Prodrug/Enzyme based acceleration of absorption of hydrophobic drugs: An in vitro study

Molecular Pharmaceutics

Volumn 10, Issue 9, 2013, Pages 3519-3524

  Kapoor, Mamta ^a   Siegel, Ronald A ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b University of Minnesota   (United States)

Author keywords

Enzymatic conversion; MDCK membrane; Poor water solubility; Prodrug; Rapid absorption; Supersaturation

Indexed keywords

ALKALINE PHOSPHATASE; ENZYME; FOSPHENYTOIN SODIUM; INULIN; PHENYTOIN; PRODRUG;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG TRANSPORT; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; IN VITRO STUDY; MDCK CELL; NONHUMAN; NOSE MUCOSA; PH; PRECIPITATION; PRIORITY JOURNAL;

ABSORPTION; ANIMALS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; ENZYMES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PRODRUGS; SOLUBILITY;

EID: 84883581197     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400272m     Document Type: Article

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