-
2
-
-
84868231910
-
Coping with thermal challenges: Physiological adaptations to environmental temperatures
-
Tattersall, G. J. et al. Coping with thermal challenges: physiological adaptations to environmental temperatures. Compr. Physiol. 2, 2151-2202 (2012).
-
(2012)
Compr. Physiol.
, vol.2
, pp. 2151-2202
-
-
Tattersall, G.J.1
-
4
-
-
84868685382
-
Accidental hypothermia
-
Brown, D. J., Brugger, H., Boyd, J.&Paal, P. Accidental hypothermia. N. Engl. J. Med. 367, 1930-1938 (2012).
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 1930-1938
-
-
Brown, D.J.1
Brugger, H.2
Boyd, J.3
Paal, P.4
-
5
-
-
79951948671
-
Molecular mechanisms of mechanotransduction in mammalian sensory neurons
-
Delmas, P., Hao, J.&Rodat-Despoix, L. Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nature Rev. Neurosci. 12, 139-153 (2011).
-
(2011)
Nature Rev. Neurosci.
, vol.12
, pp. 139-153
-
-
Delmas, P.1
Hao, J.2
Rodat-Despoix, L.3
-
6
-
-
0004023814
-
-
McGraw-Hill Companies
-
Kandel, E. R., Schwartz, J. H., Jessell, T. M., Siegelbaum, S. A.&Hudspeth, A. J. (eds) Principles of Neural Science (McGraw-Hill Companies, 2013).
-
(2013)
Principles of Neural Science
-
-
Kandel, E.R.1
Schwartz, J.H.2
Jessell, T.M.3
Siegelbaum, S.A.4
Hudspeth, A.J.5
-
7
-
-
78049420335
-
Nociceptors: The sensors of the pain pathway
-
Dubin, A. E.&Patapoutian, A. Nociceptors: the sensors of the pain pathway. J. Clin. Invest. 120, 3760-3772 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 3760-3772
-
-
Dubin, A.E.1
Patapoutian, A.2
-
9
-
-
70349845440
-
Cellular and molecular mechanisms of pain
-
Basbaum, A. I., Bautista, D. M., Scherrer, G.&Julius, D. Cellular and molecular mechanisms of pain. Cell 139, 267-284 (2009).
-
(2009)
Cell
, vol.139
, pp. 267-284
-
-
Basbaum, A.I.1
Bautista, D.M.2
Scherrer, G.3
Julius, D.4
-
10
-
-
75149138261
-
Unmyelinated afferents in human skin and their responsiveness to low temperature
-
Campero, M.&Bostock, H. Unmyelinated afferents in human skin and their responsiveness to low temperature. Neurosci. Lett. 470, 188-192 (2010).
-
(2010)
Neurosci. Lett.
, vol.470
, pp. 188-192
-
-
Campero, M.1
Bostock, H.2
-
11
-
-
0014993968
-
Analysis of cutaneous warm and cold fibres in primates
-
Hensel, H.&Iggo, A. Analysis of cutaneous warm and cold fibres in primates. Pflugers Arch. 329, 1-8 (1971).
-
(1971)
Pflugers Arch.
, vol.329
, pp. 1-8
-
-
Hensel, H.1
Iggo, A.2
-
12
-
-
59849121339
-
Phenotyping sensory nerve endings in vitro in the mouse
-
Zimmermann, K. et al. Phenotyping sensory nerve endings in vitro in the mouse. Nature Protoc. 4, 174-196 (2009).
-
(2009)
Nature Protoc.
, vol.4
, pp. 174-196
-
-
Zimmermann, K.1
-
13
-
-
34447513770
-
Neurophysiology: Channelling cold reception
-
Nilius, B.&Voets, T. Neurophysiology: channelling cold reception. Nature 448, 147-148 (2007).
-
(2007)
Nature
, vol.448
, pp. 147-148
-
-
Nilius, B.1
Voets, T.2
-
14
-
-
77954387411
-
Temporal characteristics of cold pain perception
-
Frolich, M. A., Bolding, M. S., Cutter, G. R., Ness, T. J.&Zhang, K. Temporal characteristics of cold pain perception. Neurosci. Lett. 480, 12-15 (2010).
-
(2010)
Neurosci. Lett.
, vol.480
, pp. 12-15
-
-
Frolich, M.A.1
Bolding, M.S.2
Cutter, G.R.3
Ness, T.J.4
Zhang, K.5
-
15
-
-
0021368388
-
Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: Simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C?fibers
-
Torebjork, H. E., LaMotte, R. H.&Robinson, C. J. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C?fibers. J. Neurophysiol. 51, 325-339 (1984).
-
(1984)
J. Neurophysiol.
, vol.51
, pp. 325-339
-
-
Torebjork, H.E.1
Lamotte, R.H.2
Robinson, C.J.3
-
16
-
-
84893718412
-
Peripheral gating of pain signals by endogenous lipid mediators
-
Piomelli, D.&Sasso, O. Peripheral gating of pain signals by endogenous lipid mediators. Nature Neurosci. 17, 164-174 (2014).
-
(2014)
Nature Neurosci.
, vol.17
, pp. 164-174
-
-
Piomelli, D.1
Sasso, O.2
-
17
-
-
70349659983
-
The transient receptor potential vanilloid?1 channel in thermoregulation: A thermosensor it is not
-
Romanovsky, A. A. et al. The transient receptor potential vanilloid?1 channel in thermoregulation: a thermosensor it is not. Pharmacol. Rev. 61, 228-261 (2009).
-
(2009)
Pharmacol. Rev.
, vol.61
, pp. 228-261
-
-
Romanovsky, A.A.1
-
18
-
-
80155201442
-
Central circuitries for body temperature regulation and fever
-
Nakamura, K. Central circuitries for body temperature regulation and fever. Am. J. Physiol. Regul. Integr. Comp. Physiol. 301, R1207-R1228 (2011).
-
(2011)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.301
-
-
Nakamura, K.1
-
19
-
-
84862140556
-
Central control of thermogenesis
-
Clapham, J. C. Central control of thermogenesis. Neuropharmacology 63, 111-123 (2012).
-
(2012)
Neuropharmacology
, vol.63
, pp. 111-123
-
-
Clapham, J.C.1
-
20
-
-
24644439900
-
Sensing with TRP channels
-
Voets, T., Talavera, K., Owsianik, G.&Nilius, B. Sensing with TRP channels. Nature Chem. Biol. 1, 85-92 (2005).
-
(2005)
Nature Chem. Biol.
, vol.1
, pp. 85-92
-
-
Voets, T.1
Talavera, K.2
Owsianik, G.3
Nilius, B.4
-
21
-
-
0034646740
-
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
-
Caterina, M. J. et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306-313 (2000).
-
(2000)
Science
, vol.288
, pp. 306-313
-
-
Caterina, M.J.1
-
22
-
-
0034636441
-
Vanilloid receptor?1 is essential for inflammatory thermal hyperalgesia
-
Davis, J. B. et al. Vanilloid receptor?1 is essential for inflammatory thermal hyperalgesia. Nature 405, 183-187 (2000).
-
(2000)
Nature
, vol.405
, pp. 183-187
-
-
Davis, J.B.1
-
23
-
-
59049096524
-
TRPA1 acts as a cold sensor in vitro and in vivo
-
Karashima, Y. et al. TRPA1 acts as a cold sensor in vitro and in vivo. Proc. Natl Acad. Sci. USA 106, 1273-1278 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 1273-1278
-
-
Karashima, Y.1
-
24
-
-
14644392188
-
Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin
-
Moqrich, A. et al. Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science 307, 1468-1472 (2005).
-
(2005)
Science
, vol.307
, pp. 1468-1472
-
-
Moqrich, A.1
-
25
-
-
84862007810
-
TRP channels
-
Gees, M., Owsianik, G., Nilius, B.&Voets, T. TRP channels. Compr. Physiol. 2, 563-608 (2012).
-
(2012)
Compr. Physiol.
, vol.2
, pp. 563-608
-
-
Gees, M.1
Owsianik, G.2
Nilius, B.3
Voets, T.4
-
26
-
-
0030777012
-
The capsaicin receptor: A heat-activated ion channel in the pain pathway
-
Caterina, M. J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816-824 (1997).
-
(1997)
Nature
, vol.389
, pp. 816-824
-
-
Caterina, M.J.1
-
27
-
-
84889607320
-
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
-
Liao, M., Cao, E., Julius, D.&Cheng, Y. Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature 504, 107-112 (2013).
-
(2013)
Nature
, vol.504
, pp. 107-112
-
-
Liao, M.1
Cao, E.2
Julius, D.3
Cheng, Y.4
-
28
-
-
0032169804
-
The cloned capsaicin receptor integrates multiple pain-producing stimuli
-
Tominaga, M. et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21, 531-543 (1998).
-
(1998)
Neuron
, vol.21
, pp. 531-543
-
-
Tominaga, M.1
-
29
-
-
0033614984
-
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
-
Zygmunt, P. M. et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400, 452-457 (1999).
-
(1999)
Nature
, vol.400
, pp. 452-457
-
-
Zygmunt, P.M.1
-
30
-
-
0004906771
-
Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
-
Hwang, S. W. et al. Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc. Natl Acad. Sci. USA 97, 6155-6160 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 6155-6160
-
-
Hwang, S.W.1
-
31
-
-
41949096621
-
Herbal compounds and toxins modulating TRP channels
-
Vriens, J., Nilius, B.&Vennekens, R. Herbal compounds and toxins modulating TRP channels. Curr. Neuropharmacol. 6, 79-96 (2008).
-
(2008)
Curr. Neuropharmacol.
, vol.6
, pp. 79-96
-
-
Vriens, J.1
Nilius, B.2
Vennekens, R.3
-
32
-
-
84865336959
-
Targeting TRPV1 for pain relief: Limits, losers and laurels
-
Szallasi, A.&Sheta, M. Targeting TRPV1 for pain relief: limits, losers and laurels. Expert Opin. Investig. Drugs 21, 1351-1369 (2012).
-
(2012)
Expert Opin. Investig. Drugs
, vol.21
, pp. 1351-1369
-
-
Szallasi, A.1
Sheta, M.2
-
33
-
-
84872249123
-
An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UVB-inflamed and normal skin
-
Schaffler, K. et al. An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UVB-inflamed and normal skin. Br. J. Clin. Pharmacol. 75, 404-414 (2013).
-
(2013)
Br. J. Clin. Pharmacol.
, vol.75
, pp. 404-414
-
-
Schaffler, K.1
-
34
-
-
0033119629
-
A capsaicin-receptor homologue with a high threshold for noxious heat
-
Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J.&Julius, D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398, 436-441 (1999).
-
(1999)
Nature
, vol.398
, pp. 436-441
-
-
Caterina, M.J.1
Rosen, T.A.2
Tominaga, M.3
Brake, A.J.4
Julius, D.5
-
35
-
-
80051556902
-
TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception
-
Park, U. et al. TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J. Neurosci. 31, 11425-11436 (2011).
-
(2011)
J. Neurosci.
, vol.31
, pp. 11425-11436
-
-
Park, U.1
-
36
-
-
0036703646
-
Heat-evoked activation of the ion channel, TRPV4
-
Guler, A. D. et al. Heat-evoked activation of the ion channel, TRPV4. J. Neurosci. 22, 6408-6414 (2002).
-
(2002)
J. Neurosci.
, vol.22
, pp. 6408-6414
-
-
Guler, A.D.1
-
37
-
-
0037077041
-
A heat-sensitive TRP channel expressed in keratinocytes
-
Peier, A. M. et al. A heat-sensitive TRP channel expressed in keratinocytes. Science 296, 2046-2049 (2002).
-
(2002)
Science
, vol.296
, pp. 2046-2049
-
-
Peier, A.M.1
-
38
-
-
18444408683
-
TRPV3 is a temperature-sensitive vanilloid receptor-like protein
-
Smith, G. D. et al. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418, 186-190 (2002).
-
(2002)
Nature
, vol.418
, pp. 186-190
-
-
Smith, G.D.1
-
39
-
-
0037033077
-
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells
-
Watanabe, H. et al. Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J. Biol. Chem. 277, 47044-47051 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 47044-47051
-
-
Watanabe, H.1
-
40
-
-
0037062915
-
TRPV3 is a calcium-permeable temperature-sensitive cation channel
-
Xu, H. et al. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418, 181-186 (2002).
-
(2002)
Nature
, vol.418
, pp. 181-186
-
-
Xu, H.1
-
41
-
-
0037062915
-
TRPV3 is a calcium-permeable temperature-sensitive cation channel
-
Xu, H. et al. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418, 181-186 (2002).
-
(2002)
Nature
, vol.418
, pp. 181-186
-
-
Xu, H.1
-
42
-
-
84873593440
-
Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse
-
Vandewauw, I., Owsianik, G.&Voets, T. Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse. BMC Neurosci. 14, 21 (2013).
-
(2013)
BMC Neurosci.
, vol.14
, pp. 21
-
-
Vandewauw, I.1
Owsianik, G.2
Voets, T.3
-
43
-
-
70349577888
-
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP
-
Mandadi, S. et al. TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch. 458, 1093-1102 (2009).
-
(2009)
Pflugers Arch.
, vol.458
, pp. 1093-1102
-
-
Mandadi, S.1
-
44
-
-
84880308811
-
TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin
-
Miyamoto, T., Petrus, M. J., Dubin, A. E.&Patapoutian, A. TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin. Nature Commun. 2, 369 (2011).
-
(2011)
Nature Commun.
, vol.2
, pp. 369
-
-
Miyamoto, T.1
Petrus, M.J.2
Dubin, A.E.3
Patapoutian, A.4
-
45
-
-
79960377146
-
Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes
-
Mihara, H., Boudaka, A., Sugiyama, T., Moriyama, Y.&Tominaga, M. Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes. J. Physiol. 589, 3471-3482 (2011).
-
(2011)
J. Physiol.
, vol.589
, pp. 3471-3482
-
-
Mihara, H.1
Boudaka, A.2
Sugiyama, T.3
Moriyama, Y.4
Tominaga, M.5
-
46
-
-
13944255381
-
Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4
-
Lee, H., Iida, T., Mizuno, A., Suzuki, M.&Caterina, M. J. Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J. Neurosci. 25, 1304-1310 (2005).
-
(2005)
J. Neurosci.
, vol.25
, pp. 1304-1310
-
-
Lee, H.1
Iida, T.2
Mizuno, A.3
Suzuki, M.4
Caterina, M.J.5
-
47
-
-
79955973368
-
TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation
-
Huang, S. M., Li, X., Yu, Y., Wang, J.&Caterina, M. J. TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation. Mol. Pain 7, 37 (2011).
-
(2011)
Mol. Pain
, vol.7
, pp. 37
-
-
Huang, S.M.1
Li, X.2
Yu, Y.3
Wang, J.4
Caterina, M.J.5
-
48
-
-
0035042044
-
Transgenic studies of pain and analgesia: Mutation or background genotype? J
-
Lariviere, W. R., Chesler, E. J.&Mogil, J. S. Transgenic studies of pain and analgesia: mutation or background genotype? J. Pharmacol. Exp. Ther. 297, 467-473 (2001).
-
(2001)
Pharmacol. Exp. Ther.
, vol.297
, pp. 467-473
-
-
Lariviere, W.R.1
Chesler, E.J.2
Mogil, J.S.3
-
49
-
-
57049164233
-
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic cells
-
Wagner, T. F. et al. Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic ? cells. Nature Cell Biol. 10, 1421-1430 (2008).
-
(2008)
Nature Cell Biol.
, vol.10
, pp. 1421-1430
-
-
Wagner, T.F.1
-
50
-
-
79955667133
-
TRPM3 is a nociceptor channel involved in the detection of noxious heat
-
Vriens, J. et al. TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron 70, 482-494 (2011).
-
(2011)
Neuron
, vol.70
, pp. 482-494
-
-
Vriens, J.1
-
51
-
-
84886001653
-
Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo
-
Straub, I. et al. Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo. Mol. Pharmacol. 84, 736-750 (2013).
-
(2013)
Mol. Pharmacol.
, vol.84
, pp. 736-750
-
-
Straub, I.1
-
52
-
-
84875411249
-
The cellular code for mammalian thermosensation
-
Pogorzala, L. A., Mishra, S. K.&Hoon, M. A. The cellular code for mammalian thermosensation. J. Neurosci. 33, 5533-5541 (2013).
-
(2013)
J. Neurosci.
, vol.33
, pp. 5533-5541
-
-
Pogorzala, L.A.1
Mishra, S.K.2
Hoon, M.A.3
-
53
-
-
72149111657
-
Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation
-
Mishra, S. K.&Hoon, M. A. Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation. Mol. Cell. Neurosci. 43, 157-163 (2010).
-
(2010)
Mol. Cell. Neurosci.
, vol.43
, pp. 157-163
-
-
Mishra, S.K.1
Hoon, M.A.2
-
54
-
-
0037034931
-
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
-
McKemy, D. D., Neuhausser, W. M.&Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416, 52-58 (2002).
-
(2002)
Nature
, vol.416
, pp. 52-58
-
-
McKemy, D.D.1
Neuhausser, W.M.2
Julius, D.3
-
55
-
-
18344386202
-
A TRP channel that senses cold stimuli and menthol
-
Peier, A. M. et al. A TRP channel that senses cold stimuli and menthol. Cell 108, 705-715 (2002).
-
(2002)
Cell
, vol.108
, pp. 705-715
-
-
Peier, A.M.1
-
56
-
-
34447542435
-
The menthol receptor TRPM8 is the principal detector of environmental cold
-
Bautista, D. M. et al. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448, 204-208 (2007).
-
(2007)
Nature
, vol.448
, pp. 204-208
-
-
Bautista, D.M.1
-
57
-
-
34247472646
-
Attenuated cold sensitivity in TRPM8 null mice
-
Colburn, R. W. et al. Attenuated cold sensitivity in TRPM8 null mice. Neuron 54, 379-386 (2007).
-
(2007)
Neuron
, vol.54
, pp. 379-386
-
-
Colburn, R.W.1
-
58
-
-
34247487011
-
TRPM8 is required for cold sensation in mice
-
Dhaka, A. et al. TRPM8 is required for cold sensation in mice. Neuron 54, 371-378 (2007).
-
(2007)
Neuron
, vol.54
, pp. 371-378
-
-
Dhaka, A.1
-
59
-
-
78650026896
-
Ocular surface wetness is regulated by TRPM8?dependent cold thermoreceptors of the cornea
-
Parra, A. et al. Ocular surface wetness is regulated by TRPM8?dependent cold thermoreceptors of the cornea. Nature Med. 16, 1396-1399 (2010).
-
(2010)
Nature Med.
, vol.16
, pp. 1396-1399
-
-
Parra, A.1
-
60
-
-
84873920079
-
A sensory-labeled line for cold: TRPM8?expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia
-
Knowlton, W. M. et al. A sensory-labeled line for cold: TRPM8?expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia. J. Neurosci. 33, 2837-2848 (2013).
-
(2013)
J. Neurosci.
, vol.33
, pp. 2837-2848
-
-
Knowlton, W.M.1
-
61
-
-
0345616438
-
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
-
Story, G. M. et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112, 819-829 (2003).
-
(2003)
Cell
, vol.112
, pp. 819-829
-
-
Story, G.M.1
-
62
-
-
1842475312
-
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
-
Bandell, M. et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41, 849-857 (2004).
-
(2004)
Neuron
, vol.41
, pp. 849-857
-
-
Bandell, M.1
-
63
-
-
34447342575
-
Cold sensitivity of recombinant TRPA1 channels
-
Sawada, Y., Hosokawa, H., Hori, A., Matsumura, K.&Kobayashi, S. Cold sensitivity of recombinant TRPA1 channels. Brain Res. 1160, 39-46 (2007).
-
(2007)
Brain Res.
, vol.1160
, pp. 39-46
-
-
Sawada, Y.1
Hosokawa, H.2
Hori, A.3
Matsumura, K.4
Kobayashi, S.5
-
64
-
-
50349100515
-
TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: Pharmacological and genetic evidence
-
Fajardo, O., Meseguer, V., Belmonte, C.&Viana, F. TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence. J. Neurosci. 28, 7863-7875 (2008).
-
(2008)
J. Neurosci.
, vol.28
, pp. 7863-7875
-
-
Fajardo, O.1
Meseguer, V.2
Belmonte, C.3
Viana, F.4
-
65
-
-
77953681608
-
A gain?of?function mutation in TRPA1 causes familial episodic pain syndrome
-
Kremeyer, B. et al. A gain?of?function mutation in TRPA1 causes familial episodic pain syndrome. Neuron 66, 671-680 (2010).
-
(2010)
Neuron
, vol.66
, pp. 671-680
-
-
Kremeyer, B.1
-
66
-
-
1642430679
-
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
-
Jordt, S. E. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427, 260-265 (2004).
-
(2004)
Nature
, vol.427
, pp. 260-265
-
-
Jordt, S.E.1
-
67
-
-
70349559585
-
Nicotine activates the chemosensory cation channel TRPA1
-
Talavera, K. et al. Nicotine activates the chemosensory cation channel TRPA1. Nature Neurosci. 12, 1293-1299 (2009).
-
(2009)
Nature Neurosci.
, vol.12
, pp. 1293-1299
-
-
Talavera, K.1
-
68
-
-
33646061333
-
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
-
Kwan, K. Y. et al. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 50, 277-289 (2006).
-
(2006)
Neuron
, vol.50
, pp. 277-289
-
-
Kwan, K.Y.1
-
69
-
-
76949100698
-
The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity
-
Gentry, C., Stoakley, N., Andersson, D. A.&Bevan, S. The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity. Mol. Pain 6, 4 (2010).
-
(2010)
Mol. Pain
, vol.6
, pp. 4
-
-
Gentry, C.1
Stoakley, N.2
Andersson, D.A.3
Bevan, S.4
-
70
-
-
33847241778
-
Direct activation of the ion channel TRPA1 by Ca2+
-
Zurborg, S., Yurgionas, B., Jira, J. A., Caspani, O.&Heppenstall, P. A. Direct activation of the ion channel TRPA1 by Ca2+. Nature Neurosci. 10, 277-279 (2007).
-
(2007)
Nature Neurosci.
, vol.10
, pp. 277-279
-
-
Zurborg, S.1
Yurgionas, B.2
Jira, J.A.3
Caspani, O.4
Heppenstall, P.A.5
-
71
-
-
84885145935
-
Species differences and molecular determinant of TRPA1 cold sensitivity
-
Chen, J. et al. Species differences and molecular determinant of TRPA1 cold sensitivity. Nature Commun. 4, 2501 (2013).
-
(2013)
Nature Commun.
, vol.4
, pp. 2501
-
-
Chen, J.1
-
72
-
-
33646045075
-
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
-
Bautista, D. M. et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124, 1269-1282 (2006).
-
(2006)
Cell
, vol.124
, pp. 1269-1282
-
-
Bautista, D.M.1
-
73
-
-
77955304238
-
TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo
-
Knowlton, W. M., Bifolck-Fisher, A., Bautista, D. M.&McKemy, D. D. TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Pain 150, 340-350 (2010).
-
(2010)
Pain
, vol.150
, pp. 340-350
-
-
Knowlton, W.M.1
Bifolck-Fisher, A.2
Bautista, D.M.3
McKemy, D.D.4
-
74
-
-
78149485777
-
TRPA1 contributes to cold hypersensitivity
-
del Camino, D. et al. TRPA1 contributes to cold hypersensitivity. J. Neurosci. 30, 15165-15174 (2010).
-
(2010)
J. Neurosci.
, vol.30
, pp. 15165-15174
-
-
Del Camino, D.1
-
75
-
-
81055141456
-
Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system
-
Zimmermann, K. et al. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc. Natl Acad. Sci. USA 108, 18114-18119 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 18114-18119
-
-
Zimmermann, K.1
-
76
-
-
83455199984
-
International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-activated chloride channels
-
Huang, F., Wong, X.&Jan, L. Y. International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels. Pharmacol. Rev. 64, 1-15 (2012).
-
(2012)
Pharmacol. Rev.
, vol.64
, pp. 1-15
-
-
Huang, F.1
Wong, X.2
Jan, L.Y.3
-
77
-
-
84862896642
-
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons
-
Cho, H. et al. The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nature Neurosci. 15, 1015-1021 (2012).
-
(2012)
Nature Neurosci.
, vol.15
, pp. 1015-1021
-
-
Cho, H.1
-
78
-
-
84892763451
-
Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity
-
Lee, B. et al. Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity. Mol. Pain 10, 5 (2014).
-
(2014)
Mol. Pain
, vol.10
, pp. 5
-
-
Lee, B.1
-
79
-
-
66949137457
-
STIMulating store-operated Ca2+ entry
-
Cahalan, M. D. STIMulating store-operated Ca2+ entry. Nature Cell Biol. 11, 669-677 (2009).
-
(2009)
Nature Cell Biol.
, vol.11
, pp. 669-677
-
-
Cahalan, M.D.1
-
80
-
-
85027919657
-
Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression
-
Xiao, B., Coste, B., Mathur, J.&Patapoutian, A. Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression. Nature Chem. Biol. 7, 351-358 (2011).
-
(2011)
Nature Chem. Biol.
, vol.7
, pp. 351-358
-
-
Xiao, B.1
Coste, B.2
Mathur, J.3
Patapoutian, A.4
-
81
-
-
0036183242
-
Specificity of cold thermotransduction is determined by differential ionic channel expression
-
Viana, F., de la Pena, E.&Belmonte, C. Specificity of cold thermotransduction is determined by differential ionic channel expression. Nature Neurosci. 5, 254-260 (2002).
-
(2002)
Nature Neurosci.
, vol.5
, pp. 254-260
-
-
Viana, F.1
De La Pena, E.2
Belmonte, C.3
-
82
-
-
33947360830
-
The neuronal background K2P channels: Focus on TREK1
-
Honore, E. The neuronal background K2P channels: focus on TREK1. Nature Rev. Neurosci. 8, 251-261 (2007).
-
(2007)
Nature Rev. Neurosci.
, vol.8
, pp. 251-261
-
-
Honore, E.1
-
83
-
-
0034213381
-
TREK?1 is a heat-activated background K+ channel
-
Maingret, F. et al. TREK?1 is a heat-activated background K+ channel. EMBO J. 19, 2483-2491 (2000).
-
(2000)
EMBO J.
, vol.19
, pp. 2483-2491
-
-
Maingret, F.1
-
84
-
-
17444411944
-
Thermosensitivity of the two-pore domain K+ channels TREK?2 and TRAAK
-
Kang, D., Choe, C.&Kim, D. Thermosensitivity of the two-pore domain K+ channels TREK?2 and TRAAK. J. Physiol. 564, 103-116 (2005).
-
(2005)
J. Physiol.
, vol.564
, pp. 103-116
-
-
Kang, D.1
Choe, C.2
Kim, D.3
-
85
-
-
33745741107
-
TREK?1, a K+ channel involved in polymodal pain perception
-
Alloui, A. et al. TREK?1, a K+ channel involved in polymodal pain perception. EMBO J. 25, 2368-2376 (2006).
-
(2006)
EMBO J.
, vol.25
, pp. 2368-2376
-
-
Alloui, A.1
-
86
-
-
65649147153
-
The mechano-activated K+ channels TRAAK and TREK?1 control both warm and cold perception
-
Noel, J. et al. The mechano-activated K+ channels TRAAK and TREK?1 control both warm and cold perception. EMBO J. 28, 1308-1318 (2009).
-
(2009)
EMBO J.
, vol.28
, pp. 1308-1318
-
-
Noel, J.1
-
87
-
-
84861716984
-
Voltage-gated sodium channels at 60: Structure, function and pathophysiology
-
Catterall, W. A. Voltage-gated sodium channels at 60: structure, function and pathophysiology. J. Physiol. 590, 2577-2589 (2012).
-
(2012)
J. Physiol.
, vol.590
, pp. 2577-2589
-
-
Catterall, W.A.1
-
88
-
-
34250306409
-
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures
-
Zimmermann, K. et al. Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature 447, 855-858 (2007).
-
(2007)
Nature
, vol.447
, pp. 855-858
-
-
Zimmermann, K.1
-
89
-
-
48749123103
-
The cell and molecular basis of mechanical, cold, and inflammatory pain
-
Abrahamsen, B. et al. The cell and molecular basis of mechanical, cold, and inflammatory pain. Science 321, 702-705 (2008).
-
(2008)
Science
, vol.321
, pp. 702-705
-
-
Abrahamsen, B.1
-
90
-
-
0032449839
-
Mechanical aspects of membrane thermodynamics. Estimation of the mechanical properties of lipid membranes close to the chain melting transition from calorimetry
-
Heimburg, T. Mechanical aspects of membrane thermodynamics. Estimation of the mechanical properties of lipid membranes close to the chain melting transition from calorimetry. Biochim. Biophys. Acta 1415, 147-162 (1998).
-
(1998)
Biochim. Biophys. Acta
, vol.1415
, pp. 147-162
-
-
Heimburg, T.1
-
91
-
-
83455234830
-
Decrease in phosphatidylinositol 4,5?bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels
-
Yudin, Y., Lukacs, V., Cao, C.&Rohacs, T. Decrease in phosphatidylinositol 4,5?bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels. J. Physiol. 589, 6007-6027 (2011).
-
(2011)
J. Physiol.
, vol.589
, pp. 6007-6027
-
-
Yudin, Y.1
Lukacs, V.2
Cao, C.3
Rohacs, T.4
-
92
-
-
33344459507
-
Signaling protein complexes associated with neuronal ion channels
-
Levitan, I. B. Signaling protein complexes associated with neuronal ion channels. Nature Neurosci. 9, 305-310 (2006).
-
(2006)
Nature Neurosci.
, vol.9
, pp. 305-310
-
-
Levitan, I.B.1
-
93
-
-
0024280882
-
Regulation of a heart potassium channel by protein kinase A and C
-
Walsh, K. B.&Kass, R. S. Regulation of a heart potassium channel by protein kinase A and C. Science 242, 67-69 (1988).
-
(1988)
Science
, vol.242
, pp. 67-69
-
-
Walsh, K.B.1
Kass, R.S.2
-
94
-
-
77957349183
-
The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels
-
Wang, Y. et al. The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels. Science 330, 105-109 (2010).
-
(2010)
Science
, vol.330
, pp. 105-109
-
-
Wang, Y.1
-
95
-
-
77957332175
-
The CRAC channel activator STIM1 binds and inhibits L?type voltage-gated calcium channels
-
Park, C. Y., Shcheglovitov, A.&Dolmetsch, R. The CRAC channel activator STIM1 binds and inhibits L?type voltage-gated calcium channels. Science 330, 101-105 (2010).
-
(2010)
Science
, vol.330
, pp. 101-105
-
-
Park, C.Y.1
Shcheglovitov, A.2
Dolmetsch, R.3
-
96
-
-
34447097610
-
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels
-
Yuan, J. P., Zeng, W., Huang, G. N., Worley, P. F.&Muallem, S. STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nature Cell Biol. 9, 636-645 (2007).
-
(2007)
Nature Cell Biol.
, vol.9
, pp. 636-645
-
-
Yuan, J.P.1
Zeng, W.2
Huang, G.N.3
Worley, P.F.4
Muallem, S.5
-
97
-
-
65749099406
-
TRPC channels function independently of STIM1 and Orai1
-
DeHaven, W. I. et al. TRPC channels function independently of STIM1 and Orai1. J. Physiol. 587, 2275-2298 (2009).
-
(2009)
J. Physiol.
, vol.587
, pp. 2275-2298
-
-
Dehaven, W.I.1
-
98
-
-
77956799526
-
Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers
-
Zakharian, E., Cao, C.&Rohacs, T. Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers. J. Neurosci. 30, 12526-12534 (2010).
-
(2010)
J. Neurosci.
, vol.30
, pp. 12526-12534
-
-
Zakharian, E.1
Cao, C.2
Rohacs, T.3
-
99
-
-
84874229704
-
TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids
-
Cao, E., Cordero-Morales, J. F., Liu, B., Qin, F.&Julius, D. TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron 77, 667-679 (2013).
-
(2013)
Neuron
, vol.77
, pp. 667-679
-
-
Cao, E.1
Cordero-Morales, J.F.2
Liu, B.3
Qin, F.4
Julius, D.5
-
100
-
-
30744463490
-
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste
-
Talavera, K. et al. Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature 438, 1022-1025 (2005).
-
(2005)
Nature
, vol.438
, pp. 1022-1025
-
-
Talavera, K.1
-
101
-
-
4043077669
-
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
-
Voets, T. et al. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430, 748-754 (2004).
-
(2004)
Nature
, vol.430
, pp. 748-754
-
-
Voets, T.1
-
103
-
-
77955667059
-
Kinetic and energetic analysis of thermally activated TRPV1 channels
-
Yao, J., Liu, B.&Qin, F. Kinetic and energetic analysis of thermally activated TRPV1 channels. Biophys. J. 99, 1743-1753 (2010).
-
(2010)
Biophys. J.
, vol.99
, pp. 1743-1753
-
-
Yao, J.1
Liu, B.2
Qin, F.3
-
104
-
-
33646899582
-
A hot-sensing cold receptor: C?terminal domain determines thermosensation in transient receptor potential channels
-
Brauchi, S., Orta, G., Salazar, M., Rosenmann, E.&Latorre, R. A hot-sensing cold receptor: C?terminal domain determines thermosensation in transient receptor potential channels. J. Neurosci. 26, 4835-4840 (2006).
-
(2006)
J. Neurosci.
, vol.26
, pp. 4835-4840
-
-
Brauchi, S.1
Orta, G.2
Salazar, M.3
Rosenmann, E.4
Latorre, R.5
-
105
-
-
34547953765
-
ThermoTRP channels as modular proteins with allosteric gating
-
Latorre, R., Brauchi, S., Orta, G., Zaelzer, C.&Vargas, G. ThermoTRP channels as modular proteins with allosteric gating. Cell Calcium 42, 427-438 (2007).
-
(2007)
Cell Calcium
, vol.42
, pp. 427-438
-
-
Latorre, R.1
Brauchi, S.2
Orta, G.3
Zaelzer, C.4
Vargas, G.5
-
106
-
-
50249186498
-
Pore region of TRPV3 ion channel is specifically required for heat activation
-
Grandl, J. et al. Pore region of TRPV3 ion channel is specifically required for heat activation. Nature Neurosci. 11, 1007-1013 (2008).
-
(2008)
Nature Neurosci.
, vol.11
, pp. 1007-1013
-
-
Grandl, J.1
-
107
-
-
81755185888
-
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
-
Cordero-Morales, J. F., Gracheva, E. O.&Julius, D. Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc. Natl Acad. Sci. USA 108, E1184-E1191 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
-
-
Cordero-Morales, J.F.1
Gracheva, E.O.2
Julius, D.3
-
108
-
-
84862845558
-
Quantifying and modeling the temperature-dependent gating of TRP channels
-
Voets, T. Quantifying and modeling the temperature-dependent gating of TRP channels. Rev. Physiol. Biochem. Pharmacol. 162, 91-119 (2012).
-
(2012)
Rev. Physiol. Biochem. Pharmacol.
, vol.162
, pp. 91-119
-
-
Voets, T.1
-
109
-
-
84889594608
-
TRPV1 structures in distinct conformations reveal activation mechanisms
-
Cao, E., Liao, M., Cheng, Y.&Julius, D. TRPV1 structures in distinct conformations reveal activation mechanisms. Nature 504, 113-118 (2013).
-
(2013)
Nature
, vol.504
, pp. 113-118
-
-
Cao, E.1
Liao, M.2
Cheng, Y.3
Julius, D.4
-
110
-
-
79959341776
-
Thermosensory and mechanosensory perception in human genetic disease
-
Tan, P. L.&Katsanis, N. Thermosensory and mechanosensory perception in human genetic disease. Hum. Mol. Genet. 18, R146-R155 (2009).
-
(2009)
Hum. Mol. Genet.
, vol.18
-
-
Tan, P.L.1
Katsanis, N.2
-
111
-
-
84887824401
-
Experimental pain phenotype profiles in a racially and ethnically diverse sample of healthy adults
-
Cruz-Almeida, Y., Riley, J. L.&Fillingim, R. B. Experimental pain phenotype profiles in a racially and ethnically diverse sample of healthy adults. Pain Med. 14, 1708-1718 (2013).
-
(2013)
Pain Med.
, vol.14
, pp. 1708-1718
-
-
Cruz-Almeida, Y.1
Riley, J.L.2
Fillingim, R.B.3
-
112
-
-
77249117952
-
Somesthetic senses
-
Hollins, M. Somesthetic senses. Annu. Rev. Psychol. 61, 243-271 (2010).
-
(2010)
Annu. Rev. Psychol.
, vol.61
, pp. 243-271
-
-
Hollins, M.1
-
113
-
-
33846269106
-
Genetic predictors for acute experimental cold and heat pain sensitivity in humans
-
Kim, H., Mittal, D. P., Iadarola, M. J.&Dionne, R. A. Genetic predictors for acute experimental cold and heat pain sensitivity in humans. J. Med. Genet. 43, e40 (2006).
-
(2006)
J. Med. Genet.
, vol.43
-
-
Kim, H.1
Mittal, D.P.2
Iadarola, M.J.3
Dionne, R.A.4
-
114
-
-
79953193743
-
Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients
-
Binder, A. et al. Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. PLoS ONE 6, e17387 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Binder, A.1
-
115
-
-
79951579664
-
Central sensitization: Implications for the diagnosis and treatment of pain
-
Woolf, C. J. Central sensitization: implications for the diagnosis and treatment of pain. Pain 152, S2-S15 (2011).
-
(2011)
Pain
, vol.152
-
-
Woolf, C.J.1
-
116
-
-
0035855860
-
Molecular mechanisms of nociception
-
Julius, D.&Basbaum, A. I. Molecular mechanisms of nociception. Nature 413, 203-210 (2001).
-
(2001)
Nature
, vol.413
, pp. 203-210
-
-
Julius, D.1
Basbaum, A.I.2
-
117
-
-
84892604923
-
Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice
-
Sisignano, M. et al. Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. PLoS ONE 8, e81228 (2013).
-
(2013)
PLoS ONE
, vol.8
-
-
Sisignano, M.1
-
118
-
-
0034608878
-
Acid potentiation of the capsaicin receptor determined by a key extracellular site
-
Jordt, S. E., Tominaga, M.&Julius, D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc. Natl Acad. Sci. USA 97, 8134-8139 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 8134-8139
-
-
Jordt, S.E.1
Tominaga, M.2
Julius, D.3
-
119
-
-
0035927651
-
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2?mediated inhibition
-
Chuang, H. H. et al. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2?mediated inhibition. Nature 411, 957-962 (2001).
-
(2001)
Nature
, vol.411
, pp. 957-962
-
-
Chuang, H.H.1
-
120
-
-
0037799198
-
A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity
-
Prescott, E. D.&Julius, D. A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science 300, 1284-1288 (2003).
-
(2003)
Science
, vol.300
, pp. 1284-1288
-
-
Prescott, E.D.1
Julius, D.2
-
121
-
-
33750524257
-
Phosphoinositide 3?kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane
-
Stein, A. T., Ufret-Vincenty, C. A., Hua, L., Santana, L. F.&Gordon, S. E. Phosphoinositide 3?kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane. J. Gen. Physiol. 128, 509-522 (2006).
-
(2006)
J. Gen. Physiol.
, vol.128
, pp. 509-522
-
-
Stein, A.T.1
Ufret-Vincenty, C.A.2
Hua, L.3
Santana, L.F.4
Gordon, S.E.5
-
122
-
-
61349190400
-
Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor
-
Yao, J.&Qin, F. Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor. PLoS Biol. 7, e46 (2009).
-
(2009)
PLoS Biol.
, vol.7
-
-
Yao, J.1
Qin, F.2
-
123
-
-
0034700494
-
Induction of vanilloid receptor channel activity by protein kinase C
-
Premkumar, L. S.&Ahern, G. P. Induction of vanilloid receptor channel activity by protein kinase C. Nature 408, 985-990 (2000).
-
(2000)
Nature
, vol.408
, pp. 985-990
-
-
Premkumar, L.S.1
Ahern, G.P.2
-
124
-
-
0142059776
-
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
-
Bhave, G. et al. Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc. Natl Acad. Sci. USA 100, 12480-12485 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 12480-12485
-
-
Bhave, G.1
-
125
-
-
0037104657
-
CAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation
-
Bhave, G. et al. cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 35, 721-731 (2002).
-
(2002)
Neuron
, vol.35
, pp. 721-731
-
-
Bhave, G.1
-
126
-
-
0141634247
-
Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor
-
Bonnington, J. K.&McNaughton, P. A. Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor. J. Physiol. 551, 433-446 (2003).
-
(2003)
J. Physiol.
, vol.551
, pp. 433-446
-
-
Bonnington, J.K.1
McNaughton, P.A.2
-
127
-
-
0034954583
-
VR1 protein expression increases in undamaged DRG neurons after partial nerve injury
-
Hudson, L. J. et al. VR1 protein expression increases in undamaged DRG neurons after partial nerve injury. Eur. J. Neurosci. 13, 2105-2114 (2001).
-
(2001)
Eur. J. Neurosci.
, vol.13
, pp. 2105-2114
-
-
Hudson, L.J.1
-
128
-
-
84866007786
-
Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation
-
Zakir, H. M. et al. Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation. PLoS ONE 7, e44023 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Zakir, H.M.1
-
129
-
-
12844286900
-
Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1
-
Hong, S.&Wiley, J. W. Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. J. Biol. Chem. 280, 618-627 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 618-627
-
-
Hong, S.1
Wiley, J.W.2
-
130
-
-
79960689897
-
Streptozotocin-induced early thermal hyperalgesia is independent of glycemic state of rats: Role of transient receptor potential vanilloid 1 (TRPV1) and inflammatory mediators
-
Bishnoi, M., Bosgraaf, C. A., Abooj, M., Zhong, L.&Premkumar, L. S. Streptozotocin-induced early thermal hyperalgesia is independent of glycemic state of rats: role of transient receptor potential vanilloid 1 (TRPV1) and inflammatory mediators. Mol. Pain 7, 52 (2011).
-
(2011)
Mol. Pain
, vol.7
, pp. 52
-
-
Bishnoi, M.1
Bosgraaf, C.A.2
Abooj, M.3
Zhong, L.4
Premkumar, L.S.5
-
131
-
-
37249065119
-
TRPM8 mechanism of cold allodynia after chronic nerve injury
-
Xing, H., Chen, M., Ling, J., Tan, W.&Gu, J. G. TRPM8 mechanism of cold allodynia after chronic nerve injury. J. Neurosci. 27, 13680-13690 (2007).
-
(2007)
J. Neurosci.
, vol.27
, pp. 13680-13690
-
-
Xing, H.1
Chen, M.2
Ling, J.3
Tan, W.4
Gu, J.G.5
-
132
-
-
80053596592
-
Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice
-
Knowlton, W. M., Daniels, R. L., Palkar, R., McCoy, D. D.&McKemy, D. D. Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. PLoS ONE 6, e25894 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Knowlton, W.M.1
Daniels, R.L.2
Palkar, R.3
McCoy, D.D.4
McKemy, D.D.5
-
133
-
-
17844373771
-
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain
-
Rohacs, T., Lopes, C. M., Michailidis, I.&Logothetis, D. E. PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nature Neurosci. 8, 626-634 (2005).
-
(2005)
Nature Neurosci.
, vol.8
, pp. 626-634
-
-
Rohacs, T.1
Lopes, C.M.2
Michailidis, I.3
Logothetis, D.E.4
-
134
-
-
84875998693
-
Ambient temperature affects the temperature threshold for TRPM8 activation through interaction of phosphatidylinositol 4,5?bisphosphate
-
Fujita, F., Uchida, K., Takaishi, M., Sokabe, T.&Tominaga, M. Ambient temperature affects the temperature threshold for TRPM8 activation through interaction of phosphatidylinositol 4,5?bisphosphate. J. Neurosci. 33, 6154-6159 (2013).
-
(2013)
J. Neurosci.
, vol.33
, pp. 6154-6159
-
-
Fujita, F.1
Uchida, K.2
Takaishi, M.3
Sokabe, T.4
Tominaga, M.5
-
135
-
-
14044261739
-
Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5?bisphosphate
-
Liu, B.&Qin, F. Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5?bisphosphate. J. Neurosci. 25, 1674-1681 (2005).
-
(2005)
J. Neurosci.
, vol.25
, pp. 1674-1681
-
-
Liu, B.1
Qin, F.2
-
136
-
-
30544438062
-
Downregulation of transient receptor potential melastatin 8 by protein kinase C?mediated dephosphorylation
-
Premkumar, L. S., Raisinghani, M., Pingle, S. C., Long, C.&Pimentel, F. Downregulation of transient receptor potential melastatin 8 by protein kinase C?mediated dephosphorylation. J. Neurosci. 25, 11322-11329 (2005).
-
(2005)
J. Neurosci.
, vol.25
, pp. 11322-11329
-
-
Premkumar, L.S.1
Raisinghani, M.2
Pingle, S.C.3
Long, C.4
Pimentel, F.5
-
137
-
-
84864866637
-
Direct inhibition of the cold-activated TRPM8 ion channel by G?q
-
Zhang, X. et al. Direct inhibition of the cold-activated TRPM8 ion channel by G?q. Nature Cell Biol. 14, 851-858 (2012).
-
(2012)
Nature Cell Biol.
, vol.14
, pp. 851-858
-
-
Zhang, X.1
-
138
-
-
24644462327
-
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
-
Obata, K. et al. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J. Clin. Invest. 115, 2393-2401 (2005).
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2393-2401
-
-
Obata, K.1
-
139
-
-
33746083982
-
Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats
-
Katsura, H. et al. Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp. Neurol. 200, 112-123 (2006).
-
(2006)
Exp. Neurol.
, vol.200
, pp. 112-123
-
-
Katsura, H.1
-
140
-
-
84867097862
-
TRP channel blamed for burning cold after a tropical fish meal
-
Voets, T. TRP channel blamed for burning cold after a tropical fish meal. EMBO J. 31, 3785-3787 (2012).
-
(2012)
EMBO J.
, vol.31
, pp. 3785-3787
-
-
Voets, T.1
-
141
-
-
84867100648
-
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling
-
Vetter, I. et al. Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO J. 31, 3795-3808 (2012).
-
(2012)
EMBO J.
, vol.31
, pp. 3795-3808
-
-
Vetter, I.1
-
142
-
-
84864267922
-
Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice
-
Zhao, M. et al. Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice. Mol. Pain 8, 55 (2012).
-
(2012)
Mol. Pain
, vol.8
, pp. 55
-
-
Zhao, M.1
-
143
-
-
84862622177
-
TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism
-
Materazzi, S. et al. TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism. Pflugers Arch. 463, 561-569 (2012).
-
(2012)
Pflugers Arch.
, vol.463
, pp. 561-569
-
-
Materazzi, S.1
-
144
-
-
79958744029
-
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation
-
Nassini, R. et al. Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation. Pain 152, 1621-1631 (2011).
-
(2011)
Pain
, vol.152
, pp. 1621-1631
-
-
Nassini, R.1
-
145
-
-
79955581191
-
Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors
-
Descoeur, J. et al. Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol. Med. 3, 266-278 (2011).
-
(2011)
EMBO Mol. Med.
, vol.3
, pp. 266-278
-
-
Descoeur, J.1
-
146
-
-
78651412373
-
Epidemiology of chronic non-cancer pain in Europe: Narrative review of prevalence, pain treatments and pain impact
-
Reid, K. J. et al. Epidemiology of chronic non-cancer pain in Europe: narrative review of prevalence, pain treatments and pain impact. Curr. Med. Res. Opin. 27, 449-462 (2011).
-
(2011)
Curr. Med. Res. Opin.
, vol.27
, pp. 449-462
-
-
Reid, K.J.1
-
147
-
-
79960997710
-
Transient receptor potential channels as therapeutic targets
-
Moran, M. M., McAlexander, M. A., Biro, T.&Szallasi, A. Transient receptor potential channels as therapeutic targets. Nature Rev. Drug Discov. 10, 601-620 (2011).
-
(2011)
Nature Rev. Drug Discov.
, vol.10
, pp. 601-620
-
-
Moran, M.M.1
McAlexander, M.A.2
Biro, T.3
Szallasi, A.4
-
148
-
-
0037133281
-
Attenuation of thermal nociception and hyperalgesia by VR1 blockers
-
Garcia-Martinez, C. et al. Attenuation of thermal nociception and hyperalgesia by VR1 blockers. Proc. Natl Acad. Sci. USA 99, 2374-2379 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 2374-2379
-
-
Garcia-Martinez, C.1
-
149
-
-
20144388484
-
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain
-
Ghilardi, J. R. et al. Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J. Neurosci. 25, 3126-3131 (2005).
-
(2005)
J. Neurosci.
, vol.25
, pp. 3126-3131
-
-
Ghilardi, J.R.1
-
150
-
-
23044496253
-
A-425619 [1?isoquinolin?5?yl?3- (4?trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats
-
Honore, P. et al. A-425619 [1?isoquinolin?5?yl?3- (4?trifluoromethyl- benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. J. Pharmacol. Exp. Ther. 314, 410-421 (2005).
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.314
, pp. 410-421
-
-
Honore, P.1
-
151
-
-
84878012703
-
TRPV1 antagonistic analgesic effect: A randomized study of AZD1386 in pain after third molar extraction
-
Quiding, H. et al. TRPV1 antagonistic analgesic effect: a randomized study of AZD1386 in pain after third molar extraction. Pain 154, 808-812 (2013).
-
(2013)
Pain
, vol.154
, pp. 808-812
-
-
Quiding, H.1
-
152
-
-
34047118624
-
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation
-
Gavva, N. R. et al. The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J. Neurosci. 27, 3366-3374 (2007).
-
(2007)
J. Neurosci.
, vol.27
, pp. 3366-3374
-
-
Gavva, N.R.1
-
153
-
-
34447504896
-
Nonthermal activation of transient receptor potential vanilloid?1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors
-
Steiner, A. A. et al. Nonthermal activation of transient receptor potential vanilloid?1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J. Neurosci. 27, 7459-7468 (2007).
-
(2007)
J. Neurosci.
, vol.27
, pp. 7459-7468
-
-
Steiner, A.A.1
-
154
-
-
54349127771
-
Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1
-
Gavva, N. R. Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1. Trends Pharmacol. Sci. 29, 550-557 (2008).
-
(2008)
Trends Pharmacol. Sci.
, vol.29
, pp. 550-557
-
-
Gavva, N.R.1
-
155
-
-
41749117999
-
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans
-
Gavva, N. R. et al. Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain 136, 202-210 (2008).
-
(2008)
Pain
, vol.136
, pp. 202-210
-
-
Gavva, N.R.1
-
156
-
-
75349108628
-
Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia
-
Garami, A. et al. Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia. J. Neurosci. 30, 1435-1440 (2010).
-
(2010)
J. Neurosci.
, vol.30
, pp. 1435-1440
-
-
Garami, A.1
-
157
-
-
84876576815
-
Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia
-
Fischer, M. J., Btesh, J.&McNaughton, P. A. Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia. J. Neurosci. 33, 7407-7414 (2013).
-
(2013)
J. Neurosci.
, vol.33
, pp. 7407-7414
-
-
Fischer, M.J.1
Btesh, J.2
McNaughton, P.A.3
-
158
-
-
77957551184
-
Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist
-
Fosgerau, K. et al. Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. BMC Cardiovasc. Disord. 10, 51 (2010).
-
(2010)
BMC Cardiovasc. Disord.
, vol.10
, pp. 51
-
-
Fosgerau, K.1
-
159
-
-
84892592563
-
Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion
-
Cao, Z., Balasubramanian, A.&Marrelli, S. P. Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. Am. J. Physiol. Regul. Integr. Comp. Physiol. 306, R149-R156 (2014).
-
(2014)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.306
-
-
Cao, Z.1
Balasubramanian, A.2
Marrelli, S.P.3
-
160
-
-
84884280747
-
TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain
-
Liu, B. et al. TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. Pain 154, 2169-2177 (2013).
-
(2013)
Pain
, vol.154
, pp. 2169-2177
-
-
Liu, B.1
-
161
-
-
84863012756
-
Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature
-
Almeida, M. C. et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J. Neurosci. 32, 2086-2099 (2012).
-
(2012)
J. Neurosci.
, vol.32
, pp. 2086-2099
-
-
Almeida, M.C.1
-
162
-
-
36048982077
-
Application of menthol to the skin of whole trunk in mice induces autonomic and behavioral heat-gain responses
-
Tajino, K. et al. Application of menthol to the skin of whole trunk in mice induces autonomic and behavioral heat-gain responses. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293, R2128-R2135 (2007).
-
(2007)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.293
-
-
Tajino, K.1
-
163
-
-
79954576919
-
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
-
Chen, J. et al. Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain 152, 1165-1172 (2011).
-
(2011)
Pain
, vol.152
, pp. 1165-1172
-
-
Chen, J.1
-
164
-
-
77957332682
-
Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels
-
Coste, B. et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330, 55-60 (2010).
-
(2010)
Science
, vol.330
, pp. 55-60
-
-
Coste, B.1
-
165
-
-
55249091085
-
TMEM16A confers receptor-activated calcium-dependent chloride conductance
-
Yang, Y. D. et al. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 455, 1210-1215 (2008).
-
(2008)
Nature
, vol.455
, pp. 1210-1215
-
-
Yang, Y.D.1
-
166
-
-
54949112835
-
TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity
-
Caputo, A. et al. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science 322, 590-594 (2008).
-
(2008)
Science
, vol.322
, pp. 590-594
-
-
Caputo, A.1
-
167
-
-
51549120559
-
Expression cloning of TMEM16A as a calcium-activated chloride channel subunit
-
Schroeder, B. C., Cheng, T., Jan, Y. N.&Jan, L. Y. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 134, 1019-1029 (2008).
-
(2008)
Cell
, vol.134
, pp. 1019-1029
-
-
Schroeder, B.C.1
Cheng, T.2
Jan, Y.N.3
Jan, L.Y.4
-
168
-
-
33744479684
-
CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry
-
Vig, M. et al. CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science 312, 1220-1223 (2006).
-
(2006)
Science
, vol.312
, pp. 1220-1223
-
-
Vig, M.1
-
169
-
-
33646576875
-
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
-
Feske, S. et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 441, 179-185 (2006).
-
(2006)
Nature
, vol.441
, pp. 179-185
-
-
Feske, S.1
-
170
-
-
84888865025
-
Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells
-
Kiyonaka, S. et al. Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells. Nature Methods 10, 1232-1238 (2013).
-
(2013)
Nature Methods
, vol.10
, pp. 1232-1238
-
-
Kiyonaka, S.1
-
171
-
-
83755207202
-
A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels
-
Clapham, D. E.&Miller, C. A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. Proc. Natl Acad. Sci. USA 108, 19492-19497 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 19492-19497
-
-
Clapham, D.E.1
Miller, C.2
-
172
-
-
70449864498
-
Nociceptive signals induce trafficking of TRPA1 to the plasma membrane
-
Schmidt, M., Dubin, A. E., Petrus, M. J., Earley, T. J.&Patapoutian, A. Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron 64, 498-509 (2009).
-
(2009)
Neuron
, vol.64
, pp. 498-509
-
-
Schmidt, M.1
Dubin, A.E.2
Petrus, M.J.3
Earley, T.J.4
Patapoutian, A.5
-
173
-
-
0036183319
-
Molecular basis for species-specific sensitivity to "hot" chili peppers
-
Jordt, S. E.&Julius, D. Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell 108, 421-430 (2002).
-
(2002)
Cell
, vol.108
, pp. 421-430
-
-
Jordt, S.E.1
Julius, D.2
-
174
-
-
33645352477
-
High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol
-
Bandell, M. et al. High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nature Neurosci. 9, 493-500 (2006).
-
(2006)
Nature Neurosci.
, vol.9
, pp. 493-500
-
-
Bandell, M.1
-
175
-
-
33847050898
-
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli
-
Voets, T., Owsianik, G., Janssens, A., Talavera, K.&Nilius, B. TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nature Chem. Biol. 3, 174-182 (2007).
-
(2007)
Nature Chem. Biol.
, vol.3
, pp. 174-182
-
-
Voets, T.1
Owsianik, G.2
Janssens, A.3
Talavera, K.4
Nilius, B.5
-
176
-
-
80054115971
-
Ligand stoichiometry of the cold- and menthol-activated channel TRPM8
-
Janssens, A.&Voets, T. Ligand stoichiometry of the cold- and menthol-activated channel TRPM8. J. Physiol. 589, 4827-4835 (2011).
-
(2011)
J. Physiol.
, vol.589
, pp. 4827-4835
-
-
Janssens, A.1
Voets, T.2
-
177
-
-
33846692923
-
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
-
Macpherson, L. J. et al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445, 541-545 (2007).
-
(2007)
Nature
, vol.445
, pp. 541-545
-
-
Macpherson, L.J.1
-
178
-
-
33845900989
-
TRP channel activation by reversible covalent modification
-
Hinman, A., Chuang, H. H., Bautista, D. M.&Julius, D. TRP channel activation by reversible covalent modification. Proc. Natl Acad. Sci. USA 103, 19564-19568 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 19564-19568
-
-
Hinman, A.1
Chuang, H.H.2
Bautista, D.M.3
Julius, D.4
-
179
-
-
39749169006
-
A single N?terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic
-
Salazar, H. et al. A single N?terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nature Neurosci. 11, 255-261 (2008).
-
(2008)
Nature Neurosci.
, vol.11
, pp. 255-261
-
-
Salazar, H.1
-
180
-
-
34548610605
-
Bimodal action of menthol on the transient receptor potential channel TRPA1
-
Karashima, Y. et al. Bimodal action of menthol on the transient receptor potential channel TRPA1. J. Neurosci. 27, 9874-9884 (2007).
-
(2007)
J. Neurosci.
, vol.27
, pp. 9874-9884
-
-
Karashima, Y.1
-
181
-
-
17144418518
-
Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)
-
McNamara, F. N., Randall, A.&Gunthorpe, M. J. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br. J. Pharmacol. 144, 781-790 (2005).
-
(2005)
Br. J. Pharmacol.
, vol.144
, pp. 781-790
-
-
McNamara, F.N.1
Randall, A.2
Gunthorpe, M.J.3
-
182
-
-
79951775130
-
The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil
-
Everaerts, W. et al. The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Curr. Biol. 21, 316-321 (2011).
-
(2011)
Curr. Biol.
, vol.21
, pp. 316-321
-
-
Everaerts, W.1
-
183
-
-
20144371097
-
The pungency of garlic: Activation of TRPA1 and TRPV1 in response to allicin
-
Macpherson, L. J. et al. The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr. Biol. 15, 929-934 (2005).
-
(2005)
Curr. Biol.
, vol.15
, pp. 929-934
-
-
Macpherson, L.J.1
-
184
-
-
79960580198
-
Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels
-
Yao, J., Liu, B.&Qin, F. Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels. Proc. Natl Acad. Sci. USA 108, 11109-11114 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 11109-11114
-
-
Yao, J.1
Liu, B.2
Qin, F.3
-
185
-
-
77951035804
-
Thermosensitive TRP channel pore turret is part of the temperature activation pathway
-
Yang, F., Cui, Y., Wang, K.&Zheng, J. Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc. Natl Acad. Sci. USA 107, 7083-7088 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 7083-7088
-
-
Yang, F.1
Cui, Y.2
Wang, K.3
Zheng, J.4
-
186
-
-
77952886805
-
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain
-
Grandl, J. et al. Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. Nature Neurosci. 13, 708-714 (2010).
-
(2010)
Nature Neurosci.
, vol.13
, pp. 708-714
-
-
Grandl, J.1
-
187
-
-
51349083674
-
Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor i
-
Valente, P. et al. Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I. FASEB J. 22, 3298-3309 (2008).
-
(2008)
FASEB J.
, vol.22
, pp. 3298-3309
-
-
Valente, P.1
-
188
-
-
34547200183
-
Dissection of the components for PIP2 activation and thermosensation in TRP channels
-
Brauchi, S. et al. Dissection of the components for PIP2 activation and thermosensation in TRP channels. Proc. Natl Acad. Sci. USA 104, 10246-10251 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 10246-10251
-
-
Brauchi, S.1
-
189
-
-
0037443098
-
Functional role of C?terminal cytoplasmic tail of rat vanilloid receptor 1
-
Vlachova, V. et al. Functional role of C?terminal cytoplasmic tail of rat vanilloid receptor 1. J. Neurosci. 23, 1340-1350 (2003).
-
(2003)
J. Neurosci.
, vol.23
, pp. 1340-1350
-
-
Vlachova, V.1
-
190
-
-
84872016342
-
Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli
-
Wang, H., Schupp, M., Zurborg, S.&Heppenstall, P. A. Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli. J. Physiol. 591, 185-201 (2013).
-
(2013)
J. Physiol.
, vol.591
, pp. 185-201
-
-
Wang, H.1
Schupp, M.2
Zurborg, S.3
Heppenstall, P.A.4
|