The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: A Ca2+ imaging study in adult rat dorsal root ganglion neurons

Journal of Pharmacology and Experimental Therapeutics

Volumn 301, Issue 3, 2002, Pages 981-986

  Himmel, Herbert M ^a,c   Kiss, Thomas ^a   Borvendeg, Sebestyén J ^a   Gillen, Clemens ^b   Illes, Peter ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b GRÜNENTHAL GMBH   (Germany)

^c BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE DERIVATIVE; ARGINYLARGINYLARGINYLARGINYLARGINYLTRYPTOPHANYLTRYPTOPHANAMINE; CALCIUM ION; CAPSAICIN; CAPSAZEPINE; FURA 2; HEXAPEPTIDE; RESINIFERATOXIN; UNCLASSIFIED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR ANTAGONIST;

ALLOSTERISM; ANALGESIC ACTIVITY; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; DISSOCIATION CONSTANT; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG SPECIFICITY; IMAGING SYSTEM; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; SPINAL GANGLION; STEREOCHEMISTRY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARGININE; CALCIUM; CANNABINOIDS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FLUORESCENT DYES; GANGLIA, SPINAL; NEURONS; OLIGOPEPTIDES; RATS; RECEPTORS, DRUG; STEREOISOMERISM; TRPV CATION CHANNELS;

EID: 0036260775     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.301.3.981     Document Type: Article

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