The neuronal background K2P channels: Focus on TREK1

Nature Reviews Neuroscience

Volumn 8, Issue 4, 2007, Pages 251-261

  Honoré, Eric ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROFORM; CYCLOPROPANE; DESFLURANE; ETHER; FLUOXETINE; HALOTHANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; LINOLENIC ACID; LYSOPHOSPHOLIPID; MEMBRANE RECEPTOR; NITROUS OXIDE; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; RILUZOLE; SEROTONIN UPTAKE INHIBITOR; SEVOFLURANE; TWIK RELATED ACID SENSITIVE POTASSIUM CHANNEL; TWIK RELATED ALKALINE PH ACTIVATED POTASSIUM CHANNEL; TWIK RELATED ARACHIDONIC ACID STIMULATED POTASSIUM CHANNEL; TWIK RELATED ARACHIDONIC ACID STIMULATED POTASSIUM CHANNEL 1; TWIK RELATED ARACHIDONIC ACID STIMULATED POTASSIUM CHANNEL 3; TWIK RELATED ARACHIDONIC ACID STIMULATED POTASSIUM CHANNEL 5; TWIK RELATED POTASSIUM CHANNEL 1; TWIK RELATED POTASSIUM CHANNEL 2; TWIK RELATED SPINAL CORD POTASSIUM CHANNEL; UNCLASSIFIED DRUG; XENON; ANESTHETIC AGENT; NEUROPROTECTIVE AGENT; POTASSIUM CHANNEL PROTEIN TREK 1; POTASSIUM CHANNEL PROTEIN TREK-1; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ALLODYNIA; BRAIN ISCHEMIA; CHANNEL GATING; DEPRESSION; DRUG EFFECT; ELECTRIC POTENTIAL; EXCITOTOXICITY; GENERAL ANESTHESIA; HUMAN; HYPERPOLARIZATION; MAMMAL; MEMBRANE PERMEABILITY; NEUROPROTECTION; NONHUMAN; PAIN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE; REVIEW; SECOND MESSENGER; SEIZURE; SPINAL GANGLION; TEMPERATURE SENSITIVITY; TREATMENT OUTCOME; ANIMAL; GENETICS; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANESTHETICS; ANIMALS; HUMANS; NEUROPROTECTIVE AGENTS; PAIN; POTASSIUM CHANNELS, TANDEM PORE DOMAIN;

EID: 33947360830     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn2117     Document Type: Review

References (98)

1. Castellucci, V. & Kandel, E. R. Presynaptic facilitation as a mechanism for behavioral sensitization in Aplysia. Science 194, 1176-1178 (1976). Study of the neural circuit of the gill-withdrawal reflex in the isolated abdominal ganglion of Aplysia, indicating that short-term sensitization is due to presynaptic facilitation.
2. + channel, which can account for the increases in transmitter release which underlie behavioural sensitization.
3. + current IK(An).
4. Franks, N. P. & Lieb, W. R. Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels. Science 254, 427-430 (1991).
5. Byrne, J. H. & Kandel, E. R. Presynaptic facilitation revisited: state and time dependence. J. Neurosci. 16, 425-435 (1996).
6. + channel. EMBO J. 17, 4283-4290 (1998). Demonstrates that TREK1 shares the functional properties of the Aplysia S channel.
7. 2P channels. Proc. Natl Acad. Sci. USA 103, 6859-6864 (2006).
8. -/-) mice have an increased efficacy of 5-HT neurotransmission and a resistance to depression.
9. + channel involved in polymodal pain perception. EMBO J. 25, 2368-2376 (2006).
10. + channel involved in neuroprotection and general anesthesia. EMBO J. 23, 2684-2695 (2004).
11. 2P channels TASK and TREK1 are activated by volatile general anaesthetics. Chloroform, diethyl ether, halothane and isoflurane activate TREK1, whereas only halothane and isoflurane activate TASK.
12. + channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane. Mol. Pharmacol. 65, 443-452 (2004).
13. Hervieu, G. J. et al. Distribution and expression of TREK-1, a two-pore-domain potassium channel, in the adult rat CNS. Neuroscience 103, 899-919 (2001).
14. Medhurst, A. D. et al. Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Mol. Brain Res. 86, 101-114 (2001).
15. + channel. EMBO J. 15, 6854-6862 (1996).
16. Talley, E. M., Solorzano, G., Lei, Q., Kim, D. & Bayliss, D. A. CNS distribution of members of the two-pore-domain (KCNK) potassium channel family. J. Neurosci. 21, 7491-7505 (2001).
17. + channels. Trends Neurosci. 24, 339-346 (2001).
18. Lesage, F. & Lazdunski, M. Molecular and functional properties of two-pore-domain potassium channels. Am. J. Physiol. Renal. Physiol. 279, F793-F801 (2000).
19. Goldstein, S. A. N., Bockenhauer, D., O'Kelly, I. & Zilberg, N. Potassium leak channels and the KCNK family of two-P-domain subunits. Nature Rev. Neurosci. 2, 175-184 (2001).
20. Talley, E. M., Sirois, J. E., Lei, Q. & Bayliss, D. A. Two-pore-domain (KCNK) potassium channels: dynamic roles in neuronal function. Neuroscientist 9, 46-56 (2003).
21. + channels. Trends Pharmacol. Sci. 24, 648-654 (2003).
22. + conduction and selectivity. Science 280, 69-77 (1998). Uses x-ray analysis to reveal that four identical KcsA subunits create an inverted teepee, or cone, cradling the selectivity filter of the pore in its outer end. The narrow selectivity filter is only 12 angstroms long, whereas the remainder of the pore is wider and lined with hydrophobic amino acids.
23. + channels-molecular sensors. Biochim. Biophys. Acta 1566, 152-161 (2002).
24. + channels. Curr. Opin. Cell Biol. 13, 422-428 (2001).
25. Czirjak, G. & Enyedi, P. Formation of functional heterodimers between the TASK-1 and TASK-3 two pore domain potassium channel subunits. J. Biol. Chem. 277, 5436-5432 (2001).
26. Kang, D., Han, J., Talley, E. M., Bayliss, D. A. & Kim, D. Functional expression of TASK-1/TASK-3 heteromers in cerebellar granule cells. J. Physiol. 554, 64-77 (2004).
27. Xian Tao, L. et al. The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle. Cardiovasc. Res. 69, 86-97 (2006).
28. Bockenhauer, D., Zilberberg, N. & Goldstein, S. A. KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nature Neurosci. 4, 486-491 (2001).
29. + channel with two pore domains and novel gating properties. J. Biol. Chem. 271, 4183-4187 (1996).
30. Reid, J. D. et al. The S. cerevisiae outwardly-rectifying potassium channel (DUK1) identifies a new family of channels with duplicated pore domains. Recept. Channels 4, 51-62 (1996).
31. + channel in the plasma membrane of yeast. FEBS Lett. 373, 170-176 (1995).
32. Ketchum, K. A., Joiner, W. J., Sellers, A. J., Kaczmarek, L. K. & Goldstein, S. A. N. A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature 376, 690-695 (1995).
33. 2P channel subunit TWIK1.
34. + channel to sense external pH variations near physiological pH. EMBO J. 16, 5464-5471 (1997).
35. Goldstein, S. A., Price, L. A., Rosenthal, D. N. & Pausch, M. H. ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA 93, 13256-13261 (1996).
36. + channel activated by arachidonic acid and polyunsaturated fatty acid. EMBO J. 17, 3297-3308 (1998).
37. Reyes, R. et al. Cloning and expression of a novel pH-sensitive two pore domain potassium channel from human kidney. J. Biol. Chem. 273, 30863-30869 (1998).
38. q protein-coupled receptors. J. Biol. Chem. 275, 28398-28405 (2000).
39. Hille, B. Ion Channels of Excitable Membranes (Sinauer, Sunderland, Massachusetts, 1992).
40. Ilan, N. & Goldstein, S. A. Kcnko: single, cloned potassium leak channels are multi-ion pores. Biophys. J. 80, 241-253 (2001).
41. + channel. Biochem. Biophys. Res. Commun. 292, 339-346 (2002).
42. Lopes, C. M., Gallagher, P. G., Buck, M. E., Butler, M. H. & Goldstein, S. A. Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. J. Biol. Chem. 275, 16969-16978 (2000).
43. + conductance. A C-terminal positively charged cluster is the phospholipid-sensing domain that interacts with the plasma membrane.
44. + channels. Anesthesiology 95, 1013-1025 (2001).
45. Maylie, J. & Adelman, J. P. Beam me up, Scottie! TREK channels swing both ways. Nature Neurosci. 4, 457-458 (2001).
46. + Channels. J. Physiol. 564, 117-129 (2005).
47. + channel. EMBO J. 19, 2483-2491 (2000).
48. + channel TREK-1. EMBO J. 21, 2968-2976 (2002).
49. + channels TREK-2 and TRAAK. J. Physiol. 564, 103-116 (2005).
50. Maingret, F., Patel, A. J., Lesage, F., Lazdunski, M. & Honoré, E. Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J. Biol. Chem. 274, 26691-26696 (1999).
51. 2P channel TREK-1 and the actin cytoskeleton. EMBO Rep. 6, 642-648 (2005).
52. + channels into open leak channels. EMBO J. 25, 5864-5872 (2006).
53. Murbartian, J., Lei, Q., Sando, J. J. & Bayliss, D. A. Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels. J. Biol. Chem. 280, 30175-30184 (2005).
54. Sheetz, M. P. & Singer, S. J. Biological membranes as bilayer couples. A molecular mechanism of drug-erythocyte interactions. Proc. Natl Acad. Sci. USA 71, 4457-4461 (1974). Shows that membranes whose polar lipids are distributed asymmetrically in the two halves of the membrane bilayer can act as bilayer couples, that is, the two halves can respond differently to a perturbation. This hypothesis is applied to the interactions of amphipathic drugs with human erythrocytes.
55. Martinac, B., Adler, J. & Kung, C. Mechanosensitive ion channels of E. coli activated by amphipaths. Nature 348, 261-263 (1990).
56. i. Pflugers Arch. 2001, 952-960 (2001).
57. + channels by pressure, free fatty acids and alkali. Pflugers Arch. 442, 64-72 (2001).
58. + channels TREK-1 and TRAAK. J. Biol. Chem. 275, 10128-10133 (2000).
59. + channels. J. Biol. Chem. 280, 4415-4421 (2005).
60. + channels. EMBO J. 22, 5403-5411 (2003).
61. Koh, S. D. et al. TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase. J. Biol. Chem. 47, 44338-44346 (2001).
62. Kennard, L. E. et al. Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine. Br. J. Pharmacol. 144, 821-829 (2005).
63. 2P channels and their role in general anaesthesia and neuroprotection. Trends Pharmacol. Sci. 25, 601-608 (2004).
64. + channels: an important target for volatile anesthetics? Nature Neurosci. 2, 395-396 (1999).
65. Harinath, S. & Sikdar, S. K. Trichloroethanol enhances the activity of recombinant human TREK-1 and TRAAK channels. Neuropharmacology 46, 750-760 (2004).
66. + channel TREK-1 is resistant to hypoxia: implication for ischaemic neuroprotection. J. Physiol. 562, 213-222 (2005).
67. Caley, A. J., Gruss, M. & Franks, N. P. The effects of hypoxia on the modulation of human TREK-1 potassium channels. J. Physiol. 562, 205-212 (2004).
68. Blondeau, N., Widmann, C., Lazdunski, M. & Heurteaux, C. Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience 109, 231-241 (2002).
69. Blondeau, N., Lauritzen, I., Widmann, C., Lazdunski, M. & Heurteaux, C. A potent protective role of lysophospholipids against global cerebral ischemia and glutamate excitotoxicity in neuronal cultures. J. Cereb. Blood Flow Metab. 22, 821-834 (2002).
70. Lang-Lazdunski, L., Blondeau, N., Jarretou, G., Lazdunski, M. & Heurteaux, C. Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. J. Vasc. Surg. 38, 564-575 (2003).
71. Lauritzen, I. et al. Poly-unsaturated fatty acids are potent neuroprotectors. EMBO J. 19, 1784-1793 (2000).
72. + channels TREK-1 and TRAAK. Mol. Pharmacol. 57, 906-912 (2000).
73. Clapham, D. E. TRP channels as cellular sensors. Nature 426, 517-524 (2003).
74. Nilius, B., Owsianik, G., Voets, T. & Peters, J. A. Transient receptor potential cation channels in disease. Physiol. Rev. 87, 165-217 (2007).
75. Gordon, J. A. & Hen, R. TREKing toward new antidepressants. Nature Neurosci. 9, 1081-1083 (2006).
76. + channel. J. Biol. Chem. 274, 1381-1387 (1999).
77. Byrne, J. H. & Kandel, E. R. Presynaptic facilitation revisited: state and time dependence. J. Neurosci. 16, 425-435 (1996).
78. + channels of Aplysia sensory neurones in cell-free membrane patches. Nature 313, 392-395 (1985).
79. Sweatt, D. J. et al. FMRFamide reverses protein phosphorylation produced by 5-HT and cAMP in Aplysia sensory neurons. Nature 342, 275-278 (1989).
80. + channels. Nature 325, 153-156 (1987). Demonstrates that FMRFamide produces two actions on the S channel; it increases the probability of opening of the S channels via a cAMP-independent second-messenger system, and it reverses the closures of S channels produced by serotonin or cAMP.
81. Hamill, O. P. & Martinac, B. Molecular basis of mechanotransduction in living cells. Physiol. Rev. 81, 685-740 (2001).
82. Sachs, F. & Morris, C. E. Mechanosensitive ion channels in nonspecialized cells. Rev. Physiol. Biochem. Pharmacol. 132, 1-77 (1998).
83. Kung, C. A possible unifying principle for mechanosensation. Nature 436, 647-654 (2005).
84. Kloda, A., Ghazi, A. & Martinac, B. C-terminal charged cluster of MscL, RKKEE, functions as a pH sensor. Biophys. J. 90, 1992-1998 (2006).
85. Wei, A., Jegla, T. & Salkoff, L. Eight potassium channel families revealed by the C. elegans genome project. Neuropharmacology 35, 805-829 (1996).
86. 2+ dependency. EMBO J. 16, 2565-2575 (1997).
87. + channel expressed in brainstem respiratory neurons. Respir. Physiol. 129, 159-174 (2001).
88. + channel, is modulated by multiple neurotransmitters in motoneurons. Neuron 25, 399-410 (2000).
89. Talley, E. M. & Bayliss, D. A. Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action. J. Biol. Chem. 277, 17733-17742 (2002).
90. + channel (cTBAK-1). Circ. Res. 82, 513-518 (1998).
91. Lesage, F. Pharmacology of neuronal background potassium channels. Neuropharmacology 44, 1-7 (2003).
92. Plant, L. D., Rajan, S. & Goldstein, S. A. K2P channels and their protein partners. Curr. Opin. Neurobiol. 15, 326-333 (2005).
93. 2P1. Cell 121, 37-47 (2005).
94. + channel with EFA6, a GDP/GTP exchange factor for ARF6. EMBO Rep. 5, 1171-1175 (2004).
95. + channel, TASK-1. EMBO J. 21, 4439-4448 (2002).
96. Renigunta, V. et al. The retention factor p11 confers an endoplasmic reticulum-localization signal to the potassium channel TASK-1. Traffic 7, 168-181 (2006).
97. O'Kelly, I., Butler, M. H., Zilberberg, N. & Goldstein, S. A. Forward transport: 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals. Cell 111, 577-588 (2002).
98. Hsu, K., Seharaseyon, J., Dong, P., Bour, S. & Marban, E. Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel. Mol. Cell 14, 259-267 (2004).