Transgenic studies of pain and analgesia: Mutation or background genotype?

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 2, 2001, Pages 467-473

  Lariviere, William R ^a   Chesler, Elissa J ^a   Mogil, Jeffrey S ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIA; ANIMAL EXPERIMENT; GENE MUTATION; GENE TARGETING; GENE TECHNOLOGY; GENOTYPE; HYPERSENSITIVITY; INBRED STRAIN; KNOCKOUT GENE; MOUSE; MOUSE STRAIN; NOCICEPTION; NONHUMAN; PAIN; PAIN ASSESSMENT; PHENOTYPE; PRIORITY JOURNAL; REVIEW; TRANSGENIC MOUSE;

ANALGESIA; ANIMALS; ANIMALS, GENETICALLY MODIFIED; MICE; MICE, KNOCKOUT; MUTATION; PAIN;

EID: 0035042044     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (37)

1. Mutant mice and neuroscience: Recommendations concerning genetic background
2. 1Bserotonin receptors
3. Genetics of mouse behavior: Interactions with laboratory environment
4. Enhanced analgesic potency and reduced tolerance of morphine in 129/SvEv mice: Evidence for a deficiency in GM1 ganglioside-regulated excitatory opioid receptor functions
5. Behavioral phenotypes of inbred mouse strains: Implications and recommendations for molecular studies
6. Gene-targeting studies: New methods, old problems
7. Knock-out mice: Possible solutions to the genetic background and flanking gene problem
8. Origins and characteristics of inbred strains of mice
9. Pharmacogenetic variability in neuronal nicotinic receptor-mediated antinociception
10. Gene-targeting studies of mammalia behavior: Is it the mutation or the background genotype?
11. Targeting genes associated with mammalian behavior: Past mistakes and future solutions
12. Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations
13. Genetic correlations between acute morphine sensitivity, tolerance and dependence in inbred mice
14. Sex differences in supraspinal morphine analgesia are dependent on genotype
15. Lack of morphine and enkephalin tolerance in 129/SvEv mice: Evidence for an NMDA receptor defect
16. Genetic correlation of nociception: New findings from additional assays of nociception and hypersensitivity
17. Mice, gene targeting and behaviour: More than just genetic background
18. Gene targeting in C57BL/6 ES cells. Successful germ fine transmission using recipient BALB/c blastocysts developmentally matured in vitro
19. The genetic mediation of individual differences in sensitivity to pain and its inhibition
20. Hot and cold nociception are genetically correlated
21. Transgenic studies of pain
22. Nociceptive and morphine antinociceptive sensitivity of 129 and C57BL/6 inbred mouse strains: Implications for transgenic knock-out studies
23. Heritability of nociception. I. Responses of eleven inbred mouse strains on twelve measures of nociception
24. Heritability of nociception. II. "Types" of nociception revealed by genetic correlation analysis
25. Studies on type II collagen induced arthritis in mice
26. Complications associated with genetic background effects in research using knockout mice
27. Knockout mouse fault lines
28. Strain-dependent epithelial defects in mice lacking the EGF receptor
29. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice
30. Genetic relationships between inbred strains of mice
31. Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype
32. A receptor
33. The effect of genotype on sensitivity to electroacupuncture analgesia
34. The heritability of pain inhibition: Pharmacogenetic mediation of multiple analgesia modalities
35. Manipulating the genome by homologous recombination in embryonic stem cells
36. Gene targeting and behaviour: A genetic problem requires a genetic solution