Histone deacetylase inhibitor prodrugs in nanoparticle vector enhanced gene expression in human cancer cells

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4603-4610

  Ishii, Yuta ^a   Hattori, Yoshiyuki ^b   Yamada, Toshiharu ^a   Uesato, Shinichi ^a   Maitani, Yoshie ^b   Nagaoka, Yasuo ^a  

^a KANSAI UNIVERSITY   (Japan)

^b HOSHI UNIVERSITY   (Japan)

Author keywords

Cationic cholesterol; Cationic nanoparticle; Gene expression; HDAC; Histone deacetylase inhibitor; Non viral vector

Indexed keywords

1 CHOLEST 5 EN 3 YL 4 [2 [(2 NAPHTHYLMETHYL)(4 [[(TETRAHYDRO 2H PYRAN 2 YLOXY) AMINO]CARBONYL]BENZYL)AMINO]ETHYL]SUCCINATE; 1 CHOLEST 5 EN 3 YL 4 [2 [[4 [(HYDROXYAMINO)CARBONYL]BENZYL](2 NAPHTHYLMETHYL)AMINO]ETHYL]SUCCINATE; 2 (DODECYLDISULFANYL)ETHYL 2 [(2 NAPHTHYLMETHYL)(4 [(TETRAHYDRO 2H PYRAN 2 YLOXY)AMINO]CARBONYL]BENZYL)AMINO]ETHYLCARBONATE; 2 (DODECYLDISULFANYL)ETHYL 2[[4 [(HYDROXYAMINO)CARBONYL]BENZYL](2 NAPHTHYLMETHYL)AMINO]ETHYLCARBONATE; 2 [(2 NAPHTHYLMETHYL)(4 [[(TETRAHYDRO 2H PYRAN 2 YLOXY)AMINO]CARBONYL]BENZYL)AMINO]ETHYL 2 (2 PYRIDINYLDISULFANYL)ETHYL CARBONATE; 2 [(2 NAPHTHYLMETHYL)(4 [[(TETRAHYDRO 2H PYRAN 2 YLOXY)AMINO]CARBONYL]BENZYL)AMINO]ETHYLLAURATE; 2 [[4 [(HYDROXYAMINO)CARBONYL]BENZYL](NAPHTHYLMETHYL)AMINO]ETHYLLAURATE; 4 [[(2 HYDROXYETHYL)(2 NAPHTHYLMETHYL)AMINO]METHYL]N (TETRAHYDRO 2H PYRAN 2 YLOXY)BENZAMIDE; CHOLEST 5 EN 3 YL 4 [[[4 [[(2 HYDROXYETHYL)(2 NAPHTHYLMETHYL)AMINO]METHYL]BENZOYL]AMINO]OXY] 4 OXOBUTANOATE; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; N (DODECANOYLOXY) 4 [[(2 HYDROXYETHYL)(2 NAPHTHYLMETHYL)AMINO]METHYL]BENZAMIDE; NANOCARRIER; UNCLASSIFIED DRUG;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA VECTOR; DRUG EFFECT; DRUG STRUCTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; PROSTATE CANCER;

BREAST NEOPLASMS; CELL LINE, TUMOR; CHOLESTEROL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASE INHIBITORS; HISTONES; HUMANS; MALE; NANOPARTICLES; PRODRUGS; PROSTATIC NEOPLASMS;

EID: 70349775533     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.06.036     Document Type: Article

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