YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model

International Journal of Oncology

Volumn 32, Issue 3, 2008, Pages 545-555

  Shindoh, Nobuaki ^a   Mori, Masamichi ^a   Terada, Yoh ^a   Oda, Kazuo ^a   Amino, Nobuaki ^a   Kita, Aya ^a   Taniguchi, Masatoshi ^a   Sohda, Kin Ya ^a   Nagai, Koji ^a   Sowa, Yoshihiro ^b   Masuoka, Yuhta ^a   Orita, Masaya ^a   Sasamata, Masao ^a   Matsushime, Hitoshi ^a   Furuichi, Kiyoshi ^a   Sakai, Toshiyuki ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Cyclic peptide; Histone deacetylase inhibitor; Prodrug; YM753

Indexed keywords

DITHIOTHREITOL; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; PROTEIN P21; ROMIDEPSIN; SPIRUCHOSTATIN A; SPIRUCHOSTATIN B; UNCLASSIFIED DRUG; YM 187754; YM 209139; YM 340209; YM 343242; YM 343243; YM 349972; YM 753;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER TRANSPLANTATION; COLON CANCER; CONCENTRATION RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; XENOGRAFT;

EID: 40249088767     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.32.3.545     Document Type: Article

References (42)