Novel symmetrical ureas as modulators of protein arginine methyl transferases

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 2056-2067

  Fontán, Noelia ^a   García Domínguez, Patricia ^a   Álvarez, Rosana ^a   De Lera, Ángel R ^a  

^a UNIVERSITY OF VIGO   (Spain)

Author keywords

AMI 1; Epigenetics; Histone methylation; PRMT inhibitors; Ureas

Indexed keywords

(1,3) BIS (1 FORMYL PHEN 3 YL) TETRAHYDROPYRIMIDIN 2(1H) ONE; (1,3) BIS [3 (1 ETHOXYCARBONYL ETHEN 2 YL) PHEN 1 YL] TETRAHYDROPYRIMIDIN 2(1H) ONE; (3 METHOXYCARBONYL PHEN 1 YL) METHANAMMONIUM CHLORIDE; 1 [3 (METHOXYCARBONYL) PHEN 1 YL] ETHAN 1 AMMONIUM CHLORIDE; 3,3' (UREYLEN DI N,N' ETHAN 2 YL) DIBENZOIC ACID; 3,3' (UREYLEN DI N,N' METHYL) DIBENZOIC ACID; 3,3' (UREYLENDI N,N' PHEN 3 YL) DIACRYLIC ACID; 3,3' [(2 OXODIHYDROPYRIMIDINE 1,3 DIYL) BIS (1,3 PHENYLENE)] DIACRYLIC ACID; 6,6' UREYLEN DI HEXANOIC ACID; 7 ACETAMIDONAPHTHALENE 2 SULPHONYL CHLORIDE; AMI 1; AMIDE; ANDROGEN RECEPTOR; ARGININE; ENZYME ACTIVATOR; ENZYME INHIBITOR; ETHYL 3 AMINOPHENYLACRYLATE; ETHYL 3 BROMOPHENYLACRYLATE; METHYL 3 (CYANOMETHYL)BENZOATE; N [7 (N' (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) SULPHAMOYL) NAPHTHALEN 2 YL] ACETAMIDE; N,N' BIS (3 METHOXYCARBONYL PHEN 1 YL METHYL)UREA; N,N' BIS 2 [3 (METHOXYCARBONYL) PHEN 1 YL] ETHAN 1 YLUREA; N,N' BIS [3 (ETHOXYCARBONYL ETHEN 2 YL) PHEN 1 YL]UREA; NITROGEN; PALLADIUM; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN PRMT1; PROTEIN PRMT5; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE;

ARTICLE; CANCER INHIBITION; CARBONYLATION; CATALYSIS; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL BOND; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYMATIC ASSAY; ENZYME ACTIVITY; ENZYME INHIBITION; FKBP5 GENE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ANALYSIS; TMPRSS2 GENE;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; GENE EXPRESSION REGULATION; HISTONES; HUMANS; METHYLATION; PROTEIN-ARGININE N-METHYLTRANSFERASES; RECEPTORS, ANDROGEN; RECOMBINANT PROTEINS; UREA;

EID: 84875221875     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.017     Document Type: Article

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