N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1 (2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic properties

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 1, 2003, Pages 377-386

  Valenzano, Kenneth J ^a,f   Grant, Elfrida R ^a   Wu, Gang ^a   Hachicha, Mohamed ^a   Schmid, Lori ^a   Tafesse, Laykea ^a   Sun, Qun ^a   Rotshteyn, Yakov ^b   Francis, Joseph ^c   Limberis, James ^d   Malik, Shiazah ^c   Whittemore, Edward R ^e   Hodges, Dianne ^c  

^a Purdue Pharma Discovery Research   (United States)

^b PURDUE PHARMA L P   (United States)

^c ALLERGAN INC   (United States)

^d PFIZER INC   (United States)

^e VERTEX PHARMACEUTICALS   (United States)

^f NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; CALCIUM ION; CAPSAICIN; CAPSAZEPINE; ENZYME; N (4 TERT BUTYLPHENYL) 4 (3 CHLOROPYRIDIN 2 YL)TETRAHYDROPYRAZINE 1(2H) CARBOXAMIDE; PYRAZINE DERIVATIVE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1 ANTAGONIST;

ACTION POTENTIAL; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CHRONIC PAIN; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG PENETRATION; DRUG POTENCY; DRUG SPECIFICITY; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TIME SERIES ANALYSIS;

ANALGESICS; ANIMALS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; HUMANS; HYDROGEN-ION CONCENTRATION; PYRAZINES; PYRIDINES; RATS; RECEPTORS, DRUG; SKIN; TRANSFECTION;

EID: 0038467306     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.045674     Document Type: Article

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