Histone methyltransferase inhibitors: Novel epigenetic agents for cancer treatment

Current Medicinal Chemistry

Volumn 20, Issue 2, 2013, Pages 167-185

  Zagni, C ^a   Chiacchio, U ^b   Rescifina, A ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

Chromatin; DNA methylation; Drug discovery; Epigenetic; Histone methylation; HKMT inhibitors; HMT inhibitors; HRMT inhibitors; S Adenosyl L methionine (SAM); Sadenosyl L homocysteine (SAH)

Indexed keywords

2 CYCLOHEXYL N (1 ISOPROPYL 4 PIPERIDINYL) 6 METHOXY 7 [3 (1 PYRROLIDINYL)PROPOXY] 4 QUINAZOLINAMINE; BMI1 PROTEIN; CHETOCIN; EPZ 004777; HISTONE METHYLTRANSFERASE; METHYLTRANSFERASE INHIBITOR; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; POLYCOMB GROUP PROTEIN; SINEFUNGIN; UNC 0321; UNC 0631; UNC 0646; UNCLASSIFIED DRUG;

CATALYSIS; ENZYME ACTIVE SITE; EPIGENETICS; HISTONE MODIFICATION; HUMAN; NONHUMAN; PROTEIN FUNCTION; REVIEW;

EID: 84877954369     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986713804806667     Document Type: Review

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