Chapter 7. Modification of nociceptor responses by inflammatory mediators and second messengers implicated in their action – a study in canine testicular polymodal receptors

Progress in Brain Research

Volumn 113, Issue C, 1996, Pages 115-141

  Mizumura, Kazue ^a   Kumazawa, Takao ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIHISTAMINIC AGENT; BRADYKININ; BRADYKININ RECEPTOR; DIPHENHYDRAMINE; FORSKOLIN; PHORBOL ESTER; PROSTAGLANDIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; DOG; HEAT; INFLAMMATION; MALE; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; REVIEW; TESTIS;

EID: 0030459626     PISSN: 00796123     EISSN: 18757855     Source Type: Book Series    
DOI: 10.1016/S0079-6123(08)61084-5     Document Type: Article

References (148)

1. Anderson, C., Andersson, T., Andersson, R.G.G., In vivo microdialysis estimation of histamine in human skin. Skin Pharmacol. 5 (1992), 177-183.
2. Armstrong, D., Dry, R.M.L., Keele, C.A., Markham, J.W., Observations on chemical excitants of cutaneous pain in man. J. Physiol. (Lond.) 120 (1953), 326-351.
3. 2+ influx into platelets by platelet-activating factor and other aggregation inducers. Eur. J. Biochem. 198 (1991), 267-273.
4. 2 in an inflammatory exudate: effects of nonsteroidal anti-inflammatory agents. J. Pharmacol. Exp. Ther. 201 (1977), 769-777.
5. 2-induced activation and sensitization of articular mechanonociceptors. Neurosci Lett. 124 (1991), 5-8.
6. Broadbent, J.L., Observations on itching produced by cowhage, and on the part played by histamine as a mediator of the itch sensation. Br. J. Pharmacol. 8 (1953), 263-270.
7. Brown, D.A., Higashida, H., Inositol 1,4,5-tri-sphosphate and diacylglycerol mimic bradykinin effects on mouse neuroblastoma × rat glioma hybrid cells. J. Physiol. (Lond.) 397 (1988), 185-207.
8. Brune, K., Rainsford, K.D., Wagner, K., Peskar, B.A., Inhibition by anti-inflammatory drugs of prostaglandin production in cultured macrophages. Naunyn-Schmiedeberg's Arch. Pharmacol. 315 (1981), 269-278.
9. Burgess, G.M., Mullaney, I., McNeill, M., Dunn, P.M., Rang, H.P., Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture. J. Neurosci. 9 (1989), 3314-3325.
10. Campbell, M.D., Subramaniam, S., Kotlikoff, M.I., Williamson, J.R., Fluharty, S.J., Cyclic AMP inhibits inositol polyphosphate production and calcium mobilization in neuroblastoma × glioma NG108-15 cells. Mol. Pharmacol. 38 (1990), 282-288.
11. 1 on rat cutaneous afferent nerve activity. Br. J. Pharmacol. 59 (1977), 343-347.
12. Christian, E.P., Taylor, G.E., Weinreich, D., Serotonin increases excitability of rabbit C-fiber neurons by two distinct mechanisms. J. Appl. Physiol. 67 (1989), 584-591.
13. Cohen, R.H., Perl, E.R., Contributions of arachidonic acid derivatives and substance P to the sensitization of cutaneous nociceptors. J. Neurophysiol. 64 (1990), 457-464.
14. Coleman, R.A., Smith, W.L., Narumiya, S., International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46 (1994), 205-229.
15. Coleridge, H.M., Coleridge, J.C.G., Impulse activity in afferent vagal C-fibres with endings in the intrapulmonary airways of dogs. Respir. Physiol. 29 (1977), 125-142.
16. Crunkhorn, P., Willis, A.L., Cutaneous reactions to intradermal prostaglandins. Br. J. Pharmacol. 41 (1971), 49-56.
17. 2-induced potentiation of bradykinin excitation in rat sensory neurons. Neuroscience 66 (1995), 459-466.
18. Davis, K.D., Meyer, R.A., Campbell, J.N., Chemosensitivity and sensitization of nociceptive afferents that innervate the hairy skin of monkey. J. Neurophysiol. 69 (1993), 1071-1081.
19. Dickenson, J.M., Hill, S.J., Homologous and heterologous desensitization of histamine H(1)-receptors and ATP-receptors in the smooth muscle cell line, DDT(1)MF-2 — the role of protein kinase-C. Br. J. Pharmacol. 110 (1993), 1449-1456.
20. Douglas, W.W., Histamine and 5-hydroxytryptamine (serotonin) and their antagonists. Goodman, A.G., Goodman, L.S., Rall, T.W., Murad, F., (eds.) Goodman and Gilman's The Pharmacological Basis of Therapeutics, 7th edn., 1985, Macmillan, New York/Toronto/London, 605-638.
21. Dray, A., Bettaney, J., Forster, P., Perkins, M.N., Bradykinin-induced stimulation of afferent fibres is mediated through protein kinase C. Neurosci Lett. 91 (1988), 301-307.
22. Dray, A., Patel, I.A., Perkins, M.N., Rueff, A., Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro. Br. J. Pharmacol. 107 (1992), 1129-1134.
23. 2 suppresses a potassium current in rat sensory neurons. Soc. Neurosci. Abstr., 21, 1995, 900 abstract.
24. Farré, A.J., Colombo, M., Gutierrez, B., Maximum tolerated temperature in the rat tail: a broadly sensitive test of analgesic activity. Methods Find. Exp. Clin. Pharmacol. 11 (1989), 303-307.
25. Fazekas, I.G., Kosa, F., Viragos-Kis, E., Basch, A., Free and total histamine content of the skin in experimental burn injuries. Z. Rechtmed. 72 (1973), 203-212.
26. Ferreira, S.H., Prostaglandins, aspirin-like drugs and analgesia. Nature New Biol. 240 (1972), 200-203.
27. 2+ dependent process. Prostaglandins 18 (1979), 179-189.
28. Ferreira, S.H., Moncada, S., Vane, J.R., Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature New Biol. 231 (1971), 237-239.
29. 2. Prostaglandins 16 (1978), 31-37.
30. Fjällbrant, N., Iggo, A., The effect of histamine, 5-hydroxytryptamine and acetylcholine on cutaneous afferent fibres. J. Physiol. (Lond.) 156 (1961), 578-590.
31. Fock, S., Mense, S., Excitatory effects of 5-hydroxy-tryptamine, histamine and potassium ions on muscular group IV afferent units: a comparison with bradykinin. Brain Res. 105 (1976), 459-469.
32. Fowler, J.C., Greene, R., Weinreich, D., Two calcium-sensitive spike after-hyperpolarizations in visceral sensory neurones of the rabbit. J. Physiol. (Lond.) 365 (1985), 59-75.
33. 1-receptors on astrocytes in primary cultures: a possible target for histaminergic neurones. Agents Actions 33 (1991), 161-180 Suppl.
34. + current in Xenopus oocytes. J. Neurosci. 12 (1992), 3743-3752.
35. + current in nociceptors. Proc. Natl. Acad. Sci. USA 93 (1996), 1108-1112.
36. Goodwin, L.G., Jones, C.R., Richards, W.H.G., Kohn, J., Pharmacologically active substances in the urine of burned patients. Br. J. Exp. Pathol. 44 (1963), 551-560.
37. Greaves, M.W., Songergaard, J., McDonald-Gibson, W., Recovery of prostaglandins in human cutaneous inflammation. Br. Med. J. 2 (1971), 258-260.
38. Haga, T., Haga, K., Kameyama, K., G protein-coupled receptor kinases. J. Neurochem. 63 (1994), 400-412.
39. 2 on the discharge of cutaneous nociceptive C-fibres induced by radiant heat. Pflugers Arch., 355, 1975, R116 abstract.
40. Handwerker, H.O., Pharmacological modulation of the discharge of nociceptive C-fibres. Zotterman, Y., (eds.) Sensory Functions of the Skin in Primates with Special Reference to Man Wenner-Gren Center International Symposium, Vol.27, 1976, Pergamon, Oxford, 427-439.
41. Handwerker, H.O., Forster, C., Kirchhoff, C., Discharge patterns of human C-fibers induced by itching and burning stimuli. J. Neurophysiol. 66 (1991), 307-315.
42. Hardy, J.D., Wolff, H.G., Goodell, H., The effect of analgesic agents upon pain. Hardy, J.D., Wolff, H.G., Goodell, H., (eds.) Pain Sensations and Reactions, 1952, Williams and Wilkins, Baltimore, 325-378.
43. Hardy, J.D., Wolff, H.G., Goodell, H., The nature of cutaneous hyperalgesia. Hardy, J.D., Wolff, H.G., Goodell, H., (eds.) Pain Sensations and Reactions, 1952, Williams and Wilkins, Baltimore, 173-215.
44. Häbler, C., Über den K- und Ca-Gehalt von Eiter und Exsudaten und seine Beziehungen zum Entündungs-schmerz. Klin. Wochenschr. 8 (1929), 1569-1572.
45. Hess, J.F., Borkowski, J.A., Young, G.S., Strader, C.D., Ransom, R.W., Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. Biochem. Biophys. Res. Commun. 184 (1992), 260-268.
46. 2+ as a major signal transduction pathway from bradykinin receptors. Jpn. J. Physiol. 43 (1993), S95–S99.
47. Higgs, G.A., Moncada, S., Salmon, J.A., Seager, K., The source of thromboxane and prostaglandins in experimental inflammation. Br. J. Pharmacol. 79 (1983), 863-868.
48. Hill, S.J., Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol. Rev. 42 (1990), 45-83.
49. Hill, S.J., Histamine receptors and interactions between second messenger transduction systems. Agents Actions, 1991, 145-159 Suppl. 33.
50. Ismailov, I.I., Benos, D.J., Effects of phosphorylation on ion channel function. Kidney Int. 48 (1995), 1167-1179.
51. Jensen, K., Tuxen, C., Pedersen-Bjergaard, U., Jansen, I., Edvinsson, L., Olesen, J., Pain, wheal and flare in human forearm skin induced by bradykinin and 5-hydroxy-tryptamine. Peptides 11 (1990), 1133-1138.
52. Juan, H., Sametz, W., Histamine-induced release of arachidonic acid and of prostaglandins in the peripheral vascular bed. Naunyn-Schmiedeberg's Arch. Pharmacol. 314 (1980), 183-190.
53. Kaczmarek, L.K., The role of protein kinase C in the regulation of ion channels and neurotransmitter release. Trends Neurosci. 10 (1987), 30-34.
54. Kano, M., Kawakami, T., Hikawa, N., Hori, H., Takenaka, T., Gotoh, H., Bradykinin-responsive cells of dorsal root ganglia in culture: Cell size, firing, cytosolic calcium, and substance P. Cell Mol. Neurobiol. 14 (1994), 49-57.
55. Keele, C.A., Armstrong, D., Substances Producing Pain and Itch, 1964, Arnold, London.
56. Keith, I.M., Jin, J., Saban, R., Nerve mast cell interaction in normal guinea pig urinary bladder. J. Comp. Neurol. 363 (1995), 28-36.
57. King, J.S., Gallant, P., Myerson, V., Perl, E.R., The effects of anti-inflammatory agents on the responses and the sensitization of unmyelinated (C) fiber polymodal nociceptors. Zotterman, Y., (eds.) Sensory Functions of the Skin in Primates with Special Reference to Man, Wenner-Gren Center International Symposium, Vol. 27, 1976, Pergamon, Oxford, 441-461.
58. Kitakoga, O., Kuba, K., Bradykinin-induced ion currents in cultured rat trigeminal ganglion cells. Neurosci. Res. 16 (1993), 79-93.
59. 1 receptor mediated excitation and facilitation of the heat response by histamine in canine visceral polymodal receptors studied in vitro. J. Neurophysiol, 1996 in press.
60. Koltzenburg, M., Kress, M., Reeh, P.W., The nociceptor sensitization by bradykinin does not depend on sympathetic neurons. Neuroscience 46 (1992), 465-473.
61. Kopp, U.C., Smith, L.A., A role for protein kinase C in bradykinin-mediated activation of renal pelvic sensory receptors. Am. J. Physiol. 269 (1995), R331–R338.
62. Koppert, W., Reeh, P.W., Handwerker, H.O., Conditioning of histamine by bradykinin alters responses of rat nociceptor and human itch sensation. Neurosci. Lett. 152 (1993), 117-120.
63. Kruger, L., Silverman, J.D., Mantyh, P.W., Sternini, C., Brecha, N.C., Peripheral patterns of calcitonin-gene-related peptide general somatic sensory innervation: cutaneous and deep terminations. J. Comp. Neurol. 280 (1989), 291-302.
64. Kumakura, S., Kamo, I., Tsurufuji, S., Role of bradykinin in the vascular permeability response induced by carrageenin in rats. Br. J. Pharmacol. 93 (1988), 739-746.
65. Kumazawa, T., Mizumura, K., Thin-fibre receptors responding to mechanical, chemical, and thermal stimulation in the skeletal muscle of the dog. J. Physiol. (Lond.) 273 (1977), 179-194.
66. Kumazawa, T., Mizumura, K., Mechanical and thermal responses of polymodal receptors recorded from the superior spermatic nerve of dogs. J. Physiol. (Lond.) 299 (1980), 233-245.
67. Kumazawa, T., Mizumura, K., Chemical responses of polymodal receptors of the scrotal contents in dogs. J. Physiol. (Lond.) 299 (1980), 219-231.
68. Kumazawa, T., Perl, E.R., Primate cutaneous sensory units with unmyelinated (C) afferent fibers. J. Neurophysiol. 40 (1977), 1325-1338.
69. Kumazawa, T., Mizumura, K., Sato, J., Thermally potentiated responses to algesic substances of visceral nociceptors. Pain 28 (1987), 255-264.
70. Kumazawa, T., Mizumura, K., Sato, J., Response properties of polymodal receptors studied using in vitro testis superior spermatic nerve preparations of dogs. J. Neurophysiol. 57 (1987), 702-711.
71. Kumazawa, T., Mizumura, K., Minagawa, M., Tsujii, Y., Sensitizing effects of bradykinin on the heat responses of the visceral nociceptor. J. Neurophysiol. 66 (1991), 1819-1824.
72. Kumazawa, T., Mizumura, K., Minagawa, M., Koda, H., Tujii, Y., Sato, J., Differences in the response of the polymodal receptor to heat stimulation and to bradykinin. Inoki, R., Shigenaga, Y., Tohyama, M., (eds.) Processing and Inhibition of Nociceptive Information, 1992, Elsevier, Amsterdam/London/New York/Tokyo, 3-8.
73. 2-induced enhancement of the bradykinin response of nociceptors. Brain Res. 632 (1993), 321-324.
74. 2-induced enhancement of the heat response of nociceptors. Neurosci. Lett. 175 (1994), 71-73.
75. 2-induced sensitization of polymodal receptors in responses to bradykinin and heat. J. Neurophysiol 75 (1996), 2361-2368.
76. Lang, E., Novak, A., Reeh, P.W., Handwerker, H.O., Chemosensitivity of fine afferents from rat skin in vitro. J. Neurophysiol. 63 (1990), 887-901.
77. Lazarowski, E.R., Lapetina, E.G., Activation of platelet phospholipase C by fluoride is inhibited by elevation of cyclic AMP. Biochem. Biophys. Res. Commun. 158 (1989), 440-444.
78. Lembeck, F., Popper, H., Juan, H., Release of prostaglandins by bradykinin as an intrinsic mechanism of its algesic effect. Naunyn-Schmiedeberg's Arch. Pharmacol. 294 (1976), 69-73.
79. Leng, S., Mizumura, K., Koda, H., Kumazawa, T., Excitation and sensitization of the heat response induced by a phorbol ester in canine visceral polymodal receptors studied in vitro. Neurosci. Lett. 206 (1996), 13-16.
80. Levi, R.C., Alloatti, G., Histamine modulates calcium current in guinea pig ventricular myocytes. J. Pharmacol. Exp. Ther. 246 (1988), 377-383.
81. Lewis, T., Hess, W., Pain derived from the skin and the mechanism of its production. Clin. Sci. 1 (1933), 39-61.
82. Lim, R.K.S., Guzman, F., Manifestations of pain in analgesic evaluation in animals and man. Soulairac, A., Chan, K., Chartenier, J., (eds.) Pain, 1968, Academic Press, London, 119-152.
83. Lim, R.K.S., Guzman, F., Rodgers, D.W., Goto, K., Braun, C., Dickerson, G.D., Engle, R.J., Site of action of narcotic and non-narcotic analgesics determined by blocking bradykinin-evoked visceral pain. Arch. Int. Pharmacodyn. 152 (1964), 25-58.
84. Lindsay, R.M., Rang, H.P., Effects of bradykinin on the membrane currents of rat sensory neurones in tissue culture. J. Physiol. (Lond.), 390, 1987, 74.
85. Lory, P., Nargeot, J., Cyclic AMP-dependent modulation of cardiac Ca channels expressed in Xenopus laevis oocytes. Biochem. Biophys. Res. Commun. 182 (1992), 1059-1065.
86. Lynn, B., Structure, function and control: Afferent nerve endings in the skin. Greaves, M.W., Schuster, S., (eds.) Handbook of Experimental Pharmacology, 1989, Springer-Verlag, Berlin, 175-192.
87. Manning, D.C., Raja, S.N., Meyer, R.A., Campbell, J.N., Pain and hyperalgesia after intradermal injection of bradykinin in humans. Clin. Pharmacol. Ther. 50 (1992), 721-729.
88. Martin, H.A., Tuckett, R.P., Differential response characteristics of cutaneous A δ and C fiber mechanonociceptors to pruritic stimuli. Pain, 1990, S134 Suppl. 5., abstract.
89. Matthies, H.J.G., Palfrey, H.C., Hirning, L.D., Miller, R.J., Down regulation of protein kinase C in neuronal cells: effects on neurotransmitter release. J. Neurosci. 7 (1987), 1198-1206.
90. McAtee, P., Dawson, G., Rapid dephosphorylation of protein kinase C substrates by protein kinase A activators results from inhibition of diacylglycerol release. J. Biol. Chem. 264 (1989), 11193-11199.
91. McCarty, D.J., Phelps, P., Pyenson, J., Crystal-induced inflammation in canine joints—I. An experimental model with quantification of the host response. J. Exp. Med. 124 (1966), 99-114.
92. + channels changes during cell-cleavage cycle and may be regulated by cAMP-dependent protein kinase. Proc. R. Soc. Lond. (Biol.) 245 (1991), 159-164.
93. Menke, J.G., Borkowski, J.A., Bierilo, K.K., Macneil, T., Derrick, A.W., Schneck, K.A., Ransom, R.W., Strader, C.D., Linemeyer, D.L., Hess, J.F., Expression cloning of a human B-1 bradykinin receptor. J. Biol. Chem. 269 (1994), 21583-21586.
94. 2. Brain Res. 225 (1981), 95-105.
95. Messlinger, K., Pawlak, M., Schepelmann, K., Schmidt, R.F., Responsiveness of slowly conducting articular afferents to bradykinin: effects of an experimental arthritis. Pain 59 (1994), 335-343.
96. Miller, R.J., Bradykinin highlights the role of phospholipid metabolism in the control of nerve excitability. Trends Neurosci. 10 (1987), 226-228.
97. Mizumura, K., Sato, J., Kumazawa, T., Effects of prostaglandins and other putative chemical intermediaries on the activity of canine testicular polymodal receptors studied in vitro. Pflügers Arch. 408 (1987), 565-572.
98. Mizumura, K., Minagawa, M., Tsujii, Y., Kumazawa, T., The effects of bradykinin agonists and antagonists on visceral polymodal receptor activities. Pain 40 (1990), 221-227.
99. 2 on testicular nociceptor activities studied in vitro. Naunyn-Schmiedeberg's Arch. Pharmacol. 344 (1991), 368-376.
100. Mizumura, K., Sato, J., Kumazawa, T., Strong heat stimulation sensitized the heat response as well as the bradykinin response of visceral polymodal receptors. J. Neurophysiol. 68 (1992), 1209-1215.
101. Mizumura, K., Koda, H., Kumazawa, T., Augmenting effects of cyclic AMP on the heat response of canine testicular polymodal receptors. Neurosci. Lett. 162 (1993), 75-77.
102. 2-induced sensitization of the heat response of canine visceral polymodal receptors in vitro. Neurosci. Lett. 161 (1993), 117-119.
103. Mizumura, K., Minagawa, M., Koda, H., Kumazawa, T., Forskolin does not augment the bradykinin response of canine visceral polymodal receptors in vitro. Neurosci. Lett. 166 (1994), 195-198.
104. Mizumura, K., Minagawa, M., Koda, H., Kumazawa, T., Histamine-induced sensitization of the heat response of canine visceral polymodal receptors. Neurosci. Lett. 168 (1994), 93-96.
105. Mizumura, K., Sato, J., Minagawa, M., Kumazawa, T., Incomplete suppressive effect of acetylsalicylic acid on the heat sensitization of canine testicular polymodal receptor activities. J. Neurophysiol. 72 (1994), 2729-2736.
106. Mizumura, K., Koda, H., Kumazawa, T., Different effects of protein kinase-C activation on the responses to bradykinin and to heat of visceral polymodal receptors studies in vitro. Soc. Neurosci. Abstr., 21, 1995, 643 abstract.
107. Mizumura, K., Minagawa, M., Koda, H., Kumazawa, T., Influence of histamine on the bradykinin response of canine testicular polymodal receptors in vitro. Inflamm. Res. 44 (1995), 376-378.
108. Mizumura, K., Koda, H., Kumazawa, T., Opposite effects of increased intracellular cyclic AMP on the heat and bradykinin responses of canine visceral polymodal receptors in vitro. Neurosci. Res., 1996 in press.
109. Nakamura, T., Gold, G.H., A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature 325 (1987), 442-444.
110. Neugebauer, V., Schaible, H.-G., Schmidt, R.F., Sensitization of articular afferents to mechanical stimuli by bradykinin. Pflugers Arch. 415 (1989), 330-335.
111. 2 of bradykinin activation of embryonic rat sensory neurones. J. Physiol. (Lond.) 480 (1994), 485-492.
112. Nishizuka, Y., Turnover of inositol phospholipids and signal transduction. Science 225 (1984), 1365-1370.
113. 2a in the exudate of carrageenin granuloma of rats. Biochim. Biophys. Acta 424 (1976), 439-448.
114. 2+ elevation in neuroblastoma X glioma hybrid NG108-15 cells: relationship to the action of inositol phospholipids metabolites. Brain Res. 379 (1986), 84-89.
115. Ottoson, D., Swerup, C., Studies on the role of calcium in adaptation of the crustacean stretch receptor. Effects of intracellular injection of calcium, EGTA and TEA. Brain Res. 244 (1982), 337-341.
116. Paintal, A.S., Effects of drugs on vertebrate mechano-receptors. Pharmacol. Reu. 16 (1964), 341-380.
117. 1 receptors in vivo in a model of ultra-violet irradiation-induced thermal hyperalgesia in the rat. Br. J. Pharmacol. 110 (1993), 1441-1444.
118. Perl, E.R., Kumazawa, T., Lynn, B., Sensitization of high threshold receptors with unmyelinated (C) afferent fibers. Iggo, A., Ilynsky, O.B., (eds.) Somatosensory and Visceral Receptor Mechanisms, Progress in Brain Research, Vol. 43, 1976, Elsevier, Amsterdam, 263-277.
119. Raja, S.N., Campbell, J.N., Meyer, R.A., Colman, R.W., Role of kinins in pain and hyperalgesia: psychophysical studies in a patient with kininogen deficiency. Clin. Sci. 83 (1992), 337-341.
120. Raja, S.N., Meyer, R.A., Campbell, J.N., Peripheral mechanisms of somatic pain. Anesthesiology 68 (1996), 571-590.
121. Rang, H.P., Ritchie, J.M., Depolarization of nonmyelinated fibers of the rat vagus nerve produced by activation of protein kinase C. J. Neurosci. 8 (1988), 2606-2617.
122. Rang, H.P., Bevan, S., Dray, A., Nociceptive peripheral neurons: cellular properties. Wall, P.D., Melzack, R., (eds.) Textbook of Pain, 1994, Churchill Livingstone, Edinburgh, 57-78.
123. 2 subtype. Mol. Pharmacol. 46 (1994), 213-220.
124. Regoli, D., Barabe, J., Park, W.K., Receptors for bradykinin in rabbit aortae. Can. J. Physiol. Pharmacol. 55 (1977), 855-867.
125. Regoli, D., Marceau, F., Barabe, J., De novo formation of vascular receptors for bradykinin. Can. J. Physiol. Pharmacol. 56 (1978), 674-677.
126. Rosenthal, S.R., Minard, D., Experiments on histamine as the chemical mediator for cutaneous pain. J. Exp. Med. 70 (1939), 415-425.
127. Rueff, A., Dray, A., Sensitization of peripheral afferent fibres in the in vitro neonatal rat spinal cord tail by bradykinin and prostaglandins. Neuroscience 54 (1993), 527-535.
128. Sato, J., Mizumura, K., Kumazawa, T., Effects of ionic calcium on the responses of canine testicular polymodal receptors to algesic substances. J. Neurophysiol. 62 (1989), 119-125.
129. 2. Physiol. (Lond.) 403 (1988), 91-104.
130. Schepelmann, K., Messlinger, K., Schmidt, R.F., The effects of phorbol ester on slowly conducting afferents of the cat's knee joint. Exp. Brain Res. 92 (1993), 391-398.
131. Simone, D.A., Ngeow, J.Y.F., Whitehouse, J., Becerra-Cabal, L., Putterman, G.J., Lamotte, R.H., The magnitude and duration of itch produced by intracutaneous injections of histamine. Somatosens. Res. 5 (1987), 81-92.
132. Smith, C.D., Uhing, R.J., Snyderman, R., Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters. J. Biol. Chem. 262 (1987), 6121-6127.
133. Stabel, S., Rodriguez Pena, A., Young, S., Rozengurt, E., Parker, P.J., Quantitation of protein kinase C by immunoblot—expression in different cell lines and response to phorbol esters. J. Cell Physiol. 130 (1987), 111-117.
134. 3 subtype. J. Biol. Chem. 267 (1992), 6463-6466.
135. Swerup, C., On the ionic mechanisms of adaptation in an isolated mechanoreceptor—an electrophysiological study. Acta Physiol. Scand. 520 (1983), 1-43 Suppl.
136. 2 immunoreactivity is released during inflammation of the rabbit TMJ. J. Soc. Neurosci. Abstr., 18, 1992, 690 abstract.
137. Taiwo, Y.O., Levine, J.D., Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia. Neitroscience 44 (1991), 131-135.
138. Taiwo, Y.O., Bjerknes, L.K., Goetzl, E.J., Levine, J.D., Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system. Neuroscience 32 (1989), 577-580.
139. Thayer, S.A., Perney, T.M., Miller, R.J., Regulation of calcium homeostasis in sensory neurons by bradykinin. J. Neurosci. 8 (1988), 4089-4097.
140. 1 subtype of prostaglandin E receptor. J. Biol. Chem. 268 (1993), 20175-20178.
141. Weinreich, D., Wonderlin, W.F., Inhibition of calcium-dependent spike after-hyperpolarization increases excitability of rabbit visceral sensory neurones. J. Physiol. (Lond.) 394 (1987), 415-427.
142. Westerman, R., Margerl, W., Handwerker, H., Szolcsanyi, J., Pratt, A., Itch sensation evoked by percutaneous histamine iontophoresis and cowhage spicules applied to human skin. Proc. Int. Union Physiol. Sci, 16, 1986, 571.
143. Whalley, E.T., Clegg, S., Stewart, J.M., Vavrek, R.J., The effect of kinin agonists and antagonists on the pain response of the human blister base. Naunyn-Schmiedeberg's Arch. Pharmacol. 336 (1987), 652-655.
144. Widdicombe, J.G., The site of pulmonary stretch receptors in the cat. J. Physiol. (Lond) 125 (1954), 336-351.
145. Willis, A.L., Release of histamine, kinin and prostaglandins during carrageenin-induced inflammation in the rat. Monterazza, P., Horton, E.W., (eds.) Prostaglandins, Peptides and Amines, 1969, Academic, London, 31-38.
146. Yada, Y., Nagao, S., Okano, Y., Nozawa, Y., Inhibition by cyclic AMP of guanine nucleotide-induced activation of phosphoinositide-specific phospholipase C in human platelets. FEBS Lett. 242 (1989), 368-372.
147. Yokoyama, S., Kimura, Y., Taketo, M., Black, J.A., Ransom, B.R., Higashida, H., B-2 Bradykinin receptors in NG108-15 cells — cDNA cloning and functional expression. Biochem. Biophys. Res. Commun. 200 (1994), 634-641.
148. Yoneda, Y., Ogita, K., Neurochemical aspects of the N-methyl-@sc@D!sc!-aspartate receptor complex. Neurosci. Res. 10 (1991), 1-33.