Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters

Molecules

Volumn 13, Issue 7, 2008, Pages 1441-1454

  Tsume, Yasuhiro ^a   Vig, Balvinder S ^b   Sun, Jing ^a   Landowski, Christopher P ^c   Hilfinger, John M ^d   Ramachandran, Chandrasekharan ^a   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c UNIVERSITY OF BERN   (Switzerland)

^d TSRL INC   (United States)

Author keywords

5 FU; Caco 2 permeability; Cell proliferation assays; Floxuridine; Oligopeptide transporter 1 (PEPT1); Prodrugs

Indexed keywords

AMINO ACID; ANTINEOPLASTIC ANTIMETABOLITE; COTRANSPORTER; ESTER; FLOXURIDINE; GROWTH INHIBITOR; PRODRUG; SLC15A1 PROTEIN, HUMAN;

ABSORPTION; ANIMAL; ARTICLE; BIOSYNTHESIS; CELL PROLIFERATION; CELL STRAIN CACO 2; DOG; DRUG DELIVERY SYSTEM; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; SYNTHESIS;

ABSORPTION; AMINO ACIDS; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CACO-2 CELLS; CELL PROLIFERATION; DOGS; DRUG DELIVERY SYSTEMS; ESTERS; FLOXURIDINE; GROWTH INHIBITORS; HUMANS; PRODRUGS; SYMPORTERS;

EID: 48849097095     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules13071441     Document Type: Article

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