N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine-1 (2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In vivo characterization in rat models of inflammatory and neuropathic pain

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 1, 2003, Pages 387-393

  Pomonis, James D ^a   Harrison, James E ^a   Mark, Lilly ^a   Bristol, David R ^a   Valenzano, Kenneth J ^a,b   Walker, Katharine ^a  

^a Purdue Pharma Discovery Research   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; CAPSAICIN; CAPSAZEPINE; GABAPENTIN; INDOMETACIN; N (4 TERT BUTYLPHENYL) 4 (3 CHLOROPYRIDIN 2 YL)TETRAHYDROPYRAZINE 1(2H) CARBOXAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PYRAZINE DERIVATIVE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1 ANTAGONIST;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; HYPERALGESIA; IN VIVO STUDY; INFLAMMATION; MALE; MOTOR COORDINATION; MOTOR PERFORMANCE; NERVE INJURY; NEUROPATHIC PAIN; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; THERMAL ANALYSIS; TIME SERIES ANALYSIS;

ANALGESICS; ANIMALS; ATAXIA; CAPSAICIN; HYPERALGESIA; INFLAMMATION; MALE; NERVE TISSUE; PAIN; PAIN THRESHOLD; PYRAZINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG;

EID: 0038128285     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.046268     Document Type: Article

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