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Volumn 15, Issue 9, 2014, Pages 573-589

Peripheral thermosensation in mammals

Author keywords

[No Author keywords available]

Indexed keywords

ALLICIN; ALLYL ISOTHIOCYANATE; CAPSAICIN; CINEOLE; CINNAMALDEHYDE; MENTHOL; PIPERINE; POTASSIUM CHANNEL; SODIUM CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4; CALCIUM ACTIVATED CHLORIDE CHANNEL; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; STROMAL INTERACTION MOLECULE 1;

EID: 84906327252     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn3784     Document Type: Review
Times cited : (306)

References (190)
  • 2
    • 84868231910 scopus 로고    scopus 로고
    • Coping with thermal challenges: Physiological adaptations to environmental temperatures
    • Tattersall, G. J. et al. Coping with thermal challenges: physiological adaptations to environmental temperatures. Compr. Physiol. 2, 2151-2202 (2012).
    • (2012) Compr. Physiol. , vol.2 , pp. 2151-2202
    • Tattersall, G.J.1
  • 5
    • 79951948671 scopus 로고    scopus 로고
    • Molecular mechanisms of mechanotransduction in mammalian sensory neurons
    • Delmas, P., Hao, J.&Rodat-Despoix, L. Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nature Rev. Neurosci. 12, 139-153 (2011).
    • (2011) Nature Rev. Neurosci. , vol.12 , pp. 139-153
    • Delmas, P.1    Hao, J.2    Rodat-Despoix, L.3
  • 7
    • 78049420335 scopus 로고    scopus 로고
    • Nociceptors: The sensors of the pain pathway
    • Dubin, A. E.&Patapoutian, A. Nociceptors: the sensors of the pain pathway. J. Clin. Invest. 120, 3760-3772 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 3760-3772
    • Dubin, A.E.1    Patapoutian, A.2
  • 9
    • 70349845440 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of pain
    • Basbaum, A. I., Bautista, D. M., Scherrer, G.&Julius, D. Cellular and molecular mechanisms of pain. Cell 139, 267-284 (2009).
    • (2009) Cell , vol.139 , pp. 267-284
    • Basbaum, A.I.1    Bautista, D.M.2    Scherrer, G.3    Julius, D.4
  • 10
    • 75149138261 scopus 로고    scopus 로고
    • Unmyelinated afferents in human skin and their responsiveness to low temperature
    • Campero, M.&Bostock, H. Unmyelinated afferents in human skin and their responsiveness to low temperature. Neurosci. Lett. 470, 188-192 (2010).
    • (2010) Neurosci. Lett. , vol.470 , pp. 188-192
    • Campero, M.1    Bostock, H.2
  • 11
    • 0014993968 scopus 로고
    • Analysis of cutaneous warm and cold fibres in primates
    • Hensel, H.&Iggo, A. Analysis of cutaneous warm and cold fibres in primates. Pflugers Arch. 329, 1-8 (1971).
    • (1971) Pflugers Arch. , vol.329 , pp. 1-8
    • Hensel, H.1    Iggo, A.2
  • 12
    • 59849121339 scopus 로고    scopus 로고
    • Phenotyping sensory nerve endings in vitro in the mouse
    • Zimmermann, K. et al. Phenotyping sensory nerve endings in vitro in the mouse. Nature Protoc. 4, 174-196 (2009).
    • (2009) Nature Protoc. , vol.4 , pp. 174-196
    • Zimmermann, K.1
  • 13
    • 34447513770 scopus 로고    scopus 로고
    • Neurophysiology: Channelling cold reception
    • Nilius, B.&Voets, T. Neurophysiology: channelling cold reception. Nature 448, 147-148 (2007).
    • (2007) Nature , vol.448 , pp. 147-148
    • Nilius, B.1    Voets, T.2
  • 15
    • 0021368388 scopus 로고
    • Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: Simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C?fibers
    • Torebjork, H. E., LaMotte, R. H.&Robinson, C. J. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C?fibers. J. Neurophysiol. 51, 325-339 (1984).
    • (1984) J. Neurophysiol. , vol.51 , pp. 325-339
    • Torebjork, H.E.1    Lamotte, R.H.2    Robinson, C.J.3
  • 16
    • 84893718412 scopus 로고    scopus 로고
    • Peripheral gating of pain signals by endogenous lipid mediators
    • Piomelli, D.&Sasso, O. Peripheral gating of pain signals by endogenous lipid mediators. Nature Neurosci. 17, 164-174 (2014).
    • (2014) Nature Neurosci. , vol.17 , pp. 164-174
    • Piomelli, D.1    Sasso, O.2
  • 17
    • 70349659983 scopus 로고    scopus 로고
    • The transient receptor potential vanilloid?1 channel in thermoregulation: A thermosensor it is not
    • Romanovsky, A. A. et al. The transient receptor potential vanilloid?1 channel in thermoregulation: a thermosensor it is not. Pharmacol. Rev. 61, 228-261 (2009).
    • (2009) Pharmacol. Rev. , vol.61 , pp. 228-261
    • Romanovsky, A.A.1
  • 18
    • 80155201442 scopus 로고    scopus 로고
    • Central circuitries for body temperature regulation and fever
    • Nakamura, K. Central circuitries for body temperature regulation and fever. Am. J. Physiol. Regul. Integr. Comp. Physiol. 301, R1207-R1228 (2011).
    • (2011) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.301
    • Nakamura, K.1
  • 19
    • 84862140556 scopus 로고    scopus 로고
    • Central control of thermogenesis
    • Clapham, J. C. Central control of thermogenesis. Neuropharmacology 63, 111-123 (2012).
    • (2012) Neuropharmacology , vol.63 , pp. 111-123
    • Clapham, J.C.1
  • 21
    • 0034646740 scopus 로고    scopus 로고
    • Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    • Caterina, M. J. et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306-313 (2000).
    • (2000) Science , vol.288 , pp. 306-313
    • Caterina, M.J.1
  • 22
    • 0034636441 scopus 로고    scopus 로고
    • Vanilloid receptor?1 is essential for inflammatory thermal hyperalgesia
    • Davis, J. B. et al. Vanilloid receptor?1 is essential for inflammatory thermal hyperalgesia. Nature 405, 183-187 (2000).
    • (2000) Nature , vol.405 , pp. 183-187
    • Davis, J.B.1
  • 23
    • 59049096524 scopus 로고    scopus 로고
    • TRPA1 acts as a cold sensor in vitro and in vivo
    • Karashima, Y. et al. TRPA1 acts as a cold sensor in vitro and in vivo. Proc. Natl Acad. Sci. USA 106, 1273-1278 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 1273-1278
    • Karashima, Y.1
  • 24
    • 14644392188 scopus 로고    scopus 로고
    • Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin
    • Moqrich, A. et al. Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science 307, 1468-1472 (2005).
    • (2005) Science , vol.307 , pp. 1468-1472
    • Moqrich, A.1
  • 26
    • 0030777012 scopus 로고    scopus 로고
    • The capsaicin receptor: A heat-activated ion channel in the pain pathway
    • Caterina, M. J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816-824 (1997).
    • (1997) Nature , vol.389 , pp. 816-824
    • Caterina, M.J.1
  • 27
    • 84889607320 scopus 로고    scopus 로고
    • Structure of the TRPV1 ion channel determined by electron cryo-microscopy
    • Liao, M., Cao, E., Julius, D.&Cheng, Y. Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature 504, 107-112 (2013).
    • (2013) Nature , vol.504 , pp. 107-112
    • Liao, M.1    Cao, E.2    Julius, D.3    Cheng, Y.4
  • 28
    • 0032169804 scopus 로고    scopus 로고
    • The cloned capsaicin receptor integrates multiple pain-producing stimuli
    • Tominaga, M. et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21, 531-543 (1998).
    • (1998) Neuron , vol.21 , pp. 531-543
    • Tominaga, M.1
  • 29
    • 0033614984 scopus 로고    scopus 로고
    • Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    • Zygmunt, P. M. et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400, 452-457 (1999).
    • (1999) Nature , vol.400 , pp. 452-457
    • Zygmunt, P.M.1
  • 30
    • 0004906771 scopus 로고    scopus 로고
    • Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
    • Hwang, S. W. et al. Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc. Natl Acad. Sci. USA 97, 6155-6160 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 6155-6160
    • Hwang, S.W.1
  • 31
    • 41949096621 scopus 로고    scopus 로고
    • Herbal compounds and toxins modulating TRP channels
    • Vriens, J., Nilius, B.&Vennekens, R. Herbal compounds and toxins modulating TRP channels. Curr. Neuropharmacol. 6, 79-96 (2008).
    • (2008) Curr. Neuropharmacol. , vol.6 , pp. 79-96
    • Vriens, J.1    Nilius, B.2    Vennekens, R.3
  • 32
    • 84865336959 scopus 로고    scopus 로고
    • Targeting TRPV1 for pain relief: Limits, losers and laurels
    • Szallasi, A.&Sheta, M. Targeting TRPV1 for pain relief: limits, losers and laurels. Expert Opin. Investig. Drugs 21, 1351-1369 (2012).
    • (2012) Expert Opin. Investig. Drugs , vol.21 , pp. 1351-1369
    • Szallasi, A.1    Sheta, M.2
  • 33
    • 84872249123 scopus 로고    scopus 로고
    • An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UVB-inflamed and normal skin
    • Schaffler, K. et al. An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UVB-inflamed and normal skin. Br. J. Clin. Pharmacol. 75, 404-414 (2013).
    • (2013) Br. J. Clin. Pharmacol. , vol.75 , pp. 404-414
    • Schaffler, K.1
  • 34
    • 0033119629 scopus 로고    scopus 로고
    • A capsaicin-receptor homologue with a high threshold for noxious heat
    • Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J.&Julius, D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398, 436-441 (1999).
    • (1999) Nature , vol.398 , pp. 436-441
    • Caterina, M.J.1    Rosen, T.A.2    Tominaga, M.3    Brake, A.J.4    Julius, D.5
  • 35
    • 80051556902 scopus 로고    scopus 로고
    • TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception
    • Park, U. et al. TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J. Neurosci. 31, 11425-11436 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 11425-11436
    • Park, U.1
  • 36
    • 0036703646 scopus 로고    scopus 로고
    • Heat-evoked activation of the ion channel, TRPV4
    • Guler, A. D. et al. Heat-evoked activation of the ion channel, TRPV4. J. Neurosci. 22, 6408-6414 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 6408-6414
    • Guler, A.D.1
  • 37
    • 0037077041 scopus 로고    scopus 로고
    • A heat-sensitive TRP channel expressed in keratinocytes
    • Peier, A. M. et al. A heat-sensitive TRP channel expressed in keratinocytes. Science 296, 2046-2049 (2002).
    • (2002) Science , vol.296 , pp. 2046-2049
    • Peier, A.M.1
  • 38
    • 18444408683 scopus 로고    scopus 로고
    • TRPV3 is a temperature-sensitive vanilloid receptor-like protein
    • Smith, G. D. et al. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418, 186-190 (2002).
    • (2002) Nature , vol.418 , pp. 186-190
    • Smith, G.D.1
  • 39
    • 0037033077 scopus 로고    scopus 로고
    • Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells
    • Watanabe, H. et al. Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J. Biol. Chem. 277, 47044-47051 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 47044-47051
    • Watanabe, H.1
  • 40
    • 0037062915 scopus 로고    scopus 로고
    • TRPV3 is a calcium-permeable temperature-sensitive cation channel
    • Xu, H. et al. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418, 181-186 (2002).
    • (2002) Nature , vol.418 , pp. 181-186
    • Xu, H.1
  • 41
    • 0037062915 scopus 로고    scopus 로고
    • TRPV3 is a calcium-permeable temperature-sensitive cation channel
    • Xu, H. et al. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418, 181-186 (2002).
    • (2002) Nature , vol.418 , pp. 181-186
    • Xu, H.1
  • 42
    • 84873593440 scopus 로고    scopus 로고
    • Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse
    • Vandewauw, I., Owsianik, G.&Voets, T. Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse. BMC Neurosci. 14, 21 (2013).
    • (2013) BMC Neurosci. , vol.14 , pp. 21
    • Vandewauw, I.1    Owsianik, G.2    Voets, T.3
  • 43
    • 70349577888 scopus 로고    scopus 로고
    • TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP
    • Mandadi, S. et al. TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch. 458, 1093-1102 (2009).
    • (2009) Pflugers Arch. , vol.458 , pp. 1093-1102
    • Mandadi, S.1
  • 44
    • 84880308811 scopus 로고    scopus 로고
    • TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin
    • Miyamoto, T., Petrus, M. J., Dubin, A. E.&Patapoutian, A. TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin. Nature Commun. 2, 369 (2011).
    • (2011) Nature Commun. , vol.2 , pp. 369
    • Miyamoto, T.1    Petrus, M.J.2    Dubin, A.E.3    Patapoutian, A.4
  • 45
    • 79960377146 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes
    • Mihara, H., Boudaka, A., Sugiyama, T., Moriyama, Y.&Tominaga, M. Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes. J. Physiol. 589, 3471-3482 (2011).
    • (2011) J. Physiol. , vol.589 , pp. 3471-3482
    • Mihara, H.1    Boudaka, A.2    Sugiyama, T.3    Moriyama, Y.4    Tominaga, M.5
  • 46
    • 13944255381 scopus 로고    scopus 로고
    • Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4
    • Lee, H., Iida, T., Mizuno, A., Suzuki, M.&Caterina, M. J. Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J. Neurosci. 25, 1304-1310 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 1304-1310
    • Lee, H.1    Iida, T.2    Mizuno, A.3    Suzuki, M.4    Caterina, M.J.5
  • 47
    • 79955973368 scopus 로고    scopus 로고
    • TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation
    • Huang, S. M., Li, X., Yu, Y., Wang, J.&Caterina, M. J. TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation. Mol. Pain 7, 37 (2011).
    • (2011) Mol. Pain , vol.7 , pp. 37
    • Huang, S.M.1    Li, X.2    Yu, Y.3    Wang, J.4    Caterina, M.J.5
  • 48
    • 0035042044 scopus 로고    scopus 로고
    • Transgenic studies of pain and analgesia: Mutation or background genotype? J
    • Lariviere, W. R., Chesler, E. J.&Mogil, J. S. Transgenic studies of pain and analgesia: mutation or background genotype? J. Pharmacol. Exp. Ther. 297, 467-473 (2001).
    • (2001) Pharmacol. Exp. Ther. , vol.297 , pp. 467-473
    • Lariviere, W.R.1    Chesler, E.J.2    Mogil, J.S.3
  • 49
    • 57049164233 scopus 로고    scopus 로고
    • Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic cells
    • Wagner, T. F. et al. Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic ? cells. Nature Cell Biol. 10, 1421-1430 (2008).
    • (2008) Nature Cell Biol. , vol.10 , pp. 1421-1430
    • Wagner, T.F.1
  • 50
    • 79955667133 scopus 로고    scopus 로고
    • TRPM3 is a nociceptor channel involved in the detection of noxious heat
    • Vriens, J. et al. TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron 70, 482-494 (2011).
    • (2011) Neuron , vol.70 , pp. 482-494
    • Vriens, J.1
  • 51
    • 84886001653 scopus 로고    scopus 로고
    • Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo
    • Straub, I. et al. Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo. Mol. Pharmacol. 84, 736-750 (2013).
    • (2013) Mol. Pharmacol. , vol.84 , pp. 736-750
    • Straub, I.1
  • 52
    • 84875411249 scopus 로고    scopus 로고
    • The cellular code for mammalian thermosensation
    • Pogorzala, L. A., Mishra, S. K.&Hoon, M. A. The cellular code for mammalian thermosensation. J. Neurosci. 33, 5533-5541 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 5533-5541
    • Pogorzala, L.A.1    Mishra, S.K.2    Hoon, M.A.3
  • 53
    • 72149111657 scopus 로고    scopus 로고
    • Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation
    • Mishra, S. K.&Hoon, M. A. Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation. Mol. Cell. Neurosci. 43, 157-163 (2010).
    • (2010) Mol. Cell. Neurosci. , vol.43 , pp. 157-163
    • Mishra, S.K.1    Hoon, M.A.2
  • 54
    • 0037034931 scopus 로고    scopus 로고
    • Identification of a cold receptor reveals a general role for TRP channels in thermosensation
    • McKemy, D. D., Neuhausser, W. M.&Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416, 52-58 (2002).
    • (2002) Nature , vol.416 , pp. 52-58
    • McKemy, D.D.1    Neuhausser, W.M.2    Julius, D.3
  • 55
    • 18344386202 scopus 로고    scopus 로고
    • A TRP channel that senses cold stimuli and menthol
    • Peier, A. M. et al. A TRP channel that senses cold stimuli and menthol. Cell 108, 705-715 (2002).
    • (2002) Cell , vol.108 , pp. 705-715
    • Peier, A.M.1
  • 56
    • 34447542435 scopus 로고    scopus 로고
    • The menthol receptor TRPM8 is the principal detector of environmental cold
    • Bautista, D. M. et al. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448, 204-208 (2007).
    • (2007) Nature , vol.448 , pp. 204-208
    • Bautista, D.M.1
  • 57
    • 34247472646 scopus 로고    scopus 로고
    • Attenuated cold sensitivity in TRPM8 null mice
    • Colburn, R. W. et al. Attenuated cold sensitivity in TRPM8 null mice. Neuron 54, 379-386 (2007).
    • (2007) Neuron , vol.54 , pp. 379-386
    • Colburn, R.W.1
  • 58
    • 34247487011 scopus 로고    scopus 로고
    • TRPM8 is required for cold sensation in mice
    • Dhaka, A. et al. TRPM8 is required for cold sensation in mice. Neuron 54, 371-378 (2007).
    • (2007) Neuron , vol.54 , pp. 371-378
    • Dhaka, A.1
  • 59
    • 78650026896 scopus 로고    scopus 로고
    • Ocular surface wetness is regulated by TRPM8?dependent cold thermoreceptors of the cornea
    • Parra, A. et al. Ocular surface wetness is regulated by TRPM8?dependent cold thermoreceptors of the cornea. Nature Med. 16, 1396-1399 (2010).
    • (2010) Nature Med. , vol.16 , pp. 1396-1399
    • Parra, A.1
  • 60
    • 84873920079 scopus 로고    scopus 로고
    • A sensory-labeled line for cold: TRPM8?expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia
    • Knowlton, W. M. et al. A sensory-labeled line for cold: TRPM8?expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia. J. Neurosci. 33, 2837-2848 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 2837-2848
    • Knowlton, W.M.1
  • 61
    • 0345616438 scopus 로고    scopus 로고
    • ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    • Story, G. M. et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112, 819-829 (2003).
    • (2003) Cell , vol.112 , pp. 819-829
    • Story, G.M.1
  • 62
    • 1842475312 scopus 로고    scopus 로고
    • Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    • Bandell, M. et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41, 849-857 (2004).
    • (2004) Neuron , vol.41 , pp. 849-857
    • Bandell, M.1
  • 64
    • 50349100515 scopus 로고    scopus 로고
    • TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: Pharmacological and genetic evidence
    • Fajardo, O., Meseguer, V., Belmonte, C.&Viana, F. TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence. J. Neurosci. 28, 7863-7875 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 7863-7875
    • Fajardo, O.1    Meseguer, V.2    Belmonte, C.3    Viana, F.4
  • 65
    • 77953681608 scopus 로고    scopus 로고
    • A gain?of?function mutation in TRPA1 causes familial episodic pain syndrome
    • Kremeyer, B. et al. A gain?of?function mutation in TRPA1 causes familial episodic pain syndrome. Neuron 66, 671-680 (2010).
    • (2010) Neuron , vol.66 , pp. 671-680
    • Kremeyer, B.1
  • 66
    • 1642430679 scopus 로고    scopus 로고
    • Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    • Jordt, S. E. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427, 260-265 (2004).
    • (2004) Nature , vol.427 , pp. 260-265
    • Jordt, S.E.1
  • 67
    • 70349559585 scopus 로고    scopus 로고
    • Nicotine activates the chemosensory cation channel TRPA1
    • Talavera, K. et al. Nicotine activates the chemosensory cation channel TRPA1. Nature Neurosci. 12, 1293-1299 (2009).
    • (2009) Nature Neurosci. , vol.12 , pp. 1293-1299
    • Talavera, K.1
  • 68
    • 33646061333 scopus 로고    scopus 로고
    • TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
    • Kwan, K. Y. et al. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 50, 277-289 (2006).
    • (2006) Neuron , vol.50 , pp. 277-289
    • Kwan, K.Y.1
  • 69
    • 76949100698 scopus 로고    scopus 로고
    • The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity
    • Gentry, C., Stoakley, N., Andersson, D. A.&Bevan, S. The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity. Mol. Pain 6, 4 (2010).
    • (2010) Mol. Pain , vol.6 , pp. 4
    • Gentry, C.1    Stoakley, N.2    Andersson, D.A.3    Bevan, S.4
  • 71
    • 84885145935 scopus 로고    scopus 로고
    • Species differences and molecular determinant of TRPA1 cold sensitivity
    • Chen, J. et al. Species differences and molecular determinant of TRPA1 cold sensitivity. Nature Commun. 4, 2501 (2013).
    • (2013) Nature Commun. , vol.4 , pp. 2501
    • Chen, J.1
  • 72
    • 33646045075 scopus 로고    scopus 로고
    • TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
    • Bautista, D. M. et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124, 1269-1282 (2006).
    • (2006) Cell , vol.124 , pp. 1269-1282
    • Bautista, D.M.1
  • 73
    • 77955304238 scopus 로고    scopus 로고
    • TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo
    • Knowlton, W. M., Bifolck-Fisher, A., Bautista, D. M.&McKemy, D. D. TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Pain 150, 340-350 (2010).
    • (2010) Pain , vol.150 , pp. 340-350
    • Knowlton, W.M.1    Bifolck-Fisher, A.2    Bautista, D.M.3    McKemy, D.D.4
  • 74
    • 78149485777 scopus 로고    scopus 로고
    • TRPA1 contributes to cold hypersensitivity
    • del Camino, D. et al. TRPA1 contributes to cold hypersensitivity. J. Neurosci. 30, 15165-15174 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 15165-15174
    • Del Camino, D.1
  • 75
    • 81055141456 scopus 로고    scopus 로고
    • Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system
    • Zimmermann, K. et al. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc. Natl Acad. Sci. USA 108, 18114-18119 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 18114-18119
    • Zimmermann, K.1
  • 76
    • 83455199984 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-activated chloride channels
    • Huang, F., Wong, X.&Jan, L. Y. International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels. Pharmacol. Rev. 64, 1-15 (2012).
    • (2012) Pharmacol. Rev. , vol.64 , pp. 1-15
    • Huang, F.1    Wong, X.2    Jan, L.Y.3
  • 77
    • 84862896642 scopus 로고    scopus 로고
    • The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons
    • Cho, H. et al. The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nature Neurosci. 15, 1015-1021 (2012).
    • (2012) Nature Neurosci. , vol.15 , pp. 1015-1021
    • Cho, H.1
  • 78
    • 84892763451 scopus 로고    scopus 로고
    • Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity
    • Lee, B. et al. Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity. Mol. Pain 10, 5 (2014).
    • (2014) Mol. Pain , vol.10 , pp. 5
    • Lee, B.1
  • 79
    • 66949137457 scopus 로고    scopus 로고
    • STIMulating store-operated Ca2+ entry
    • Cahalan, M. D. STIMulating store-operated Ca2+ entry. Nature Cell Biol. 11, 669-677 (2009).
    • (2009) Nature Cell Biol. , vol.11 , pp. 669-677
    • Cahalan, M.D.1
  • 80
    • 85027919657 scopus 로고    scopus 로고
    • Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression
    • Xiao, B., Coste, B., Mathur, J.&Patapoutian, A. Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression. Nature Chem. Biol. 7, 351-358 (2011).
    • (2011) Nature Chem. Biol. , vol.7 , pp. 351-358
    • Xiao, B.1    Coste, B.2    Mathur, J.3    Patapoutian, A.4
  • 81
    • 0036183242 scopus 로고    scopus 로고
    • Specificity of cold thermotransduction is determined by differential ionic channel expression
    • Viana, F., de la Pena, E.&Belmonte, C. Specificity of cold thermotransduction is determined by differential ionic channel expression. Nature Neurosci. 5, 254-260 (2002).
    • (2002) Nature Neurosci. , vol.5 , pp. 254-260
    • Viana, F.1    De La Pena, E.2    Belmonte, C.3
  • 82
    • 33947360830 scopus 로고    scopus 로고
    • The neuronal background K2P channels: Focus on TREK1
    • Honore, E. The neuronal background K2P channels: focus on TREK1. Nature Rev. Neurosci. 8, 251-261 (2007).
    • (2007) Nature Rev. Neurosci. , vol.8 , pp. 251-261
    • Honore, E.1
  • 83
    • 0034213381 scopus 로고    scopus 로고
    • TREK?1 is a heat-activated background K+ channel
    • Maingret, F. et al. TREK?1 is a heat-activated background K+ channel. EMBO J. 19, 2483-2491 (2000).
    • (2000) EMBO J. , vol.19 , pp. 2483-2491
    • Maingret, F.1
  • 84
    • 17444411944 scopus 로고    scopus 로고
    • Thermosensitivity of the two-pore domain K+ channels TREK?2 and TRAAK
    • Kang, D., Choe, C.&Kim, D. Thermosensitivity of the two-pore domain K+ channels TREK?2 and TRAAK. J. Physiol. 564, 103-116 (2005).
    • (2005) J. Physiol. , vol.564 , pp. 103-116
    • Kang, D.1    Choe, C.2    Kim, D.3
  • 85
    • 33745741107 scopus 로고    scopus 로고
    • TREK?1, a K+ channel involved in polymodal pain perception
    • Alloui, A. et al. TREK?1, a K+ channel involved in polymodal pain perception. EMBO J. 25, 2368-2376 (2006).
    • (2006) EMBO J. , vol.25 , pp. 2368-2376
    • Alloui, A.1
  • 86
    • 65649147153 scopus 로고    scopus 로고
    • The mechano-activated K+ channels TRAAK and TREK?1 control both warm and cold perception
    • Noel, J. et al. The mechano-activated K+ channels TRAAK and TREK?1 control both warm and cold perception. EMBO J. 28, 1308-1318 (2009).
    • (2009) EMBO J. , vol.28 , pp. 1308-1318
    • Noel, J.1
  • 87
    • 84861716984 scopus 로고    scopus 로고
    • Voltage-gated sodium channels at 60: Structure, function and pathophysiology
    • Catterall, W. A. Voltage-gated sodium channels at 60: structure, function and pathophysiology. J. Physiol. 590, 2577-2589 (2012).
    • (2012) J. Physiol. , vol.590 , pp. 2577-2589
    • Catterall, W.A.1
  • 88
    • 34250306409 scopus 로고    scopus 로고
    • Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures
    • Zimmermann, K. et al. Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature 447, 855-858 (2007).
    • (2007) Nature , vol.447 , pp. 855-858
    • Zimmermann, K.1
  • 89
    • 48749123103 scopus 로고    scopus 로고
    • The cell and molecular basis of mechanical, cold, and inflammatory pain
    • Abrahamsen, B. et al. The cell and molecular basis of mechanical, cold, and inflammatory pain. Science 321, 702-705 (2008).
    • (2008) Science , vol.321 , pp. 702-705
    • Abrahamsen, B.1
  • 90
    • 0032449839 scopus 로고    scopus 로고
    • Mechanical aspects of membrane thermodynamics. Estimation of the mechanical properties of lipid membranes close to the chain melting transition from calorimetry
    • Heimburg, T. Mechanical aspects of membrane thermodynamics. Estimation of the mechanical properties of lipid membranes close to the chain melting transition from calorimetry. Biochim. Biophys. Acta 1415, 147-162 (1998).
    • (1998) Biochim. Biophys. Acta , vol.1415 , pp. 147-162
    • Heimburg, T.1
  • 91
    • 83455234830 scopus 로고    scopus 로고
    • Decrease in phosphatidylinositol 4,5?bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels
    • Yudin, Y., Lukacs, V., Cao, C.&Rohacs, T. Decrease in phosphatidylinositol 4,5?bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels. J. Physiol. 589, 6007-6027 (2011).
    • (2011) J. Physiol. , vol.589 , pp. 6007-6027
    • Yudin, Y.1    Lukacs, V.2    Cao, C.3    Rohacs, T.4
  • 92
    • 33344459507 scopus 로고    scopus 로고
    • Signaling protein complexes associated with neuronal ion channels
    • Levitan, I. B. Signaling protein complexes associated with neuronal ion channels. Nature Neurosci. 9, 305-310 (2006).
    • (2006) Nature Neurosci. , vol.9 , pp. 305-310
    • Levitan, I.B.1
  • 93
    • 0024280882 scopus 로고
    • Regulation of a heart potassium channel by protein kinase A and C
    • Walsh, K. B.&Kass, R. S. Regulation of a heart potassium channel by protein kinase A and C. Science 242, 67-69 (1988).
    • (1988) Science , vol.242 , pp. 67-69
    • Walsh, K.B.1    Kass, R.S.2
  • 94
    • 77957349183 scopus 로고    scopus 로고
    • The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels
    • Wang, Y. et al. The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels. Science 330, 105-109 (2010).
    • (2010) Science , vol.330 , pp. 105-109
    • Wang, Y.1
  • 95
    • 77957332175 scopus 로고    scopus 로고
    • The CRAC channel activator STIM1 binds and inhibits L?type voltage-gated calcium channels
    • Park, C. Y., Shcheglovitov, A.&Dolmetsch, R. The CRAC channel activator STIM1 binds and inhibits L?type voltage-gated calcium channels. Science 330, 101-105 (2010).
    • (2010) Science , vol.330 , pp. 101-105
    • Park, C.Y.1    Shcheglovitov, A.2    Dolmetsch, R.3
  • 96
    • 34447097610 scopus 로고    scopus 로고
    • STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels
    • Yuan, J. P., Zeng, W., Huang, G. N., Worley, P. F.&Muallem, S. STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nature Cell Biol. 9, 636-645 (2007).
    • (2007) Nature Cell Biol. , vol.9 , pp. 636-645
    • Yuan, J.P.1    Zeng, W.2    Huang, G.N.3    Worley, P.F.4    Muallem, S.5
  • 97
    • 65749099406 scopus 로고    scopus 로고
    • TRPC channels function independently of STIM1 and Orai1
    • DeHaven, W. I. et al. TRPC channels function independently of STIM1 and Orai1. J. Physiol. 587, 2275-2298 (2009).
    • (2009) J. Physiol. , vol.587 , pp. 2275-2298
    • Dehaven, W.I.1
  • 98
    • 77956799526 scopus 로고    scopus 로고
    • Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers
    • Zakharian, E., Cao, C.&Rohacs, T. Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers. J. Neurosci. 30, 12526-12534 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 12526-12534
    • Zakharian, E.1    Cao, C.2    Rohacs, T.3
  • 99
    • 84874229704 scopus 로고    scopus 로고
    • TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids
    • Cao, E., Cordero-Morales, J. F., Liu, B., Qin, F.&Julius, D. TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron 77, 667-679 (2013).
    • (2013) Neuron , vol.77 , pp. 667-679
    • Cao, E.1    Cordero-Morales, J.F.2    Liu, B.3    Qin, F.4    Julius, D.5
  • 100
    • 30744463490 scopus 로고    scopus 로고
    • Heat activation of TRPM5 underlies thermal sensitivity of sweet taste
    • Talavera, K. et al. Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature 438, 1022-1025 (2005).
    • (2005) Nature , vol.438 , pp. 1022-1025
    • Talavera, K.1
  • 101
    • 4043077669 scopus 로고    scopus 로고
    • The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
    • Voets, T. et al. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430, 748-754 (2004).
    • (2004) Nature , vol.430 , pp. 748-754
    • Voets, T.1
  • 103
    • 77955667059 scopus 로고    scopus 로고
    • Kinetic and energetic analysis of thermally activated TRPV1 channels
    • Yao, J., Liu, B.&Qin, F. Kinetic and energetic analysis of thermally activated TRPV1 channels. Biophys. J. 99, 1743-1753 (2010).
    • (2010) Biophys. J. , vol.99 , pp. 1743-1753
    • Yao, J.1    Liu, B.2    Qin, F.3
  • 104
    • 33646899582 scopus 로고    scopus 로고
    • A hot-sensing cold receptor: C?terminal domain determines thermosensation in transient receptor potential channels
    • Brauchi, S., Orta, G., Salazar, M., Rosenmann, E.&Latorre, R. A hot-sensing cold receptor: C?terminal domain determines thermosensation in transient receptor potential channels. J. Neurosci. 26, 4835-4840 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 4835-4840
    • Brauchi, S.1    Orta, G.2    Salazar, M.3    Rosenmann, E.4    Latorre, R.5
  • 105
    • 34547953765 scopus 로고    scopus 로고
    • ThermoTRP channels as modular proteins with allosteric gating
    • Latorre, R., Brauchi, S., Orta, G., Zaelzer, C.&Vargas, G. ThermoTRP channels as modular proteins with allosteric gating. Cell Calcium 42, 427-438 (2007).
    • (2007) Cell Calcium , vol.42 , pp. 427-438
    • Latorre, R.1    Brauchi, S.2    Orta, G.3    Zaelzer, C.4    Vargas, G.5
  • 106
    • 50249186498 scopus 로고    scopus 로고
    • Pore region of TRPV3 ion channel is specifically required for heat activation
    • Grandl, J. et al. Pore region of TRPV3 ion channel is specifically required for heat activation. Nature Neurosci. 11, 1007-1013 (2008).
    • (2008) Nature Neurosci. , vol.11 , pp. 1007-1013
    • Grandl, J.1
  • 107
    • 81755185888 scopus 로고    scopus 로고
    • Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
    • Cordero-Morales, J. F., Gracheva, E. O.&Julius, D. Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc. Natl Acad. Sci. USA 108, E1184-E1191 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108
    • Cordero-Morales, J.F.1    Gracheva, E.O.2    Julius, D.3
  • 108
    • 84862845558 scopus 로고    scopus 로고
    • Quantifying and modeling the temperature-dependent gating of TRP channels
    • Voets, T. Quantifying and modeling the temperature-dependent gating of TRP channels. Rev. Physiol. Biochem. Pharmacol. 162, 91-119 (2012).
    • (2012) Rev. Physiol. Biochem. Pharmacol. , vol.162 , pp. 91-119
    • Voets, T.1
  • 109
    • 84889594608 scopus 로고    scopus 로고
    • TRPV1 structures in distinct conformations reveal activation mechanisms
    • Cao, E., Liao, M., Cheng, Y.&Julius, D. TRPV1 structures in distinct conformations reveal activation mechanisms. Nature 504, 113-118 (2013).
    • (2013) Nature , vol.504 , pp. 113-118
    • Cao, E.1    Liao, M.2    Cheng, Y.3    Julius, D.4
  • 110
    • 79959341776 scopus 로고    scopus 로고
    • Thermosensory and mechanosensory perception in human genetic disease
    • Tan, P. L.&Katsanis, N. Thermosensory and mechanosensory perception in human genetic disease. Hum. Mol. Genet. 18, R146-R155 (2009).
    • (2009) Hum. Mol. Genet. , vol.18
    • Tan, P.L.1    Katsanis, N.2
  • 111
    • 84887824401 scopus 로고    scopus 로고
    • Experimental pain phenotype profiles in a racially and ethnically diverse sample of healthy adults
    • Cruz-Almeida, Y., Riley, J. L.&Fillingim, R. B. Experimental pain phenotype profiles in a racially and ethnically diverse sample of healthy adults. Pain Med. 14, 1708-1718 (2013).
    • (2013) Pain Med. , vol.14 , pp. 1708-1718
    • Cruz-Almeida, Y.1    Riley, J.L.2    Fillingim, R.B.3
  • 112
    • 77249117952 scopus 로고    scopus 로고
    • Somesthetic senses
    • Hollins, M. Somesthetic senses. Annu. Rev. Psychol. 61, 243-271 (2010).
    • (2010) Annu. Rev. Psychol. , vol.61 , pp. 243-271
    • Hollins, M.1
  • 113
    • 33846269106 scopus 로고    scopus 로고
    • Genetic predictors for acute experimental cold and heat pain sensitivity in humans
    • Kim, H., Mittal, D. P., Iadarola, M. J.&Dionne, R. A. Genetic predictors for acute experimental cold and heat pain sensitivity in humans. J. Med. Genet. 43, e40 (2006).
    • (2006) J. Med. Genet. , vol.43
    • Kim, H.1    Mittal, D.P.2    Iadarola, M.J.3    Dionne, R.A.4
  • 114
    • 79953193743 scopus 로고    scopus 로고
    • Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients
    • Binder, A. et al. Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. PLoS ONE 6, e17387 (2011).
    • (2011) PLoS ONE , vol.6
    • Binder, A.1
  • 115
    • 79951579664 scopus 로고    scopus 로고
    • Central sensitization: Implications for the diagnosis and treatment of pain
    • Woolf, C. J. Central sensitization: implications for the diagnosis and treatment of pain. Pain 152, S2-S15 (2011).
    • (2011) Pain , vol.152
    • Woolf, C.J.1
  • 116
    • 0035855860 scopus 로고    scopus 로고
    • Molecular mechanisms of nociception
    • Julius, D.&Basbaum, A. I. Molecular mechanisms of nociception. Nature 413, 203-210 (2001).
    • (2001) Nature , vol.413 , pp. 203-210
    • Julius, D.1    Basbaum, A.I.2
  • 117
    • 84892604923 scopus 로고    scopus 로고
    • Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice
    • Sisignano, M. et al. Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. PLoS ONE 8, e81228 (2013).
    • (2013) PLoS ONE , vol.8
    • Sisignano, M.1
  • 118
    • 0034608878 scopus 로고    scopus 로고
    • Acid potentiation of the capsaicin receptor determined by a key extracellular site
    • Jordt, S. E., Tominaga, M.&Julius, D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc. Natl Acad. Sci. USA 97, 8134-8139 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 8134-8139
    • Jordt, S.E.1    Tominaga, M.2    Julius, D.3
  • 119
    • 0035927651 scopus 로고    scopus 로고
    • Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2?mediated inhibition
    • Chuang, H. H. et al. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2?mediated inhibition. Nature 411, 957-962 (2001).
    • (2001) Nature , vol.411 , pp. 957-962
    • Chuang, H.H.1
  • 120
    • 0037799198 scopus 로고    scopus 로고
    • A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity
    • Prescott, E. D.&Julius, D. A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science 300, 1284-1288 (2003).
    • (2003) Science , vol.300 , pp. 1284-1288
    • Prescott, E.D.1    Julius, D.2
  • 121
    • 33750524257 scopus 로고    scopus 로고
    • Phosphoinositide 3?kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane
    • Stein, A. T., Ufret-Vincenty, C. A., Hua, L., Santana, L. F.&Gordon, S. E. Phosphoinositide 3?kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane. J. Gen. Physiol. 128, 509-522 (2006).
    • (2006) J. Gen. Physiol. , vol.128 , pp. 509-522
    • Stein, A.T.1    Ufret-Vincenty, C.A.2    Hua, L.3    Santana, L.F.4    Gordon, S.E.5
  • 122
    • 61349190400 scopus 로고    scopus 로고
    • Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor
    • Yao, J.&Qin, F. Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor. PLoS Biol. 7, e46 (2009).
    • (2009) PLoS Biol. , vol.7
    • Yao, J.1    Qin, F.2
  • 123
    • 0034700494 scopus 로고    scopus 로고
    • Induction of vanilloid receptor channel activity by protein kinase C
    • Premkumar, L. S.&Ahern, G. P. Induction of vanilloid receptor channel activity by protein kinase C. Nature 408, 985-990 (2000).
    • (2000) Nature , vol.408 , pp. 985-990
    • Premkumar, L.S.1    Ahern, G.P.2
  • 124
    • 0142059776 scopus 로고    scopus 로고
    • Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
    • Bhave, G. et al. Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc. Natl Acad. Sci. USA 100, 12480-12485 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 12480-12485
    • Bhave, G.1
  • 125
    • 0037104657 scopus 로고    scopus 로고
    • CAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation
    • Bhave, G. et al. cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 35, 721-731 (2002).
    • (2002) Neuron , vol.35 , pp. 721-731
    • Bhave, G.1
  • 126
    • 0141634247 scopus 로고    scopus 로고
    • Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor
    • Bonnington, J. K.&McNaughton, P. A. Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor. J. Physiol. 551, 433-446 (2003).
    • (2003) J. Physiol. , vol.551 , pp. 433-446
    • Bonnington, J.K.1    McNaughton, P.A.2
  • 127
    • 0034954583 scopus 로고    scopus 로고
    • VR1 protein expression increases in undamaged DRG neurons after partial nerve injury
    • Hudson, L. J. et al. VR1 protein expression increases in undamaged DRG neurons after partial nerve injury. Eur. J. Neurosci. 13, 2105-2114 (2001).
    • (2001) Eur. J. Neurosci. , vol.13 , pp. 2105-2114
    • Hudson, L.J.1
  • 128
    • 84866007786 scopus 로고    scopus 로고
    • Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation
    • Zakir, H. M. et al. Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation. PLoS ONE 7, e44023 (2012).
    • (2012) PLoS ONE , vol.7
    • Zakir, H.M.1
  • 129
    • 12844286900 scopus 로고    scopus 로고
    • Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1
    • Hong, S.&Wiley, J. W. Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. J. Biol. Chem. 280, 618-627 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 618-627
    • Hong, S.1    Wiley, J.W.2
  • 130
    • 79960689897 scopus 로고    scopus 로고
    • Streptozotocin-induced early thermal hyperalgesia is independent of glycemic state of rats: Role of transient receptor potential vanilloid 1 (TRPV1) and inflammatory mediators
    • Bishnoi, M., Bosgraaf, C. A., Abooj, M., Zhong, L.&Premkumar, L. S. Streptozotocin-induced early thermal hyperalgesia is independent of glycemic state of rats: role of transient receptor potential vanilloid 1 (TRPV1) and inflammatory mediators. Mol. Pain 7, 52 (2011).
    • (2011) Mol. Pain , vol.7 , pp. 52
    • Bishnoi, M.1    Bosgraaf, C.A.2    Abooj, M.3    Zhong, L.4    Premkumar, L.S.5
  • 131
    • 37249065119 scopus 로고    scopus 로고
    • TRPM8 mechanism of cold allodynia after chronic nerve injury
    • Xing, H., Chen, M., Ling, J., Tan, W.&Gu, J. G. TRPM8 mechanism of cold allodynia after chronic nerve injury. J. Neurosci. 27, 13680-13690 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 13680-13690
    • Xing, H.1    Chen, M.2    Ling, J.3    Tan, W.4    Gu, J.G.5
  • 132
    • 80053596592 scopus 로고    scopus 로고
    • Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice
    • Knowlton, W. M., Daniels, R. L., Palkar, R., McCoy, D. D.&McKemy, D. D. Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. PLoS ONE 6, e25894 (2011).
    • (2011) PLoS ONE , vol.6
    • Knowlton, W.M.1    Daniels, R.L.2    Palkar, R.3    McCoy, D.D.4    McKemy, D.D.5
  • 133
    • 17844373771 scopus 로고    scopus 로고
    • PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain
    • Rohacs, T., Lopes, C. M., Michailidis, I.&Logothetis, D. E. PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nature Neurosci. 8, 626-634 (2005).
    • (2005) Nature Neurosci. , vol.8 , pp. 626-634
    • Rohacs, T.1    Lopes, C.M.2    Michailidis, I.3    Logothetis, D.E.4
  • 134
    • 84875998693 scopus 로고    scopus 로고
    • Ambient temperature affects the temperature threshold for TRPM8 activation through interaction of phosphatidylinositol 4,5?bisphosphate
    • Fujita, F., Uchida, K., Takaishi, M., Sokabe, T.&Tominaga, M. Ambient temperature affects the temperature threshold for TRPM8 activation through interaction of phosphatidylinositol 4,5?bisphosphate. J. Neurosci. 33, 6154-6159 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 6154-6159
    • Fujita, F.1    Uchida, K.2    Takaishi, M.3    Sokabe, T.4    Tominaga, M.5
  • 135
    • 14044261739 scopus 로고    scopus 로고
    • Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5?bisphosphate
    • Liu, B.&Qin, F. Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5?bisphosphate. J. Neurosci. 25, 1674-1681 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 1674-1681
    • Liu, B.1    Qin, F.2
  • 136
    • 30544438062 scopus 로고    scopus 로고
    • Downregulation of transient receptor potential melastatin 8 by protein kinase C?mediated dephosphorylation
    • Premkumar, L. S., Raisinghani, M., Pingle, S. C., Long, C.&Pimentel, F. Downregulation of transient receptor potential melastatin 8 by protein kinase C?mediated dephosphorylation. J. Neurosci. 25, 11322-11329 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 11322-11329
    • Premkumar, L.S.1    Raisinghani, M.2    Pingle, S.C.3    Long, C.4    Pimentel, F.5
  • 137
    • 84864866637 scopus 로고    scopus 로고
    • Direct inhibition of the cold-activated TRPM8 ion channel by G?q
    • Zhang, X. et al. Direct inhibition of the cold-activated TRPM8 ion channel by G?q. Nature Cell Biol. 14, 851-858 (2012).
    • (2012) Nature Cell Biol. , vol.14 , pp. 851-858
    • Zhang, X.1
  • 138
    • 24644462327 scopus 로고    scopus 로고
    • TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
    • Obata, K. et al. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J. Clin. Invest. 115, 2393-2401 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 2393-2401
    • Obata, K.1
  • 139
    • 33746083982 scopus 로고    scopus 로고
    • Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats
    • Katsura, H. et al. Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp. Neurol. 200, 112-123 (2006).
    • (2006) Exp. Neurol. , vol.200 , pp. 112-123
    • Katsura, H.1
  • 140
    • 84867097862 scopus 로고    scopus 로고
    • TRP channel blamed for burning cold after a tropical fish meal
    • Voets, T. TRP channel blamed for burning cold after a tropical fish meal. EMBO J. 31, 3785-3787 (2012).
    • (2012) EMBO J. , vol.31 , pp. 3785-3787
    • Voets, T.1
  • 141
    • 84867100648 scopus 로고    scopus 로고
    • Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling
    • Vetter, I. et al. Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO J. 31, 3795-3808 (2012).
    • (2012) EMBO J. , vol.31 , pp. 3795-3808
    • Vetter, I.1
  • 142
    • 84864267922 scopus 로고    scopus 로고
    • Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice
    • Zhao, M. et al. Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice. Mol. Pain 8, 55 (2012).
    • (2012) Mol. Pain , vol.8 , pp. 55
    • Zhao, M.1
  • 143
    • 84862622177 scopus 로고    scopus 로고
    • TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism
    • Materazzi, S. et al. TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism. Pflugers Arch. 463, 561-569 (2012).
    • (2012) Pflugers Arch. , vol.463 , pp. 561-569
    • Materazzi, S.1
  • 144
    • 79958744029 scopus 로고    scopus 로고
    • Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation
    • Nassini, R. et al. Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation. Pain 152, 1621-1631 (2011).
    • (2011) Pain , vol.152 , pp. 1621-1631
    • Nassini, R.1
  • 145
    • 79955581191 scopus 로고    scopus 로고
    • Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors
    • Descoeur, J. et al. Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol. Med. 3, 266-278 (2011).
    • (2011) EMBO Mol. Med. , vol.3 , pp. 266-278
    • Descoeur, J.1
  • 146
    • 78651412373 scopus 로고    scopus 로고
    • Epidemiology of chronic non-cancer pain in Europe: Narrative review of prevalence, pain treatments and pain impact
    • Reid, K. J. et al. Epidemiology of chronic non-cancer pain in Europe: narrative review of prevalence, pain treatments and pain impact. Curr. Med. Res. Opin. 27, 449-462 (2011).
    • (2011) Curr. Med. Res. Opin. , vol.27 , pp. 449-462
    • Reid, K.J.1
  • 148
    • 0037133281 scopus 로고    scopus 로고
    • Attenuation of thermal nociception and hyperalgesia by VR1 blockers
    • Garcia-Martinez, C. et al. Attenuation of thermal nociception and hyperalgesia by VR1 blockers. Proc. Natl Acad. Sci. USA 99, 2374-2379 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 2374-2379
    • Garcia-Martinez, C.1
  • 149
    • 20144388484 scopus 로고    scopus 로고
    • Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain
    • Ghilardi, J. R. et al. Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J. Neurosci. 25, 3126-3131 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 3126-3131
    • Ghilardi, J.R.1
  • 150
    • 23044496253 scopus 로고    scopus 로고
    • A-425619 [1?isoquinolin?5?yl?3- (4?trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats
    • Honore, P. et al. A-425619 [1?isoquinolin?5?yl?3- (4?trifluoromethyl- benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. J. Pharmacol. Exp. Ther. 314, 410-421 (2005).
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 410-421
    • Honore, P.1
  • 151
    • 84878012703 scopus 로고    scopus 로고
    • TRPV1 antagonistic analgesic effect: A randomized study of AZD1386 in pain after third molar extraction
    • Quiding, H. et al. TRPV1 antagonistic analgesic effect: a randomized study of AZD1386 in pain after third molar extraction. Pain 154, 808-812 (2013).
    • (2013) Pain , vol.154 , pp. 808-812
    • Quiding, H.1
  • 152
    • 34047118624 scopus 로고    scopus 로고
    • The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation
    • Gavva, N. R. et al. The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J. Neurosci. 27, 3366-3374 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 3366-3374
    • Gavva, N.R.1
  • 153
    • 34447504896 scopus 로고    scopus 로고
    • Nonthermal activation of transient receptor potential vanilloid?1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors
    • Steiner, A. A. et al. Nonthermal activation of transient receptor potential vanilloid?1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J. Neurosci. 27, 7459-7468 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 7459-7468
    • Steiner, A.A.1
  • 154
    • 54349127771 scopus 로고    scopus 로고
    • Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1
    • Gavva, N. R. Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1. Trends Pharmacol. Sci. 29, 550-557 (2008).
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 550-557
    • Gavva, N.R.1
  • 155
    • 41749117999 scopus 로고    scopus 로고
    • Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans
    • Gavva, N. R. et al. Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain 136, 202-210 (2008).
    • (2008) Pain , vol.136 , pp. 202-210
    • Gavva, N.R.1
  • 156
    • 75349108628 scopus 로고    scopus 로고
    • Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia
    • Garami, A. et al. Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia. J. Neurosci. 30, 1435-1440 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 1435-1440
    • Garami, A.1
  • 157
    • 84876576815 scopus 로고    scopus 로고
    • Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia
    • Fischer, M. J., Btesh, J.&McNaughton, P. A. Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia. J. Neurosci. 33, 7407-7414 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 7407-7414
    • Fischer, M.J.1    Btesh, J.2    McNaughton, P.A.3
  • 158
    • 77957551184 scopus 로고    scopus 로고
    • Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist
    • Fosgerau, K. et al. Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. BMC Cardiovasc. Disord. 10, 51 (2010).
    • (2010) BMC Cardiovasc. Disord. , vol.10 , pp. 51
    • Fosgerau, K.1
  • 159
    • 84892592563 scopus 로고    scopus 로고
    • Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion
    • Cao, Z., Balasubramanian, A.&Marrelli, S. P. Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. Am. J. Physiol. Regul. Integr. Comp. Physiol. 306, R149-R156 (2014).
    • (2014) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.306
    • Cao, Z.1    Balasubramanian, A.2    Marrelli, S.P.3
  • 160
    • 84884280747 scopus 로고    scopus 로고
    • TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain
    • Liu, B. et al. TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. Pain 154, 2169-2177 (2013).
    • (2013) Pain , vol.154 , pp. 2169-2177
    • Liu, B.1
  • 161
    • 84863012756 scopus 로고    scopus 로고
    • Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature
    • Almeida, M. C. et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J. Neurosci. 32, 2086-2099 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 2086-2099
    • Almeida, M.C.1
  • 162
    • 36048982077 scopus 로고    scopus 로고
    • Application of menthol to the skin of whole trunk in mice induces autonomic and behavioral heat-gain responses
    • Tajino, K. et al. Application of menthol to the skin of whole trunk in mice induces autonomic and behavioral heat-gain responses. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293, R2128-R2135 (2007).
    • (2007) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.293
    • Tajino, K.1
  • 163
    • 79954576919 scopus 로고    scopus 로고
    • Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
    • Chen, J. et al. Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain 152, 1165-1172 (2011).
    • (2011) Pain , vol.152 , pp. 1165-1172
    • Chen, J.1
  • 164
    • 77957332682 scopus 로고    scopus 로고
    • Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels
    • Coste, B. et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330, 55-60 (2010).
    • (2010) Science , vol.330 , pp. 55-60
    • Coste, B.1
  • 165
    • 55249091085 scopus 로고    scopus 로고
    • TMEM16A confers receptor-activated calcium-dependent chloride conductance
    • Yang, Y. D. et al. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 455, 1210-1215 (2008).
    • (2008) Nature , vol.455 , pp. 1210-1215
    • Yang, Y.D.1
  • 166
    • 54949112835 scopus 로고    scopus 로고
    • TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity
    • Caputo, A. et al. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science 322, 590-594 (2008).
    • (2008) Science , vol.322 , pp. 590-594
    • Caputo, A.1
  • 167
    • 51549120559 scopus 로고    scopus 로고
    • Expression cloning of TMEM16A as a calcium-activated chloride channel subunit
    • Schroeder, B. C., Cheng, T., Jan, Y. N.&Jan, L. Y. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 134, 1019-1029 (2008).
    • (2008) Cell , vol.134 , pp. 1019-1029
    • Schroeder, B.C.1    Cheng, T.2    Jan, Y.N.3    Jan, L.Y.4
  • 168
    • 33744479684 scopus 로고    scopus 로고
    • CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry
    • Vig, M. et al. CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science 312, 1220-1223 (2006).
    • (2006) Science , vol.312 , pp. 1220-1223
    • Vig, M.1
  • 169
    • 33646576875 scopus 로고    scopus 로고
    • A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
    • Feske, S. et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 441, 179-185 (2006).
    • (2006) Nature , vol.441 , pp. 179-185
    • Feske, S.1
  • 170
    • 84888865025 scopus 로고    scopus 로고
    • Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells
    • Kiyonaka, S. et al. Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells. Nature Methods 10, 1232-1238 (2013).
    • (2013) Nature Methods , vol.10 , pp. 1232-1238
    • Kiyonaka, S.1
  • 171
    • 83755207202 scopus 로고    scopus 로고
    • A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels
    • Clapham, D. E.&Miller, C. A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. Proc. Natl Acad. Sci. USA 108, 19492-19497 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 19492-19497
    • Clapham, D.E.1    Miller, C.2
  • 172
    • 70449864498 scopus 로고    scopus 로고
    • Nociceptive signals induce trafficking of TRPA1 to the plasma membrane
    • Schmidt, M., Dubin, A. E., Petrus, M. J., Earley, T. J.&Patapoutian, A. Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron 64, 498-509 (2009).
    • (2009) Neuron , vol.64 , pp. 498-509
    • Schmidt, M.1    Dubin, A.E.2    Petrus, M.J.3    Earley, T.J.4    Patapoutian, A.5
  • 173
    • 0036183319 scopus 로고    scopus 로고
    • Molecular basis for species-specific sensitivity to "hot" chili peppers
    • Jordt, S. E.&Julius, D. Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell 108, 421-430 (2002).
    • (2002) Cell , vol.108 , pp. 421-430
    • Jordt, S.E.1    Julius, D.2
  • 174
    • 33645352477 scopus 로고    scopus 로고
    • High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol
    • Bandell, M. et al. High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nature Neurosci. 9, 493-500 (2006).
    • (2006) Nature Neurosci. , vol.9 , pp. 493-500
    • Bandell, M.1
  • 175
    • 33847050898 scopus 로고    scopus 로고
    • TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli
    • Voets, T., Owsianik, G., Janssens, A., Talavera, K.&Nilius, B. TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nature Chem. Biol. 3, 174-182 (2007).
    • (2007) Nature Chem. Biol. , vol.3 , pp. 174-182
    • Voets, T.1    Owsianik, G.2    Janssens, A.3    Talavera, K.4    Nilius, B.5
  • 176
    • 80054115971 scopus 로고    scopus 로고
    • Ligand stoichiometry of the cold- and menthol-activated channel TRPM8
    • Janssens, A.&Voets, T. Ligand stoichiometry of the cold- and menthol-activated channel TRPM8. J. Physiol. 589, 4827-4835 (2011).
    • (2011) J. Physiol. , vol.589 , pp. 4827-4835
    • Janssens, A.1    Voets, T.2
  • 177
    • 33846692923 scopus 로고    scopus 로고
    • Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
    • Macpherson, L. J. et al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445, 541-545 (2007).
    • (2007) Nature , vol.445 , pp. 541-545
    • Macpherson, L.J.1
  • 179
    • 39749169006 scopus 로고    scopus 로고
    • A single N?terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic
    • Salazar, H. et al. A single N?terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nature Neurosci. 11, 255-261 (2008).
    • (2008) Nature Neurosci. , vol.11 , pp. 255-261
    • Salazar, H.1
  • 180
    • 34548610605 scopus 로고    scopus 로고
    • Bimodal action of menthol on the transient receptor potential channel TRPA1
    • Karashima, Y. et al. Bimodal action of menthol on the transient receptor potential channel TRPA1. J. Neurosci. 27, 9874-9884 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 9874-9884
    • Karashima, Y.1
  • 181
    • 17144418518 scopus 로고    scopus 로고
    • Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)
    • McNamara, F. N., Randall, A.&Gunthorpe, M. J. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br. J. Pharmacol. 144, 781-790 (2005).
    • (2005) Br. J. Pharmacol. , vol.144 , pp. 781-790
    • McNamara, F.N.1    Randall, A.2    Gunthorpe, M.J.3
  • 182
    • 79951775130 scopus 로고    scopus 로고
    • The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil
    • Everaerts, W. et al. The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Curr. Biol. 21, 316-321 (2011).
    • (2011) Curr. Biol. , vol.21 , pp. 316-321
    • Everaerts, W.1
  • 183
    • 20144371097 scopus 로고    scopus 로고
    • The pungency of garlic: Activation of TRPA1 and TRPV1 in response to allicin
    • Macpherson, L. J. et al. The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr. Biol. 15, 929-934 (2005).
    • (2005) Curr. Biol. , vol.15 , pp. 929-934
    • Macpherson, L.J.1
  • 184
    • 79960580198 scopus 로고    scopus 로고
    • Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels
    • Yao, J., Liu, B.&Qin, F. Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels. Proc. Natl Acad. Sci. USA 108, 11109-11114 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 11109-11114
    • Yao, J.1    Liu, B.2    Qin, F.3
  • 185
    • 77951035804 scopus 로고    scopus 로고
    • Thermosensitive TRP channel pore turret is part of the temperature activation pathway
    • Yang, F., Cui, Y., Wang, K.&Zheng, J. Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc. Natl Acad. Sci. USA 107, 7083-7088 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 7083-7088
    • Yang, F.1    Cui, Y.2    Wang, K.3    Zheng, J.4
  • 186
    • 77952886805 scopus 로고    scopus 로고
    • Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain
    • Grandl, J. et al. Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. Nature Neurosci. 13, 708-714 (2010).
    • (2010) Nature Neurosci. , vol.13 , pp. 708-714
    • Grandl, J.1
  • 187
    • 51349083674 scopus 로고    scopus 로고
    • Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor i
    • Valente, P. et al. Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I. FASEB J. 22, 3298-3309 (2008).
    • (2008) FASEB J. , vol.22 , pp. 3298-3309
    • Valente, P.1
  • 188
    • 34547200183 scopus 로고    scopus 로고
    • Dissection of the components for PIP2 activation and thermosensation in TRP channels
    • Brauchi, S. et al. Dissection of the components for PIP2 activation and thermosensation in TRP channels. Proc. Natl Acad. Sci. USA 104, 10246-10251 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 10246-10251
    • Brauchi, S.1
  • 189
    • 0037443098 scopus 로고    scopus 로고
    • Functional role of C?terminal cytoplasmic tail of rat vanilloid receptor 1
    • Vlachova, V. et al. Functional role of C?terminal cytoplasmic tail of rat vanilloid receptor 1. J. Neurosci. 23, 1340-1350 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 1340-1350
    • Vlachova, V.1
  • 190
    • 84872016342 scopus 로고    scopus 로고
    • Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli
    • Wang, H., Schupp, M., Zurborg, S.&Heppenstall, P. A. Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli. J. Physiol. 591, 185-201 (2013).
    • (2013) J. Physiol. , vol.591 , pp. 185-201
    • Wang, H.1    Schupp, M.2    Zurborg, S.3    Heppenstall, P.A.4


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