Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis

Cancer Chemotherapy and Pharmacology

Volumn 55, Issue 1, 2005, Pages 79-90

  Liu, Ming Jie ^a   Wang, Zhao ^a   Ju, Yong ^a   Wong, Ricky Ngok Shun ^b   Wu, Qing Yu ^a  

^a TSINGHUA UNIVERSITY   (China)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

Apoptosis; Ca2+ homeostasis; Cell cycle arrest; Diosgenin; Mitochondrial hyperpolarization

Indexed keywords

CASPASE 3; CYCLIN B1; DIOSGENIN; DNA FRAGMENT; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL CYCLE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DEPOLARIZATION; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IMMUNOFLUORESCENCE; LEUKEMIA CELL LINE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; STAINING; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; CALCIUM; CELL CYCLE; DIOSGENIN; DNA DAMAGE; DOWN-REGULATION; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; LEUKEMIA, MYELOID, CHRONIC; MEMBRANE POTENTIALS; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 11244325805     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-004-0849-3     Document Type: Article

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