A phase i study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin®) in cancer patients

Cancer Chemotherapy and Pharmacology

Volumn 71, Issue 6, 2013, Pages 1521-1530

  Kanai, Masashi ^a   Otsuka, Yoshihiko ^b   Otsuka, Kazunori ^c   Sato, Maremi ^d   Nishimura, Takafumi ^a   Mori, Yukiko ^a   Kawaguchi, Michiya ^e   Hatano, Etsuro ^e   Kodama, Yuzo ^e   Matsumoto, Shigemi ^a   Murakami, Yoshiki ^f   Imaizumi, Atsushi ^b   Chiba, Tsutomu ^a,e   Nishihira, Jun ^d   Shibata, Hiroyuki ^c  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b Theravalues Corporation   (Japan)

^c AKITA UNIVERSITY   (Japan)

^d HOKKAIDO INFORMATION UNIVERSITY   (Japan)

^e KYOTO UNIVERSITY   (Japan)

^f OSAKA CITY UNIVERSITY HOSPITAL   (Japan)

Author keywords

Bioavailability; Curcumin; Gemcitabine; Pancreatic cancer; Theracurmin

Indexed keywords

CURCUMIN; CYTOKINE; GEMCITABINE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; THERACURMIN; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADD ON THERAPY; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANEMIA; ANOREXIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIARY TRACT CANCER; BILIARY TRACT INFECTION; BILIRUBIN BLOOD LEVEL; CANCER PATIENT; CLINICAL ARTICLE; CONSTIPATION; CREATININE BLOOD LEVEL; DIARRHEA; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG ERUPTION; DRUG FEVER; DRUG SAFETY; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; HUMAN; HYPERBILIRUBINEMIA; LEUKOPENIA; MALE; NAUSEA; NEUTROPENIA; NEUTROPHIL COUNT; PANCREAS CANCER; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS INHIBITION; QUALITY OF LIFE; SIDE EFFECT; STOMATITIS; THROMBOCYTE COUNT; THROMBOCYTOPENIA; VOMITING;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BILIARY TRACT NEOPLASMS; BIOLOGICAL AVAILABILITY; CURCUMIN; CYTOKINES; DISEASE-FREE SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG COMPOUNDING; DRUG STABILITY; FEMALE; HUMANS; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; NF-KAPPA B; PANCREATIC NEOPLASMS; QUALITY OF LIFE; SOLUBILITY;

EID: 84878654571     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-013-2151-8     Document Type: Article

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