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Volumn 15, Issue 16, 2014, Pages 6463-6475

The mTOR signalling pathway in cancer and the potential: MTOR inhibitory activities of natural phytochemicals

Author keywords

mTOR inhibitors; mTOR signalling pathway; Natural compounds; PI3K Akt mTOR

Indexed keywords

ANTINEOPLASTIC AGENT; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MTOR PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT MEDICINAL PRODUCT; PROTEIN KINASE B; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

EID: 84906842272     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.16.6463     Document Type: Review
Times cited : (48)

References (158)
  • 1
    • 84890297953 scopus 로고    scopus 로고
    • Phosphatase and tensin homologue deleted on chromosome 10
    • Abdulkareem IH, Blair M (2013). Phosphatase and tensin homologue deleted on chromosome 10. Niger Med J, 54, 79-86.
    • (2013) Niger Med J , vol.54 , pp. 79-86
    • Abdulkareem, I.H.1    Blair, M.2
  • 2
    • 0031833563 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signalling
    • Abraham RT (1998). Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signalling. Curr Opin Immunol, 10, 330-6.
    • (1998) Curr Opin Immunol , vol.10 , pp. 330-336
    • Abraham, R.T.1
  • 3
    • 6944250259 scopus 로고    scopus 로고
    • Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies
    • Aggarwal BB, Bhardwaj A, Aggarwal RS, et al (2004). Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res, 24, 2783-840.
    • (2004) Anticancer Res , vol.24 , pp. 2783-2840
    • Aggarwal, B.B.1    Bhardwaj, A.2    Aggarwal, R.S.3
  • 4
    • 67449083453 scopus 로고    scopus 로고
    • Evidence that low-dose, long-term genistein treatment inhibits oestradiol-stimulated growth in MCF-7 cells by down-regulation of the PI3-kinase/Akt signalling pathway
    • Anastasius N, Boston S, Lacey M, Storing N, Whitehead SA (2009). Evidence that low-dose, long-term genistein treatment inhibits oestradiol-stimulated growth in MCF-7 cells by down-regulation of the PI3-kinase/Akt signalling pathway. J Steroid Biochem Mol Biol, 116, 50-5.
    • (2009) J Steroid Biochem Mol Biol , vol.116 , pp. 50-55
    • Anastasius, N.1    Boston, S.2    Lacey, M.3    Storing, N.4    Whitehead, S.A.5
  • 5
    • 34347238938 scopus 로고    scopus 로고
    • Evidence that curcumin suppresses the growth of malignant gliomas In vitro and In vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signalling pathways
    • Aoki H, Takada Y, Kondo S, et al (2007). Evidence that curcumin suppresses the growth of malignant gliomas In vitro and In vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signalling pathways. Mol Pharmacol, 72, 29-39.
    • (2007) Mol Pharmacol , vol.72 , pp. 29-39
    • Aoki, H.1    Takada, Y.2    Kondo, S.3
  • 6
    • 6344256753 scopus 로고    scopus 로고
    • mTOR: a protein kinase switching between life and death
    • Asnaghi L, Bruno P, Priulla M, et al (2004). mTOR: a protein kinase switching between life and death. Pharmacol Res 50, 545-9.
    • (2004) Pharmacol Res , vol.50 , pp. 545-549
    • Asnaghi, L.1    Bruno, P.2    Priulla, M.3
  • 7
    • 33745089904 scopus 로고    scopus 로고
    • Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/ Akt pathway and Bcl-2 family proteins
    • Aziz MH, Nihal M, Fu VX, et al (2006). Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/ Akt pathway and Bcl-2 family proteins. Mol Cancer Ther 5, 1335-41.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1335-1341
    • Aziz, M.H.1    Nihal, M.2    Fu, V.X.3
  • 8
    • 70449390905 scopus 로고    scopus 로고
    • Rapamycin and mTOR kinase inhibitors
    • Ballou LM, Lin RZ (2008). Rapamycin and mTOR kinase inhibitors. J Chem Biol, 1, 27-36.
    • (2008) J Chem Biol , vol.1 , pp. 27-36
    • Ballou, L.M.1    Lin, R.Z.2
  • 9
    • 33846646439 scopus 로고    scopus 로고
    • In vitro and In vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer
    • Banerjee S, Zhang Y, Wang Z, et al (2007). In vitro and In vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer. Int J Cancer, 120, 906-17.
    • (2007) Int J Cancer , vol.120 , pp. 906-917
    • Banerjee, S.1    Zhang, Y.2    Wang, Z.3
  • 10
    • 79959508436 scopus 로고    scopus 로고
    • Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer
    • Baselga J (2011). Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer. Oncologist, 16, 12-9.
    • (2011) Oncologist , vol.16 , pp. 12-19
    • Baselga, J.1
  • 11
    • 59149091041 scopus 로고    scopus 로고
    • Curcumin disrupts the mammalian target of rapamycin-raptor complex
    • Beevers CS, Chen L, Liu L, et al (2009). Curcumin disrupts the mammalian target of rapamycin-raptor complex. Cancer Res, 69, 1000-8.
    • (2009) Cancer Res , vol.69 , pp. 1000-1008
    • Beevers, C.S.1    Chen, L.2    Liu, L.3
  • 12
    • 33745918631 scopus 로고    scopus 로고
    • Curcumin inhibits the mammalian target of rapamycin-mediated signalling pathways in cancer cells
    • Beevers CS, Li F, Liu L, et al (2006). Curcumin inhibits the mammalian target of rapamycin-mediated signalling pathways in cancer cells. Int J Cancer, 119, 757-64.
    • (2006) Int J Cancer , vol.119 , pp. 757-764
    • Beevers, C.S.1    Li, F.2    Liu, L.3
  • 13
    • 0036709174 scopus 로고    scopus 로고
    • Nuclear factor-kappa B and cancer: its role in prevention and therapy
    • Bharti AC, Aggarwal BB (2002). Nuclear factor-kappa B and cancer: its role in prevention and therapy. Biochem Pharmacol, 64, 883-8.
    • (2002) Biochem Pharmacol , vol.64 , pp. 883-888
    • Bharti, A.C.1    Aggarwal, B.B.2
  • 14
    • 67349122064 scopus 로고    scopus 로고
    • Resveratrol inhibits the mTOR mitogenic signalling evoked by oxidized LDL in smooth muscle cells
    • Brito PM, Devillard R, Negre-Salvayre A, et al (2009). Resveratrol inhibits the mTOR mitogenic signalling evoked by oxidized LDL in smooth muscle cells. Atherosclerosis 205, 126-34.
    • (2009) Atherosclerosis , vol.205 , pp. 126-134
    • Brito, P.M.1    Devillard, R.2    Negre-Salvayre, A.3
  • 15
    • 78549288940 scopus 로고    scopus 로고
    • Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis
    • Brown VA, Patel KR, Viskaduraki M, et al (2010). Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res, 70, 9003-11.
    • (2010) Cancer Res , vol.70 , pp. 9003-9011
    • Brown, V.A.1    Patel, K.R.2    Viskaduraki, M.3
  • 16
    • 78650647490 scopus 로고    scopus 로고
    • A comprehensive map of the mTOR signalling network
    • Caron E, Ghosh S, Matsuoka Y, et al (2010). A comprehensive map of the mTOR signalling network. Mol Syst Biol, 6, 453.
    • (2010) Mol Syst Biol , vol.6 , pp. 453
    • Caron, E.1    Ghosh, S.2    Matsuoka, Y.3
  • 17
    • 79955804832 scopus 로고    scopus 로고
    • Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia
    • Carroll RE, Benya RV, Turgeon DK, et al (2011). Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res, 4, 354-64.
    • (2011) Cancer Prev Res , vol.4 , pp. 354-364
    • Carroll, R.E.1    Benya, R.V.2    Turgeon, D.K.3
  • 18
    • 7944223834 scopus 로고    scopus 로고
    • Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer
    • Chan S (2004). Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer. Br J Cancer 91, 1420-4.
    • (2004) Br J Cancer , vol.91 , pp. 1420-1424
    • Chan, S.1
  • 19
    • 84877313224 scopus 로고    scopus 로고
    • IGF-1R as an anti-cancer target-- trials and tribulations
    • Chen HX, Sharon E (2013). IGF-1R as an anti-cancer target-- trials and tribulations. Chin J Cancer, 32, 242-52.
    • (2013) Chin J Cancer , vol.32 , pp. 242-252
    • Chen, H.X.1    Sharon, E.2
  • 20
    • 0035174504 scopus 로고    scopus 로고
    • Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions
    • Cheng AL, Hsu CH, Lin JK, et al (2001). Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res, 21, 2895-900.
    • (2001) Anticancer Res , vol.21 , pp. 2895-2900
    • Cheng, A.L.1    Hsu, C.H.2    Lin, J.K.3
  • 21
    • 36849074161 scopus 로고    scopus 로고
    • Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation
    • Chiang CT, Way TD, Tsai SJ, et al (2007). Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation. FEBS Lett, 581, 5735-42.
    • (2007) FEBS Lett , vol.581 , pp. 5735-5742
    • Chiang, C.T.1    Way, T.D.2    Tsai, S.J.3
  • 22
    • 77956412951 scopus 로고    scopus 로고
    • Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study
    • Chow HH, Garland LL, Hsu CH, et al (2010). Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res, 3, 1168-75.
    • (2010) Cancer Prev Res , vol.3 , pp. 1168-1175
    • Chow, H.H.1    Garland, L.L.2    Hsu, C.H.3
  • 23
    • 0037021625 scopus 로고    scopus 로고
    • Antioxidant and antiproliferative activities of common vegetables
    • Chu Y-F, Sun J, Wu X, et al (2002). Antioxidant and antiproliferative activities of common vegetables. J Agr Food Chem, 50, 6910-6.
    • (2002) J Agr Food Chem , vol.50 , pp. 6910-6916
    • Chu, Y.-F.1    Sun, J.2    Wu, X.3
  • 24
    • 0031028432 scopus 로고    scopus 로고
    • Natural products in drug discovery and development
    • Cragg GM, Newman DJ, Snader KM (1997). Natural products in drug discovery and development. J Nat Prod, 60, 52-60.
    • (1997) J Nat Prod , vol.60 , pp. 52-60
    • Cragg, G.M.1    Newman, D.J.2    Snader, K.M.3
  • 26
    • 12744269542 scopus 로고    scopus 로고
    • Pilot study: effect of 3 3'-Diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer
    • Dalessandri KM, Firestone GL, Fitch MD, et al (2004). Pilot study: effect of 3,3'-Diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer, 50, 161-7.
    • (2004) Nutr Cancer , vol.50 , pp. 161-167
    • Dalessandri, K.M.1    Firestone, G.L.2    Fitch, M.D.3
  • 27
    • 74549127500 scopus 로고    scopus 로고
    • Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes
    • Das A, Banik NL, Ray SK (2010). Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes. Cancer, 116, 164-76.
    • (2010) Cancer , vol.116 , pp. 164-176
    • Das, A.1    Banik, N.L.2    Ray, S.K.3
  • 28
    • 51649118928 scopus 로고    scopus 로고
    • Phase II trial of curcumin in patients with advanced pancreatic cancer
    • Dhillon N, Aggarwal BB, Newman RA, et al (2008). Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res, 14, 4491-9.
    • (2008) Clin Cancer Res , vol.14 , pp. 4491-4499
    • Dhillon, N.1    Aggarwal, B.B.2    Newman, R.A.3
  • 29
    • 75349087887 scopus 로고    scopus 로고
    • Dissecting the role of mTOR: lessons from mTOR inhibitors
    • Dowling RJ, Topisirovic I, Fonseca BD, et al (2010). Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochim Biophys Acta, 1804, 433-9.
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 433-439
    • Dowling, R.J.1    Topisirovic, I.2    Fonseca, B.D.3
  • 30
    • 80054010018 scopus 로고    scopus 로고
    • Chapter 36 - Pomegranate in human health: an overview
    • (W. Ronald Ross and R. P. Victor, Ed.^ Eds). Academic Press, San Diego
    • Faria A, Calhau C (2010). Chapter 36 - Pomegranate in human health: an overview (W. Ronald Ross and R. P. Victor, Ed.^ Eds). Academic Press, San Diego, pp. 551-63.
    • (2010) , pp. 551-563
    • Faria, A.1    Calhau, C.2
  • 31
    • 33947726393 scopus 로고    scopus 로고
    • Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines
    • Faried A, Kurnia D, Faried LS, et al (2007). Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines. Int J Oncol, 30, 605-13.
    • (2007) Int J Oncol , vol.30 , pp. 605-613
    • Faried, A.1    Kurnia, D.2    Faried, L.S.3
  • 32
    • 0345732640 scopus 로고    scopus 로고
    • mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
    • Fingar DC, Richardson CJ, Tee AR, et al (2004). mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol, 24, 200-16.
    • (2004) Mol Cell Biol , vol.24 , pp. 200-216
    • Fingar, D.C.1    Richardson, C.J.2    Tee, A.R.3
  • 33
    • 84893249799 scopus 로고    scopus 로고
    • PI3K and cancer: lessons, challenges and opportunities
    • Fruman DA, Rommel C (2014). PI3K and cancer: lessons, challenges and opportunities. Nat Rev Drug Discov, 13, 140-56.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 140-156
    • Fruman, D.A.1    Rommel, C.2
  • 34
    • 42049089700 scopus 로고    scopus 로고
    • To die or not to die: that is the autophagic question
    • Galluzzi L, Vicencio JM, Kepp O, et al (2008). To die or not to die: that is the autophagic question. Curr Mol Med, 8, 78-91.
    • (2008) Curr Mol Med , vol.8 , pp. 78-91
    • Galluzzi, L.1    Vicencio, J.M.2    Kepp, O.3
  • 35
    • 66449083078 scopus 로고    scopus 로고
    • ULK1. ATG13. FIP200 complex mediates mTOR signalling and is essential for autophagy
    • Ganley IG, Lam du H, Wang J, et al (2009). ULK1.ATG13. FIP200 complex mediates mTOR signalling and is essential for autophagy. J Biol Chem, 284, 12297-305.
    • (2009) J Biol Chem , vol.284 , pp. 12297-12305
    • Ganley, I.G.1    Lam du, H.2    Wang, J.3
  • 36
    • 77955430762 scopus 로고    scopus 로고
    • Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment
    • Garcia-Echeverria C (2010). Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment. Bioorg Med Chem Lett, 20, 4308-12.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 4308-4312
    • Garcia-Echeverria, C.1
  • 37
    • 29644444307 scopus 로고    scopus 로고
    • 3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer
    • Garikapaty VP, Ashok BT, Tadi K, et al (2006). 3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer. Biochem Biophys Res Commun, 340, 718-25.
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 718-725
    • Garikapaty, V.P.1    Ashok, B.T.2    Tadi, K.3
  • 38
    • 1642535431 scopus 로고    scopus 로고
    • AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression
    • Gera JF, Mellinghoff IK, Shi Y, et al (2004). AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression. J Biol Chem, 279, 2737-46.
    • (2004) J Biol Chem , vol.279 , pp. 2737-2746
    • Gera, J.F.1    Mellinghoff, I.K.2    Shi, Y.3
  • 39
    • 77649268890 scopus 로고    scopus 로고
    • Inhibitors of the PI3K/Akt/mTOR pathway: new hope for breast cancer patients
    • Ghayad SE, Cohen PA (2010). Inhibitors of the PI3K/Akt/mTOR pathway: new hope for breast cancer patients. Recent Pat Anticancer Drug Discov, 5, 29-57.
    • (2010) Recent Pat Anticancer Drug Discov , vol.5 , pp. 29-57
    • Ghayad, S.E.1    Cohen, P.A.2
  • 40
    • 84859999866 scopus 로고    scopus 로고
    • mTOR signalling pathway and mTOR inhibitors in cancer therapy
    • Gomez-Pinillos A, Ferrari AC (2012). mTOR signalling pathway and mTOR inhibitors in cancer therapy. Hematol Oncol Clin North Am, 26, 483-505.
    • (2012) Hematol Oncol Clin North Am , vol.26 , pp. 483-505
    • Gomez-Pinillos, A.1    Ferrari, A.C.2
  • 41
    • 33544469820 scopus 로고    scopus 로고
    • Growth control through the mTOR network
    • In 'Cell Growth: Control of Cell Size' (Hall MN et al., eds), Cold Spring Harbor Laboratory Press
    • Guertin DA, Kim D-H, Sabatini DM (2004). Growth control through the mTOR network. In 'Cell Growth: Control of Cell Size' (Hall MN et al., eds), Cold Spring Harbor Laboratory Press, pp. 193-234.
    • (2004) , pp. 193-234
    • Guertin, D.A.1    Kim, D.-H.2    Sabatini, D.M.3
  • 42
    • 68149096799 scopus 로고    scopus 로고
    • The pharmacology of mTOR inhibition
    • Guertin DA, Sabatini DM (2009). The pharmacology of mTOR inhibition. Sci Signal, 2, 24.
    • (2009) Sci Signal , vol.2 , pp. 24
    • Guertin, D.A.1    Sabatini, D.M.2
  • 44
    • 84885456615 scopus 로고    scopus 로고
    • LKB1/AMPK/mTOR signalling pathway in non-small-cell lung cancer
    • Han D, Li SJ, Zhu YT, et al (2013). LKB1/AMPK/mTOR signalling pathway in non-small-cell lung cancer. Asian Pac J Cancer Prev, 14, 4033-9.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 4033-4039
    • Han, D.1    Li, S.J.2    Zhu, Y.T.3
  • 45
    • 0033592983 scopus 로고    scopus 로고
    • Rapamycin-modulated transcription defines the subset of nutrient-sensitive signalling pathways directly controlled by the Tor proteins
    • Hardwick JS, Kuruvilla FG, Tong JK, et al (1999). Rapamycin-modulated transcription defines the subset of nutrient-sensitive signalling pathways directly controlled by the Tor proteins. Proc Natl Acad Sci USA, 96, 14866-70.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14866-14870
    • Hardwick, J.S.1    Kuruvilla, F.G.2    Tong, J.K.3
  • 47
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N (2004). Upstream and downstream of mTOR. Genes Dev, 18, 1926-45.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 48
    • 78651428992 scopus 로고    scopus 로고
    • Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signalling
    • He X, Wang Y, Zhu J, et al (2010). Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signalling. Cancer Lett, 28, 168-76
    • (2010) Cancer Lett , vol.28 , pp. 168-176
    • He, X.1    Wang, Y.2    Zhu, J.3
  • 49
    • 84887072931 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton
    • He Y, Li D, Cook SL, et al (2013). Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton. Mol Biol Cell, 24, 3369-80.
    • (2013) Mol Biol Cell , vol.24 , pp. 3369-3380
    • He, Y.1    Li, D.2    Cook, S.L.3
  • 50
    • 77957372039 scopus 로고    scopus 로고
    • A Phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer
    • Heath EI, Heilbrun LK, Li J, et al (2010). A Phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am J Transl Res, 2, 402-11.
    • (2010) Am J Transl Res , vol.2 , pp. 402-411
    • Heath, E.I.1    Heilbrun, L.K.2    Li, J.3
  • 51
    • 0034722888 scopus 로고    scopus 로고
    • The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
    • Hidalgo M, Rowinsky EK (2000). The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene, 19, 6680-6.
    • (2000) Oncogene , vol.19 , pp. 6680-6686
    • Hidalgo, M.1    Rowinsky, E.K.2
  • 52
    • 70349644856 scopus 로고    scopus 로고
    • Atg101, a novel mammalian autophagy protein interacting with Atg13
    • Hosokawa N, Sasaki T, Iemura S, et al (2009). Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy, 5, 973-9.
    • (2009) Autophagy , vol.5 , pp. 973-979
    • Hosokawa, N.1    Sasaki, T.2    Iemura, S.3
  • 53
    • 84906840090 scopus 로고    scopus 로고
    • mTOR and Cancer Therapy: General Principles
    • (V. A. Polunovsky and P. J. Houghton, Ed.^ Eds.), Humana Press, Springer New York Dordrecht Heidelberg London
    • Houghton PJ (2010). mTOR and Cancer Therapy: General Principles (V. A. Polunovsky and P. J. Houghton, Ed.^ Eds.), pp. 113-31. Humana Press, Springer New York Dordrecht Heidelberg London.
    • (2010) , pp. 113-131
    • Houghton, P.J.1
  • 54
    • 80052572943 scopus 로고    scopus 로고
    • Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases-- safety, pharmacokinetics, and pharmacodynamics
    • Howells LM, Berry DP, Elliott PJ, et al (2011). Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases-- safety, pharmacokinetics, and pharmacodynamics. Cancer Prev Res, 4, 1419-25.
    • (2011) Cancer Prev Res , vol.4 , pp. 1419-1425
    • Howells, L.M.1    Berry, D.P.2    Elliott, P.J.3
  • 55
    • 71949123654 scopus 로고    scopus 로고
    • Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin
    • Hsieh TC, Wu JM (2009). Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin. Anticancer Res, 29, 4025-32.
    • (2009) Anticancer Res , vol.29 , pp. 4025-4032
    • Hsieh, T.C.1    Wu, J.M.2
  • 56
    • 70349649506 scopus 로고    scopus 로고
    • EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells
    • Huang CH, Tsai SJ, Wang YJ, et al (2009). EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells. Mol Nutr Food Res, 53, 1156-65.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 1156-1165
    • Huang, C.H.1    Tsai, S.J.2    Wang, Y.J.3
  • 57
    • 0041802820 scopus 로고    scopus 로고
    • Targeting mTOR signalling for cancer therapy
    • Huang S, Houghton PJ (2003). Targeting mTOR signalling for cancer therapy. Curr Opin Pharmacol, 3, 371-7.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 371-377
    • Huang, S.1    Houghton, P.J.2
  • 58
    • 70449652525 scopus 로고    scopus 로고
    • Soy food consumption and risk of prostate cancer: a meta-analysis of observational studies
    • Hwang YW, Kim SY, Jee SH, et al (2009). Soy food consumption and risk of prostate cancer: a meta-analysis of observational studies. Nutr Cancer, 61, 598-606.
    • (2009) Nutr Cancer , vol.61 , pp. 598-606
    • Hwang, Y.W.1    Kim, S.Y.2    Jee, S.H.3
  • 59
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, et al (2002). TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol, 4, 648-57.
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3
  • 60
    • 84874471422 scopus 로고    scopus 로고
    • Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability
    • Irving GR, Howells LM, Sale S, et al (2013). Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability. Cancer Prev Res (Phila), 6, 119-28.
    • (2013) Cancer Prev Res (Phila) , vol.6 , pp. 119-128
    • Irving, G.R.1    Howells, L.M.2    Sale, S.3
  • 61
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • Jacinto E, Loewith R, Schmidt A, et al (2004). Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol, 6, 1122-8.
    • (2004) Nat Cell Biol , vol.6 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3
  • 62
    • 70349098422 scopus 로고    scopus 로고
    • Resveratrol downregulates PI3K/Akt/mTOR signalling pathways in human U251 glioma cells
    • Jiang H, Shang X, Wu H, et al (2009). Resveratrol downregulates PI3K/Akt/mTOR signalling pathways in human U251 glioma cells. J Exp Ther Oncol, 8, 25-33.
    • (2009) J Exp Ther Oncol , vol.8 , pp. 25-33
    • Jiang, H.1    Shang, X.2    Wu, H.3
  • 63
    • 68549083507 scopus 로고    scopus 로고
    • Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/ mTOR signalling
    • Johnson SM, Gulhati P, Arrieta I, et al (2009). Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/ mTOR signalling. Anticancer Res, 29, 3185-90.
    • (2009) Anticancer Res , vol.29 , pp. 3185-3190
    • Johnson, S.M.1    Gulhati, P.2    Arrieta, I.3
  • 64
    • 65249176304 scopus 로고    scopus 로고
    • ULK-Atg13-FIP200 complexes mediate mTOR signalling to the autophagy machinery
    • Jung CH, Jun CB, Ro SH, et al (2009). ULK-Atg13-FIP200 complexes mediate mTOR signalling to the autophagy machinery. Mol Biol Cell, 20, 1992-2003.
    • (2009) Mol Biol Cell , vol.20 , pp. 1992-2003
    • Jung, C.H.1    Jun, C.B.2    Ro, S.H.3
  • 65
    • 0038050536 scopus 로고    scopus 로고
    • Amino acids as regulators of proteolysis
    • Kadowaki M, Kanazawa T (2003). Amino acids as regulators of proteolysis. J Nutr, 133, 2052-6.
    • (2003) J Nutr , vol.133 , pp. 2052-2056
    • Kadowaki, M.1    Kanazawa, T.2
  • 66
    • 84878654571 scopus 로고    scopus 로고
    • A Phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients
    • Kanai M, Otsuka Y, Otsuka K, et al (2013). A Phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients. Cancer Chemother Pharmacol, 71, 1521-30.
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 1521-1530
    • Kanai, M.1    Otsuka, Y.2    Otsuka, K.3
  • 67
    • 79959612772 scopus 로고    scopus 로고
    • A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer
    • Kanai M, Yoshimura K, Asada M, et al (2011). A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer Chemother Pharmacol, 68, 157-64.
    • (2011) Cancer Chemother Pharmacol , vol.68 , pp. 157-164
    • Kanai, M.1    Yoshimura, K.2    Asada, M.3
  • 68
    • 79955412969 scopus 로고    scopus 로고
    • Cytotoxic and antineoplastic activity of timosaponin a-iii for human colon cancer cells
    • Kang Y-J, Chung H-J, Nam J-W, et al (2011). Cytotoxic and antineoplastic activity of timosaponin a-iii for human colon cancer cells. J Nat Prod, 74, 701-6.
    • (2011) J Nat Prod , vol.74 , pp. 701-706
    • Kang, Y.-J.1    Chung, H.-J.2    Nam, J.-W.3
  • 69
    • 34247136212 scopus 로고    scopus 로고
    • Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair
    • Katiyar S, Elmets CA, Katiyar SK (2007). Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair. J Nutr Biochem, 18, 287-96.
    • (2007) J Nutr Biochem , vol.18 , pp. 287-296
    • Katiyar, S.1    Elmets, C.A.2    Katiyar, S.K.3
  • 70
    • 34248215034 scopus 로고    scopus 로고
    • Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice
    • Khan N, Afaq F, Kweon MH, et al (2007a). Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res, 67, 3475-82.
    • (2007) Cancer Res , vol.67 , pp. 3475-3482
    • Khan, N.1    Afaq, F.2    Kweon, M.H.3
  • 71
    • 33845612815 scopus 로고    scopus 로고
    • Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice
    • Khan N, Hadi N, Afaq F, et al (2007b). Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinogenesis, 28, 163-73.
    • (2007) Carcinogenesis , vol.28 , pp. 163-173
    • Khan, N.1    Hadi, N.2    Afaq, F.3
  • 72
    • 0037178786 scopus 로고    scopus 로고
    • mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim DH, Sarbassov DD, Ali SM, et al (2002a). mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell, 110, 163-75.
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3
  • 73
    • 0036201937 scopus 로고    scopus 로고
    • Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer
    • Kim ND, Mehta R, Yu W, et al (2002b). Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat, 71, 203-17.
    • (2002) Breast Cancer Res Treat , vol.71 , pp. 203-217
    • Kim, N.D.1    Mehta, R.2    Yu, W.3
  • 74
    • 69149098095 scopus 로고    scopus 로고
    • Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells
    • Kim SH, Kim YB, Jeon YT, et al (2009). Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells. Ann NY Acad Sci, 1171, 495-500.
    • (2009) Ann NY Acad Sci , vol.1171 , pp. 495-500
    • Kim, S.H.1    Kim, Y.B.2    Jeon, Y.T.3
  • 75
    • 70349645385 scopus 로고    scopus 로고
    • Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress
    • King FW, Fong S, Griffin C, et al (2009). Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. PloS one, 4, 7283.
    • (2009) PloS one , vol.4 , pp. 7283
    • King, F.W.1    Fong, S.2    Griffin, C.3
  • 76
    • 0037623419 scopus 로고    scopus 로고
    • Molecular actions of sirolimus: sirolimus and mTor
    • Kirken RA, Wang YL (2003). Molecular actions of sirolimus: sirolimus and mTor. Transplant Proc, 35, 227-30.
    • (2003) Transplant Proc , vol.35 , pp. 227-230
    • Kirken, R.A.1    Wang, Y.L.2
  • 77
    • 40949131914 scopus 로고    scopus 로고
    • Mammalian target of rapamycin repression by 3,3'-Diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor- D-overexpressing PC3 cells
    • Kong D, Banerjee S, Huang W, et al (2008). Mammalian target of rapamycin repression by 3,3'-Diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor- D-overexpressing PC3 cells. Cancer Res, 68, 1927-34.
    • (2008) Cancer Res , vol.68 , pp. 1927-1934
    • Kong, D.1    Banerjee, S.2    Huang, W.3
  • 79
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signalling in growth control and disease
    • Laplante M, Sabatini DM (2012). mTOR signalling in growth control and disease. Cell, 149, 274-93.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 80
    • 84877965001 scopus 로고    scopus 로고
    • Regulation of mTORC1 and its impact on gene expression at a glance
    • Laplante M, Sabatini DM (2013). Regulation of mTORC1 and its impact on gene expression at a glance. J Cell Sci, 126, 1713-9.
    • (2013) J Cell Sci , vol.126 , pp. 1713-1719
    • Laplante, M.1    Sabatini, D.M.2
  • 81
    • 24644445998 scopus 로고    scopus 로고
    • Rapamycin: an anti-cancer immunosuppressant?
    • Law BK (2005). Rapamycin: an anti-cancer immunosuppressant? Crit Rev Oncol Hematol, 56, 47-60.
    • (2005) Crit Rev Oncol Hematol , vol.56 , pp. 47-60
    • Law, B.K.1
  • 82
    • 0038418500 scopus 로고    scopus 로고
    • Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells
    • Le HT, Schaldach CM, Firestone GL, et al (2003). Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem, 278, 21136-45.
    • (2003) J Biol Chem , vol.278 , pp. 21136-21145
    • Le, H.T.1    Schaldach, C.M.2    Firestone, G.L.3
  • 83
    • 84890487089 scopus 로고    scopus 로고
    • Roles of mTOR and p-mTOR in gastrointestinal stromal tumors
    • Li JC, Zhu HY, Chen TX, et al (2013). Roles of mTOR and p-mTOR in gastrointestinal stromal tumors. Asian Pac J Cancer Prev, 14, 5925-8.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 5925-5928
    • Li, J.C.1    Zhu, H.Y.2    Chen, T.X.3
  • 84
    • 33947270928 scopus 로고    scopus 로고
    • Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway
    • Li M, Zhang Z, Hill DL, et al (2007). Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Res, 67, 1988-96.
    • (2007) Cancer Res , vol.67 , pp. 1988-1996
    • Li, M.1    Zhang, Z.2    Hill, D.L.3
  • 85
    • 0035992417 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signalling pathway
    • Li Y, Sarkar FH (2002). Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signalling pathway. Clin Cancer Res, 8, 2369-77.
    • (2002) Clin Cancer Res , vol.8 , pp. 2369-2377
    • Li, Y.1    Sarkar, F.H.2
  • 86
    • 34547135737 scopus 로고    scopus 로고
    • Regulation of FOXO3a/beta-catenin/GSK-3beta signalling by 3,3'-Diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells
    • Li Y, Wang Z, Kong D, et al (2007). Regulation of FOXO3a/beta-catenin/GSK-3beta signalling by 3,3'-Diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. J Biol Chem, 282, 21542-50.
    • (2007) J Biol Chem , vol.282 , pp. 21542-21550
    • Li, Y.1    Wang, Z.2    Kong, D.3
  • 87
    • 76449110705 scopus 로고    scopus 로고
    • Resveratrol modulates tumor cell proliferation and protein translation via SIRT1- dependent AMPK activation
    • Lin JN, Lin VC, Rau KM, et al (2010). Resveratrol modulates tumor cell proliferation and protein translation via SIRT1- dependent AMPK activation. J Agric Food Chem, 58, 1584-92.
    • (2010) J Agric Food Chem , vol.58 , pp. 1584-1592
    • Lin, J.N.1    Lin, V.C.2    Rau, K.M.3
  • 89
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu P, Cheng H, Roberts TM, et al (2009a). Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov, 8, 627-44.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3
  • 91
    • 0036753494 scopus 로고    scopus 로고
    • Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    • Loewith R, Jacinto E, Wullschleger S, et al (2002). Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell, 10, 457-68.
    • (2002) Mol Cell , vol.10 , pp. 457-468
    • Loewith, R.1    Jacinto, E.2    Wullschleger, S.3
  • 92
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations
    • LoPiccolo J, Blumenthal GM, Bernstein WB, et al (2008). Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat, 11, 32-50.
    • (2008) Drug Resist Updat , vol.11 , pp. 32-50
    • LoPiccolo, J.1    Blumenthal, G.M.2    Bernstein, W.B.3
  • 93
    • 26844566479 scopus 로고    scopus 로고
    • Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer
    • Malik A, Afaq F, Sarfaraz S, et al (2005). Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci USA, 102, 14813-8.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14813-14818
    • Malik, A.1    Afaq, F.2    Sarfaraz, S.3
  • 94
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signalling: navigating downstream
    • Manning BD, Cantley LC (2007). AKT/PKB signalling: navigating downstream. Cell, 129, 1261-74.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 95
    • 70349265983 scopus 로고    scopus 로고
    • Resveratrol: cellular actions of a potent natural chemical that confers a diversity of health benefits
    • Marques FZ, Markus MA, Morris BJ (2009). Resveratrol: cellular actions of a potent natural chemical that confers a diversity of health benefits. Int J Biochem Cell Biol, 41, 2125-8.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 2125-2128
    • Marques, F.Z.1    Markus, M.A.2    Morris, B.J.3
  • 96
    • 84864830787 scopus 로고    scopus 로고
    • A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients
    • Messing E, Gee JR, Saltzstein DR, et al (2012). A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients. Cancer Prev Res, 5, 621-30.
    • (2012) Cancer Prev Res , vol.5 , pp. 621-630
    • Messing, E.1    Gee, J.R.2    Saltzstein, D.R.3
  • 97
    • 1542751639 scopus 로고    scopus 로고
    • The molecular target of rapamycin (mTOR) as a therapeutic target against cancer
    • Mita MM, Mita A, Rowinsky EK (2003). The molecular target of rapamycin (mTOR) as a therapeutic target against cancer. Cancer Biol Ther, 2, 169-77.
    • (2003) Cancer Biol Ther , vol.2 , pp. 169-177
    • Mita, M.M.1    Mita, A.2    Rowinsky, E.K.3
  • 98
    • 0035850836 scopus 로고    scopus 로고
    • A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells
    • Moalic S, Liagre B, Corbiere C, et al (2001). A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. FEBS Lett, 506, 225-30.
    • (2001) FEBS Lett , vol.506 , pp. 225-230
    • Moalic, S.1    Liagre, B.2    Corbiere, C.3
  • 99
    • 84904975147 scopus 로고    scopus 로고
    • Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations
    • [Epub ahead of print]
    • Moschetta M, Reale A, Marasco C, et al (2014). Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations. Br J Pharmacol, [Epub ahead of print]
    • (2014) Br J Pharmacol
    • Moschetta, M.1    Reale, A.2    Marasco, C.3
  • 100
    • 33747877987 scopus 로고    scopus 로고
    • Epigallocatechin-3- gallate (EGCG): chemical and biomedical perspectives
    • Nagle DG, Ferreira D, Zhou YD (2006). Epigallocatechin-3- gallate (EGCG): chemical and biomedical perspectives. Phytochemistry, 67, 1849-55.
    • (2006) Phytochemistry , vol.67 , pp. 1849-1855
    • Nagle, D.G.1    Ferreira, D.2    Zhou, Y.D.3
  • 101
    • 71049121968 scopus 로고    scopus 로고
    • A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy
    • Nakamura Y, Yogosawa S, Izutani Y, et al (2009). A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Mol Cancer, 8, 100.
    • (2009) Mol Cancer , vol.8 , pp. 100
    • Nakamura, Y.1    Yogosawa, S.2    Izutani, Y.3
  • 102
    • 0033429554 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
    • Nave BT, Ouwens M, Withers DJ, et al (1999). Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J, 344, 427-31.
    • (1999) Biochem J , vol.344 , pp. 427-431
    • Nave, B.T.1    Ouwens, M.2    Withers, D.J.3
  • 103
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/ Akt signalling pathway in human malignancy
    • Nicholson KM, Anderson NG (2002). The protein kinase B/ Akt signalling pathway in human malignancy. Cell Signal 14, 381-95.
    • (2002) Cell Signal , vol.14 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 104
    • 1042267229 scopus 로고    scopus 로고
    • Determinants of rapamycin sensitivity in breast cancer cells
    • Noh WC, Mondesire WH, Peng J, et al (2004). Determinants of rapamycin sensitivity in breast cancer cells. Clin Cancer Res, 10, 1013-23.
    • (2004) Clin Cancer Res , vol.10 , pp. 1013-1023
    • Noh, W.C.1    Mondesire, W.H.2    Peng, J.3
  • 105
    • 32944457518 scopus 로고    scopus 로고
    • mTOR inhibition induces upstream receptor tyrosine kinase signalling and activates Akt
    • O'Reilly KE, Rojo F, She QB, et al (2006). mTOR inhibition induces upstream receptor tyrosine kinase signalling and activates Akt. Cancer Res, 66, 1500-8.
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.B.3
  • 106
    • 84870853860 scopus 로고    scopus 로고
    • PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes
    • Pal I, Mandal M (2012). PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes. Acta Pharmacol Sin, 33, 1441-58.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 1441-1458
    • Pal, I.1    Mandal, M.2
  • 107
    • 84873714541 scopus 로고    scopus 로고
    • A randomized Phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer
    • Paller CJ, Ye X, Wozniak PJ, et al (2013). A randomized Phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis, 16, 50-5.
    • (2013) Prostate Cancer Prostatic Dis , vol.16 , pp. 50-55
    • Paller, C.J.1    Ye, X.2    Wozniak, P.J.3
  • 108
    • 84880255103 scopus 로고    scopus 로고
    • Potential targets for prevention of colorectal cancer: a focus on PI3K/Akt/mTOR and Wnt pathways
    • Pandurangan AK (2013). Potential targets for prevention of colorectal cancer: a focus on PI3K/Akt/mTOR and Wnt pathways. Asian Pac J Cancer Prev, 14, 2201-5.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 2201-2205
    • Pandurangan, A.K.1
  • 109
    • 33746073732 scopus 로고    scopus 로고
    • Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer
    • Pantuck AJ, Leppert JT, Zomorodian N, et al (2006). Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res, 12, 4018-26.
    • (2006) Clin Cancer Res , vol.12 , pp. 4018-4026
    • Pantuck, A.J.1    Leppert, J.T.2    Zomorodian, N.3
  • 110
    • 0242695672 scopus 로고    scopus 로고
    • Resveratrol: from grapevines to mammalian biology
    • Pervaiz S (2003). Resveratrol: from grapevines to mammalian biology. FASEB J, 17, 1975-85.
    • (2003) FASEB J , vol.17 , pp. 1975-1985
    • Pervaiz, S.1
  • 111
    • 67349241955 scopus 로고    scopus 로고
    • DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
    • Peterson TR, Laplante M, Thoreen CC, et al (2009). DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell, 137, 873-86.
    • (2009) Cell , vol.137 , pp. 873-886
    • Peterson, T.R.1    Laplante, M.2    Thoreen, C.C.3
  • 112
    • 70349397276 scopus 로고    scopus 로고
    • Induction of apoptosis in human bladder cancer cells by green tea catechins
    • Philips BJ, Coyle CH, Morrisroe SN, et al (2009). Induction of apoptosis in human bladder cancer cells by green tea catechins. Biomed Res, 30, 207-15.
    • (2009) Biomed Res , vol.30 , pp. 207-215
    • Philips, B.J.1    Coyle, C.H.2    Morrisroe, S.N.3
  • 113
    • 27844526600 scopus 로고    scopus 로고
    • Akt-dependent transformation: there is more to growth than just surviving
    • Plas DR, Thompson CB (2005). Akt-dependent transformation: there is more to growth than just surviving. Oncogene, 24, 7435-42.
    • (2005) Oncogene , vol.24 , pp. 7435-7442
    • Plas, D.R.1    Thompson, C.B.2
  • 114
    • 84873996774 scopus 로고    scopus 로고
    • A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma
    • Popat R, Plesner T, Davies F, et al (2013). A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma. Br J Haematol 160, 714-7.
    • (2013) Br J Haematol , vol.160 , pp. 714-717
    • Popat, R.1    Plesner, T.2    Davies, F.3
  • 115
    • 84901008792 scopus 로고    scopus 로고
    • Targeting PI3K/Akt/mTOR signalling in cancer
    • Porta C, Paglino C, Mosca A (2014). Targeting PI3K/Akt/mTOR signalling in cancer. Fron Oncol, 4, 64.
    • (2014) Fron Oncol , vol.4 , pp. 64
    • Porta, C.1    Paglino, C.2    Mosca, A.3
  • 116
    • 0032915417 scopus 로고    scopus 로고
    • Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signalling pathway in Saccharomyces cerevisiae
    • Powers T, Walter P (1999). Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signalling pathway in Saccharomyces cerevisiae. Mol Biol Cell, 10, 987-1000.
    • (1999) Mol Biol Cell , vol.10 , pp. 987-1000
    • Powers, T.1    Walter, P.2
  • 117
    • 0036440779 scopus 로고    scopus 로고
    • Regulation of mammalian translation factors by nutrients
    • Proud CG (2002). Regulation of mammalian translation factors by nutrients. Eur J Biochem, 269, 5338-49.
    • (2002) Eur J Biochem , vol.269 , pp. 5338-5349
    • Proud, C.G.1
  • 118
    • 35448967382 scopus 로고    scopus 로고
    • The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
    • Pyrko P, Schonthal AH, Hofman FM, et al (2007). The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res, 67, 9809-16.
    • (2007) Cancer Res , vol.67 , pp. 9809-9816
    • Pyrko, P.1    Schonthal, A.H.2    Hofman, F.M.3
  • 119
    • 70349558215 scopus 로고    scopus 로고
    • Cell growth inhibition and gene expression regulation by (-)-epigallocatechin-3-gallate in human cervical cancer cells
    • Qiao Y, Cao J, Xie L, et al (2009). Cell growth inhibition and gene expression regulation by (-)-epigallocatechin-3-gallate in human cervical cancer cells. Arch Pharm Res, 32, 1309-15.
    • (2009) Arch Pharm Res , vol.32 , pp. 1309-1315
    • Qiao, Y.1    Cao, J.2    Xie, L.3
  • 120
    • 12144255588 scopus 로고    scopus 로고
    • Anticancer therapeutic potential of soy isoflavone, genistein
    • Ravindranath MH, Muthugounder S, Presser N, et al (2004). Anticancer therapeutic potential of soy isoflavone, genistein. Adv Exp Med Biol, 546, 121-65.
    • (2004) Adv Exp Med Biol , vol.546 , pp. 121-165
    • Ravindranath, M.H.1    Muthugounder, S.2    Presser, N.3
  • 121
    • 84874650275 scopus 로고    scopus 로고
    • Development of PI3K inhibitors: lessons learned from early clinical trials
    • Rodon J, Dienstmann R, Serra V, et al (2013). Development of PI3K inhibitors: lessons learned from early clinical trials. Nat Rev Clin Oncol, 10, 143-53.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 143-153
    • Rodon, J.1    Dienstmann, R.2    Serra, V.3
  • 122
    • 84880532170 scopus 로고    scopus 로고
    • Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients
    • Ryan JL, Heckler CE, Ling M, et al (2013). Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res, 180, 34-43.
    • (2013) Radiat Res , vol.180 , pp. 34-43
    • Ryan, J.L.1    Heckler, C.E.2    Ling, M.3
  • 123
    • 0028239893 scopus 로고
    • RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    • Sabatini DM, Erdjument-Bromage H, Lui M, et al (1994). RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell, 78, 35-43.
    • (1994) Cell , vol.78 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3
  • 124
    • 0028950217 scopus 로고
    • Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
    • Sabers CJ, Martin MM, Brunn GJ, et al (1995). Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem, 270, 815-22.
    • (1995) J Biol Chem , vol.270 , pp. 815-822
    • Sabers, C.J.1    Martin, M.M.2    Brunn, G.J.3
  • 125
    • 77955841346 scopus 로고    scopus 로고
    • Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells
    • Sakamoto T, Horiguchi H, Oguma E, et al (2010). Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells. J Nutr Biochem, 21, 856-64.
    • (2010) J Nutr Biochem , vol.21 , pp. 856-864
    • Sakamoto, T.1    Horiguchi, H.2    Oguma, E.3
  • 126
    • 33947264077 scopus 로고    scopus 로고
    • PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
    • Sancak Y, Thoreen CC, Peterson TR, et al (2007). PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol. Cell, 25, 903-15.
    • (2007) Mol. Cell , vol.25 , pp. 903-915
    • Sancak, Y.1    Thoreen, C.C.2    Peterson, T.R.3
  • 127
    • 4344602002 scopus 로고    scopus 로고
    • The biology and clinical relevance of the PTEN tumor suppressor pathway
    • Sansal I, Sellers WR (2004). The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol, 22, 2954-63.
    • (2004) J Clin Oncol , vol.22 , pp. 2954-2963
    • Sansal, I.1    Sellers, W.R.2
  • 128
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov DD, Ali SM, Kim DH, et al (2004). Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol, 14, 1296-302.
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3
  • 129
    • 33646023695 scopus 로고    scopus 로고
    • Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/ PKB
    • Sarbassov DD, Ali SM, Sengupta S, et al (2006). Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/ PKB. Mol Cell, 22, 159-68.
    • (2006) Mol Cell , vol.22 , pp. 159-168
    • Sarbassov, D.D.1    Ali, S.M.2    Sengupta, S.3
  • 130
    • 0016713286 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
    • Sehgal SN, Baker H, Vezina C (1975). Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot (Tokyo), 28, 727-32.
    • (1975) J Antibiot (Tokyo) , vol.28 , pp. 727-732
    • Sehgal, S.N.1    Baker, H.2    Vezina, C.3
  • 131
    • 84899728380 scopus 로고    scopus 로고
    • Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235- induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability
    • Seo BR, Min KJ, Cho IJ, et al (2014). Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235- induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability. PloS one, 9, 95588.
    • (2014) PloS one , vol.9 , pp. 95588
    • Seo, B.R.1    Min, K.J.2    Cho, I.J.3
  • 132
    • 0034772953 scopus 로고    scopus 로고
    • Pharmacodynamic and pharmacokinetic study of oral curcuma extract in patients with colorectal cancer
    • Sharma RA, McLelland HR, Hill KA, et al (2001). Pharmacodynamic and pharmacokinetic study of oral curcuma extract in patients with colorectal cancer. Clin Cancer Res, 7, 1894-900.
    • (2001) Clin Cancer Res , vol.7 , pp. 1894-1900
    • Sharma, R.A.1    McLelland, H.R.2    Hill, K.A.3
  • 133
    • 79957532005 scopus 로고    scopus 로고
    • Aging and cancer: can mTOR inhibitors kill two birds with one drug?
    • Sharp Z, Richardson A (2011). Aging and cancer: can mTOR inhibitors kill two birds with one drug? Target Oncol, 6, 41-51.
    • (2011) Target Oncol , vol.6 , pp. 41-51
    • Sharp, Z.1    Richardson, A.2
  • 134
    • 84894523716 scopus 로고    scopus 로고
    • Making new contacts: the mTOR network in metabolism and signalling crosstalk
    • Shimobayashi M, Hall MN (2014). Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat Rev Mol Cell Biol, 15, 155-62.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 155-162
    • Shimobayashi, M.1    Hall, M.N.2
  • 136
    • 74849131091 scopus 로고    scopus 로고
    • Targeting mTOR globally in cancer: thinking beyond rapamycin
    • Shor B, Gibbons JJ, Abraham RT, et al (2009). Targeting mTOR globally in cancer: thinking beyond rapamycin. Cell Cycle 8, 3831-7.
    • (2009) Cell Cycle , vol.8 , pp. 3831-3837
    • Shor, B.1    Gibbons, J.J.2    Abraham, R.T.3
  • 137
    • 77950900079 scopus 로고    scopus 로고
    • mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action
    • Soliman GA, Acosta-Jaquez HA, Dunlop EA, et al (2010). mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J Biol Chem, 285, 7866-79.
    • (2010) J Biol Chem , vol.285 , pp. 7866-7879
    • Soliman, G.A.1    Acosta-Jaquez, H.A.2    Dunlop, E.A.3
  • 138
    • 67650067290 scopus 로고    scopus 로고
    • Diosgenin targets Akt-mediated prosurvival signalling in human breast cancer cells
    • Srinivasan S, Koduru S, Kumar R, et al (2009). Diosgenin targets Akt-mediated prosurvival signalling in human breast cancer cells. Int J Cancer, 125, 961-7.
    • (2009) Int J Cancer , vol.125 , pp. 961-967
    • Srinivasan, S.1    Koduru, S.2    Kumar, R.3
  • 139
    • 0037021625 scopus 로고    scopus 로고
    • Antioxidant and antiproliferative activities of common fruits
    • Sun J, Chu Y-F, Wu X, et al (2002). Antioxidant and antiproliferative activities of common fruits. J Agric Food Chem, 50, 7449-54.
    • (2002) J Agric Food Chem , vol.50 , pp. 7449-7454
    • Sun, J.1    Chu, Y.-F.2    Wu, X.3
  • 140
    • 23844438209 scopus 로고    scopus 로고
    • Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
    • Sun SY, Rosenberg LM, Wang X, et al (2005). Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res, 65, 7052-8.
    • (2005) Cancer Res , vol.65 , pp. 7052-7058
    • Sun, S.Y.1    Rosenberg, L.M.2    Wang, X.3
  • 141
    • 57749085555 scopus 로고    scopus 로고
    • Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells
    • Sy LK, Yan SC, Lok CN, et al (2008). Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells. Cancer Res, 68, 10229-37.
    • (2008) Cancer Res , vol.68 , pp. 10229-10237
    • Sy, L.K.1    Yan, S.C.2    Lok, C.N.3
  • 142
    • 43249131245 scopus 로고    scopus 로고
    • Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a Phase I tumor pharmacodynamic study in patients with advanced solid tumors
    • Tabernero J, Rojo F, Calvo E, et al (2008). Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a Phase I tumor pharmacodynamic study in patients with advanced solid tumors. J Clin Oncol 26, 1603-10.
    • (2008) J Clin Oncol , vol.26 , pp. 1603-1610
    • Tabernero, J.1    Rojo, F.2    Calvo, E.3
  • 143
    • 84898821195 scopus 로고    scopus 로고
    • Activation of the Akt/mammalian target of rapamycin pathway in myxofibrosarcomas
    • Takahashi Y, Kohashi K, Yamada Y, et al (2014). Activation of the Akt/mammalian target of rapamycin pathway in myxofibrosarcomas. Human pathol, 45, 984-93.
    • (2014) Human pathol , vol.45 , pp. 984-993
    • Takahashi, Y.1    Kohashi, K.2    Yamada, Y.3
  • 144
    • 84906091340 scopus 로고    scopus 로고
    • Targeting Drug-Resistant Prostate Cancer with Dual PI3K/MTOR Inhibition
    • [Epub ahead of print]
    • Tang KD, Ling MT (2014). Targeting Drug-Resistant Prostate Cancer with Dual PI3K/MTOR Inhibition. Curr Med Chem, [Epub ahead of print].
    • (2014) Curr Med Chem
    • Tang, K.D.1    Ling, M.T.2
  • 145
  • 146
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mTOR) for health and diseases
    • Tsang CK, Qi H, Liu LF, et al (2007). Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today, 12, 112-24.
    • (2007) Drug Discov Today , vol.12 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3
  • 147
    • 77957679078 scopus 로고    scopus 로고
    • Induction of autophagy by dual mTORC1-mTORC2 inhibition in BCR-ABL-expressing leukemic cells
    • Vakana E, Sassano A, Platanias LC (2010). Induction of autophagy by dual mTORC1-mTORC2 inhibition in BCR-ABL-expressing leukemic cells. Autophagy, 6, 966-7.
    • (2010) Autophagy , vol.6 , pp. 966-967
    • Vakana, E.1    Sassano, A.2    Platanias, L.C.3
  • 148
    • 0016724057 scopus 로고
    • Rapamycin (AY- 22 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
    • Vezina C, Kudelski A, Sehgal SN (1975). Rapamycin (AY- 22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot, 28, 721-6.
    • (1975) J Antibiot , vol.28 , pp. 721-726
    • Vezina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 149
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL (2002). The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer, 2, 489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 151
    • 33947538050 scopus 로고    scopus 로고
    • Rapamycin induces feedback activation of Akt signalling through an IGF-1R-dependent mechanism
    • Wan X, Harkavy B, Shen N, et al (2007). Rapamycin induces feedback activation of Akt signalling through an IGF-1R-dependent mechanism. Oncogene, 26, 1932-40.
    • (2007) Oncogene , vol.26 , pp. 1932-1940
    • Wan, X.1    Harkavy, B.2    Shen, N.3
  • 152
    • 84898871677 scopus 로고    scopus 로고
    • Targeting mTOR network in colorectal cancer therapy
    • Wang XW, Zhang YJ (2014). Targeting mTOR network in colorectal cancer therapy. World J Gastroenterol, 20, 4178-88.
    • (2014) World J Gastroenterol , vol.20 , pp. 4178-4188
    • Wang, X.W.1    Zhang, Y.J.2
  • 153
    • 84899489414 scopus 로고    scopus 로고
    • Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice
    • Wu Y, Kim J, Elshimali Y, et al (2014). Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice. BMC Cancer, 14, 266.
    • (2014) BMC Cancer , vol.14 , pp. 266
    • Wu, Y.1    Kim, J.2    Elshimali, Y.3
  • 154
    • 51449095342 scopus 로고    scopus 로고
    • Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises
    • Yap TA, Garrett MD, Walton MI, et al (2008). Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Curr Opin Pharmacol, 8, 393-412.
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 393-412
    • Yap, T.A.1    Garrett, M.D.2    Walton, M.I.3
  • 155
    • 0034790016 scopus 로고    scopus 로고
    • mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
    • Yu K, Toral-Barza L, Discafani C, et al (2001). mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer, 8, 249-58.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 249-258
    • Yu, K.1    Toral-Barza, L.2    Discafani, C.3
  • 156
    • 0032701952 scopus 로고    scopus 로고
    • Effect of six steroidal saponins isolated from anemarrhenae rhizoma on platelet aggregation and hemolysis in human blood
    • Zhang J, Meng Z, Zhang M, et al (1999). Effect of six steroidal saponins isolated from anemarrhenae rhizoma on platelet aggregation and hemolysis in human blood. Clin Chim Acta, 289, 79-88.
    • (1999) Clin Chim Acta , vol.289 , pp. 79-88
    • Zhang, J.1    Meng, Z.2    Zhang, M.3
  • 157
    • 33751100885 scopus 로고    scopus 로고
    • Green tea extract and (-)-epigallocatechin-3-gallate inhibit mast cell-stimulated type I collagen expression in keloid fibroblasts via blocking PI-3K/AkT signalling pathways
    • Zhang Q, Kelly AP, Wang L, et al (2006). Green tea extract and (-)-epigallocatechin-3-gallate inhibit mast cell-stimulated type I collagen expression in keloid fibroblasts via blocking PI-3K/AkT signalling pathways. J Invest Dermatol, 126, 2607-13.
    • (2006) J Invest Dermatol , vol.126 , pp. 2607-2613
    • Zhang, Q.1    Kelly, A.P.2    Wang, L.3
  • 158
    • 33750826279 scopus 로고    scopus 로고
    • The p110α isoform of PI3K is essential for proper growth factor signalling and oncogenic transformation
    • Zhao JJ, Cheng H, Jia S, et al (2006). The p110α isoform of PI3K is essential for proper growth factor signalling and oncogenic transformation. Proc Natl Acad Sci USA, 103, 16296-300.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16296-16300
    • Zhao, J.J.1    Cheng, H.2    Jia, S.3


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