Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia

Neuroscience Letters

Volumn 228, Issue 1, 1997, Pages 29-32

  Liu, L ^a   Simon, S A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Capsaicin; Desensitization; Nicotine; Pain

Indexed keywords

CAPSAZEPINE; NICOTINIC RECEPTOR; VANILLOID RECEPTOR;

ANIMAL TISSUE; ARTICLE; DESENSITIZATION; DRUG RECEPTOR BINDING; NONHUMAN; PAIN; PEPPER; PRIORITY JOURNAL; RAT; TRIGEMINUS GANGLION;

ANIMALS; CAPSAICIN; ELECTRIC CONDUCTIVITY; NICOTINE; NICOTINIC ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG; RECEPTORS, NICOTINIC; TRIGEMINAL GANGLION;

EID: 0030792361     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00358-3     Document Type: Article

References (25)

1. 3H]Resiniferatoxin binding to pig dorsal horn membranes displays positive cooperativity, Life Sci., 55 (1994) 337-346.
2. Amann, R. and Maggi, C.A., Ruthenium red as a capsaicin agonist, Life Sci., 49 (1991) 849-856.
3. Belmonte, C., Gallar, J., Pozo, M.A. and Rebollo, I., Excitation by irritant chemical substances of sensory afferent units in the cats cornea, J. Physiol. (Lond.), 437 (1991) 709-725.
4. Bevan, S., Hothi, S., Hughes, G., James, I.F., Rang, H.P., Shah, K., Walpole, C.S.J. and Yeats, J.C., Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin, Br. J. Pharmacol., 107 (1992) 544-552.
5. Docherty, R.J., Robertson, B. and Bevan, S., Capsaicin causes prolonged inhibition of voltage-activated calcium currents in adult dorsal root ganglion neurons in culture, Neuroscience, 40 (1991) 513-521.
6. Duner-Engstrom, M., Fredholm, B.B., Larsson, O., Lundberg, J.M. and Saria, A., Autonomie mechanisms underlying capsaicin induced oral sensations and salivation in man, J. Physiol., 373 (1996) 87-95.
7. Franco-Cereceda, A., Kallner, G. and Lundberg, J.M., Capsazepine-sensitive release of calcitonin gene related peptide from C-fibre afferents in the guinea pig heart by low pH and lactic acid, Eur. J. Pharmacol., 238 (1993) 311-316.
8. Green, B.G., Capsaicin sensitization and desensitization on the tongue produced by brief exposures to a low concentration, Neurosci. Lett., 107 (1989) 173-178.
9. Hansson, L., Choudry, N.B., Karlsson, J.A. and Fuller, R.W., Inhaled nicotine in humans: effect on the respiratory and cardiovascular systems, J. Appl. Physiol., 76 (1994) 2420-2427.
10. Holzer, P., Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons, Pharmacol. Rev., 43 (1991) 143-201.
11. + currents in melantrophs of rat pituitary, Br. J. Pharmacol., 112 (1994) 616-624.
12. Lena, C. and Changeux, J.-P., Allosteric modulations of the nicotinic acetylcholine receptor, Trends Neurosci., 16 (1993) 1981-1986.
13. Liu, L., Keiger, C.H.J. and Simon, S.A., Nicotinic acetylcholine and capsaicin receptors in rat trigeminal ganglia, Chem. Sens., 21 (1996) 635.
14. Liu, L., Ma, H., Pugh, W. and Simon, S.A., Identification of acetylcholine receptors in adult rat trigeminal ganglion neurons, Brain Res., 617 (1993) 37-42.
15. Liu, L. and Simon, S.A., A rapid capsaicin-activated current in rat trigeminal ganglion neurons, Proc. Natl. Acad. Sci. USA, 91 (1994) 738-741.
16. Liu, L. and Simon, S.A., Capsaicin and nicotine both activate a subset of rat trigeminal ganglion neurons, Am. J. Physiol. (Cell), 39 (1996) C1807-C1814.
17. Liu, L. and Simon, S.A., Capsaicin-induced currents with distinct desensitization and Ca++ dependence in rat trigeminal ganglion cells, J. Neurophysiol., 75 (1996) 1503-1514.
18. Lou, Y. and Lundberg, J.M., Inhibition of low pH evoked activation of airway sensory nerves by capsazepine, Biochem. Biophys. Res. Commun., 189 (1992) 537-544.
19. Oh, U., Hwang, S.W. and Kim, D., Capsaicin activates a nonselective cation channel in cultured neonatal dorsal root ganglion neurons, J. Neurosci., 16 (1996) 1659-1667.
20. Petersen, P., LaMotte, R.H., Klusch, A. and Kniffki, K.D., Multiple capsaicin-evoked currents in isolated rat sensory neurons, Neuroscience, 75 (1996) 495-505.
21. Poth, K., Nutter, T.J., Cuevas, J., Parker, M.J., Adams, D.J. and Luetje, C.W., Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from the rat, J. Neurosci., 17 (1997) 586-596.
22. Satoh, H., Lou, Y.-P. and Lundberg, J.M., Inhibitory effects of capsazepine and SP 48968 on citric acid-induced bronchoconstriction in guinea-pigs, Eur. J. Pharmacol., 236 (1993) 367-372.
23. Szallasi, A. and Blumberg, P., Vanilloid receptors: new insights enhance potential as a therapeutic target, Pain, 68 (1996) 195-208.
24. Szolcsanyi, J. and Jancso-Gabor, A., Sensory effects of capsaicin congeners. II. Importance of chemical structure and pungency in desensitizing activity of capsaicin-type compounds, ArzneimForsch., 25 (1975) 33-37.
25. Vlachova, V. and Vyklicky, L., Capsaicin-induced membrane currents in cultured sensory neurons of the rat, Physiol. Res., 42 (1993) 301-311.