3843151628
-
Phase II trial of the histone deacetylase inhibitor pivaloyloxymethyl butyrate (Pivanex, AN-9) in advanced non-small cell lung cancer
-
T. Reid Phase II trial of the histone deacetylase inhibitor pivaloyloxymethyl butyrate (Pivanex, AN-9) in advanced non-small cell lung cancer Lung Cancer 45 2004 381 386
-
(2004)
Lung Cancer
, vol.45
, pp. 381-386
-
-
Reid, T.1
-
55
-
-
33745021853
-
The selectivity and anti-metastatic activity of oral bioavailable butyric acid prodrugs
-
A. Rephaeli The selectivity and anti-metastatic activity of oral bioavailable butyric acid prodrugs Invest. New Drugs 24 2006 383 392
-
(2006)
Invest. New Drugs
, vol.24
, pp. 383-392
-
-
Rephaeli, A.1
-
56
-
-
84857916369
-
A histone deacetylase inhibitory prodrug - Butyroyloxymethyl diethyl phosphate - Protects the heart and cardiomyocytes against ischemia injury
-
G. Kessler-Icekson A histone deacetylase inhibitory prodrug - butyroyloxymethyl diethyl phosphate - protects the heart and cardiomyocytes against ischemia injury Eur. J. Pharm. Sci. 45 2012 592 599
-
(2012)
Eur. J. Pharm. Sci.
, vol.45
, pp. 592-599
-
-
Kessler-Icekson, G.1
-
57
-
-
53949087611
-
Histone deacetylase inhibitors: The anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex)
-
N. Tarasenko Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex) Clin. Exp. Metastasis 25 2008 703 716
-
(2008)
Clin. Exp. Metastasis
, vol.25
, pp. 703-716
-
-
Tarasenko, N.1
-
58
-
-
0142089014
-
A retinoid/butyric acid prodrug overcomes retinoic acid resistance in leukemias by induction of apoptosis
-
K.K. Mann A retinoid/butyric acid prodrug overcomes retinoic acid resistance in leukemias by induction of apoptosis Mol. Cancer Res. 1 2003 903 912
-
(2003)
Mol. Cancer Res.
, vol.1
, pp. 903-912
-
-
Mann, K.K.1
-
59
-
-
84870218444
-
Conjugate of Pt(IV)-histone deacetylase inhibitor as a prodrug for cancer chemotherapy
-
J. Yang Conjugate of Pt(IV)-histone deacetylase inhibitor as a prodrug for cancer chemotherapy Mol. Pharm. 9 2012 2793 2800
-
(2012)
Mol. Pharm.
, vol.9
, pp. 2793-2800
-
-
Yang, J.1
-
60
-
-
0033807852
-
Influence of nanoparticles on the brain-to-serum distribution and the metabolism of valproic acid in mice
-
J. Darius Influence of nanoparticles on the brain-to-serum distribution and the metabolism of valproic acid in mice J. Pharm. Pharmacol. 52 2000 1043 1047
-
(2000)
J. Pharm. Pharmacol.
, vol.52
, pp. 1043-1047
-
-
Darius, J.1
-
61
-
-
0023236004
-
Brominated tyrosine metabolites from an unidentified sponge
-
L. Arabshahi, and F.J. Schmitz Brominated tyrosine metabolites from an unidentified sponge J. Org. Chem. 52 1987 3584 3586
-
(1987)
J. Org. Chem.
, vol.52
, pp. 3584-3586
-
-
Arabshahi, L.1
Schmitz, F.J.2
-
62
-
-
0038627550
-
Psammaplins from the sponge Pseudoceratina purpurea: Inhibition of both histone deacetylase and DNA methyltransferase
-
I.C. Piña Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase J. Org. Chem. 68 2003 3866 3873
-
(2003)
J. Org. Chem.
, vol.68
, pp. 3866-3873
-
-
Piña, I.C.1
-
63
-
-
0037261269
-
Identification of thiols and glutathione conjugates of depsipeptide FK228 (FR901228), a novel histone protein deacetylase inhibitor, in the blood
-
J.J. Xiao Identification of thiols and glutathione conjugates of depsipeptide FK228 (FR901228), a novel histone protein deacetylase inhibitor, in the blood Rapid Commun. Mass Spectrom. 17 2003 757 766
-
(2003)
Rapid Commun. Mass Spectrom.
, vol.17
, pp. 757-766
-
-
Xiao, J.J.1
-
64
-
-
46049100010
-
Total synthesis and molecular target of largazole, a histone deacetylase inhibitor
-
Y. Ying Total synthesis and molecular target of largazole, a histone deacetylase inhibitor J. Am. Chem. Soc. 130 2008 8455 8459
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 8455-8459
-
-
Ying, Y.1
-
65
-
-
40249088767
-
YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model
-
N. Shindoh YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model Int. J. Oncol. 32 2008 545 555
-
(2008)
Int. J. Oncol.
, vol.32
, pp. 545-555
-
-
Shindoh, N.1
-
66
-
-
33847213896
-
Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor
-
T. Suzuki Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor Bioorg. Med. Chem. Lett. 17 2007 1558 1561
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 1558-1561
-
-
Suzuki, T.1
-
67
-
-
34447093841
-
Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors
-
T. Suzuki Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors Bioorg. Med. Chem. Lett. 17 2007 4208 4212
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 4208-4212
-
-
Suzuki, T.1
-
68
-
-
33746759383
-
A chromatography-electrospray ionization tandem mass spectrometric assay for quantitation of the histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamicacid, SAHA), and its metabolites in human serum
-
R.A. Parise A chromatography-electrospray ionization tandem mass spectrometric assay for quantitation of the histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamicacid, SAHA), and its metabolites in human serum J. Chromatogr. B 840 2006 108 115
-
(2006)
J. Chromatogr. B
, vol.840
, pp. 108-115
-
-
Parise, R.A.1
-
69
-
-
71049151580
-
Hydroxamates: Relationships between structure and plasma stability
-
M. Flipo Hydroxamates: relationships between structure and plasma stability J. Med. Chem. 52 2009 6790 6802
-
(2009)
J. Med. Chem.
, vol.52
, pp. 6790-6802
-
-
Flipo, M.1
-
70
-
-
33846578183
-
Synthesis and biological evaluation of the suberoylanilide hydroxamic acid (SAHA) beta-glucuronide and beta-galactoside for application in selective prodrug chemotherapy
-
M. Thomas Synthesis and biological evaluation of the suberoylanilide hydroxamic acid (SAHA) beta-glucuronide and beta-galactoside for application in selective prodrug chemotherapy Bioorg. Med. Chem. Lett. 17 2007 983 986
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 983-986
-
-
Thomas, M.1
-
71
-
-
84889080607
-
Design of pH responsive clickable prodrugs applied to histone deacetylases inhibitors: A new strategy for anticancer therapy
-
R. Delatouche Design of pH responsive clickable prodrugs applied to histone deacetylases inhibitors: a new strategy for anticancer therapy Eur. J. Pharm. Biopharm. 85 2013 862 872
-
(2013)
Eur. J. Pharm. Biopharm.
, vol.85
, pp. 862-872
-
-
Delatouche, R.1
-
72
-
-
0037452775
-
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
-
E. Hockly Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease Proc. Natl. Acad. Sci. U. S. A. 100 2003 2041 2046
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 2041-2046
-
-
Hockly, E.1
-
73
-
-
84865384016
-
Vorinostat with sustained exposure and high solubility in poly(ethylene glycol)-b-poly(dl-lactic acid) micelle nanocarriers: Characterization and effects on pharmacokinetics in rat serum and urine
-
E.A. Mohamed Vorinostat with sustained exposure and high solubility in poly(ethylene glycol)-b-poly(dl-lactic acid) micelle nanocarriers: characterization and effects on pharmacokinetics in rat serum and urine J. Pharm. Sci. 101 2012 3787 3798
-
(2012)
J. Pharm. Sci.
, vol.101
, pp. 3787-3798
-
-
Mohamed, E.A.1
-
74
-
-
84859985337
-
Biodegradable thermosensitive hydrogel for SAHA and DDP delivery: Therapeutic effects on oral squamous cell carcinoma xenografts
-
J. Li Biodegradable thermosensitive hydrogel for SAHA and DDP delivery: therapeutic effects on oral squamous cell carcinoma xenografts PLoS ONE 7 2012 e33860
-
(2012)
PLoS ONE
, vol.7
, pp. 33860
-
-
Li, J.1
-
75
-
-
84862809560
-
Tumor vasculature targeting following co-delivery of heparin-taurocholate conjugate and suberoylanilide hydroxamic acid using cationic nanolipoplex
-
J.Y. Kim Tumor vasculature targeting following co-delivery of heparin-taurocholate conjugate and suberoylanilide hydroxamic acid using cationic nanolipoplex Biomaterials 33 2012 4424 4430
-
(2012)
Biomaterials
, vol.33
, pp. 4424-4430
-
-
Kim, J.Y.1
-
76
-
-
70349775533
-
Histone deacetylase inhibitor prodrugs in nanoparticle vector enhanced gene expression in human cancer cells
-
Y. Ishii Histone deacetylase inhibitor prodrugs in nanoparticle vector enhanced gene expression in human cancer cells Eur. J. Med. Chem. 44 2009 4603 4610
-
(2009)
Eur. J. Med. Chem.
, vol.44
, pp. 4603-4610
-
-
Ishii, Y.1
-
77
-
-
66249127951
-
A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation
-
J. Datta A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation Cancer Res. 69 2009 4277 4285
-
(2009)
Cancer Res.
, vol.69
, pp. 4277-4285
-
-
Datta, J.1
-
78
-
-
50349099688
-
Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy
-
M. Thomas Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy Bioorg. Med. Chem. 16 2008 8109 8116
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 8109-8116
-
-
Thomas, M.1
-
79
-
-
46849096306
-
Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro
-
K. Lalji Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro J. Med. Chem. 51 2008 3895 3904
-
(2008)
J. Med. Chem.
, vol.51
, pp. 3895-3904
-
-
Lalji, K.1
-
80
-
-
0029947983
-
Retroviral transfer of deoxycytidine kinase into tumor cell lines enhances nucleoside toxicity
-
D.M. Hapke Retroviral transfer of deoxycytidine kinase into tumor cell lines enhances nucleoside toxicity Cancer Res. 56 1996 2343 2347
-
(1996)
Cancer Res.
, vol.56
, pp. 2343-2347
-
-
Hapke, D.M.1
-
81
-
-
43949136445
-
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
-
C. Stresemann, and F. Lyko Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine Int. J. Cancer 123 2008 8 13
-
(2008)
Int. J. Cancer
, vol.123
, pp. 8-13
-
-
Stresemann, C.1
Lyko, F.2
-
82
-
-
84856221213
-
Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs
-
E.-J. Geutjes Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs Breast Cancer Res. Treat. 131 2012 809 818
-
(2012)
Breast Cancer Res. Treat.
, vol.131
, pp. 809-818
-
-
Geutjes, E.-J.1
-
83
-
-
78649505459
-
Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation
-
A. Schafer Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation PLoS ONE 5 2010 e14060
-
(2010)
PLoS ONE
, vol.5
, pp. 14060
-
-
Schafer, A.1
-
84
-
-
83055179604
-
Mechanisms underlying gemcitabine resistance in pancreatic cancer and sensitisation by the iMiDTM lenalidomide
-
R.A. Fryer Mechanisms underlying gemcitabine resistance in pancreatic cancer and sensitisation by the iMiDTM lenalidomide Anticancer Res. 31 2011 3747 3756
-
(2011)
Anticancer Res.
, vol.31
, pp. 3747-3756
-
-
Fryer, R.A.1
-
85
-
-
10744233452
-
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-20-deoxycytidine (decitabine) in hematopoietic malignancies
-
J.P. Issa Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-20-deoxycytidine (decitabine) in hematopoietic malignancies Blood 1103 2004 1635 1640
-
(2004)
Blood
, vol.1103
, pp. 1635-1640
-
-
Issa, J.P.1
-
86
-
-
21244447049
-
Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies
-
M.A. Rudek Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies J. Clin. Oncol. 123 2005 3906 3911
-
(2005)
J. Clin. Oncol.
, vol.123
, pp. 3906-3911
-
-
Rudek, M.A.1
-
87
-
-
21844466446
-
Pharmacology of 5-aza-20-deoxycytidine (decitabine)
-
R.L. Momparler Pharmacology of 5-aza-20-deoxycytidine (decitabine) Semin. Hematol. 142 2005 S9 S16
-
(2005)
Semin. Hematol.
, vol.142
, pp. 9-S16
-
-
Momparler, R.L.1
-
88
-
-
0016838872
-
Kinetics and mechanisms of degradation of the antileukemic agent 5-azacytidine in aqueous solutions
-
R.E. Notari, and J.L. DeYoung Kinetics and mechanisms of degradation of the antileukemic agent 5-azacytidine in aqueous solutions J. Pharm. Sci. 164 1975 1148 1157
-
(1975)
J. Pharm. Sci.
, vol.164
, pp. 1148-1157
-
-
Notari, R.E.1
Deyoung, J.L.2
-
89
-
-
77957878987
-
Mechanistic insights on the inhibition of C5 DNA methyltransferases by zebularine
-
C. Champion Mechanistic insights on the inhibition of C5 DNA methyltransferases by zebularine PLoS ONE 5 2010 e12388
-
(2010)
PLoS ONE
, vol.5
, pp. 12388
-
-
Champion, C.1
-
90
-
-
60249094793
-
Mechanisms of resistance to 5-aza-20-deoxycytidine in human cancer cell lines
-
T. Qin Mechanisms of resistance to 5-aza-20-deoxycytidine in human cancer cell lines Blood 113 2009 659 667
-
(2009)
Blood
, vol.113
, pp. 659-667
-
-
Qin, T.1
-
91
-
-
0033714888
-
HATs off: Selective synthetic inhibitors of histone acetyltransferase p300 and PCAF
-
D.O. Lau HATs off: selective synthetic inhibitors of histone acetyltransferase p300 and PCAF Mol. Cell 5 2000 589 595
-
(2000)
Mol. Cell
, vol.5
, pp. 589-595
-
-
Lau, D.O.1
-
92
-
-
58949095757
-
Bisubstrate inhibitors of the MYST HATs Esa1 and Tip60
-
J. Wu Bisubstrate inhibitors of the MYST HATs Esa1 and Tip60 Bioorg. Med. Chem. 17 2009 1381 1386
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 1381-1386
-
-
Wu, J.1
-
93
-
-
0038692967
-
Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300
-
M. Cebrat Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300 Bioorg. Med. Chem. 11 2003 3307 3313
-
(2003)
Bioorg. Med. Chem.
, vol.11
, pp. 3307-3313
-
-
Cebrat, M.1
-
94
-
-
29044440879
-
Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor
-
Y. Zheng Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor J. Am. Chem. Soc. 127 2005 17182 17183
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 17182-17183
-
-
Zheng, Y.1
-
95
-
-
84881322895
-
A carrier-mediated prodrug approach to improve the oral absorption of antileukemic drug decitabine
-
Y. Zhang A carrier-mediated prodrug approach to improve the oral absorption of antileukemic drug decitabine Mol. Pharm. 10 2013 3195 3202
-
(2013)
Mol. Pharm.
, vol.10
, pp. 3195-3202
-
-
Zhang, Y.1
-
96
-
-
84865075565
-
Selection of suitable prodrug candidates for in vivo studies via in vitro studies; The correlation of prodrug stability in between cell culture homogenates and human tissue homogenates
-
Y. Tsume, and G.L. Amidon Selection of suitable prodrug candidates for in vivo studies via in vitro studies; the correlation of prodrug stability in between cell culture homogenates and human tissue homogenates J. Pharm. Pharm. Sci. 15 2012 433 446
-
(2012)
J. Pharm. Pharm. Sci.
, vol.15
, pp. 433-446
-
-
Tsume, Y.1
Amidon, G.L.2
-
97
-
-
48849097095
-
Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters
-
Y. Tsume Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters Molecules 13 2008 1441 1454
-
(2008)
Molecules
, vol.13
, pp. 1441-1454
-
-
Tsume, Y.1
-
98
-
-
84873108331
-
An HPLC-MS/MS method for simultaneous determination of decitabine and its valyl prodrug valdecitabine in rat plasma
-
A. Zhanga An HPLC-MS/MS method for simultaneous determination of decitabine and its valyl prodrug valdecitabine in rat plasma J. Chromatogr. B 917 2013 78 83
-
(2013)
J. Chromatogr. B
, vol.917
, pp. 78-83
-
-
Zhanga, A.1
-
99
-
-
84863847393
-
Development of an oral form of azacytidine: 2,3,5-triacetyl-5-azacytidine
-
Article ID: 965826
-
A. Ziemba Development of an oral form of azacytidine: 2,3,5-triacetyl-5-azacytidine Chemother. Res. Pract. 2011 1 9 Article ID: 965826
-
(2011)
Chemother. Res. Pract.
, pp. 1-9
-
-
Ziemba, A.1
-
100
-
-
45049086493
-
2′-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: A novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase
-
H.M. Byun 2′-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase Cancer Lett. 266 2008 238 248
-
(2008)
Cancer Lett.
, vol.266
, pp. 238-248
-
-
Byun, H.M.1
-
101
-
-
0018385346
-
Stabilization of 5-azacytidine by nucleophilic addition of bisulfite ion
-
D.C. Chatterji, and J.F. Gallelli Stabilization of 5-azacytidine by nucleophilic addition of bisulfite ion J. Pharm. Sci. 68 1979 822 826
-
(1979)
J. Pharm. Sci.
, vol.68
, pp. 822-826
-
-
Chatterji, D.C.1
Gallelli, J.F.2
-
103
-
-
84881243546
-
Folate-based near-infrared fluorescent theranostic gemcitabine delivery
-
Z. Yang Folate-based near-infrared fluorescent theranostic gemcitabine delivery J. Am. Chem. Soc. 135 2013 11657 11662
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 11657-11662
-
-
Yang, Z.1
-
104
-
-
78651287394
-
Prodrugs of aza nucleosides based on proton transfer reaction
-
R. Karaman Prodrugs of aza nucleosides based on proton transfer reaction J. Comput. Aided Mol. Des. 24 2010 961 970
-
(2010)
J. Comput. Aided Mol. Des.
, vol.24
, pp. 961-970
-
-
Karaman, R.1
-
105
-
-
0032771837
-
Suicide prodrugs activated by thymidylate synthase: Rationale for treatment and noninvasive imaging of tumors with deoxyuridine analogues
-
J.M. Collins Suicide prodrugs activated by thymidylate synthase: rationale for treatment and noninvasive imaging of tumors with deoxyuridine analogues Clin. Cancer Res. 5 1999 1976 1981
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 1976-1981
-
-
Collins, J.M.1
-
106
-
-
0030198183
-
Novel acid labile COL1 trityl-linked difluoronucleoside immunoconjugates: Synthesis, characterization, and biological activity
-
V.F. Patel Novel acid labile COL1 trityl-linked difluoronucleoside immunoconjugates: synthesis, characterization, and biological activity Bioconjug. Chem. 7 1996 497 510
-
(1996)
Bioconjug. Chem.
, vol.7
, pp. 497-510
-
-
Patel, V.F.1
-
107
-
-
0028909983
-
Heterobifunctional trityl derivatives as linking reagents for the recovery of nucleic acids after labeling and immobilization
-
E. Leikauf Heterobifunctional trityl derivatives as linking reagents for the recovery of nucleic acids after labeling and immobilization Tetrahedron 51 1995 3793 3802
-
(1995)
Tetrahedron
, vol.51
, pp. 3793-3802
-
-
Leikauf, E.1
-
108
-
-
9244219656
-
Acetals as pH-sensitive linkages for drug delivery
-
J.M.J. Fréchet Acetals as pH-sensitive linkages for drug delivery Bioconjug. Chem. 15 2004 1254 1263
-
(2004)
Bioconjug. Chem.
, vol.15
, pp. 1254-1263
-
-
Fréchet, J.M.J.1
-
109
-
-
79953249026
-
Triazolyl derivatives for acidic release of alcohols
-
M. Mondon Triazolyl derivatives for acidic release of alcohols Eur. J. Org. Chem. 2011 2111 2119
-
(2011)
Eur. J. Org. Chem.
, pp. 2111-2119
-
-
Mondon, M.1
-
110
-
-
84855847439
-
Stearoyl gemcitabine nanoparticles overcome resistance related to the over-expression of ribonucleotide reductase subunit M1
-
W.G. Chung Stearoyl gemcitabine nanoparticles overcome resistance related to the over-expression of ribonucleotide reductase subunit M1 J. Control. Release 157 2012 132 140
-
(2012)
J. Control. Release
, vol.157
, pp. 132-140
-
-
Chung, W.G.1
-
111
-
-
84872386589
-
The effect of the acid-sensitivity of 4-(N)-stearoyl gemcitabine-loaded micelles on drug resistance caused by RRM1 overexpression
-
S. Zhu The effect of the acid-sensitivity of 4-(N)-stearoyl gemcitabine-loaded micelles on drug resistance caused by RRM1 overexpression Biomaterials 34 2013 2327 2339
-
(2013)
Biomaterials
, vol.34
, pp. 2327-2339
-
-
Zhu, S.1
-
112
-
-
79955012698
-
In vitro and in vivo anti-tumor activities of a gemcitabine derivative carried by nanoparticles
-
B.R. Sloat In vitro and in vivo anti-tumor activities of a gemcitabine derivative carried by nanoparticles Int. J. Pharm. 409 2011 278 288
-
(2011)
Int. J. Pharm.
, vol.409
, pp. 278-288
-
-
Sloat, B.R.1
-
113
-
-
9644302465
-
Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs
-
M.L. Immordino Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs J. Control. Release 100 2004 331 346
-
(2004)
J. Control. Release
, vol.100
, pp. 331-346
-
-
Immordino, M.L.1
-
114
-
-
61549106604
-
Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6 glioma cells of a brain tumor model
-
C.X. Wang Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6 glioma cells of a brain tumor model Brain Res. 1261 2009 91 99
-
(2009)
Brain Res.
, vol.1261
, pp. 91-99
-
-
Wang, C.X.1
-
115
-
-
84877279679
-
Lipid-polymer nanoparticles encapsulating doxorubicin and 2′-deoxy-5-azacytidine enhance the sensitivity of cancer cells to chemical therapeutics
-
X. Su Lipid-polymer nanoparticles encapsulating doxorubicin and 2′-deoxy-5-azacytidine enhance the sensitivity of cancer cells to chemical therapeutics Mol. Pharm. 10 2013 1901 1909
-
(2013)
Mol. Pharm.
, vol.10
, pp. 1901-1909
-
-
Su, X.1
-
116
-
-
78650994500
-
EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment
-
D. Chen EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment Adv. Clin. Chem. 53 2011 155 177
-
(2011)
Adv. Clin. Chem.
, vol.53
, pp. 155-177
-
-
Chen, D.1
-
117
-
-
25144507259
-
Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids
-
W.J. Lee Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids Mol. Pharmacol. 68 2005 1018 1030
-
(2005)
Mol. Pharmacol.
, vol.68
, pp. 1018-1030
-
-
Lee, W.J.1
-
118
-
-
33845969839
-
Dietary polyphenols may affect DNA methylation
-
M. Fang Dietary polyphenols may affect DNA methylation J. Nutr. 137 2007 223 228S
-
(2007)
J. Nutr.
, vol.137
, pp. 223-228S
-
-
Fang, M.1
-
119
-
-
77249089947
-
Resveratrol (trans-3,5,40-trihydroxystilbene) induces SIRT1 and down-regulates NF-kB activation to abrogate DSS-induced colitis
-
U.P. Singh Resveratrol (trans-3,5,40-trihydroxystilbene) induces SIRT1 and down-regulates NF-kB activation to abrogate DSS-induced colitis J. Pharmacol. Exp. Ther. 332 2009 829 839
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.332
, pp. 829-839
-
-
Singh, U.P.1
-
120
-
-
0037403751
-
Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate
-
H. Lu Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate Drug Metab. Dispos. 31 2003 572 579
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 572-579
-
-
Lu, H.1
-
121
-
-
78651347259
-
Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells
-
W.-J. Lee Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells Oncol. Rep. 25 2011 583 591
-
(2011)
Oncol. Rep.
, vol.25
, pp. 583-591
-
-
Lee, W.-J.1
-
122
-
-
58349094740
-
Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation
-
K.C. Choi Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation Cancer Res. 69 2009 583 592
-
(2009)
Cancer Res.
, vol.69
, pp. 583-592
-
-
Choi, K.C.1
-
123
-
-
33751517433
-
Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallate
-
J.D. Lambert Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallate Drug Metab. Dispos. 34 2006 2111 2116
-
(2006)
Drug Metab. Dispos.
, vol.34
, pp. 2111-2116
-
-
Lambert, J.D.1
-
124
-
-
84881339346
-
Mutual regioselective inhibition of human UGT1A1-mediated glucuronidation of four flavonoids
-
G. Ma Mutual regioselective inhibition of human UGT1A1-mediated glucuronidation of four flavonoids Mol. Pharm. 10 2013 2891 2903
-
(2013)
Mol. Pharm.
, vol.10
, pp. 2891-2903
-
-
Ma, G.1
-
125
-
-
8844236064
-
Identification of 14 quercetin phase II mono- and mixed conjugates and their formation by rat and human phase II in vitro model systems
-
H. Van der Woude Identification of 14 quercetin phase II mono- and mixed conjugates and their formation by rat and human phase II in vitro model systems Chem. Res. Toxicol. 17 2004 1520 1530
-
(2004)
Chem. Res. Toxicol.
, vol.17
, pp. 1520-1530
-
-
Van Der Woude, H.1
-
126
-
-
84859739725
-
Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer
-
W. Zhu Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer Nutr. Cancer 64 2012 393 400
-
(2012)
Nutr. Cancer
, vol.64
, pp. 393-400
-
-
Zhu, W.1
-
127
-
-
64549090647
-
Effect of a low dose of dietary resveratrol on colonic microbiota, gene expression, inflammation markers, and tissue damage in a DSS-induced colitis rat model
-
M. Larrosa Effect of a low dose of dietary resveratrol on colonic microbiota, gene expression, inflammation markers, and tissue damage in a DSS-induced colitis rat model J. Agric. Food Chem. 57 2009 2211 2220
-
(2009)
J. Agric. Food Chem.
, vol.57
, pp. 2211-2220
-
-
Larrosa, M.1
-
128
-
-
36248957463
-
Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells
-
Y. Chen Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells Basic Clin. Pharmacol. Toxicol. 101 2007 427 433
-
(2007)
Basic Clin. Pharmacol. Toxicol.
, vol.101
, pp. 427-433
-
-
Chen, Y.1
-
129
-
-
0030839940
-
Stability of curcumin in buffer solutions and characterization of its degradation products
-
Y.J. Wang Stability of curcumin in buffer solutions and characterization of its degradation products J. Pharm. Biomed. Anal. 15 1997 1867 1876
-
(1997)
J. Pharm. Biomed. Anal.
, vol.15
, pp. 1867-1876
-
-
Wang, Y.J.1
-
130
-
-
84883456347
-
Targeted delivery of curcumin for treating type 2 diabetes
-
M.R. Maradana Targeted delivery of curcumin for treating type 2 diabetes Mol. Nutr. Food Res. 57 2013 1550 1556
-
(2013)
Mol. Nutr. Food Res.
, vol.57
, pp. 1550-1556
-
-
Maradana, M.R.1
-
131
-
-
84876833549
-
Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands
-
D.S. Hewings Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands J. Med. Chem. 56 2013 3217 3227
-
(2013)
J. Med. Chem.
, vol.56
, pp. 3217-3227
-
-
Hewings, D.S.1
-
132
-
-
84876590335
-
Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva
-
S.-H. Kim Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva Org. Lett. 15 2013 1834 1837
-
(2013)
Org. Lett.
, vol.15
, pp. 1834-1837
-
-
Kim, S.-H.1
-
133
-
-
33846413961
-
Ester-based precursors to increase the bioavailability of quercetin
-
L. Biasutto Ester-based precursors to increase the bioavailability of quercetin J. Med. Chem. 50 2007 241 253
-
(2007)
J. Med. Chem.
, vol.50
, pp. 241-253
-
-
Biasutto, L.1
-
134
-
-
46749091209
-
Prodrugs of fluoro-substituted benzoates of EGCG as tumor cellular proteasome inhibitors and apoptosis inducers
-
Z. Yu Prodrugs of fluoro-substituted benzoates of EGCG as tumor cellular proteasome inhibitors and apoptosis inducers Int. J. Mol. Sci. 9 2008 951 961
-
(2008)
Int. J. Mol. Sci.
, vol.9
, pp. 951-961
-
-
Yu, Z.1
-
135
-
-
70450235238
-
Absorption and metabolism of resveratrol carboxyesters and methanesulfonate by explanted rat intestinal segments
-
L. Biasutto Absorption and metabolism of resveratrol carboxyesters and methanesulfonate by explanted rat intestinal segments Cell. Physiol. Biochem. 24 2009 557 566
-
(2009)
Cell. Physiol. Biochem.
, vol.24
, pp. 557-566
-
-
Biasutto, L.1
-
136
-
-
77958452907
-
Preventive oral treatment with resveratrol pro-prodrugs drastically reduces colon inflammation in rodents
-
M. Larrosa Preventive oral treatment with resveratrol pro-prodrugs drastically reduces colon inflammation in rodents J. Med. Chem. 53 2010 7365 7376
-
(2010)
J. Med. Chem.
, vol.53
, pp. 7365-7376
-
-
Larrosa, M.1
-
137
-
-
36049010331
-
Preparation of curcumin prodrugs and their in vitro anti-tumor activities
-
P. Lu Preparation of curcumin prodrugs and their in vitro anti-tumor activities J. Huazhong Univ. Sci. Technol. Med. Sci. 25 2005 668 670
-
(2005)
J. Huazhong Univ. Sci. Technol. Med. Sci.
, vol.25
, pp. 668-670
-
-
Lu, P.1
-
138
-
-
84907816657
-
Curcumin nanomedicine: A road to cancer therapeutics
-
M.M. Yallapu Curcumin nanomedicine: a road to cancer therapeutics J. Drug Target. 20 2012 831 840
-
(2012)
J. Drug Target.
, vol.20
, pp. 831-840
-
-
Yallapu, M.M.1
-
139
-
-
84883581837
-
Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: Implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity
-
A.K. Jain Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity Mol. Pharm. 10 2013 3459 3474
-
(2013)
Mol. Pharm.
, vol.10
, pp. 3459-3474
-
-
Jain, A.K.1
-
140
-
-
84877269846
-
Enhanced neuroprotective effects of resveratrol delivered by nanoparticles on hydrogen peroxide-induced oxidative stress in rat cortical cell culture
-
X. Lu Enhanced neuroprotective effects of resveratrol delivered by nanoparticles on hydrogen peroxide-induced oxidative stress in rat cortical cell culture Mol. Pharm. 10 2013 2045 2053
-
(2013)
Mol. Pharm.
, vol.10
, pp. 2045-2053
-
-
Lu, X.1
-
141
-
-
84881363517
-
Crystal engineering of green tea epigallocatechin-3-gallate (EGCG) cocrystals and pharmacokinetic modulation in rats
-
A.J. Smith Crystal engineering of green tea epigallocatechin-3-gallate (EGCG) cocrystals and pharmacokinetic modulation in rats Mol. Pharm. 10 2013 2948 2961
-
(2013)
Mol. Pharm.
, vol.10
, pp. 2948-2961
-
-
Smith, A.J.1
-
142
-
-
84860710981
-
Using the epigenetic code to promote the unpackaging and transcriptional activation of DNA polyplexes for gene delivery
-
J.D. Larsen Using the epigenetic code to promote the unpackaging and transcriptional activation of DNA polyplexes for gene delivery Mol. Pharm. 9 2012 1041 1051
-
(2012)
Mol. Pharm.
, vol.9
, pp. 1041-1051
-
-
Larsen, J.D.1
-
143
-
-
42049117592
-
Intracellular delivery of acetyl-histone peptides inhibits native bromodomain-chromatin interactions and impairs mitotic progression
-
A. Nishiyama Intracellular delivery of acetyl-histone peptides inhibits native bromodomain-chromatin interactions and impairs mitotic progression FEBS Lett. 582 2008 1501 1507
-
(2008)
FEBS Lett.
, vol.582
, pp. 1501-1507
-
-
Nishiyama, A.1
-
144
-
-
84883581197
-
Prodrug/Enzyme based acceleration of absorption of hydrophobic drugs: An in vitro study
-
M. Kapoor, and R.A. Siegel Prodrug/Enzyme based acceleration of absorption of hydrophobic drugs: an in vitro study Mol. Pharm. 10 2013 3519 3524
-
(2013)
Mol. Pharm.
, vol.10
, pp. 3519-3524
-
-
Kapoor, M.1
Siegel, R.A.2
-
145
-
-
84888312897
-
Innovative in vitro method to predict rate and extent of drug delivery to the brain across the blood-brain barrier
-
V. Mangas-Sanjuán Innovative in vitro method to predict rate and extent of drug delivery to the brain across the blood-brain barrier Mol. Pharm. 10 2013 3519 3524
-
(2013)
Mol. Pharm.
, vol.10
, pp. 3519-3524
-
-
Mangas-Sanjuán, V.1
-
146
-
-
84880036112
-
Nanomedicine as a promising approach for the treatment and diagnosis of brain diseases: The example of Alzheimer's disease
-
K. Andrieux, and P. Couvreur Nanomedicine as a promising approach for the treatment and diagnosis of brain diseases: the example of Alzheimer's disease Ann. Pharm. 71 2013 225 233
-
(2013)
Ann. Pharm.
, vol.71
, pp. 225-233
-
-
Andrieux, K.1
Couvreur, P.2
-
147
-
-
84888390732
-
Drug delivery interfaces in the 21st century: From science fiction ideas to viable technologies
-
B. Chertok Drug delivery interfaces in the 21st century: from science fiction ideas to viable technologies Mol. Pharm. 10 2013 3531 3543
-
(2013)
Mol. Pharm.
, vol.10
, pp. 3531-3543
-
-
Chertok, B.1
|