α-Substituted N-(4-tert-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 18, 2007, Pages 6043-6053

  Chung, Jae Uk ^a   Kim, Su Yeon ^a   Lim, Ju Ok ^a   Choi, Hyun Kyung ^a   Kang, Sang Uk ^a   Yoon, Hae Seok ^a   Ryu, HyungChul ^a   Kang, Dong Wook ^a   Lee, Jeewoo ^a   Kang, Bomi ^b   Choi, Sun ^b   Toth, Attila ^c   Pearce, Larry V ^c   Pavlyukovets, Vladimir A ^c   Lundberg, Daniel J ^c   Blumberg, Peter M ^c  

^a Seoul National University   (South Korea)

^b Ewha Womans University   (South Korea)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Analgesic; TRPV1 antagonists

Indexed keywords

ANALGESIC AGENT; CAPSAICIN; N (4 TERT BUTYLBENZYL) N' [(4 METHYLSULFONYLAMINO)BENZYL]THIOUREA DERIVATIVE; N (4 TERT BUTYLBENZYL) N' [1 (4 METHYLSULFONYLAMINO)PHENYLETHYL]THIOUREA; N (4 TERT BUTYLBENZYL) N' [1 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]ETHYL]THIOUREA; RECEPTOR BLOCKING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ANALGESIA; ANIMAL CELL; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; CHO CELL; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; NOCICEPTION; NONHUMAN; PAIN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALCIUM; CAPSAICIN; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; TRPV CATION CHANNELS;

CRICETULUS GRISEUS; RATTUS;

EID: 34447632844     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.041     Document Type: Article

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