Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation

FEBS Letters

Volumn 581, Issue 30, 2007, Pages 5735-5742

  Chiang, Chun Te ^a   Way, Tzong Der ^b   Tsai, Shang Jie ^b   Lin, Jen Kun ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Akt; Diosgenin; FAS; HER2; JNK; mTOR

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; DIOSGENIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FATTY ACID SYNTHASE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PACLITAXEL; PROTEIN KINASE B; RAPAMYCIN; SOLASODINE; STRESS ACTIVATED PROTEIN KINASE; TOMATIDINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL PROLIFERATION; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG MECHANISM; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME BLOOD LEVEL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DIOSGENIN; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; FATTY ACID SYNTHETASE COMPLEX; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PALMITIC ACID; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ERBB-2; SOLANACEOUS ALKALOIDS; TOMATINE; UP-REGULATION;

EID: 36849074161     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.11.021     Document Type: Article

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