Different uptake of gentamicin through TRPV1 and TRPV4 channels determines cochlear hair cell vulnerability

Experimental and Molecular Medicine

Volumn 45, Issue 3, 2013, Pages

  Lee, Jeong Han ^a,b   Park, Channy ^a,c   Kim, Se Jin ^a   Kim, Hyung Jin ^a   Oh, Gi Su ^a   Shen, Aihua ^a   So, Hong Seob ^a   Park, Raekil ^a  

^a Wonkwang University School of Medicine   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOUSE RESEARCH INSTITUTE   (United States)

Author keywords

Gentamicin; Hair cells; Ototoxicity; TRPV1; TRPV4

Indexed keywords

CALCIUM; FLUORESCENT DYE; GADOLINIUM; GENTAMICIN; RUTHENIUM RED; TEXAS RED; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 4; TRPV1 PROTEIN, RAT; TRPV4 PROTEIN, RAT; VANILLOID RECEPTOR; XANTHENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL MIGRATION; COCHLEA; CONTROLLED STUDY; CUTICLE; CYTOTOXICITY; DRUG CONJUGATION; DRUG UPTAKE; EMBRYO; EXPLANT; HAIR CELL; NONHUMAN; OTOTOXICITY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; STEREOCILIUM; ANIMAL; CELL DEATH; CELL POLARITY; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECT; METABOLISM; SPRAGUE DAWLEY RAT; TIME; ZEBRA FISH;

ANIMALS; CELL DEATH; CELL POLARITY; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GADOLINIUM; GENTAMICINS; HAIR CELLS, AUDITORY; HAIR CELLS, AUDITORY, INNER; RATS; RATS, SPRAGUE-DAWLEY; RUTHENIUM RED; TIME FACTORS; TRPV CATION CHANNELS; XANTHENES; ZEBRAFISH;

EID: 84875973128     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2013.25     Document Type: Article

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