A histone deacetylase inhibitory prodrug - Butyroyloxymethyl diethyl phosphate - Protects the heart and cardiomyocytes against ischemia injury

European Journal of Pharmaceutical Sciences

Volumn 45, Issue 5, 2012, Pages 592-599

  Kessler Icekson, G ^a   Hochhauser, E ^a   Sinai, T ^a   Kremer, A ^a   Dick, J ^a   Tarasenko, N ^a   Nudelman, V ^a   Schlesinger, H ^a   Abraham, S ^a   Nudelman, A ^b   Rephaeli, A ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b BAR ILAN UNIVERSITY   (Israel)

Author keywords

Butyric acid; Cardioprotection; Heme oxygenase 1; Histone deacetylase inhibitor; Ischemia reperfusion; Prodrug

Indexed keywords

BUTYROYLOXYMETHYL DIETHYLPHOSPHATE; HEME OXYGENASE 1; HISTONE DEACETYLASE INHIBITOR; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; CONVALESCENCE; CORONARY ARTERY BLOOD FLOW; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EX VIVO STUDY; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HEART PROTECTION; HYPOXIA; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SINGLE DRUG DOSE; WESTERN BLOTTING;

ANIMALS; ANOXIA; BUTYRIC ACIDS; CELL DEATH; HEART; HEME OXYGENASE-1; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHORIC ACID ESTERS; PRODRUGS; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; REPERFUSION;

EID: 84857916369     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.12.013     Document Type: Article

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