Specificity of cold thermotransduction is determined by differential ionic channel expression

Nature Neuroscience

Volumn 5, Issue 3, 2002, Pages 254-260

  Viana, Félix ^a   De la Peña, Elvira ^a   Belmonte, Carlos ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MENTHOL; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION;

ALLODYNIA; ANIMAL CELL; ARTICLE; CELL SUBPOPULATION; CHANNEL GATING; COLD SENSATION; COLD SENSITIVITY; CONTROLLED STUDY; COOLING; IN VIVO STUDY; LOW TEMPERATURE; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROPATHIC PAIN; NEUROTRANSMISSION; NEWBORN; NONHUMAN; PAIN; PHARMACOLOGICAL BLOCKING; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY NERVE; SIGNAL TRANSDUCTION; THERMORECEPTOR; TRIGEMINUS GANGLION;

4-AMINOPYRIDINE; ACTION POTENTIALS; ANIMALS; CALCIUM; COLD; MENTHOL; MICE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; SIGNAL TRANSDUCTION; TEMPERATURE SENSE; THERMORECEPTORS; TRIGEMINAL GANGLION;

EID: 0036183242     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn809     Document Type: Article

References (47)

1. Warm and cold specific somatosensory systems. Psychophysical thresholds, reaction times and peripheral conduction velocities
2. Thermosensory activation of insular cortex
3. Nociceptive and thermoreceptive lamina I neurons are anatomically distinct
4. The response of the cold receptors to constant cooling
5. Analysis of cutaneous warm and cold fibres in primates
6. Multiple temperature-sensitive spots innervated by single nerve fibers
7. A quantitative study of sensitive cutaneous thermoreceptors with C afferent fibers
8. Response of sensory units with unmyelinated fibres to mechanical, thermal and chemical stimulation of the cat's cornea
9. Differences between nerve terminal impulses of polymodal nociceptors and cold sensory receptors of the guineapig cornea
10. Thermoreceptors: Recent heat in thermosensation
11. A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin
12. The capsaicin receptor: A heat-activated ion channel in the pain pathway
13. Effect of ouabain and potassium-free solution on mammalian thermosensitive afferents in vitro
14. Functional and structural basis of thermoreception
15. Metabolic dependence of frog cold receptor sensitivity
16. Ionic and metabolic bases of neuronal thermosensitivity
17. Cutaneous temperature receptors
18. TREK-1 is a heat-activated background K(+) channel
19. Cold transduction by inhibition of a background potassium conductance in rat primary sensory neurones
20. Physiology. Cold current in thermoreceptive neurons
21. Structure and function of cold receptors
22. Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea
23. Swelling-activated calcium signalling in cultured mouse primary sensory neurons
24. Sensory neuron-specific actions of capsaicin: Mechanisms and applications
25. Response properties of high-threshold cutaneous cold receptors in the primate
26. Effect of menthol on cold receptor activity. Analysis of receptor processes
27. Menthol and related cooling compounds
28. The sensory effects of l-menthol on human skin
29. Analysis of cold and warm receptor activity in vampire bats and mice
30. Static and dynamic discharge patterns of bursting cold fibers related to hypothetical receptor mechanisms
31. Cutaneous thermoreceptors and thermal nociceptors
32. Functional heterogeneity of dorsal root ganglion cells
33. Queer current and pacemaker: The hyperpolarization-activated cation current in neurons
34. + current in hippocampal neurons
35. Quantitative response characteristics of thermoreceptive and nociceptive lamina I spinothalamic neurons in the cat
36. Molecular and functional properties of two-pore-domain potassium channels
37. Potassium leak channels and the KCNK family of two-P-domain subunits
38. Distribution and expression of TREK-1, a two-pore-domain potassium channel, in the adult rat CNS
39. 4-Aminopyridine and dendrotoxin induce repetitive firing in rat visceral sensory neurones by blocking a slowly inactivating outward current
40. Distinct potassium channels on pain-sensing neurons
41. LEAK between acutely isolated adult rat dorsal root ganglion neurons of different size
42. Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues
43. Function of the hyperpolarization-activated inward rectification in nonmyelinated peripheral rat and human axons
44. H in peripheral mammalian nerve fibres
45. H(+)-gated cation channels: Neuronal acid sensors in the NaC/DEG family of ion channels
46. The molecules of mechanosensation
47. Molecular basis of mechanotransduction in living cells