Virtual ligand screening of the p300/CBP histone acetyltransferase: Identification of a selective small molecule inhibitor

Chemistry and Biology

Volumn 17, Issue 5, 2010, Pages 471-482

  Bowers, Erin M ^a   Yan, Gai ^a   Mukherjee, Chandrani ^a   Orry, Andrew ^b   Wang, Ling ^a   Holbert, Marc A ^a   Crump, Nicholas T ^c   Hazzalin, Catherine A ^c   Liszczak, Glen ^d   Yuan, Hua ^d   Larocca, Cecilia ^a   Saldanha, S Adrian ^e   Abagyan, Ruben ^f   Sun, Yan ^a   Meyers, David J ^a   Marmorstein, Ronen ^d,g   Mahadevan, Louis C ^c   Alani, Rhoda M ^a,h   Cole, Philip A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOLSOFT LLC   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d WISTAR INSTITUTE   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZOIC ACID DERIVATIVE; ENZYME INHIBITOR; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE PCAF; LIGAND; PYRAZOLE DERIVATIVE; PYRAZOLONE; PYRAZOLONE DERIVATIVE;

ACETYLATION; ANIMAL; ARTICLE; BINDING COMPETITION; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; ENZYME ACTIVE SITE; METABOLISM; MOLECULAR LIBRARY; MOUSE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ACETYLATION; ANIMALS; ANTINEOPLASTIC AGENTS; BENZOIC ACIDS; BINDING SITES; BINDING, COMPETITIVE; CATALYTIC DOMAIN; CELL LINE, TUMOR; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HISTONE ACETYLTRANSFERASES; LIGANDS; MICE; P300-CBP TRANSCRIPTION FACTORS; PYRAZOLES; PYRAZOLONES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77954204335     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2010.03.006     Document Type: Article

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