Plant-derived 3,3′-diindolylmethane is a strong androgen antagonist in human prostate cancer cells

Journal of Biological Chemistry

Volumn 278, Issue 23, 2003, Pages 21136-21145

  Le, Hien T ^a   Schaldach, Charlene M ^b   Firestone, Gary L ^a   Bjeldanes, Leonard F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CONFORMATIONS; DNA; SYNTHESIS (CHEMICAL); TUMORS;

CANCER CELLS;

BIOCHEMISTRY;

3,3' DIINDOLYLMETHANE; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANTIANDROGEN; BICALUTAMIDE; COMPLEMENTARY DNA; CYPROTERONE ACETATE; MESSENGER RNA; PLANT EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; DNA SYNTHESIS; GENE EXPRESSION; HORMONE BINDING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIGAND BINDING; MALE; NORTHERN BLOTTING; PLASMID; PRIORITY JOURNAL; PROSTATE CANCER;

ADENOCARCINOMA; ANDROGEN ANTAGONISTS; ANILIDES; ANIMALS; ANTICARCINOGENIC AGENTS; BINDING, COMPETITIVE; CELL DIVISION; CELL NUCLEUS; CYTOPLASM; DIHYDROTESTOSTERONE; DNA; GENE EXPRESSION REGULATION, NEOPLASTIC; INDOLES; MALE; METRIBOLONE; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RNA, MESSENGER; SIGNAL TRANSDUCTION; TESTOSTERONE CONGENERS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; VEGETABLES;

EID: 0038418500     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300588200     Document Type: Article

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