Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase

European Journal of Medicinal Chemistry

Volumn 44, Issue 12, 2009, Pages 4855-4861

  Ghizzoni, Massimo ^a   Haisma, Hidde J ^a   Dekker, Frank J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Antitumour; Epigenetics; Histone acetyltransferase; Isothiazolone; Isothiazolone 1 oxide; PCAF

Indexed keywords

5 CHLOROISOTHIAZOLONE 1 OXIDE DERIVATIVE; 5 CHLOROISOTHIAZOLONE DERIVATIVE; CHLORINE; HISTONE ACETYLTRANSFERASE PCAF; METHYL GROUP; PHOSALONE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE;

CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; OXIDES; P300-CBP TRANSCRIPTION FACTORS; THIAZOLES;

EID: 70449640307     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.07.025     Document Type: Article

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