3,3′-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer

Biochemical and Biophysical Research Communications

Volumn 340, Issue 2, 2006, Pages 718-725

  Garikapaty, Venkata P S ^a   Ashok, Badithe T ^a   Tadi, Kiranmayi ^a   Mittelman, Abraham ^a   Tiwari, Raj K ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Akt; Chemoprevention; Cruciferous vegetables; Cyclin dependent kinases; Diindolylmethane; Prostate cancer; Signal transduction

Indexed keywords

3 INDOLEMETHANOL; 3,3' DIINDOYLMETHANE; ANTIMITOTIC AGENT; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; HORMONE; METHANE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; 3,3' DIINDOLYLMETHANE; 3,3'-DIINDOLYLMETHANE; ANDROGEN; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; GROWTH INHIBITOR; INDOLE DERIVATIVE; INDOLE-3-CARBINOL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER SURVIVAL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG POTENCY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER; SIGNAL TRANSDUCTION; APOPTOSIS; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL SURVIVAL; COMPARATIVE STUDY; DNA REPLICATION; DRUG ANTAGONISM; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROGENS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BIOLOGICAL MARKERS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA REPLICATION; DOWN-REGULATION; G1 PHASE; GROWTH INHIBITORS; HUMANS; INDOLES; MALE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; S PHASE; SIGNAL TRANSDUCTION;

EID: 29644444307     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.12.059     Document Type: Article

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